LOCUS       NP_955793                537 aa            linear   ROD 23-MAR-2023
DEFINITION  leucine-rich repeat LGI family member 4 precursor [Rattus
            norvegicus].
ACCESSION   NP_955793 XP_341837
VERSION     NP_955793.1
DBSOURCE    REFSEQ: accession NM_199499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 537)
  AUTHORS   Xue S, Maluenda J, Marguet F, Shboul M, Quevarec L, Bonnard C, Ng
            AY, Tohari S, Tan TT, Kong MK, Monaghan KG, Cho MT, Siskind CE,
            Sampson JB, Rocha CT, Alkazaleh F, Gonzales M, Rigonnot L, Whalen
            S, Gut M, Gut I, Bucourt M, Venkatesh B, Laquerriere A, Reversade B
            and Melki J.
  TITLE     Loss-of-Function Mutations in LGI4, a Secreted Ligand Involved in
            Schwann Cell Myelination, Are Responsible for Arthrogryposis
            Multiplex Congenita
  JOURNAL   Am J Hum Genet 100 (4), 659-665 (2017)
   PUBMED   28318499
REFERENCE   2  (residues 1 to 537)
  AUTHORS   Nishino J, Saunders TL, Sagane K and Morrison SJ.
  TITLE     Lgi4 promotes the proliferation and differentiation of glial
            lineage cells throughout the developing peripheral nervous system
  JOURNAL   J Neurosci 30 (45), 15228-15240 (2010)
   PUBMED   21068328
REFERENCE   3  (residues 1 to 537)
  AUTHORS   Ozkaynak E, Abello G, Jaegle M, van Berge L, Hamer D, Kegel L,
            Driegen S, Sagane K, Bermingham JR Jr and Meijer D.
  TITLE     Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell
            signaling
  JOURNAL   J Neurosci 30 (10), 3857-3864 (2010)
   PUBMED   20220021
REFERENCE   4  (residues 1 to 537)
  AUTHORS   Bermingham JR Jr, Shearin H, Pennington J, O'Moore J, Jaegle M,
            Driegen S, van Zon A, Darbas A, Ozkaynak E, Ryu EJ, Milbrandt J and
            Meijer D.
  TITLE     The claw paw mutation reveals a role for Lgi4 in peripheral nerve
            development
  JOURNAL   Nat Neurosci 9 (1), 76-84 (2006)
   PUBMED   16341215
REFERENCE   5  (residues 1 to 537)
  AUTHORS   Darbas A, Jaegle M, Walbeehm E, van den Burg H, Driegen S, Broos L,
            Uyl M, Visser P, Grosveld F and Meijer D.
  TITLE     Cell autonomy of the mouse claw paw mutation
  JOURNAL   Dev Biol 272 (2), 470-482 (2004)
   PUBMED   15282162
REFERENCE   6  (residues 1 to 537)
  AUTHORS   Gu W, Sander T, Becker T and Steinlein OK.
  TITLE     Genotypic association of exonic LGI4 polymorphisms and childhood
            absence epilepsy
  JOURNAL   Neurogenetics 5 (1), 41-44 (2004)
   PUBMED   14505228
REFERENCE   7  (residues 1 to 537)
  AUTHORS   Koszowski AG, Owens GC and Levinson SR.
  TITLE     The effect of the mouse mutation claw paw on myelination and nodal
            frequency in sciatic nerves
  JOURNAL   J Neurosci 18 (15), 5859-5868 (1998)
   PUBMED   9671673
REFERENCE   8  (residues 1 to 537)
  AUTHORS   Henry EW, Eicher EM and Sidman RL.
  TITLE     The mouse mutation claw paw: forelimb deformity and delayed
            myelination throughout the peripheral nervous system
  JOURNAL   J Hered 82 (4), 287-294 (1991)
   PUBMED   1652607
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064659.1.
            
            On Jan 24, 2004 this sequence version replaced XP_341837.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..537
                     /product="leucine-rich repeat LGI family member 4
                     precursor"
                     /calculated_mol_wt=57542
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1834
     Region          54..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          76..136
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          131..>192
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          150..162
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          <220..250
                     /region_name="EPTP"
                     /note="EPTP domain; pfam03736"
                     /db_xref="CDD:461033"
     Region          396..437
                     /region_name="EPTP"
                     /note="EPTP domain; pfam03736"
                     /db_xref="CDD:461033"
     Region          441..480
                     /region_name="EPTP"
                     /note="EPTP domain; pfam03736"
                     /db_xref="CDD:461033"
     CDS             1..537
                     /gene="Lgi4"
                     /coded_by="NM_199499.1:210..1823"
                     /db_xref="GeneID:361549"
                     /db_xref="RGD:735035"
ORIGIN      
        1 mggagillfl lawtgagvsw sppkgkcppr cscskestlc egspelpesf sttllslslv
       61 rmgvsrlkag sflkmpslhl llftsntfsv iegdafigls ylqylfiedn kigsisknal
      121 rglrslthls lannhlealp rflfqgletl thvdlrgnpf qcdcrvlwll qwmpmvnasv
      181 gtgacagpsa laqiqlnhld pkkfkckate lswlqtvges alsvesfsyq gephmvlaqp
      241 fagrclilvw dyslqrfrse eelsapsvvs ckplvlgprl filaarlwgg sqlwsrsspd
      301 lrltpvqvla pqrllrpnda ellwldgqpc fvvadaskag sttllcrdgp gfyprqslha
      361 whrdtdaeal eldgrphlll asasqrpvlf hwfggrferr tdipeaedvy atkhfqaggd
      421 vflcltryig dsmvmrwdgs mfrllqqlps rgshvfqpll iasdqlailg sdfafsqvfr
      481 fepdkgilep lqelgppalv aprafgqvtv agrrflfaac fkgptqiyqh heldlsa
//
