LOCUS       NM_053862               2525 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus galectin 8 (Lgals8), mRNA.
ACCESSION   NM_053862 XM_001066972
VERSION     NM_053862.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2525)
  AUTHORS   Staring,J., von Castelmur,E., Blomen,V.A., van den Hengel,L.G.,
            Brockmann,M., Baggen,J., Thibaut,H.J., Nieuwenhuis,J., Janssen,H.,
            van Kuppeveld,F.J., Perrakis,A., Carette,J.E. and Brummelkamp,T.R.
  TITLE     PLA2G16 represents a switch between entry and clearance of
            Picornaviridae
  JOURNAL   Nature 541 (7637), 412-416 (2017)
   PUBMED   28077878
REFERENCE   2  (bases 1 to 2525)
  AUTHORS   Tribulatti,M.V., Figini,M.G., Carabelli,J., Cattaneo,V. and
            Campetella,O.
  TITLE     Redundant and antagonistic functions of galectin-1, -3, and -8 in
            the elicitation of T cell responses
  JOURNAL   J Immunol 188 (7), 2991-2999 (2012)
   PUBMED   22357632
REFERENCE   3  (bases 1 to 2525)
  AUTHORS   Thurston,T.L., Wandel,M.P., von Muhlinen,N., Foeglein,A. and
            Randow,F.
  TITLE     Galectin 8 targets damaged vesicles for autophagy to defend cells
            against bacterial invasion
  JOURNAL   Nature 482 (7385), 414-418 (2012)
   PUBMED   22246324
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2525)
  AUTHORS   Tsai,C.M., Guan,C.H., Hsieh,H.W., Hsu,T.L., Tu,Z., Wu,K.J.,
            Lin,C.H. and Lin,K.I.
  TITLE     Galectin-1 and galectin-8 have redundant roles in promoting plasma
            cell formation
  JOURNAL   J Immunol 187 (4), 1643-1652 (2011)
   PUBMED   21753146
REFERENCE   5  (bases 1 to 2525)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2525)
  AUTHORS   Cueni,L.N. and Detmar,M.
  TITLE     Galectin-8 interacts with podoplanin and modulates lymphatic
            endothelial cell functions
  JOURNAL   Exp Cell Res 315 (10), 1715-1723 (2009)
   PUBMED   19268462
REFERENCE   7  (bases 1 to 2525)
  AUTHORS   Hadari,Y.R., Paz,K., Dekel,R., Mestrovic,T., Accili,D. and Zick,Y.
  TITLE     Galectin-8. A new rat lectin, related to galectin-4
  JOURNAL   J Biol Chem 270 (7), 3447-3453 (1995)
   PUBMED   7852431
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072488.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001066972.1, NM_053862.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072488.1, U09824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..2525
                     /gene="Lgals8"
                     /note="galectin 8"
                     /db_xref="GeneID:116641"
                     /db_xref="RGD:621272"
     exon            1..39
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     exon            40..182
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1091
                     /gene="Lgals8"
                     /note="RL-30; 30 kDa S-type lectin; gal-8; lectin,
                     galactose binding, soluble 8; lectin, galactoside-binding,
                     soluble, 8"
                     /codon_start=1
                     /product="galectin-8"
                     /protein_id="NP_446314.2"
                     /db_xref="GeneID:116641"
                     /db_xref="RGD:621272"
                     /translation="MLSLSNLQNIIYNPTIPYVSTITEQLKPGSLIVIRGHVPKDSER
                     FQVDFQHGNSLKPRADVAFHFNPRFKRSNCIVCNTLTNEKWGWEEITHDMPFRKEKSF
                     EIVIMVLKNKFQVAVNGKHILLYAHRINPEKIDTLGIYGKVNIHSIGFRFSSDLQSME
                     TSTLGLTQISKENIQKSGKLHLSLPFEARLNASMGPGRTVVVKGEVNTNAKSFNVDLV
                     AGRSRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITCFPFSSGMYFEMIIYCDVRE
                     FKVAVNGVHSLEYKHRFKDLSSIDTLAVDGDIRLLDVRSW"
     exon            183..271
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     exon            272..482
