LOCUS       NM_001106784            3130 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus leucine rich repeat containing G protein coupled
            receptor 5 (Lgr5), mRNA.
ACCESSION   NM_001106784 XM_235149
VERSION     NM_001106784.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3130)
  AUTHORS   Lee,C., Minich,A., Li,B., Miyake,H., Seo,S. and Pierro,A.
  TITLE     Influence of stress factors on intestinal epithelial injury and
            regeneration
  JOURNAL   Pediatr Surg Int 34 (2), 155-160 (2018)
   PUBMED   29018960
  REMARK    GeneRIF: IL-6 expression increased in all groups compared to
            control. Lgr5 expression was up-regulated in cells exposed to a
            single stressor, but down-regulated when multiple stressors were
            administered.
REFERENCE   2  (bases 1 to 3130)
  AUTHORS   Chen,X., Hao,J., Fu,T., Liu,J., Yu,M., He,S., Qian,R. and Zhang,F.
  TITLE     Temporal and Spatial Expression of LGR5 After Acute Spinal Cord
            Injury in Adult Rats
  JOURNAL   Neurochem Res 41 (10), 2645-2654 (2016)
   PUBMED   27339869
  REMARK    GeneRIF: that Leucine-rich repeat-containing G-protein coupled
            receptor 5might be of great significance in CNS pathophysiology
            after spinal cord injury
REFERENCE   3  (bases 1 to 3130)
  AUTHORS   Junttila,M.R., Mao,W., Wang,X., Wang,B.E., Pham,T., Flygare,J.,
            Yu,S.F., Yee,S., Goldenberg,D., Fields,C., Eastham-Anderson,J.,
            Singh,M., Vij,R., Hongo,J.A., Firestein,R., Schutten,M.,
            Flagella,K., Polakis,P. and Polson,A.G.
  TITLE     Targeting LGR5+ cells with an antibody-drug conjugate for the
            treatment of colon cancer
  JOURNAL   Sci Transl Med 7 (314), 314ra186 (2015)
   PUBMED   26582901
  REMARK    GeneRIF: Report targeting LGR5+ tumor stem cells with an
            antibody-drug conjugate as effective treatment for colon cancer.
REFERENCE   4  (bases 1 to 3130)
  AUTHORS   Li,W., Wu,J., Yang,J., Sun,S., Chai,R., Chen,Z.Y. and Li,H.
  TITLE     Notch inhibition induces mitotically generated hair cells in
            mammalian cochleae via activating the Wnt pathway
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 166-171 (2015)
   PUBMED   25535395
REFERENCE   5  (bases 1 to 3130)
  AUTHORS   Rastetter,R.H., Bernard,P., Palmer,J.S., Chassot,A.A., Chen,H.,
            Western,P.S., Ramsay,R.G., Chaboissier,M.C. and Wilhelm,D.
  TITLE     Marker genes identify three somatic cell types in the fetal mouse
            ovary
  JOURNAL   Dev Biol 394 (2), 242-252 (2014)
   PUBMED   25158167
REFERENCE   6  (bases 1 to 3130)
  AUTHORS   Cruciat,C.M. and Niehrs,C.
  TITLE     Secreted and transmembrane wnt inhibitors and activators
  JOURNAL   Cold Spring Harb Perspect Biol 5 (3), a015081 (2013)
   PUBMED   23085770
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3130)
  AUTHORS   Ruffner,H., Sprunger,J., Charlat,O., Leighton-Davies,J.,
            Grosshans,B., Salathe,A., Zietzling,S., Beck,V., Therier,M.,
            Isken,A., Xie,Y., Zhang,Y., Hao,H., Shi,X., Liu,D., Song,Q.,
            Clay,I., Hintzen,G., Tchorz,J., Bouchez,L.C., Michaud,G., Finan,P.,
            Myer,V.E., Bouwmeester,T., Porter,J., Hild,M., Bassilana,F.,
            Parker,C.N. and Cong,F.
  TITLE     R-Spondin potentiates Wnt/beta-catenin signaling through orphan
            receptors LGR4 and LGR5
  JOURNAL   PLoS One 7 (7), e40976 (2012)
   PUBMED   22815884
REFERENCE   8  (bases 1 to 3130)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   9  (bases 1 to 3130)
  AUTHORS   Carmon,K.S., Gong,X., Lin,Q., Thomas,A. and Liu,Q.
