LOCUS       NM_145769               2128 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus leucine-rich, glioma inactivated 1 (Lgi1), mRNA.
ACCESSION   NM_145769 XM_346592
VERSION     NM_145769.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2128)
  AUTHORS   Cuhadar,U., Calzado-Reyes,L., Pascual-Caro,C., Aberra,A.S.,
            Ritzau-Jost,A., Aggarwal,A., Ibata,K., Podgorski,K., Yuzaki,M.,
            Geis,C., Hallerman,S., Hoppa,M.B. and de Juan-Sanz,J.
  TITLE     Activity-driven synaptic translocation of LGI1 controls excitatory
            neurotransmission
  JOURNAL   Cell Rep 43 (5), 114186 (2024)
   PUBMED   38700985
  REMARK    GeneRIF: Activity-driven synaptic translocation of LGI1 controls
            excitatory neurotransmission.
REFERENCE   2  (bases 1 to 2128)
  AUTHORS   Tao,H., Tang,X. and Tao,H.
  TITLE     TLR4 activation inhibits the proliferation and osteogenic
            differentiation of skeletal muscle stem cells by downregulating
            LGI1
  JOURNAL   J Physiol Biochem 78 (3), 667-678 (2022)
   PUBMED   35294724
  REMARK    GeneRIF: TLR4 activation inhibits the proliferation and osteogenic
            differentiation of skeletal muscle stem cells by downregulating
            LGI1.
REFERENCE   3  (bases 1 to 2128)
  AUTHORS   Kinboshi,M., Shimizu,S., Mashimo,T., Serikawa,T., Ito,H., Ikeda,A.,
            Takahashi,R. and Ohno,Y.
  TITLE     Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic
            Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant
            Rats
  JOURNAL   Int J Mol Sci 20 (5), 1013 (2019)
   PUBMED   30813600
  REMARK    GeneRIF: he down-regulation of Kir4.1 channels in astrocytes is
            involved in audiogenic epileptogenesis caused by Lgi1 mutation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2128)
  AUTHORS   Hivert,B., Marien,L., Agbam,K.N. and Faivre-Sarrailh,C.
  TITLE     ADAM22 and ADAM23 modulate the targeting of the Kv1
            channel-associated protein LGI1 to the axon initial segment
  JOURNAL   J Cell Sci 132 (2) (2019)
   PUBMED   30598502
  REMARK    GeneRIF: ADAM22 and ADAM23 modulate the targeting of the Kv1
            channel-associated protein LGI1 to the axon initial segment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2128)
  AUTHORS   Fumoto,N., Mashimo,T., Masui,A., Ishida,S., Mizuguchi,Y.,
            Minamimoto,S., Ikeda,A., Takahashi,R., Serikawa,T. and Ohno,Y.
  TITLE     Evaluation of seizure foci and genes in the Lgi1(L385R/+) mutant
            rat
  JOURNAL   Neurosci Res 80, 69-75 (2014)
   PUBMED   24406746
  REMARK    GeneRIF: These results of this study suggest that Lgi1(L385R/+)
            rats are useful as an animal model of human autosomal dominant
            lateral temporal lobe epilepsy.
REFERENCE   6  (bases 1 to 2128)
  AUTHORS   Kunapuli,P., Chitta,K.S. and Cowell,J.K.
  TITLE     Suppression of the cell proliferation and invasion phenotypes in
            glioma cells by the LGI1 gene
  JOURNAL   Oncogene 22 (26), 3985-3991 (2003)
   PUBMED   12821932
REFERENCE   7  (bases 1 to 2128)
  AUTHORS   Staub,E., Perez-Tur,J., Siebert,R., Nobile,C., Moschonas,N.K.,
            Deloukas,P. and Hinzmann,B.
  TITLE     The novel EPTP repeat defines a superfamily of proteins implicated
            in epileptic disorders
  JOURNAL   Trends Biochem Sci 27 (9), 441-444 (2002)
   PUBMED   12217514
  REMARK    Review article
REFERENCE   8  (bases 1 to 2128)
  AUTHORS   Scheel,H., Tomiuk,S. and Hofmann,K.
  TITLE     A common protein interaction domain links two recently identified
            epilepsy genes
  JOURNAL   Hum Mol Genet 11 (15), 1757-1762 (2002)
   PUBMED   12095917
REFERENCE   9  (bases 1 to 2128)
  AUTHORS   Somerville,R.P., Chernova,O., Liu,S., Shoshan,Y. and Cowell,J.K.
  TITLE     Identification of the promoter, genomic structure, and mouse
            ortholog of LGI1
  JOURNAL   Mamm Genome 11 (8), 622-627 (2000)
   PUBMED   10920229
REFERENCE   10 (bases 1 to 2128)
  AUTHORS   Owens,M.J., Ritchie,J.C. and Nemeroff,C.B.
