LOCUS       NM_199499               2630 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus leucine-rich repeat LGI family, member 4 (Lgi4),
            mRNA.
ACCESSION   NM_199499 XM_341836
VERSION     NM_199499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2630)
  AUTHORS   Xue S, Maluenda J, Marguet F, Shboul M, Quevarec L, Bonnard C, Ng
            AY, Tohari S, Tan TT, Kong MK, Monaghan KG, Cho MT, Siskind CE,
            Sampson JB, Rocha CT, Alkazaleh F, Gonzales M, Rigonnot L, Whalen
            S, Gut M, Gut I, Bucourt M, Venkatesh B, Laquerriere A, Reversade B
            and Melki J.
  TITLE     Loss-of-Function Mutations in LGI4, a Secreted Ligand Involved in
            Schwann Cell Myelination, Are Responsible for Arthrogryposis
            Multiplex Congenita
  JOURNAL   Am J Hum Genet 100 (4), 659-665 (2017)
   PUBMED   28318499
REFERENCE   2  (bases 1 to 2630)
  AUTHORS   Nishino J, Saunders TL, Sagane K and Morrison SJ.
  TITLE     Lgi4 promotes the proliferation and differentiation of glial
            lineage cells throughout the developing peripheral nervous system
  JOURNAL   J Neurosci 30 (45), 15228-15240 (2010)
   PUBMED   21068328
REFERENCE   3  (bases 1 to 2630)
  AUTHORS   Ozkaynak E, Abello G, Jaegle M, van Berge L, Hamer D, Kegel L,
            Driegen S, Sagane K, Bermingham JR Jr and Meijer D.
  TITLE     Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell
            signaling
  JOURNAL   J Neurosci 30 (10), 3857-3864 (2010)
   PUBMED   20220021
REFERENCE   4  (bases 1 to 2630)
  AUTHORS   Bermingham JR Jr, Shearin H, Pennington J, O'Moore J, Jaegle M,
            Driegen S, van Zon A, Darbas A, Ozkaynak E, Ryu EJ, Milbrandt J and
            Meijer D.
  TITLE     The claw paw mutation reveals a role for Lgi4 in peripheral nerve
            development
  JOURNAL   Nat Neurosci 9 (1), 76-84 (2006)
   PUBMED   16341215
REFERENCE   5  (bases 1 to 2630)
  AUTHORS   Darbas A, Jaegle M, Walbeehm E, van den Burg H, Driegen S, Broos L,
            Uyl M, Visser P, Grosveld F and Meijer D.
  TITLE     Cell autonomy of the mouse claw paw mutation
  JOURNAL   Dev Biol 272 (2), 470-482 (2004)
   PUBMED   15282162
REFERENCE   6  (bases 1 to 2630)
  AUTHORS   Gu W, Sander T, Becker T and Steinlein OK.
  TITLE     Genotypic association of exonic LGI4 polymorphisms and childhood
            absence epilepsy
  JOURNAL   Neurogenetics 5 (1), 41-44 (2004)
   PUBMED   14505228
REFERENCE   7  (bases 1 to 2630)
  AUTHORS   Koszowski AG, Owens GC and Levinson SR.
  TITLE     The effect of the mouse mutation claw paw on myelination and nodal
            frequency in sciatic nerves
  JOURNAL   J Neurosci 18 (15), 5859-5868 (1998)
   PUBMED   9671673
REFERENCE   8  (bases 1 to 2630)
  AUTHORS   Henry EW, Eicher EM and Sidman RL.
  TITLE     The mouse mutation claw paw: forelimb deformity and delayed
            myelination throughout the peripheral nervous system
  JOURNAL   J Hered 82 (4), 287-294 (1991)
   PUBMED   1652607
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064659.1.
