LOCUS       XM_573455               6428 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus leucine-rich repeat-containing G
            protein-coupled receptor 6 (Lgr6), transcript variant X1, mRNA.
ACCESSION   XM_573455
VERSION     XM_573455.8
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051348.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_001427357.1.
            
            On Jan 21, 2021 this sequence version replaced XM_573455.7.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6428
                     /gene="Lgr6"
                     /note="leucine-rich repeat-containing G protein-coupled
                     receptor 6; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 16 ESTs, 7 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 10 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:498233"
                     /db_xref="RGD:1560339"
     CDS             219..3116
                     /gene="Lgr6"
                     /codon_start=1
                     /product="leucine-rich repeat-containing G-protein coupled
                     receptor 6 isoform X1"
                     /protein_id="XP_573455.1"
                     /db_xref="GeneID:498233"
                     /db_xref="RGD:1560339"
                     /translation="MHSSPLLLALCLCVVLCALARAGSDPQPGPGRPACPAPCHCQED
                     GIMLSADCSELGLSEVPADLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHL
                     SHIPRQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEG
                     LSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRIRHIPDYAFQNLTSLVVLHLH
                     NNRIQHVGTHSFEGLHNLETLDLNYNELQEFPVAIRTLGRLQELGFHNNNIKAIPEKA
                     FMGNPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILT
                     LTRAGIRLLPAGMCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGAD
                     TFSQLSSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKL
                     KGNLALSQAFSKDSFPKLRILEVPYAYQCCAYGLCANFFKTSGQWQAEDFHAEEEEAP
                     KRPLGLLAGQAENHYDLDLDELQMETEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRL
                     AVWAIVLLSVLCNGLVLLTVFAGGPSPLSPVKLVVGAIAGANALTGISCGLLASVDAL
                     TFGQFAEYGARWETGLGCQATGFLAVLGSEASVLLLTLAAVQCSVSVTCVRAYGKAPS
                     PGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGRPAALGFAVALVMMN
                     SLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASML
                     GLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFREDLRRLWPSPRSPGPLAYTAA
                     GELEKSSCDSTQALVAFSDVDLILEASEAGQPPGLETYGFPSVTLISRHQPGATRLEG
                     NHFVEPDGTKLGNPQPPMNEELLLRAEGATLADCSAGGALWPSGPLFASHL"
ORIGIN      
        1 ataacgaaga tcactcaaca atgcctgccc ctctctgact gcactgtccc gccgccgctg
       61 ctgccgccgc cgcgcccaag ccaagtcgag cgggggcggt ccccaccgac ggcgcagccc
      121 tcgggcccgc ccggaaccag gaggtgagcc gcgcgctcac agctccgtgc gcccgcccgt
      181 cccagcgccc gccaggtgcc ccaaagcctg ccgccgagat gcacagctcg ccgttgctcc
      241 tggcgctgtg tctttgcgtt gtgctgtgcg cattggcgcg cgcgggcagc gacccccagc
      301 ctggcccggg gcgtcccgcc tgccccgctc cctgccactg ccaggaggat ggcatcatgc
      361 tgtcagctga ctgctccgag ctcggtctct cagaggtgcc agcggacctg gaccccctga
      421 cggcttacct agacctcagt atgaacaacc tcacggagct tcagccgggt ctcttccacc
      481 acctgcgctt cctggaggag ctgcggctct cggggaacca cctctcacac atcccaagac
      541 aggcattctc tggcctccac agcctcaaaa ttctgatgct gcagagcaac cagctccgag
      601 ggatcccagc agaggcgctg tgggagctgc ccagcctgca gtcgctgcgc ctagatgcta
      661 acctcatctc cctggtccct gagagaagct ttgaggggct gtcctccctc cgccacctct