  TITLE     5 alpha-pregnane-3 alpha, 21-diol-20-one (THDOC) attenuates mild
            stress-induced increases in plasma corticosterone via a
            non-glucocorticoid mechanism: comparison with alprazolam
  JOURNAL   Brain Res 573 (2), 353-355 (1992)
   PUBMED   1504771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 4, 2022 this sequence version replaced NM_145769.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089222.1, AJ487517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000001.1  245455691-245456012
            323-394             JAXUCZ010000001.1  245456438-245456509
            395-466             JAXUCZ010000001.1  245475800-245475871
            467-538             JAXUCZ010000001.1  245475975-245476046
            539-610             JAXUCZ010000001.1  245488205-245488276
            611-780             JAXUCZ010000001.1  245490954-245491123
            781-945             JAXUCZ010000001.1  245491410-245491574
            946-2128            JAXUCZ010000001.1  245495854-245497036
FEATURES             Location/Qualifiers
     source          1..2128
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..2128
                     /gene="Lgi1"
                     /note="leucine-rich, glioma inactivated 1"
                     /db_xref="GeneID:252892"
                     /db_xref="RGD:628742"
     exon            1..322
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1781
                     /gene="Lgi1"
                     /note="leucine-rich glioma-inactivated protein 1;
                     leucine-rich repeat LGI family, member 1; leucine-rich
                     glioma-inactivated protein 1-like"
                     /codon_start=1
                     /product="leucine-rich glioma-inactivated protein 1
                     precursor"
                     /protein_id="NP_665712.1"
                     /db_xref="GeneID:252892"
                     /db_xref="RGD:628742"
                     /translation="MESESIRRMGNACIPLKRIAYFLCLFSVVLLTEGKKPAKPKCPA
                     VCTCSKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNS
                     FDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK
                     GLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKD
                     FDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD
                     NITGTSTVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFANKFIKIQDIEVLKIRKPND
                     IETFKIEDNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPL
                     TLRTPHLILSSSSQRPVIYQWSKATQLFINQTDIPNMEDVYAVKHFSVKGDVYICLTR
                     FIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEK
                     AKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA"
     exon            323..394
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..466
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..538
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..610
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..780
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..945
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..2128
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcagaga agggtggaac tcctatgtga cctgttctta gagcgagaca accagcagct
       61 gaattccaga agcccttgtt catgtgtggg gatattctct cgactgcatg gaatcagaaa
      121 gcatcagaag gatgggaaat gcctgcattc ccctgaaaag aattgcctat ttcctatgcc
      181 tcttttctgt ggttttgctg actgagggga agaaaccagc gaagccaaaa tgccctgctg
      241 tgtgtacttg tagcaaagat aacgctttat gtgagaatgc gagatccatt ccacgcaccg
      301 ttcctcctga tgttatctca ctatcctttg tgagatctgg ttttactgaa atctcagaag
      361 ggagtttctt gttcacacca tcgctgcagc tcttgttatt cacgtcgaac tcctttgatg
      421 tgatcagtga cgatgctttt attggtcttc cacacctaga atatttattc atagaaaaca
      481 acaatatcaa gtccatttca agacatactt tccggggact caagtctctg attcacttga
      541 gtcttgcaaa caacaatctc cagacactcc caaaagacat tttcaaaggc ctggattctt
      601 taacaaatgt ggacctaaga gggaactcat ttaactgtga ctgtaaactg aagtggctgg
      661 tggaatggct cggccacacc aacgcaaccg tggaagacat ctactgcgaa ggaccaccgg
      721 agtataagaa acgtaaaatc aacagcctct cccccaagga ttttgactgt atcattacag
      781 aatttgcaaa gtcccaagac ctgccttacc agtcactgtc catagatacc ttttcttatt
      841 tgaatgatga atatgtagtc attgctcagc cttttactgg aaaatgcatt ttcctggaat
      901 gggaccatgt agagaagacc ttccggaatt atgacaacat tacaggcacg tccactgtgg
      961 tgtgcaagcc catagtcatt gacactcagc tctatgtcat tgtggcccag ctgtttggtg
     1021 gctctcatat ctataagcgg gatggctttg caaacaaatt cataaaaatc caagatattg
     1081 aagttctcaa aattcgaaaa cccaatgaca tcgaaacatt caagattgaa gacaactggt
     1141 actttgtagt tgctgacagt tccaaagctg gctttactac catttacaaa tggaatggaa
     1201 acggattcta ctcccaccaa tccttacatg cttggtacag ggatactgat gtggaatacc
     1261 tagaaatagc cagaccacca ttgaccctca gaacacctca tttgatcctg tccagtagtt
     1321 ctcagcgccc tgttatttac cagtggagca aagcaacaca gttattcatt aaccagactg
     1381 acattcccaa catggaggat gtgtatgcag tgaagcactt ctctgtgaaa ggtgatgtgt
     1441 acatttgctt gaccagattc attggcgact ccaaagtcat gaagtggggc ggctcctcct
     1501 tccaggacat tcagaggatg ccatctcgag gatccatggt gttccagcct cttcagataa
     1561 ataattacca atatgcaatt ctgggaagcg attactcctt tactcaagtg tataactggg
     1621 atgcagagaa agccaagttt gtgaagtttc aggagttaaa tgttcaggca cccagatcat
     1681 tcacgcacgt gtccattaac aagcgtaatt ttctcttcgc ttccagtttt aagggaaaca
     1741 cacagattta caaacatgtc atagttgact taagcgcatg agacaccaaa ttccatggct
     1801 gccatcggaa actttctaca gtgcgtgtga cctggatgaa ctcaatgcat gatgactctt
     1861 cttatcacac ttgcggatga attacctttc aacattgaga ctgctaaagc caatactact
     1921 agaatcacca tccttaactg tccagtccag tggtgtggga agttaccttt tataagacaa
     1981 agtttcatta cgtaactgtt ctttgcagtg taaataagcg tttaatggta tctgttactc
     2041 caagaggaaa tattcatatg tacttttcca tttatttatt cacgcgtccc gaaacaactg
     2101 ccaaataaaa tgtttacact ttctttca
//