  TITLE     R-spondins function as ligands of the orphan receptors LGR4 and
            LGR5 to regulate Wnt/beta-catenin signaling
  JOURNAL   Proc Natl Acad Sci U S A 108 (28), 11452-11457 (2011)
   PUBMED   21693646
REFERENCE   10 (bases 1 to 3130)
  AUTHORS   de Lau,W., Barker,N., Low,T.Y., Koo,B.K., Li,V.S., Teunissen,H.,
            Kujala,P., Haegebarth,A., Peters,P.J., van de Wetering,M.,
            Stange,D.E., van Es,J.E., Guardavaccaro,D., Schasfoort,R.B.,
            Mohri,Y., Nishimori,K., Mohammed,S., Heck,A.J. and Clevers,H.
  TITLE     Lgr5 homologues associate with Wnt receptors and mediate R-spondin
            signalling
  JOURNAL   Nature 476 (7360), 293-297 (2011)
   PUBMED   21727895
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On Oct 4, 2007 this sequence version replaced XM_235149.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3130
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /note="leucine rich repeat containing G protein coupled
                     receptor 5"
                     /db_xref="GeneID:299802"
                     /db_xref="RGD:1307733"
     CDS             1..2724
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /note="G protein-coupled receptor 49"
                     /codon_start=1
                     /product="leucine-rich repeat-containing G-protein coupled
                     receptor 5 precursor"
                     /protein_id="NP_001100254.1"
                     /db_xref="GeneID:299802"
                     /db_xref="RGD:1307733"
                     /translation="MDTSRVRMLLSLLALLQLVAAGSPPRPDTMPRGCPSYCHCELDG
                     RMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLPASLLHRLRFLEELRLAGNAL
                     THIPKGAFAGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSG
                     LHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADHAFGNLSSLVVLHLH
                     NNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERA
                     FVGNPSLITIHFYDNPIQFVGISAFQHLPELRTLTLNGASQITEFPDLTGTATLESLT
                     LTGAKISSLPQTVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGG
                     TFQQLFNLRSLNLARNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHLKL
                     TGNRALQSLIPSANFPELKIIEMPYAYQCCAFGGCENVYKIPNQWNKDDSSSVDDLRK
                     KDAGLFQVQDERDLEDFLLDFEEDLKVLHSVQCSPPPGPFKPCEHLFGSWLIRIGVWT
                     TAVLALSCNALVAFTVFRTPLYISSIKLLIGVIAVVDILMGVSSAILAVVDTFTFGSF
                     AQHGAWWEGGIGCQIVGFLSIFASESSVFLLTLAALERGFSVKCSSKFEMKAPLSSLK
                     AIILLCVLLALTIATVPLLGGSEYNASPLCLPLPFGEPSTTGYMVALVLLNSLCFLIM
                     TIAYTRLYCSLEKGELENLWDCSMVKHTALLLFTNCILYCPVAFLSFSSLLNLTFISP
                     EVIKFILLVIVPLPACLNPLLYIVFNPHFKEDMGSLGKQTRFWTRAKHPSLLSINSDD
                     VEKRSCDSTQALVSFTHASIAYDLPSDSGSSPAYPMTESCHLSSVAFVPCL"
     exon            1..212
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            213..284
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            285..356
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            357..428
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            429..644
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            645..716
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            717..785
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            786..857
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            858..929
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            930..998
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1070
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1136
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1208
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1280
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1406
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1552
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1636
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..3130
                     /gene="Lgr5"