      721 ggttggatga caatgcactc accgagatcc ctgtcagagc tctcaacaac cttcctgccc
      781 tacaggccat gaccttggct ctcaaccgca tccgccacat ccctgactat gccttccaga
      841 acctcaccag tcttgtggtg ctgcatctac ataacaaccg catccagcat gtggggaccc
      901 acagcttcga ggggctgcac aatctggaga cactagactt gaactataat gagctgcagg
      961 agttccccgt ggctatccgg accctgggca ggctgcagga attgggtttc cacaacaaca
     1021 acatcaaggc tatcccagag aaggccttca tgggcaaccc tctcctgcag acaatacact
     1081 tttatgacaa cccgatccag tttgtgggaa ggtcagcatt ccagtacctg tctaaactgc
     1141 atacgctatc cttgaatggt gccactgaca tccaggagtt cccagacctc aaaggcacca
     1201 ctagcctgga gattctgacc ctgacccgtg caggcatcag actgctccca gcgggaatgt
     1261 gtcaacagct gcctaggctc cgaatcctgg agctgtctca taatcagatt gaggagctac
     1321 ccagcctgca caggtgtcag aagttggagg aaattggcct ccagcataac cggatctggg
     1381 aaattggtgc agataccttc agccagctga gttccttgca agctctagat ctgagttgga
     1441 atgccatccg tgccattcac cccgaggctt tctcaaccct tcgatccttg gttaagctgg
     1501 acctgactga caaccagctg accacactgc ccctggctgg gctgggaggc ctgatgcacc
     1561 tgaagctcaa ggggaacttg gccctgtctc aggccttctc caaggacagt ttccccaaac
     1621 tgaggatcct ggaggtgcct tacgcctacc agtgctgtgc ctatggcctc tgtgccaact
     1681 tcttcaagac ctctgggcag tggcaggccg aggactttca tgcagaggaa gaagaggcac
     1741 caaagaggcc cctgggtctc cttgctggac aagctgagaa ccactatgac ctagacctgg
     1801 atgagctcca gatggagaca gaggactcaa agccacaccc cagtgtccag tgcagccctg
     1861 ttccaggccc cttcaagccc tgcgagcacc tctttgagag ctggggcatc cgccttgctg
     1921 tgtgggccat cgtgctgctc tcggtactct gtaacgggct ggtgctgctt acagtctttg
     1981 ctggcgggcc cagcccgttg tctccggtca agcttgtggt gggtgcgatc gctggcgcca
     2041 acgccctaac gggcatttcc tgcggcctcc tggcctcagt ggacgccttg accttcggcc
     2101 agttcgcgga gtatggagcc cgctgggaga ccgggctagg ctgccaggct acgggcttcc
     2161 tagccgtcct ggggtcggag gcgtcggtgc tgctgctcac gctggcggcc gtgcagtgca
     2221 gcgtctctgt gacctgcgtc cgggcctacg ggaaggcgcc gtcgcccggt agcgtccgcg
     2281 caggcgcact gggatgcttg gcgctggctg ggctggccgc cgcgctgccg ctggcctcgg
     2341 tgggggagta tggtgcctcc ccgctctgcc tgccctacgc ccctcccgag ggccgcccgg
     2401 ccgccctagg cttcgccgta gccctggtga tgatgaactc gctctgcttc ctcgtggtgg
     2461 ccggtgccta catcaagctc tactgcgacc tgcctcgggg tgactttgag gccgtgtggg
     2521 actgcgccat ggtgcggcat gtggcctggc tcatctttgc agatggcctt ctctactgcc
     2581 ccgtggcctt cctcagcttt gcctccatgc tgggcctctt cccggtcacc cctgaggctg
     2641 tcaagtcggt tcttctggtg gtgttgcctc tgcccgcctg cctgaaccca ctgctctacc
     2701 tgctcttcaa ccctcacttc cgggaagacc ttcggaggct ctggccgagc cctcggtccc
     2761 cagggcctct agcttatact gcagccggtg agctggagaa gagctcctgc gactccaccc
     2821 aagccctggt ggctttctct gatgtggatc ttattctgga agcttctgag gctgggcagc
     2881 ctcctgggct agagacctat ggcttccctt cagtgaccct catctcccgt catcagccag
     2941 gggctaccag gctggaggga aaccattttg tggagcctga tggaaccaag ttagggaacc
     3001 cacaacctcc catgaatgaa gaactgctgc tgagggcaga gggagccaca ctggcagact
     3061 gttctgcagg tggagccctc tggccctctg gccctctctt tgcctctcac ttgtaaataa
     3121 cccccccccc caatttgtcc tccctcctcc caatgatggc tgcttataaa agaaagacaa
     3181 ctacagctcc gcagcagaat ggccaacgcc cctggctcca ttgttcaccg tggccataac
     3241 aaggtgtgct tccaggtctt gctttgtctt ggccttcagc ttcacggtca ccctgggcct
     3301 tccctgtcca atccgagtat gtatgacaga gacctgggaa atttacttag gagaaaggag
     3361 gaaagcaaaa gacagtgaag gctgtgggag gctgacagag ttgcgaccag tgagttacac
     3421 agtgagcggg gaggcctcac agagaaaggc actggaaggc aactaccaaa gacattggag
     3481 tgtcccgcct acggcgtgtg gatagcatag aaaacgtgtt ctgcgtccca ccaatcttga
     3541 cctatgctgt gccaaagtgc ttccagttaa gatacgcttt ggcagacatt gcatattatg
