LOCUS       NM_012977               1454 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus galectin 9 (Lgals9), transcript variant 2, mRNA.
ACCESSION   NM_012977
VERSION     NM_012977.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1454)
  AUTHORS   Ramirez Hernandez,E., Hernandez Zimbron,L.F., Segura Perez,E.,
            Sanchez Salgado,J.L., Pereyra Morales,M.A. and Zenteno,E.
  TITLE     Galectin-9 and Tim-3 are upregulated in response to microglial
            activation induced by the peptide Amyloid-beta (25-35)
  JOURNAL   Neuropeptides 105, 102426 (2024)
   PUBMED   38527407
  REMARK    GeneRIF: Galectin-9 and Tim-3 are upregulated in response to
            microglial activation induced by the peptide Amyloid-beta (25-35).
REFERENCE   2  (bases 1 to 1454)
  AUTHORS   Liang,T., Ma,C., Wang,T., Deng,R., Ding,J., Wang,W., Xu,Z., Li,X.,
            Li,H., Sun,Q., Shen,H., Wang,Z. and Chen,G.
  TITLE     Galectin-9 Promotes Neuronal Restoration via Binding TLR-4 in a Rat
            Intracerebral Hemorrhage Model
  JOURNAL   Neuromolecular Med 23 (2), 267-284 (2021)
   PUBMED   32865657
  REMARK    GeneRIF: Galectin-9 Promotes Neuronal Restoration via Binding TLR-4
            in a Rat Intracerebral Hemorrhage Model.
REFERENCE   3  (bases 1 to 1454)
  AUTHORS   Li,Y.H., Zhou,W.H., Tao,Y., Wang,S.C., Jiang,Y.L., Zhang,D.,
            Piao,H.L., Fu,Q., Li,D.J. and Du,M.R.
  TITLE     The Galectin-9/Tim-3 pathway is involved in the regulation of NK
            cell function at the maternal-fetal interface in early pregnancy
  JOURNAL   Cell Mol Immunol 13 (1), 73-81 (2016)
   PUBMED   25578313
REFERENCE   4  (bases 1 to 1454)
  AUTHORS   Hsu,Y.L., Wang,M.Y., Ho,L.J., Huang,C.Y. and Lai,J.H.
  TITLE     Up-regulation of galectin-9 induces cell migration in human
            dendritic cells infected with dengue virus
  JOURNAL   J Cell Mol Med 19 (5), 1065-1076 (2015)
   PUBMED   25754930
REFERENCE   5  (bases 1 to 1454)
  AUTHORS   Moriyama,K., Kukita,A., Li,Y.J., Uehara,N., Zhang,J.Q.,
            Takahashi,I. and Kukita,T.
  TITLE     Regulation of osteoclastogenesis through Tim-3: possible
            involvement of the Tim-3/galectin-9 system in the modulation of
            inflammatory bone destruction
  JOURNAL   Lab Invest 94 (11), 1200-1211 (2014)
   PUBMED   25264706
  REMARK    GeneRIF: Osteoclasts and osteoclast precursors express Tim-3, and
            osteoclast differentiation is negatively regulated by its ligand
            galectin-9.
REFERENCE   6  (bases 1 to 1454)
  AUTHORS   Lensch,M., Lohr,M., Russwurm,R., Vidal,M., Kaltner,H., Andre,S. and
            Gabius,H.J.
  TITLE     Unique sequence and expression profiles of rat galectins-5 and -9
            as a result of species-specific gene divergence
  JOURNAL   Int J Biochem Cell Biol 38 (10), 1741-1758 (2006)
   PUBMED   16740401
  REMARK    GeneRIF: The presented results on galectin-5 relative to galectin-9
            intimate distinct functions especially in erythropoiesis and imply
            currently unknown mechanisms to compensate its absence from the
            galectin network in other mammals.
REFERENCE   7  (bases 1 to 1454)
  AUTHORS   Dai,S.Y., Nakagawa,R., Itoh,A., Murakami,H., Kashio,Y., Abe,H.,
            Katoh,S., Kontani,K., Kihara,M., Zhang,S.L., Hata,T., Nakamura,T.,
            Yamauchi,A. and Hirashima,M.
  TITLE     Galectin-9 induces maturation of human monocyte-derived dendritic
            cells
  JOURNAL   J Immunol 175 (5), 2974-2981 (2005)
   PUBMED   16116184
REFERENCE   8  (bases 1 to 1454)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   9  (bases 1 to 1454)
  AUTHORS   Wada,J. and Kanwar,Y.S.
  TITLE     Identification and characterization of galectin-9, a novel
            beta-galactoside-binding mammalian lectin
  JOURNAL   J Biol Chem 272 (9), 6078-6086 (1997)
   PUBMED   9038233
REFERENCE   10 (bases 1 to 1454)
  AUTHORS   Leal-Pinto,E., Tao,W., Rappaport,J., Richardson,M., Knorr,B.A. and
            Abramson,R.G.
