LOCUS       NM_012975               1052 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus galectin 4 (Lgals4), mRNA.
ACCESSION   NM_012975
VERSION     NM_012975.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1052)
  AUTHORS   Arikawa,T., Liao,S., Shimada,H., Inoue,T., Sakata-Haga,H.,
            Nakamura,T., Hatta,T. and Shoji,H.
  TITLE     Galectin-4 expression is down-regulated in response to autophagy
            during differentiation of rat trophoblast cells
  JOURNAL   Sci Rep 6, 32248 (2016)
   PUBMED   27572741
  REMARK    GeneRIF: Data suggest a possible mechanism by which autophagy
            regulates trophoblast differentiation via regulation of galectin-4
            (Gal-4) expression in order to establish the maternal-fetal
            interface.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1052)
  AUTHORS   Velasco,S., Diez-Revuelta,N., Hernandez-Iglesias,T., Kaltner,H.,
            Andre,S., Gabius,H.J. and Abad-Rodriguez,J.
  TITLE     Neuronal Galectin-4 is required for axon growth and for the
            organization of axonal membrane L1 delivery and clustering
  JOURNAL   J Neurochem 125 (1), 49-62 (2013)
   PUBMED   23311731
  REMARK    GeneRIF: Gal-4 sorts to axon plasma membrane segments by binding to
            sulfatide-containing microtubule-associated carriers and organizes
            the transport of L1, and likely other axonal glycoproteins, by
            attaching them to the carriers through their LacNAc termini.
REFERENCE   3  (bases 1 to 1052)
  AUTHORS   Arikawa,T., Simamura,E., Shimada,H., Nishi,N., Tatsuno,T.,
            Ishigaki,Y., Tomosugi,N., Yamashiro,C., Hata,T., Takegami,T.,
            Mogami,H., Yamaguchi,K., Nakamura,T., Otani,H., Hatta,T. and
            Shoji,H.
  TITLE     Expression pattern of Galectin 4 in rat placentation
  JOURNAL   Placenta 33 (10), 885-887 (2012)
   PUBMED   22877695
  REMARK    GeneRIF: In the rat placenta, immunohistochemical analysis showed
            that Gal4 is preferentially located in the maternal-fetal
            junctional zone. These results suggest that down-regulation of Gal4
            may be involved in the promotion of trophoblast cell
            differentiation
REFERENCE   4  (bases 1 to 1052)
  AUTHORS   Stancic,M., Slijepcevic,D., Nomden,A., Vos,M.J., de Jonge,J.C.,
            Sikkema,A.H., Gabius,H.J., Hoekstra,D. and Baron,W.
  TITLE     Galectin-4, a novel neuronal regulator of myelination
  JOURNAL   Glia 60 (6), 919-935 (2012)
   PUBMED   22431161
  REMARK    GeneRIF: This study demonistrated that neuronal galectin-4 as a
            candidate for a soluble regulator of OLG differentiation and,
            hence, myelination.
REFERENCE   5  (bases 1 to 1052)
  AUTHORS   Markova,V., Smetana,K. Jr., Jenikova,G., Lachova,J.,
            Krejcirikova,V., Poplstein,M., Fabry,M., Brynda,J., Alvarez,R.A.,
            Cummings,R.D. and Maly,P.
  TITLE     Role of the carbohydrate recognition domains of mouse galectin-4 in
            oligosaccharide binding and epitope recognition and expression of
            galectin-4 and galectin-6 in mouse cells and tissues
  JOURNAL   Int J Mol Med 18 (1), 65-76 (2006)
   PUBMED   16786157
REFERENCE   6  (bases 1 to 1052)
  AUTHORS   Niepceron,E., Simian,F., Louisot,P. and Biol-N'garagba,M.C.
  TITLE     Expression of galectin 4 in the rat small intestine during
            postnatal development
  JOURNAL   Biochimie 86 (2), 115-118 (2004)
   PUBMED   15016449
  REMARK    GeneRIF: The expression of galectin 4 was determined in the rat
            small intestine during postnatal development.
REFERENCE   7  (bases 1 to 1052)
  AUTHORS   Tardy,F., Deviller,P., Louisot,P. and Martin,A.
  TITLE     Purification and characterization of the N-terminal domain of
            galectin-4 from rat small intestine
  JOURNAL   FEBS Lett 359 (2-3), 169-172 (1995)
   PUBMED   7867792
REFERENCE   8  (bases 1 to 1052)
  AUTHORS   Oda,Y., Herrmann,J., Gitt,M.A., Turck,C.W., Burlingame,A.L.,
            Barondes,S.H. and Leffler,H.