     3601 cccctttctt agagtcatgg ggtcatgtta gtgtctaaaa ggtcctaaga attaggacct
     3661 tttggcttaa tgatgacagc agttaaacgt acttatttga tgataggttt ctgtttgctt
     3721 ttcatggaac gcttacaaat ctctcgcaga acttagcacg gttttctccc agggacctcg
     3781 tcttaacacc gtggagtgca accctatgac atcacaagat gccaccctct tcgaaagccc
     3841 ctaagaagtc aagcgtcaga ggtgactggc atcatccggg acagattttg cattctgctc
     3901 ctctcccacc ccacttatcc tactggggca gacacctgca gagcctgcct cagtcccaca
     3961 ggtggggtgg ggagaaagag atccttgtgc gtgctcccac cccaacccaa ccccaagcaa
     4021 taatgaaatt tctgccctca gcaagacagg attctaaggt cctggcaaga tttgcactgc
     4081 tctatgggct tccccaactc ttacgttacc ttcatatggt tttacactgt atgcatctca
     4141 ccgcggcccg gaacctttct tctcatccca atcctgtttg aggggacggg gggcagggac
     4201 ggacaaccca agacaaggga tatttgtgct gtgggtattg catcttatgg agggctgtag
     4261 ctaactggga ctcctgggtg accccaacag gcctttgatc ctctgtctct ccccgcttga
     4321 tctttcttac cttatgcttc cccaagtgca gctgagggac tacacagtgg ctcccgcccc
     4381 actccaaaca caggaaatca atctcaggga gaggagataa gaagtgagga gaagccaaga
     4441 ttcagccaat agatggtaat tgctcctggg accgcccccc caagcatcat ttccatagga
     4501 aggactgagt ttggctcctg aagcccagtg gagtaccttt ctctgcctga attctgttgt
     4561 gatccctggc caagtcctct ttccagaaac cccaccttta aaaccagctg agaaggacct
     4621 tcttctctat gtttaatagt taactttcca tagcttagct tccctgcagt ctcccgagtg
     4681 cccagttaaa attctgccat aggtcaaaag tggggttgag aggtgagtca gaggccatgc
     4741 atggagctca gaacgtttct aaacctcctg tgattcattg agtagcccct agactctaga
     4801 aggctcagat gccaaaaagg gtgactttat aatttcttag ggtcttctca tgggatcgtt
     4861 ttcagagtgg gcattcacta aatgatagca agtttattaa ttgtttccca gtgcctgatc
     4921 tctttatttc cccagggctt ccaaccagag cccttggttg aaagtctccc acccaccccc
     4981 caccctgaga cttggtggtt ttctgagatt ccccagggat ggcaaaattg gcattcttac
     5041 agggagccct gacttctagc acgttaccta gattttttac cctgctctct ctgcctattt
     5101 tactatggga tcactgttct ctttggactt aaggaaccag ccttgaagta gagtgaggtg
     5161 accacgtgtt ggtggtcgaa gaatataggc attgttcctt aaagagatct tctatgaagt
     5221 cagccagccc ctttgggctg caagctttag catggcacag ttgtcacctt actgcctgct
     5281 aagtctggat gtcaaccaaa gttcaactct ctaattaaag aagaggcaag ggagaagaga
     5341 gttgaagtgt cttccataaa cttttatcca aaaatgtcta gccaggaatg gtggtgcaca
     5401 ccaataatcc caacatgtgg gatgtggagg caggaagatg gatggtaagg ggcatcctca
     5461 gctacataat gagtttgagg ctagactagg ctagactctg tctcaaaaaa aaaaaaaaaa
     5521 aaccaaatca ggcaaacaaa caaaacaccg aaatactagt tcatatacct ttaccccaat
     5581 aagattgagt agtaaacttt ctttgtgttt tattttgggt caagtttcta gcaagtcaga
     5641 acgccattcc tttggttatc tcctttgtaa tcagttgaag accacgtgtc ttcttctaag
     5701 caaatttctg ggtctctgtt ctacatattt ggatctgaca agaaagacca caagtctttg
     5761 actgatcatg ggatgaaaat ttgaactgtt cagagcacct aagtcctctg tcgttatcat
     5821 taacaaaatc ttcccaaata gcggccaagg aaaagaatcc actccagggg ctaagatggc
     5881 ggtggtggaa aggccaggac gtgtgtgtcc cagcttgagc tctgtgtgct gtgccattag
     5941 gtagtgccca gcgctatctt ctcttagaag agaactcaca gcgggtcacg gattgtcaag
     6001 tatctcatca aaatgaaaaa ccaaaaacaa atgtagagct aacattggga gactgttatg
     6061 cgttgactga gcttcttacg ggcccgaccc tccctcctta cctcctctcc tagtcctttg
     6121 ggctcacttt tccaggaaga gtaaaggctt acaaagtaaa gtaggaggag aaggaagcgc
     6181 tggcaatggg cagtaggctc ttggagcgag gatggaagag gtattaggaa ccccattggt
     6241 ccttgcccca gtccctacga ctacctctgc tcttggttac caagttctcc tacctatgac
     6301 ttaccacctc cacacccttt ctgggttcca gtcccatgcc ccgccccacc ccccagccat
     6361 gtgaactata aaaattgtca agatgtaaat atctggttct tctgtataat aaagcaccta
     6421 tgaagtac
//
