LOCUS       NM_031832                948 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus galectin 3 (Lgals3), mRNA.
ACCESSION   NM_031832
VERSION     NM_031832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 948)
  AUTHORS   Jimenez-Gonzalez,S., Delgado-Valero,B., Islas,F.,
            Romero-Miranda,A., Luaces,M., Ramchandani,B., Cuesta-Corral,M.,
            Montoro-Garrido,A., Martinez-Martinez,E. and Cachofeiro,V.
  TITLE     The detrimental role of galectin-3 and endoplasmic reticulum stress
            in the cardiac consequences of myocardial ischemia in the context
            of obesity
  JOURNAL   FASEB J 38 (14), e23818 (2024)
   PUBMED   38989572
  REMARK    GeneRIF: The detrimental role of galectin-3 and endoplasmic
            reticulum stress in the cardiac consequences of myocardial ischemia
            in the context of obesity.
REFERENCE   2  (bases 1 to 948)
  AUTHORS   Yan,L., Li,Z., Li,C., Chen,J., Zhou,X., Cui,J., Liu,P., Shen,C.,
            Chen,C., Hong,H., Xu,G. and Cui,Z.
  TITLE     Hspb1 and Lgals3 in spinal neurons are closely associated with
            autophagy following excitotoxicity based on machine learning
            algorithms
  JOURNAL   PLoS One 19 (5), e0303235 (2024)
   PUBMED   38728287
  REMARK    GeneRIF: Hspb1 and Lgals3 in spinal neurons are closely associated
            with autophagy following excitotoxicity based on machine learning
            algorithms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 948)
  AUTHORS   Li,J., Han,N., Liu,Z., Osman,A., Xu,L., Song,J., Xiao,Y. and Hu,W.
  TITLE     Role of Galectin-3 in intervertebral disc degeneration: an
            experimental study
  JOURNAL   BMC Musculoskelet Disord 25 (1), 249 (2024)
   PUBMED   38561725
  REMARK    GeneRIF: Role of Galectin-3 in intervertebral disc degeneration: an
            experimental study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 948)
  AUTHORS   Sun,W., Hao,Y., Li,C., Zhao,Y., Yu,H. and Wang,L.
  TITLE     Inhibition of Galectin-3 in a Rat Model of Epilepsy and
            Kainate-Activated BV2 Cells Limits Microglial Activation Through
            the NLRP3/Pyroptosis Pathway
  JOURNAL   Neuroimmunomodulation 30 (1), 325-337 (2023)
   PUBMED   37926077
  REMARK    GeneRIF: Inhibition of Galectin-3 in a Rat Model of Epilepsy and
            Kainate-Activated BV2 Cells Limits Microglial Activation Through
            the NLRP3/Pyroptosis Pathway.
REFERENCE   5  (bases 1 to 948)
  AUTHORS   Cervantes-Alvarez,E., la Rosa,N.L., la Mora,M.S.,
            Valdez-Sandoval,P., Palacios-Jimenez,M., Rodriguez-Alvarez,F.,
            Vera-Maldonado,B.I., Aguirre-Aguilar,E., Escobar-Valderrama,J.M.,
            Alanis-Mendizabal,J., Mendez-Guerrero,O., Tejeda-Dominguez,F.,
            Torres-Ruiz,J., Gomez-Martin,D., Colborn,K.L., Kershenobich,D.,
            Huang,C.A. and Navarro-Alvarez,N.
  TITLE     Galectin-3 as a potential prognostic biomarker of severe COVID-19
            in SARS-CoV-2 infected patients
  JOURNAL   Sci Rep 12 (1), 1856 (2022)
   PUBMED   35115644
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 948)
  AUTHORS   Frigeri,L.G., Robertson,M.W. and Liu,F.T.
  TITLE     Expression of biologically active recombinant rat IgE-binding
            protein in Escherichia coli
  JOURNAL   J Biol Chem 265 (34), 20763-20769 (1990)
   PUBMED   2249984
REFERENCE   7  (bases 1 to 948)
  AUTHORS   Robertson,M.W., Albrandt,K., Keller,D. and Liu,F.T.
  TITLE     Human IgE-binding protein: a soluble lectin exhibiting a highly
            conserved interspecies sequence and differential recognition of IgE
            glycoforms
  JOURNAL   Biochemistry 29 (35), 8093-8100 (1990)
   PUBMED   2261464
REFERENCE   8  (bases 1 to 948)
  AUTHORS   Cherayil,B.J., Chaitovitz,S., Wong,C. and Pillai,S.
  TITLE     Molecular cloning of a human macrophage lectin specific for
            galactose
  JOURNAL   Proc Natl Acad Sci U S A 87 (18), 7324-7328 (1990)
   PUBMED   2402511
REFERENCE   9  (bases 1 to 948)
  AUTHORS   Leffler,H., Masiarz,F.R. and Barondes,S.H.
