LOCUS       NM_012858                533 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus luteinizing hormone subunit beta (Lhb),
            transcript variant 1, mRNA.
ACCESSION   NM_012858
VERSION     NM_012858.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 533)
  AUTHORS   Gajewska,A., Herman,A.P., Wolinska-Witort,E., Kochman,K. and
            Zwierzchowski,L.
  TITLE     In vivo oestrogenic modulation of Egr1 and Pitx1 gene expression in
            female rat pituitary gland
  JOURNAL   J Mol Endocrinol 53 (3), 355-366 (2014)
   PUBMED   25258388
  REMARK    GeneRIF: Orchestrated Egr1 and Pitx1 activities depending on
            specific central and peripheral regulatory inputs could be
            responsible for physiologically variable Lhb gene promoter
            activation in vivo.
REFERENCE   2  (bases 1 to 533)
  AUTHORS   Fortin,J., Boehm,U., Deng,C.X., Treier,M. and Bernard,D.J.
  TITLE     Follicle-stimulating hormone synthesis and fertility depend on
            SMAD4 and FOXL2
  JOURNAL   FASEB J 28 (8), 3396-3410 (2014)
   PUBMED   24739304
REFERENCE   3  (bases 1 to 533)
  AUTHORS   Jablonka-Shariff,A. and Boime,I.
  TITLE     A novel carboxyl-terminal heptapeptide initiates the regulated
            secretion of LH from unique sub-domains of the ER
  JOURNAL   PLoS One 8 (5), e65002 (2013)
   PUBMED   23734233
  REMARK    GeneRIF: data suggest that the molecular decision for LHbeta
            subunit to enter the regulated secretory pathway is a pre-Golgi
            event controlled by the C-terminal heptapeptide.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 533)
  AUTHORS   Andrade,J., Quinn,J., Becker,R.Z. and Shupnik,M.A.
  TITLE     AMP-activated protein kinase is a key intermediary in
            GnRH-stimulated LHbeta gene transcription
  JOURNAL   Mol Endocrinol 27 (5), 828-839 (2013)
   PUBMED   23518923
  REMARK    GeneRIF: GnRH stimulates AMPK, and AMPK inhibition suppresses
            GnRH-stimulated LHbeta transcription.
REFERENCE   5  (bases 1 to 533)
  AUTHORS   Abtahi,H., Shabani,M., Jameie,S.B., Zarnani,A.H., Talebi,S.,
            Lakpour,N., Heidari-Vala,H., Edalatkhah,H., Akhondi,M.A., Amiri,M.,
            Mahmoudi,A.R. and Sadeghi,M.R.
  TITLE     Regulation of luteinizing hormone receptor in hippocampal neurons
            following different long-lasting treatments of castrated adult rats
  JOURNAL   Indian J Exp Biol 51 (3), 218-227 (2013)
   PUBMED   23678542
  REMARK    GeneRIF: increased LH concentration induces production of
            incomplete LHR transcripts in hippocampal cells and decreases
            immature LHR at the protein level
REFERENCE   6  (bases 1 to 533)
  AUTHORS   Kaiser,U.B., Sabbagh,E., Chen,M.T., Chin,W.W. and Saunders,B.D.
  TITLE     Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene
            promoter and mediates gonadotropin-releasing hormone-stimulated
            expression of the LHbeta subunit gene
  JOURNAL   J Biol Chem 273 (21), 12943-12951 (1998)
   PUBMED   9582327
REFERENCE   7  (bases 1 to 533)
  AUTHORS   Zhang,F.P., Rannikko,A. and Huhtaniemi,I.
  TITLE     Isolation and characterization of testis-specific cDNAs for
            luteinizing hormone beta-subunit in the rat
  JOURNAL   Biochem Biophys Res Commun 210 (3), 858-865 (1995)
   PUBMED   7763258
REFERENCE   8  (bases 1 to 533)
  AUTHORS   Jameson,L., Chin,W.W., Hollenberg,A.N., Chang,A.S. and Habener,J.F.
  TITLE     The gene encoding the beta-subunit of rat luteinizing hormone.
            Analysis of gene structure and evolution of nucleotide sequence
  JOURNAL   J Biol Chem 259 (24), 15474-15480 (1984)
   PUBMED   6096374
REFERENCE   9  (bases 1 to 533)
  AUTHORS   Kourides,I.A., Gurr,J.A. and Wolf,O.
  TITLE     The regulation and organization of thyroid stimulating hormone
            genes
  JOURNAL   Recent Prog Horm Res 40, 79-120 (1984)
   PUBMED   6207569
  REMARK    Review article
REFERENCE   10 (bases 1 to 533)
  AUTHORS   Chin,W.W., Godine,J.E., Klein,D.R., Chang,A.S., Tan,L.K. and
            Habener,J.F.
  TITLE     Nucleotide sequence of the cDNA encoding the precursor of the beta
            subunit of rat lutropin
  JOURNAL   Proc Natl Acad Sci U S A 80 (15), 4649-4653 (1983)
   PUBMED   6192440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB566905.1, V01542.1 and BG379148.1.
            
            On Oct 6, 2005 this sequence version replaced NM_012858.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: V01542.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CB566905.1         4-12
            10-515              V01542.1           2-507
            516-533             BG379148.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..533
                     /gene="Lhb"
                     /note="luteinizing hormone subunit beta"
                     /db_xref="GeneID:25329"
                     /db_xref="RGD:3006"
     exon            1..25
                     /gene="Lhb"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..436
                     /gene="Lhb"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lutropin subunit beta; LH-B; LSH-B; LSH-beta;
                     lutropin beta chain; luteinizing hormone beta polypeptide;
                     Luteinizing hormone (lutropin) subunit beta; luteinizing
                     hormone beta subunit"
                     /codon_start=1
                     /product="lutropin subunit beta isoform 1 precursor"
                     /protein_id="NP_036990.1"
                     /db_xref="GeneID:25329"
                     /db_xref="RGD:3006"
                     /translation="MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCP
                     VCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELRFASVRLPGCPPGVDPIVSF
                     PVALSCRCGPCRLSSSDCGGPRTQPMTCDLPHLPGLLLF"
     exon            26..193
                     /gene="Lhb"
                     /inference="alignment:Splign:2.1.0"
     exon            194..516
                     /gene="Lhb"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      516
                     /gene="Lhb"
                     /note="polyA addition site"
ORIGIN      
        1 ggtatcaaga atggagaggc tccaggggct gctgctgtgg ctgctgctga gcccaagtgt
       61 ggtgtgggcc tccaggggcc cccttcggcc actgtgccgg cctgtcaacg caaccctggc
      121 tgcagagaat gagttctgcc cagtctgcat caccttcacc accagcatct gtgccggcta
      181 ctgtcctagc atggttcgag tactgccagc tgccttgcct cccgtgcctc agccagtgtg
      241 cacctaccgt gagctgcgct tcgcctctgt ccgcctccct ggctgcccac ctggtgtaga
      301 ccccatagtc tcctttcctg tggccctcag ctgccgctgt gggccctgcc gtctcagtag
      361 ctctgactgt gggggtccca ggactcaacc aatgacctgt gaccttcccc acctccccgg
      421 ccttctcctc ttctgatgcc cacccactaa ctccccattc ttctggagcc agcaggtgtt
      481 ctaaccatcc ctcccaataa aggctttaca actgcaaaaa aaaaaaaaaa aaa
//
