LOCUS       NM_012978               2907 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus luteinizing hormone/choriogonadotropin receptor
            (Lhcgr), mRNA.
ACCESSION   NM_012978
VERSION     NM_012978.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2907)
  AUTHORS   Zheng,C., Gulappa,T., Menon,B. and Menon,K.M.J.
  TITLE     Association between LH receptor regulation and ovarian
            hyperstimulation syndrome in a rodent model
  JOURNAL   Reproduction 160 (2), 239-245 (2020)
   PUBMED   32422603
  REMARK    GeneRIF: Association between LH receptor regulation and ovarian
            hyperstimulation syndrome in a rodent model.
REFERENCE   2  (bases 1 to 2907)
  AUTHORS   Ameli,M., Moghimian,M., Saeb,F., Bashtani,E., Shokoohi,M.,
            Salimnejad,R. and Abtahi,H.
  TITLE     The effect of clomiphene citrate and human chorionic gonadotropin
            on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as
            well as the structural changes in testicular tissue of adult rats
  JOURNAL   Mol Reprod Dev 86 (6), 738-748 (2019)
   PUBMED   31041823
  REMARK    GeneRIF: The effect of clomiphene citrate and human chorionic
            gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and
            SF1 genes, as well as the structural changes in testicular tissue
            of adult rats.
REFERENCE   3  (bases 1 to 2907)
  AUTHORS   Gulappa,T., Menon,B. and Menon,K.M.J.
  TITLE     LHCGR Expression During Follicle Stimulating Hormone-Induced
            Follicle Growth Is Negatively Regulated by Eukaryotic Initiation
            Factor 5A
  JOURNAL   Endocrinology 158 (8), 2672-2679 (2017)
   PUBMED   28605466
  REMARK    GeneRIF: The results of this study support the notion that by
            inhibiting eIF5A hypusination, FSH reduces the expression of an
            LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR
            mRNA expression by abrogating the inhibitory action of LRBP.
REFERENCE   4  (bases 1 to 2907)
  AUTHORS   Menon,B., Gulappa,T. and Menon,K.M.
  TITLE     Molecular regulation of LHCGR expression by miR-122 during follicle
            growth in the rat ovary
  JOURNAL   Mol Cell Endocrinol 442, 81-89 (2017)
   PUBMED   27940300
  REMARK    GeneRIF: MiR-122 plays a regulatory role in LHCGR expression.
REFERENCE   5  (bases 1 to 2907)
  AUTHORS   Nakao,K., Kishi,H., Imai,F., Suwa,H., Hirakawa,T. and Minegishi,T.
  TITLE     TNF-alpha Suppressed FSH-Induced LH Receptor Expression Through
            Transcriptional Regulation in Rat Granulosa Cells
  JOURNAL   Endocrinology 156 (9), 3192-3202 (2015)
   PUBMED   26125466
  REMARK    GeneRIF: interaction of NF-kappaB p65 with histone deacetylase in
            the promoter region of Lhcgr might be responsible for TNF-alpha
            action on the regulation of LH receptor
REFERENCE   6  (bases 1 to 2907)
  AUTHORS   Aatsinki,J.T., Pietila,E.M., Lakkakorpi,J.T. and Rajaniemi,H.J.
  TITLE     Expression of the LH/CG receptor gene in rat ovarian tissue is
            regulated by an extensive alternative splicing of the primary
            transcript
  JOURNAL   Mol Cell Endocrinol 84 (1-2), 127-135 (1992)
   PUBMED   1353463
REFERENCE   7  (bases 1 to 2907)
  AUTHORS   Ji,I. and Ji,T.H.
  TITLE     Asp383 in the second transmembrane domain of the lutropin receptor
            is important for high affinity hormone binding and cAMP production
  JOURNAL   J Biol Chem 266 (23), 14953-14957 (1991)
   PUBMED   1714448
REFERENCE   8  (bases 1 to 2907)
  AUTHORS   Koo,Y.B., Ji,I., Slaughter,R.G. and Ji,T.H.
  TITLE     Structure of the luteinizing hormone receptor gene and multiple
            exons of the coding sequence
  JOURNAL   Endocrinology 128 (5), 2297-2308 (1991)
   PUBMED   2019252
REFERENCE   9  (bases 1 to 2907)
  AUTHORS   Rodriguez,M.C. and Segaloff,D.L.
