LOCUS       NM_012976                870 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus galectin 5 (Lgals5), mRNA.
ACCESSION   NM_012976
VERSION     NM_012976.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Ruiz,F.M., Medrano,F.J., Ludwig,A.K., Kaltner,H., Shilova,N.V.,
            Bovin,N.V., Gabius,H.J. and Romero,A.
  TITLE     Structural Characterization of Rat Galectin-5, an N-Tailed
            Monomeric Proto-Type-like Galectin
  JOURNAL   Biomolecules 11 (12), 1854 (2021)
   PUBMED   34944498
  REMARK    GeneRIF: Structural Characterization of Rat Galectin-5, an N-Tailed
            Monomeric Proto-Type-like Galectin.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Barres,C., Blanc,L., Bette-Bobillo,P., Andre,S., Mamoun,R.,
            Gabius,H.J. and Vidal,M.
  TITLE     Galectin-5 is bound onto the surface of rat reticulocyte exosomes
            and modulates vesicle uptake by macrophages
  JOURNAL   Blood 115 (3), 696-705 (2010)
   PUBMED   19903899
  REMARK    GeneRIF: Galectin-5 functionality in the exosomal sorting pathway
            during rat reticulocyte maturation.
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Than,N.G., Romero,R., Goodman,M., Weckle,A., Xing,J., Dong,Z.,
            Xu,Y., Tarquini,F., Szilagyi,A., Gal,P., Hou,Z., Tarca,A.L.,
            Kim,C.J., Kim,J.S., Haidarian,S., Uddin,M., Bohn,H., Benirschke,K.,
            Santolaya-Forgas,J., Grossman,L.I., Erez,O., Hassan,S.S.,
            Zavodszky,P., Papp,Z. and Wildman,D.E.
  TITLE     A primate subfamily of galectins expressed at the maternal-fetal
            interface that promote immune cell death
  JOURNAL   Proc Natl Acad Sci U S A 106 (24), 9731-9736 (2009)
   PUBMED   19497882
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Lensch,M., Lohr,M., Russwurm,R., Vidal,M., Kaltner,H., Andre,S. and
            Gabius,H.J.
  TITLE     Unique sequence and expression profiles of rat galectins-5 and -9
            as a result of species-specific gene divergence
  JOURNAL   Int J Biochem Cell Biol 38 (10), 1741-1758 (2006)
   PUBMED   16740401
  REMARK    GeneRIF: The presented results on galectin-5 relative to galectin-9
            intimate distinct functions especially in erythropoiesis and imply
            currently unknown mechanisms to compensate its absence from the
            galectin network in other mammals.
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Gitt,M.A., Wiser,M.F., Leffler,H., Herrmann,J., Xia,Y.R.,
            Massa,S.M., Cooper,D.N., Lusis,A.J. and Barondes,S.H.
  TITLE     Sequence and mapping of galectin-5, a beta-galactoside-binding
            lectin, found in rat erythrocytes
  JOURNAL   J Biol Chem 270 (10), 5032-5038 (1995)
   PUBMED   7890611
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L36862.1.
            
            On Feb 21, 2013 this sequence version replaced NM_012976.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225984.1, FQ226981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680437, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-870               L36862.1           1-870
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..870
                     /gene="Lgals5"
                     /note="galectin 5"
                     /db_xref="GeneID:25475"
                     /db_xref="RGD:3004"
     exon            1..73
                     /gene="Lgals5"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..472
                     /gene="Lgals5"
                     /function="beta-galactoside binding protein"
                     /note="RL-18; gal-5; lectin, galactose binding, soluble 5"
                     /codon_start=1
                     /product="galectin-5"
                     /protein_id="NP_037108.1"
                     /db_xref="GeneID:25475"
                     /db_xref="RGD:3004"
                     /translation="MSSFSTQTPYPNLAVPFFTSIPNGLYPSKSIVISGVVLSDAKRF
                     QINLRCGGDIAFHLNPRFDENAVVRNTQINNSWGPEERSLPGSMPFSRGQRFSVWILC
                     EGHCFKVAVDGQHICEYSHRLMNLPDINTLEVAGDIQLTHVET"
     exon            74..162
                     /gene="Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            163..325
                     /gene="Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            326..870
                     /gene="Lgals5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagagagc gttggttctc ccaagacaga agagatgtct tccttcagca cccagactcc
       61 atacccgaac ctagctgtac ctttcttcac cagcatccca aatgggcttt acccatccaa
      121 gtccatcgtc atatcaggcg tggtcttgtc agatgctaag aggttccaga tcaaccttcg
      181 ctgtgggggt gacattgctt tccacctgaa cccccgtttt gatgagaatg ctgtggtccg
      241 aaacactcag atcaacaact cctgggggcc cgaagagcga agcctgcctg ggagtatgcc
      301 cttcagtcgt ggccagagat tctcagtgtg gatcttatgt gaaggtcact gcttcaaggt
      361 ggccgtggac ggtcagcata tttgtgaata cagccaccgc ctgatgaact tgccggatat
      421 caacactcta gaggtggctg gtgatatcca gctaacacac gtggagacct aggaaggtct
      481 ctggcctagg gatgaaggct gaggaaccct acctgagtct tgtcacctct tccctgtctc
      541 agccctgcct ccccaaatcc tgtcatcaaa gagagcctca ttggcaggag ttccaggaag
      601 gtgacattcc caattcacac cctccacaaa gggggagtcc tgggctgtgg gacacatggc
      661 tgtgagccca cagtgtcagc cattgctccc aagctagtca tcttctgagg gaagtgacct
      721 ccctgggttt gcccctttct ctgacccttt cccttcaccc ctccaggagg gccaccttga
      781 tgtcatccca ctggcctcca actgacccag aatgtccaca ttaacttttc cccaatcttt
      841 cccaatgccc ataaaataaa gaatatcaac
//