  TITLE     Soluble lactose-binding lectin from rat intestine with two
            different carbohydrate-binding domains in the same peptide chain
  JOURNAL   J Biol Chem 268 (8), 5929-5939 (1993)
   PUBMED   8449956
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012975.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M73553.1, SRR26643288.1749.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000001.1  93252285-93252339
            56-144              JAXUCZ010000001.1  93252561-93252649
            145-349             JAXUCZ010000001.1  93253918-93254122
            350-490             JAXUCZ010000001.1  93256264-93256404
            491-517             JAXUCZ010000001.1  93258478-93258504
            518-556             JAXUCZ010000001.1  93258610-93258648
            557-586             JAXUCZ010000001.1  93258777-93258806
            587-675             JAXUCZ010000001.1  93259069-93259157
            676-838             JAXUCZ010000001.1  93259547-93259709
            839-1052            JAXUCZ010000001.1  93259785-93259998
FEATURES             Location/Qualifiers
     source          1..1052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1052
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /note="galectin 4"
                     /db_xref="GeneID:25474"
                     /db_xref="RGD:3003"
     exon            1..55
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..985
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /note="L36LBP; lactose-binding lectin 4; L-36
                     lactose-binding protein; gal-4; Lectin, galactose binding,
                     soluble 4 (Galectin-4); lectin, galactoside-binding,
                     soluble, 4 (galectin 4)"
                     /codon_start=1
                     /product="galectin-4"
                     /protein_id="NP_037107.1"
                     /db_xref="GeneID:25474"
                     /db_xref="RGD:3003"
                     /translation="MAYVPAPGYQPTYNPTLPYKRPIPGGLSVGMSIYIQGIAKDNMR
                     RFHVNFAVGQDEGADIAFHFNPRFDGWDKVVFNTMQSGQWGKEEKKKSMPFQKGHHFE
                     LVFMVMSEHYKVVVNGTPFYEYGHRLPLQMVTHLQVDGDLELQSINFLGGQPAASQYP
                     GTMTIPAYPSAGYNPPQMNSLPVMAGPPIFNPPVPYVGTLQGGLTARRTIIIKGYVLP
                     TAKNLIINFKVGSTGDIAFHMNPRIGDCVVRNSYMNGSWGSEERKIPYNPFGAGQFFD
                     LSIRCGTDRFKVFANGQHLFDFSHRFQAFQRVDMLEIKGDITLSYVQI"
     exon            56..144
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     exon            145..349
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     exon            350..490
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     exon            491..517
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     exon            518..556
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     exon            557..586
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     exon            587..675
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     exon            676..838
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1052
                     /gene="Lgals4"
                     /gene_synonym="L-36; L36LBI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactctcaag atggcctatg tcccagcacc cggctaccag cccacctaca atccgacgct
       61 gccctacaag aggcccatcc caggtggcct cagtgtcgga atgtccattt acatccaagg
      121 aatagccaaa gacaacatga gacggttcca cgtgaacttt gctgtggggc aggatgaggg
      181 ggcagatatt gctttccact tcaacccccg gtttgatggc tgggacaagg tggtcttcaa
      241 tacgatgcaa agcggacagt ggggcaagga agagaagaag aagagcatgc ctttccaaaa
      301 gggtcaccac ttcgagctgg tgttcatggt catgtctgag cactacaagg tcgtggtaaa
      361 cggaactccc ttctacgaat atgggcaccg gttgccccta cagatggtca cccacttgca
      421 agtggatggg gacctggaac ttcagtcaat caacttcctt gggggccaac ctgctgcatc
      481 ccagtatccg ggaaccatga ctattccagc ttatcctagt gctgggtaca accctccaca
      541 gatgaacagc ctgcctgtca tggcgggacc cccgatcttc aatccgcctg tgccatatgt
      601 ggggaccctg caggggggcc ttacagcccg aagaaccatc ataatcaagg gatatgtact
      661 tcctacagcc aagaacctta tcatcaactt caaggtgggg tcgaccggag acatagcttt
      721 tcacatgaac ccccgcatag gtgattgtgt ggttcgcaac agctatatga atggctcttg
      781 gggctccgaa gagaggaaga taccctacaa cccgtttggc gctgggcagt tctttgatct
      841 gtcaatccgc tgcggcacgg atcgattcaa ggtgtttgcc aacggccagc accttttcga
      901 cttctcacat cggttccaag cattccaaag ggtagacatg ctggagatca aaggcgacat
      961 caccttgtcc tatgtccaga tctgagctcc tcctggggaa ggaagcagag agatacccaa
     1021 gttccatcta atcccctaat aaaatgttga ag
//