  TITLE     Soluble lactose-binding vertebrate lectins: a growing family
  JOURNAL   Biochemistry 28 (23), 9222-9229 (1989)
   PUBMED   2605254
REFERENCE   10 (bases 1 to 948)
  AUTHORS   Albrandt,K., Orida,N.K. and Liu,F.T.
  TITLE     An IgE-binding protein with a distinctive repetitive sequence and
            homology with an IgG receptor
  JOURNAL   Proc Natl Acad Sci U S A 84 (19), 6859-6863 (1987)
   PUBMED   2958848
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J02962.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218337.1, FQ219929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..948
                     /gene="Lgals3"
                     /gene_synonym="AGE-R3; CBP30; gal-3; L-34"
                     /note="galectin 3"
                     /db_xref="GeneID:83781"
                     /db_xref="RGD:69356"
     exon            1..36
                     /gene="Lgals3"
                     /gene_synonym="AGE-R3; CBP30; gal-3; L-34"
                     /inference="alignment:Splign:2.1.0"
     exon            37..58
                     /gene="Lgals3"
                     /gene_synonym="AGE-R3; CBP30; gal-3; L-34"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..829
                     /gene="Lgals3"
                     /gene_synonym="AGE-R3; CBP30; gal-3; L-34"
                     /note="lectin, galactose binding, soluble 3; CBP 35;
                     lectin L-29; 35 kDa lectin; mac-2 antigen; igE-binding
                     protein; laminin-binding protein; galactose-specific
                     lectin 3; carbohydrate-binding protein 35; IgE binding
                     protein; lectin, galactoside-binding, soluble, 3; lectin
                     galactoside-binding soluble 3 protein; epsilon BP"
                     /codon_start=1
                     /product="galectin-3"
                     /protein_id="NP_114020.1"
                     /db_xref="GeneID:83781"
                     /db_xref="RGD:69356"
                     /translation="MADGFSLNDALAGSGNPNPRGWPGAWGNQPGAGGYPGASYPGAY
                     PGQAPPGGYPGQAPPSAYPGPTGPSAYPGPTAPGAYPGPTAPGAFPGQPGGPGAYPSA
                     PGAYPSAPGAYPATGPFGAPTGPLTVPYDMPLPGGVMPRMLITIIGTVKPNANSITLN
                     FKKGNDIAFHFNPRFNENNRRVIVCNTKQDNNWGREERQSAFPFESGKPFKIQVLVEA
                     DHFKVAVNDVHLLQYNHRMKNLREISQLGIIGDITLTSASHAMI"
     exon            59..418
                     /gene="Lgals3"
                     /gene_synonym="AGE-R3; CBP30; gal-3; L-34"
                     /inference="alignment:Splign:2.1.0"
     exon            419..507
                     /gene="Lgals3"
                     /gene_synonym="AGE-R3; CBP30; gal-3; L-34"
                     /inference="alignment:Splign:2.1.0"
     exon            508..673
                     /gene="Lgals3"
                     /gene_synonym="AGE-R3; CBP30; gal-3; L-34"
                     /inference="alignment:Splign:2.1.0"
     exon            674..948
                     /gene="Lgals3"
                     /gene_synonym="AGE-R3; CBP30; gal-3; L-34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagctagc ggagcggcag gaggagcact aaccaggaaa atggcagacg gcttctcact
       61 taatgatgcc ttagctggct ctggaaaccc aaaccctcga ggatggcctg gtgcatgggg
      121 gaaccagcct ggggcaggag gctacccagg ggcctcctat cctggggcct acccaggaca
      181 ggctcctcca gggggttatc ctggacaggc tcctcctagt gcctatccgg gcccaactgg
      241 ccctagtgct tatcctggcc caactgcccc tggagcttat cctggcccaa ctgcccccgg
      301 agccttccca gggcaacctg ggggacctgg agcctacccc agtgctcctg gggcctaccc
      361 cagtgctcct ggggcctatc ctgctactgg cccctttggt gccccgactg gaccactgac
      421 agtgccctac gatatgccct tgcctggagg agtcatgcct cgcatgctga tcacaatcat
      481 aggcacagtg aagcccaacg caaacagtat cactctgaat ttcaagaaag ggaacgacat
      541 cgccttccac tttaaccccc gcttcaatga gaacaacaga agagtcatcg tgtgcaacac
      601 gaagcaggac aataactggg gaagggaaga aagacagtca gctttcccct ttgagagcgg
      661 caaaccattc aaaatacagg tcctggttga agccgaccac ttcaaggttg cggtcaatga
      721 tgttcatctg ttgcagtata accatcggat gaagaacctc agggaaatca gccaactggg
      781 gatcattggt gacataaccc tcaccagcgc ttcccacgcc atgatctaag ccagaagggg
      841 tgggccggca ccagaactgc cctgtgtgtt atgagcggga aactttgcat ttctctctcc
      901 ttatacttct tgtaagacat ccatttaata aagtctcgtg ctgagaga
//