            
            On Jan 24, 2004 this sequence version replaced XM_341836.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2630
                     /gene="Lgi4"
                     /note="leucine-rich repeat LGI family, member 4"
                     /db_xref="GeneID:361549"
                     /db_xref="RGD:735035"
     exon            1..379
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1823
                     /gene="Lgi4"
                     /codon_start=1
                     /product="leucine-rich repeat LGI family member 4
                     precursor"
                     /protein_id="NP_955793.1"
                     /db_xref="GeneID:361549"
                     /db_xref="RGD:735035"
                     /translation="MGGAGILLFLLAWTGAGVSWSPPKGKCPPRCSCSKESTLCEGSP
                     ELPESFSTTLLSLSLVRMGVSRLKAGSFLKMPSLHLLLFTSNTFSVIEGDAFIGLSYL
                     QYLFIEDNKIGSISKNALRGLRSLTHLSLANNHLEALPRFLFQGLETLTHVDLRGNPF
                     QCDCRVLWLLQWMPMVNASVGTGACAGPSALAQIQLNHLDPKKFKCKATELSWLQTVG
                     ESALSVESFSYQGEPHMVLAQPFAGRCLILVWDYSLQRFRSEEELSAPSVVSCKPLVL
                     GPRLFILAARLWGGSQLWSRSSPDLRLTPVQVLAPQRLLRPNDAELLWLDGQPCFVVA
                     DASKAGSTTLLCRDGPGFYPRQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHW
                     FGGRFERRTDIPEAEDVYATKHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPS
                     RGSHVFQPLLIASDQLAILGSDFAFSQVFRFEPDKGILEPLQELGPPALVAPRAFGQV
                     TVAGRRFLFAACFKGPTQIYQHHELDLSA"
     exon            380..451
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
     exon            452..523
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
     exon            524..595
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
     exon            596..667
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
     exon            668..837
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1002
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1508
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..2538
                     /gene="Lgi4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaataata gaaagatagg gagagaaaga tactgataga aaatccacac tccagatact
       61 ggaagagggg cacaggctgg aggagggaac aaggtcagcc agccacagga cagcatggcc
      121 agcagcagga tggaggggca tcccacagag atgtagtggt tcaggtctgg cagggtggag
      181 ccagggggag cctgggctgg ggcaggggca tgggaggggc aggcattctg ttgttcctgt
      241 tggcctggac tggggcagga gtgtcctgga gtccccccaa gggaaagtgt cctccacgct
      301 gctcctgctc caaggagagc accctgtgtg agggctcccc cgagctgcct gagagcttct
      361 ccaccacgct cctgtcactc tctctcgtca ggatgggggt ctcccggctg aaggctggaa
      421 gctttttaaa gatgccgtca ctgcacttgc tcctcttcac gtccaatacc ttctctgtaa
      481 ttgagggtga tgccttcatc ggcctgtcct acctgcagta cctcttcatt gaggacaaca
      541 agatcggctc catctctaag aacgccctga ggggactccg ctcactgacc cacctaagcc
      601 tggccaacaa ccaccttgag gctctaccca gattcctgtt ccaaggcttg gagactctga
      661 ctcatgtgga cctccgtggt aacccgttcc agtgtgactg ccgagtactt tggttgctac
      721 agtggatgcc tatggtgaat gccagtgtgg gcacgggggc ctgtgcgggc ccctctgcac
      781 ttgctcaaat acaactgaat cacctcgacc ctaagaagtt caagtgtaaa gccacagaac
      841 tctcctggct ccagactgtt ggggagtcgg cactgagcgt ggagtccttc tcctatcagg
      901 gggaacctca catggtcctg gcacagccct tcgctggccg ttgcctgatc ctggtgtggg
      961 actacagcct gcagcgcttc aggtctgagg aagagctgtc cgcgccctca gtggtgtcct
     1021 gcaaacctct ggtgctgggc ccacgcctct tcatactggc tgctcgccta tggggaggct
     1081 cacagctgtg gtcacggtcc agccccgacc tgcgtctgac ccctgtgcaa gtcctagccc
     1141 ctcaacggct gctgcgaccc aatgatgccg agctcctgtg gctggatggg cagccctgct
     1201 tcgtggtggc tgatgcttcc aaggctggca gcaccacgct gctgtgtcgt gatgggccgg
     1261 gcttctaccc acgccagagc ctgcacgcct ggcaccgcga caccgatgca gaggccctgg
     1321 agctggacgg ccgaccgcac ctgttgcttg cttccgcctc ccagaggcct gtgctctttc
     1381 actggtttgg tggccgattc gagaggcgca cagacatccc agaggcagag gacgtctatg
     1441 ccacaaaaca ctttcaggcg ggaggagacg tgttcctgtg cctgactcga tacattgggg
     1501 actccatggt catgcgctgg gacggctcca tgttccgtct gctgcagcaa cttccatctc
     1561 gaggctccca tgtcttccag ccactactaa ttgccagcga ccagttggcc attctgggca
     1621 gcgacttcgc cttcagccaa gtcttccgct ttgagcccga taaagggatc ctggagccac
     1681 tacaggagct gggcccaccg gccttggtgg ccccccgagc ctttggccaa gtcactgtag
     1741 caggaagacg ctttttattc gcagcgtgct tcaaggggcc cacgcagatc taccagcacc
     1801 atgagttgga tctcagtgcc tgaggctggg aaagaccctg gaagtggcta tgggactggc
     1861 aagggcattc tgggacatct gggtaacctc tctgggctgg cctcctggat gtcacagaca
     1921 gtcctgggtg atacagacca caagccaagt gcatcagcct gagttaggct tagtccactt
     1981 ttcggaggat ctgtacctaa ggggcaagtg ggaggtctct ttactcccaa ctatgtttag
     2041 ggcccctcca gtctgaagcc acatttgggc tgaggacaga tgctcccatg cacaacatct
     2101 tgggagttcc tcctggaaca caacttggag ctgggataca gaaactaaaa gggcaatctg
     2161 ctgagctcca agaggtttgg acaccccgcc ctcaacgtcc ccttggtcct gctgcatata
     2221 aagaaccgag agagagcatt agttccactc aaaccctatc tggccattgg tttcgtggag
     2281 tatgcgtctc tgtgacgtca cagttgctgg gcagtttctt ggcctggtac tctgctgcct
     2341 gtgcgcatgc ctggtacttt gctgcccgtg cgcatgtcta tttccgaaga ctgattgctt
     2401 ttacacgtgt gcagtaaaag tgaagcagcg aagatgaagt ctagaggcgt cacagagagc
     2461 actgggtacc tttttccaga atgtgacagg ggcaagaaca gggagtgtat gaattcaata
     2521 aatgccccgc gcacccaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2581 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