  TITLE     The orientation of the lutropin/choriogonadotropin receptor in rat
            luteal cells as revealed by site-specific antibodies
  JOURNAL   Endocrinology 127 (2), 674-681 (1990)
   PUBMED   1695568
REFERENCE   10 (bases 1 to 2907)
  AUTHORS   Bernard,M.P., Myers,R.V. and Moyle,W.R.
  TITLE     Cloning of rat lutropin (LH) receptor analogs lacking the soybean
            lectin domain
  JOURNAL   Mol Cell Endocrinol 71 (3), R19-R23 (1990)
   PUBMED   1976554
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            [WARNING] On Aug 7, 2024 this sequence was replaced by NM_012978.3.
            
            On Nov 27, 2020 this sequence version replaced NM_012978.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M26199.1, SRR26643429.22316.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000006.1  11415415-11415630
            217-288             JAXUCZ010000006.1  11433655-11433726
            289-363             JAXUCZ010000006.1  11435933-11436007
            364-438             JAXUCZ010000006.1  11438616-11438690
            439-513             JAXUCZ010000006.1  11440902-11440976
            514-591             JAXUCZ010000006.1  11441065-11441142
            592-660             JAXUCZ010000006.1  11448105-11448173
            661-735             JAXUCZ010000006.1  11451209-11451283
            736-921             JAXUCZ010000006.1  11453785-11453970
            922-1002            JAXUCZ010000006.1  11457161-11457241
            1003-2907           JAXUCZ010000006.1  11476157-11478061
FEATURES             Location/Qualifiers
     source          1..2907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2907
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /note="luteinizing hormone/choriogonadotropin receptor"
                     /db_xref="GeneID:25477"
                     /db_xref="RGD:3007"
     exon            1..216
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2146
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /note="LH receptor; lutropin-choriogonadotropic hormone
                     receptor; luteinizing hormone receptor; LH/CG receptor;
                     luteinizing hormone/chorionic gonadotropin receptor"
                     /codon_start=1
                     /product="lutropin-choriogonadotropic hormone receptor
                     precursor"
                     /protein_id="NP_037110.1"
                     /db_xref="GeneID:25477"
                     /db_xref="RGD:3007"
                     /translation="MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDG
                     ALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLL
                     NLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEIC
                     DNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMH
                     SGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVAT
                     LTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWD
                     YDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSR
                     YKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFT
                     VFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVG
                     ISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPN
                     KDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANP
                     FLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATL
                     KLSTVHCQQPIPPRALTH"
     exon            217..288
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            289..363
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            364..438
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            439..513
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            514..591
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            592..660
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            661..735