                     /gene_synonym="Gpr49"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacacct cccgcgtccg catgctcctg tccttgctgg cgctgctgca gctggtggct
       61 gccggcagcc caccgagacc ggacacgatg ccgcggggct gcccatcata ctgtcactgt
      121 gagctggatg gcaggatgct gctcagggtg gactgctccg acctggggct ctcggagctg
      181 ccctccaacc tcagcgtctt cacctcctac ctggacctca gtatgaacaa catcagtcag
      241 ctacctgcca gtctcctgca tcgcctccgc ttcctagaag agttgcgtct tgctggaaat
      301 gctttgacac acattcccaa gggagcattc gcaggccttc acagtctcaa agttctcatg
      361 ctgcagaata accagctgag acaggttccg gaggaagcgc tacagaacct gagaagcctt
      421 cagtccctgc gcttggatgc caaccacatc agctacgtgc cacccagctg tttcagtggt
      481 ctgcactccc tgaggcacct gtggctagat gacaacgctc tcacagatgt ccctgtccag
      541 gctttcagaa gtttatcagc cctgcaagcc atgaccttgg ccctgaacaa aatacaccac
      601 atagcagacc atgcctttgg aaacctctcc agcctcgtgg ttctgcatct ccataataat
      661 agaatccact ccctgggaaa gaaatgcttt gatggactcc acagcctgga gactttagat
      721 ttaaattata ataaccttga cgaattcccc actgcaatca agacactctc caacctcaag
      781 gaactaggat tccacagcaa caatatcaga tcaataccag agcgagcatt cgtaggcaac
      841 ccttctctta tcacaataca tttctatgac aatcccatcc agtttgttgg aatctctgct
      901 tttcaacact tgcctgaact aagaacgctg actttgaatg gtgcctcgca aattactgaa
      961 ttccctgact taacggggac cgcaaccctg gagagcctga ctttaactgg agcaaagatc
     1021 tcgtctcttc cccaaaccgt ctgtgatcag ttacctaatc tccaagtgct agatttgtct
     1081 tacaacctgc tcgaagactt acccagtttg tcgggctgcc aaaagcttca gaaaattgac
     1141 ctgcggcata atgaaatcta tgaaattaaa ggtggcactt ttcagcagtt gttcaacctc
     1201 cgatctctga acttagcccg gaataaaatt gccattattc accccaacgc tttctctacg
     1261 ttgccgtctc taataaagct ggacctatca tccaacctcc tttcgtcttt ccctgtgact
     1321 gggttacacg gtttaactca cttaaaatta acggggaacc gcgccttgca gagcctgata
     1381 ccatctgcaa acttcccgga gctcaagatt atagaaatgc catacgctta ccagtgctgt
     1441 gcatttgggg ggtgtgagaa tgtctataaa attcctaatc aatggaacaa agatgacagc
     1501 agcagtgtgg acgaccttcg taagaaagat gctggcttat ttcaagttca agatgagcgg
     1561 gaccttgaag acttcctact tgactttgag gaagacctga aggttcttca ctccgtgcag
     1621 tgctcacctc ccccaggtcc cttcaagccc tgtgagcacc tgtttggtag ctggctgatc
     1681 cgaatcgggg tgtggaccac agcagtcctg gcgctttcct gcaatgcctt ggtggctttc
     1741 acagtgttca gaacccctct gtacatctct tccataaaac tgctaatcgg ggtaattgcg
     1801 gtagtggaca tactcatggg ggtctccagt gcaattctgg ctgtcgtgga cacgttcact
     1861 tttggcagtt ttgctcaaca cggtgcatgg tgggaaggtg gaattggctg ccaaattgtt
     1921 ggttttttgt ccatttttgc ttccgaatca tcggtcttcc tgctcactct ggcggcactg
     1981 gaacgtggtt tttctgtcaa gtgctcttca aagtttgaaa tgaaagctcc cctttctagc
     2041 ctgaaagcga tcattttgct gtgtgtcctc ttggccctga ccattgccac cgtccccttg
     2101 ctaggaggca gtgagtacaa tgcctctccc ctctgcctgc ccttaccctt tggggagccc
     2161 agcaccacag gctacatggt ggctctcgta ttgctcaact ccctctgttt cctcataatg
     2221 accattgcct atacaaggct ctactgcagt ttggagaagg gagagctgga gaacctttgg
     2281 gactgttcta tggtgaagca cactgctctg ttgctcttca ccaactgtat cctttactgc
     2341 cccgtggctt tcttatcctt ctcctctttg ctaaacctca cgtttatcag tcccgaagta
     2401 attaaattta tacttctagt gattgtccca cttccggcat gcctcaaccc ccttctctac
     2461 attgtcttca acccccattt taaggaggat atgggcagcc tgggaaagca aacccgtttc
     2521 tggacaagag caaaacaccc aagtctgctg tccattaact cggacgatgt tgagaaacgg
     2581 tcctgtgact caacccaagc cttagtatcc tttacccacg ccagcatagc ctatgacttg
     2641 ccttccgatt ccgggtcatc accagcttac ccaatgactg aaagctgtca cctctcttca
     2701 gttgcatttg tcccatgtct ctagttaaca tgagaggggg acgtttttaa gagttggaaa
     2761 ccccgaaaga caatttatat cagagcggta gctaagaaaa gctgagctga aacttaaaac
     2821 acaagcaagc ttctctaaat tggtatggaa acgccgatac cttaccgacg cctgagagtg
     2881 accatcagtc tgaacactgc ctgtatcatt tgttcagcta agaggtagat ccatcaagtc
     2941 acctagagga acccagatga gaaaagcaga ctgaaatgct cttcagaaaa catactctct
     3001 ggttttaact gtattctctt caaactcacc agcagagtca ccagcaccgg acgggaaggt
     3061 tcgttggatg acgactcagt gtcaatttaa atccacaaat tccctttttt taaaaagcta
     3121 gagttataag
//