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     exon            483..602
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     exon            603..659
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     exon            660..686
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     exon            687..775
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     exon            776..941
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
     exon            942..2507
                     /gene="Lgals8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacgtcgg agcgcagcac ctactaccac ctggctgggg acaagttatt actttgagta
       61 atccttaaat gaagagtggg taaagcccat atacggaaga gagactccag tcaacaatat
      121 caataagttg aagaagaaaa atgttgtcct taagcaatct acaaaatatc atctataacc
      181 cgacaatccc ctatgtcagt accattactg agcagttgaa gcctggctct ttgatcgtga
      241 tccgtggcca tgttcctaaa gattcagaaa gattccaagt agactttcag catggcaaca
      301 gcctgaagcc gagagctgat gtggccttcc actttaaccc tcgcttcaaa aggtccaact
      361 gcattgtttg taacacactg acaaatgaga aatggggctg ggaggagatc acccacgaca
      421 tgcctttcag aaaagaaaag tcctttgaga ttgtgatcat ggtgctaaag aacaaattcc
      481 aggtggctgt gaatggaaag cacattctgc tgtatgccca caggatcaac ccagagaaga
      541 tagacacact gggcatctac ggcaaagtga acattcactc catcgggttc agattcagct
      601 cggatttaca gagtatggaa acatctactc tgggactgac acagataagt aaagaaaata
      661 tacaaaagtc tggcaagctc catttgagcc tgccatttga agcaaggttg aatgcctcca
      721 tgggccctgg acgaaccgtt gtcgttaaag gagaagtgaa tacaaatgcc aaaagcttta
      781 atgttgacct agtggcagga aggtcaaggg atatcgctct gcacttgaac ccacgcctga
      841 atgtgaaagc gtttgtaaga aactcctttc ttcaggatgc ctggggagaa gaggagagaa
      901 acattacctg cttcccattt agttctggga tgtactttga gatgataatt tactgtgatg
      961 tccgagagtt caaggttgca gtaaatggtg tgcacagcct ggagtacaag cacagattta
     1021 aagacctaag cagcatcgac acactagcag ttgatggcga tatccgtttg ctggatgtaa
     1081 ggagctggta gctatcatga ctgccagaac cctggaaata caaaatggct tatccgatac
     1141 tggccatgtc aaatgcatct cgctttcacc acattgttat actgttaagt tgagctcgca
     1201 caacatcaag tcctactggt gttgtcaggc ctggccatgc agtgtggcta cctctgaatt
     1261 cccaggaaca gatggggcag tcacagctca ctgcgagcga ggctctgcac accgggtccc
     1321 tcttataaaa ctgcactcaa caaatatcta agtgcctaat atactacata tgctagctga
     1381 cagggatggc aagcgtactt cctctgtaca ttctctgagc tggccagaca tggcagtgcc
     1441 cacaacttgt gtggtgcctg ttttctggca ctcacatgtc atgcgaccag tttctgatgt
     1501 agggtcttcc tgctagcatt gcatttaccc cactaggggc ctttgcagtt aagatcagaa
     1561 aaatatacta atggatggaa aacactactt ccccagtaat cctgtcataa tcaacattct
     1621 atcatatctc ataactgaag actgcataac atttatttag ctctcactgc tttaaacttt
     1681 ataaaatata tgatgctgaa cacagcaaaa aaactgaggc caaaacgctg aattatgaca
     1741 aaacaagtgt tctgctccag gcagatttct gctggttgat tggcagatta agtccagggt
     1801 gtttgtgggt gcctgtggca aagcgcggta gaagtttata gtttgaaaaa ccctcttggg
     1861 taactaacat caaggtatac agtgagtata taaaacaggc actgtcagag caaaaccgat
     1921 ccaggagggc agtgtgaaaa ggttgagctg gtgtggagac cagccctcgt gcctttgggt
     1981 ctgaagatgt cggcacatca tcagtgaggt caagcactgc tctgcctgct aagtcgactt
     2041 gtatcagcag atacagcttc tgtactcctg taacctccag gatttgactg gagccctagg
     2101 tagtctttct tcactggttg tcacagatgt caaaggtttg gctgttggga gggggaagtg
     2161 ttactttcat caggtcattg tatgatatta aaccacagga tagcattttg ccagggttta
     2221 ggagtattca gtcaacttgc ccagatacac gtatcataca taggaaataa cagcatcagc
     2281 aatcttactt tttaggaagt actcaaggca gcaactgcta gtccttcatt ttcatgcaaa
     2341 tttattatgt ttactctaaa aaattcatat ggggtggtgg atggaactgg gcaattcgta
     2401 gggagcccag gaggctctag aatcccccag ttacttcctt catgcattac tgagatgttg
     2461 ggggttgaaa ggccctcagt taaaaataaa agcccattca tacaaaaaaa aaaaaaaaaa
     2521 aaaaa
//
