LOCUS       NM_133599                610 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus galectin 2 (Lgals2), mRNA.
ACCESSION   NM_133599
VERSION     NM_133599.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 610)
  AUTHORS   Paclik,D., Berndt,U., Guzy,C., Dankof,A., Danese,S.,
            Holzloehner,P., Rosewicz,S., Wiedenmann,B., Wittig,B.M.,
            Dignass,A.U. and Sturm,A.
  TITLE     Galectin-2 induces apoptosis of lamina propria T lymphocytes and
            ameliorates acute and chronic experimental colitis in mice
  JOURNAL   J Mol Med (Berl) 86 (12), 1395-1406 (2008)
   PUBMED   18064431
  REMARK    GeneRIF: Galectin-2 treatment induced apoptosis of mucosal T cells
            and thus ameliorated acute and chronic
            dextran-sodium-sulfate-induced colitis and in a T-helper-cell
            1-driven model of antigen-specific transfer colitis.
REFERENCE   2  (bases 1 to 610)
  AUTHORS   Asselbergs,F.W., Pai,J.K., Rexrode,K.M., Hunter,D.J. and Rimm,E.B.
  TITLE     Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms
            on inflammatory biomarkers, cellular adhesion molecules and risk of
            coronary heart disease
  JOURNAL   Clin Sci (Lond) 112 (5), 291-298 (2007)
   PUBMED   17040205
REFERENCE   3  (bases 1 to 610)
  AUTHORS   Ozaki,K., Inoue,K., Sato,H., Iida,A., Ohnishi,Y., Sekine,A.,
            Sato,H., Odashiro,K., Nobuyoshi,M., Hori,M., Nakamura,Y. and
            Tanaka,T.
  TITLE     Functional variation in LGALS2 confers risk of myocardial
            infarction and regulates lymphotoxin-alpha secretion in vitro
  JOURNAL   Nature 429 (6987), 72-75 (2004)
   PUBMED   15129282
REFERENCE   4  (bases 1 to 610)
  AUTHORS   Oka,T., Murakami,S., Arata,Y., Hirabayashi,J., Kasai,K., Wada,Y.
            and Futai,M.
  TITLE     Identification and cloning of rat galectin-2: expression is
            predominantly in epithelial cells of the stomach
  JOURNAL   Arch Biochem Biophys 361 (2), 195-201 (1999)
   PUBMED   9882446
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133599.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001075.1, BP495487.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000007.1  112290091-112290123 c
            34-116              JAXUCZ010000007.1  112285111-112285193 c
            117-276             JAXUCZ010000007.1  112284081-112284240 c
            277-610             JAXUCZ010000007.1  112283633-112283966 c
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..610
                     /gene="Lgals2"
                     /note="galectin 2"
                     /db_xref="GeneID:171134"
                     /db_xref="RGD:621269"
     exon            1..33
                     /gene="Lgals2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..420
                     /gene="Lgals2"
                     /note="gal-2; lectin, galactoside-binding, soluble, 2
                     (galectin 2)"
                     /codon_start=1
                     /product="galectin-2"
                     /protein_id="NP_598283.1"
                     /db_xref="GeneID:171134"
                     /db_xref="RGD:621269"
                     /translation="MSEKFEVTNLNMKSGMSLKIKGKIHNDVNSFTINLGQGKETLNL
                     HFNPRFNESTIVCNTLDGSSWGQEQRENHSCFSPGSEVKLTLTFQDKDFKVTLPDGHS
                     LTFPNRLGHNHLRYLSMDGLQISSFKLE"
     exon            34..116
                     /gene="Lgals2"
                     /inference="alignment:Splign:2.1.0"
     exon            117..276
                     /gene="Lgals2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..610
                     /gene="Lgals2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagctgt gtccaggagc cgtcaccatg tcggagaaat tcgaggtcac aaacctgaac
       61 atgaaatcag ggatgtccct gaagattaaa ggcaagatcc acaatgatgt taacagcttc
      121 accattaacc tgggccaggg gaaagaaacg ctgaacctgc attttaaccc tcgcttcaat
      181 gaatccacca ttgtctgtaa cacccttgac ggtagcagct ggggacaaga gcaacgagaa
      241 aaccattcct gtttcagtcc agggtcagag gtcaagctca cccttacctt ccaagacaaa
      301 gacttcaagg tgacgctgcc tgatggacac tcgctgacct tccccaacag gctgggccac
      361 aaccacctgc gctacttaag catggatggg ctccagatct cctccttcaa gctcgagtga
      421 gcatctcctc agaagacctt agccccaaac cagcttcagc cagccctcca gcaagccccc
      481 accagaaccg cagtctttat aggttctgct cttactcacc gttcactctg aactcctgcc
      541 ctaactaatt aaccccttcc ccaagttcaa ggccaaataa aagaatccat ttttattatt
      601 tccacagcaa
//