  TITLE     Molecular cloning and functional reconstitution of a urate
            transporter/channel
  JOURNAL   J Biol Chem 272 (1), 617-625 (1997)
   PUBMED   8995305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 20, 2020 this sequence version replaced NM_012977.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67958.1, BC061566.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN11044071,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000010.1  64427961-64428070   c
            111-199             JAXUCZ010000010.1  64419960-64420048   c
            200-401             JAXUCZ010000010.1  64415673-64415874   c
            402-512             JAXUCZ010000010.1  64413504-64413614   c
            513-548             JAXUCZ010000010.1  64410038-64410073   c
            549-599             JAXUCZ010000010.1  64409489-64409539   c
            600-641             JAXUCZ010000010.1  64408855-64408896   c
            642-730             JAXUCZ010000010.1  64407927-64408015   c
            731-893             JAXUCZ010000010.1  64407618-64407780   c
            894-1454            JAXUCZ010000010.1  64405044-64405604   c
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1454
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /note="galectin 9"
                     /db_xref="GeneID:25476"
                     /db_xref="RGD:3005"
     exon            1..110
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1040
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /note="isoform 2 is encoded by transcript variant 2; urate
                     transporter/channel; 36 kDa beta-galactoside-binding
                     lectin; gal-9; Lectin, galactose binding, soluble 9
                     (Galectin-9); lectin, galactoside-binding, soluble, 9"
                     /codon_start=1
                     /product="galectin-9 isoform 2"
                     /protein_id="NP_037109.1"
                     /db_xref="GeneID:25476"
                     /db_xref="RGD:3005"
                     /translation="MAFFSTQPPYMNPVIPFTGIIQGGLQNGLQITLQGTVHPFPNRI
                     AVNFQTGFSGNDIAFHFNPRFEEGGYVVCNTKQNGKWGPEERKMQMPFQKGMPFELCF
                     LVQRSEFKVMVNKNFFVQYSHRVPYHLVDTISVSGCLHLSFINFQTQGFQPAHQAPVA
                     QTIIHTVHSIPGQMLSTPGIPPMAYPTPAYTIPFFTSIPNGFYPSKSINISGVVLPDA
                     KRFHINLRCGGDIAFHLNPRFNEKVVVRNTQINNSWGPEERSLPGRMPFNRGQSFSVW
                     ILCEGHCFKVAVDGQHICEYYHRLKNLPDINTLEVAGDIQLTHVQT"
     exon            111..199
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     exon            200..401
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     exon            402..512
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     exon            513..548
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     exon            549..599
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     exon            600..641
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     exon            642..730
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     exon            731..893
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1454
                     /gene="Lgals9"
                     /gene_synonym="UAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtcccgcc ctgtgcagag ttctgtccag caagtgagga agagagcgtt ggttctcccg
       61 aaacagaaga gatggctttc ttcagcaccc agcctccata catgaaccca gtcatcccct
      121 ttactggaat aatccaagga gggttgcaga acggacttca gatcaccctc caggggaccg
      181 tccacccttt tccaaatagg attgcggtga actttcagac tggcttcagt ggaaatgaca
      241 ttgccttcca cttcaatccc cggtttgagg aaggaggata tgtggtttgc aacacaaagc
      301 agaatggaaa gtgggggcct gaggagagga agatgcagat gcccttccag aaggggatgc
      361 cctttgagct ttgcttcctg gtacagaggt cggaattcaa ggtgatggtg aacaagaact
      421 tctttgtaca gtactcacac cgcgtgccct accacctcgt ggacaccatt tcggtctcgg
      481 gatgcttgca cctgtccttc atcaacttcc agactcaggg ctttcagcct gcccaccagg
      541 cacccgtggc tcaaactatc atccacacag ttcacagcat ccctggacag atgctctcta
      601 ctcctggaat ccctcctatg gcatacccca ccccagccta tactatacct ttcttcacca
      661 gcatcccaaa tgggttttac ccatccaagt ccatcaacat atcaggcgtg gtcttgccag
      721 atgctaagag gttccatatc aaccttcgct gtgggggtga cattgctttc cacctgaacc
      781 cccgtttcaa tgagaaggtt gtggtccgaa acactcagat caacaactcc tgggggcccg
      841 aggagcgaag cctgcctggg agaatgccct tcaatcgtgg ccagagtttc tcagtgtgga
      901 tcttatgtga aggtcactgc ttcaaggtgg ccgtggatgg tcagcatatt tgtgaatatt
      961 accaccgcct gaagaacttg ccggatatca acactctaga ggtggccggt gatatccagc
     1021 tgacacacgt gcagacctag gaaggtctct ggcttaggga tgaaggctga ggaaccctac
     1081 ctgagtcttg tcacctcctc cctgtctcag ccctgcctcc ccaaatcctg tcatcaaaga
     1141 gagcctcatt ggcaggagtt ccaggaaggt ggcattccca attcacaccc tccacaaagg
     1201 gggagtcctg ggctatggga cacatggctg tgagcccaca gtgtcagcca ttgctcccaa
     1261 gctagtcatc ttctgaggga agtgacctcc ctgggtttgc ccctttctct gacctttccc
     1321 ttcacccctc caggagggcc accttgatgt catcccattg gcctccagct gacccagaat
     1381 gtccacatta ccttttcccc aatctttccc aatgcccata aaataaagaa tatcaacgct
     1441 tgtctacaca caca
//