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            736..921
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1002
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..2907
                     /gene="Lhcgr"
                     /gene_synonym="LH/CG-R; Lhr; LSH-R; LSHR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atactggctc aacctcggga gctcacactc aggctggcgg gccatggggc ggcgagtccc
       61 agctctgaga cagctgctgg tgctggcagt gctgctgctg aagccttcac agctgcagtc
      121 ccgagagctg tcagggtcgc gctgccccga gccctgcgac tgcgcaccgg atggcgccct
      181 gcgctgtcct ggccctcgag ccggcctcgc cagactatct ctcacctatc tccctgtcaa
      241 agtaattcca tcacaagctt tcaggggact taatgaggtc gtaaaaattg aaatctctca
      301 gagtgattcc ctggaaagga tagaagctaa tgcctttgac aacctcctca atttgtctga
      361 actactgatc cagaacacca aaaacctgct atacattgaa cctggtgctt ttacaaacct
      421 ccctcggtta aaatacctga gcatctgtaa cacaggcatc cgaacccttc cagatgttac
      481 gaagatctcc tcctctgaat ttaatttcat tctggaaatc tgtgataact tacacataac
      541 caccataccc gggaatgctt tccaagggat gaataacgag tctgtcacac taaaactgta
      601 tggaaatgga tttgaagaag tacaaagcca tgcattcaat gggacgactc taatctcgct
      661 ggagctaaaa gaaaacatct acctggagaa gatgcacagt ggagccttcc agggggccac
      721 ggggcccagc atcctggata tttcttccac caaattgcag gccctgccga gccacgggct
      781 ggagtccatt cagacgctca tcgccctgtc ttcctactca ctgaaaacac tgccctccaa
      841 agaaaaattc acgagcctcc tggtcgccac gctgacctac cccagccact gctgcgcctt
      901 caggaatttg ccgaagaaag aacagaattt ttcattttcc atttttgaaa acttctccaa
      961 acaatgcgaa agcacagtta gaaaagcaga taacgagacg ctttattccg ccatctttga
     1021 ggagaatgaa ctcagtggct gggattatga ttatggcttc tgttcaccca agacactcca
     1081 atgtgctcca gaaccagatg ctttcaaccc ctgtgaagat attatgggct atgccttcct
     1141 tagggtcctg atttggctga ttaatatact agccatcttt ggcaacctga cagtcctctt
     1201 tgttctcctg accagtcgtt ataaactgac agtgccccgc ttcctcatgt gtaatctctc
     1261 ctttgcagac ttttgcatgg ggctctacct gctgctcatt gcctccgtgg actcccaaac
     1321 aaaaggccag tactataacc acgccataga ctggcagaca gggagtggct gcggtgcagc
     1381 tggcttcttt actgtgtttg ccagtgaact ctctgtctac accctgacgg ttatcaccct
     1441 ggaaaggtgg cacaccatca cctatgctgt acagctagac caaaagctaa gactgaggca
     1501 tgccatccca attatgctcg gaggatggct cttttctacg ctgatcgcca cgatgcccct
     1561 tgtgggtatc agcaattaca tgaaggtcag catctgcctc cccatggatg tggaatccac
     1621 tctgtcccaa gtctacatat tatccatctt aatcctcaac gtggtggcct tcgtcgtcat
     1681 ctgtgcttgc tacattagga tctactttgc agttcaaaat ccagagctga cagctcctaa
     1741 caaggacaca aaaattgcta agaagatggc catcctcatc ttcacagact tcacgtgcat
     1801 ggcgcccatc tctttctttg ccatctcggc tgccttcaaa gtgcccctta tcactgtcac
     1861 caactcgaaa atcttactgg tcctttttta tcctgtcaat tcttgtgcca atccatttct
     1921 gtatgcgatc ttcacgaagg cgtttcagag agatttcctt ctgctgctga gccgattcgg
     1981 ctgctgtaaa cgccgggcgg agctttacag aaggaaggaa ttttctgcat atacttccaa
     2041 ctgcaaaaat ggcttcccag gagcaagtaa gccgtcccag gctaccctga agttgtccac
     2101 agtgcactgt caacagccca taccaccgag agcgttaact cactagcatt acaaaattgt
     2161 gcctaaatat gttttttaaa aagtgtttta gaaaaatatt tatccttagg cacttcagga
     2221 gaattgtacc tgcttcagag gacggcctat aacacttggt cacataagtt tcaggaaggt
     2281 ttagaaattt ttatagtaat ttaggcagaa taattttttg ttgaatctaa tactaaggaa
     2341 atctaagttg tcatttttca cgtctctgac atttttcatt tcaatcttgt gatttacatt
     2401 gtaatctcca aatatattac ttcatagcag attgaaaatt taaactggtc tttgtcctca
     2461 gatagtttga taaatatatt caagagatgc actgtgcagt gtgactgcta gccttgcatg
     2521 gtaaatagaa gtttcttagc catattccaa gtgcttcaca tgtcacacta ggaggcacag
     2581 atgcaaactg tttacatcag tgcaaggaat tctattagcc agctctattc tagagacttc
     2641 tatttcccat tgacactctg cttaactttc catctgaagg cacatgctgc atatttgttt
     2701 ggcttacaga tcatgagtac ctcatggcca ggagcccatc tcagcccatc ttgttcctcg
     2761 tctatctcag gatcttggaa atgctacaca gcaagcatgc ctagccagtt aaactcccta
     2821 aatctacaca ggaaaatatt tctaccacct tagcatattg ttttcgatga ttacatgctt
     2881 tctgtatttt gccctcctcc tagtatc
//
