LOCUS       NM_181387                978 bp    mRNA    linear   ROD 20-FEB-2024
DEFINITION  Rattus norvegicus LHFPL tetraspan subfamily member 4 (Lhfpl4),
            mRNA.
ACCESSION   NM_181387
VERSION     NM_181387.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 978)
  AUTHORS   Wu,M., Tian,H.L., Liu,X., Lai,J.H.C., Du,S. and Xia,J.
  TITLE     Impairment of Inhibitory Synapse Formation and Motor Behavior in
            Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4
  JOURNAL   Cell Rep 23 (6), 1691-1705 (2018)
   PUBMED   29742426
REFERENCE   2  (bases 1 to 978)
  AUTHORS   Davenport,E.C., Pendolino,V., Kontou,G., McGee,T.P., Sheehan,D.F.,
            Lopez-Domenech,G., Farrant,M. and Kittler,J.T.
  TITLE     An Essential Role for the Tetraspanin LHFPL4 in the
            Cell-Type-Specific Targeting and Clustering of Synaptic GABAA
            Receptors
  JOURNAL   Cell Rep 21 (1), 70-83 (2017)
   PUBMED   28978485
  REMARK    GeneRIF: The results establish LHFPL4 as a synapse-specific
            tetraspanin essential for inhibitory synapse function and provide
            fresh insights into the molecular make-up of inhibitory synapses.
REFERENCE   3  (bases 1 to 978)
  AUTHORS   Yamasaki,T., Hoyos-Ramirez,E., Martenson,J.S., Morimoto-Tomita,M.
            and Tomita,S.
  TITLE     GARLH Family Proteins Stabilize GABAA Receptors at Synapses
  JOURNAL   Neuron 93 (5), 1138-1152 (2017)
   PUBMED   28279354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000148.1 and AY278321.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_181387.4.
            
            On Mar 30, 2023 this sequence version replaced NM_181387.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY278321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JACYVU010000148.1  43669975-43670075   c
            102-321             JACYVU010000148.1  43668857-43669076   c
            322-538             AY278321.1         322-538
            539-588             JACYVU010000148.1  43668591-43668640   c
            589-657             JACYVU010000148.1  43651308-43651376   c
            658-740             AY278321.1         658-740
            741-825             JACYVU010000148.1  43651138-43651222   c
            826-978             JACYVU010000148.1  43647112-43647264   c
FEATURES             Location/Qualifiers
     source          1..978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..978
                     /gene="Lhfpl4"
                     /note="LHFPL tetraspan subfamily member 4"
                     /db_xref="GeneID:353230"
                     /db_xref="RGD:727967"
     exon            1..101
                     /gene="Lhfpl4"
                     /inference="alignment:Splign:2.1.0"
     exon            102..588
                     /gene="Lhfpl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..926
                     /gene="Lhfpl4"
                     /note="HMGIC fusion partner-like protein 4; lipoma HMGIC
                     fusion partner-like protein 4; lipoma HMGIC fusion
                     partner-like 4 protein"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 4 protein"
                     /protein_id="NP_852052.2"
                     /db_xref="GeneID:353230"
                     /db_xref="RGD:727967"
                     /translation="MLPSQEASKLYHDTTCGDSRAIGVLWAIFTICFAIINVVVFIQP
                     YWVGDSVSTPKPGYFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLS
                     MVLILGCITCFALFFFCNTATVYKICAWMQLLAALCRVLGCMIFPEGWDAETILEMCG
                     AKTGKYSLGDCSVRWAYILAIIGILNALILSFLAFVLGNRQTDLLQEELKQENKDFVG
                     TTVSSVLRPGGDVSGWGVLPCPVAHTQGP"
     exon            589..825
                     /gene="Lhfpl4"
                     /inference="alignment:Splign:2.1.0"
     exon            826..978
                     /gene="Lhfpl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggacg ccgcctgagc cacggcaacc gctgtcagga cgcatcgagc cccggagctt
       61 gagccctgcc ggtcccggat cagccgcccg actcggccca gctcccgccc cgcatcccgg
      121 tggtcagtcc tgggccggcg gcccctgtca gccgccgacg gccggccccg cccccgggca
      181 ccatgctgcc ctcgcaggag gcctccaagc tctaccatga cactacatgc ggagactcgc
      241 gggccatcgg cgtgctgtgg gccatcttca ccatctgctt cgccatcatc aacgtggtgg
      301 tcttcatcca gccctactgg gtaggcgaca gcgtgagcac tcccaagcct ggctacttcg
      361 gcctcttcca ctactgcgtg ggcagcgggc tagcgggccg cgagctcacc tgccggggtt
      421 ctttcaccga cttcagcacc atcccgtcca gcgccttcaa ggcggccgcc ttcttcgtgt
      481 tgctttccat ggtgctgatt ctcggctgca tcacctgctt cgctcttttc ttcttctgca
      541 acaccgccac tgtctacaag atctgcgcct ggatgcagct cctggcagcc ctgtgccgcg
      601 tcttgggctg catgatcttc cctgaaggct gggatgctga gaccattctg gaaatgtgcg
      661 gggccaagac ggggaagtac tccctggggg actgttcggt gcgctgggcg tacattctgg
      721 ccattatcgg catcctcaac gcgctcatcc tgtccttcct cgccttcgtg ctgggcaacc
      781 ggcagacgga cctgctgcag gaggagctca aacaggagaa caaagatttt gtgggcacta
      841 cagtaagttc cgtgctgcgg ccaggaggtg atgtctccgg ttggggagtc ctaccatgcc
      901 ctgttgctca cacacaggga ccctgaaagc ccgggttgta gttccggagt tggcctgacc
      961 tcagcatatc ctgtctgc
//
