LOCUS       NM_019904                519 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus galectin 1 (Lgals1), mRNA.
ACCESSION   NM_019904
VERSION     NM_019904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Kiss,T., Mir,Y., Stefancsik,G., Ganbat,G., Askarova,A.,
            Monostori,E., Dulka,K., Szebeni,G.J., Nyul-Toth,A., Csiszar,A. and
            Legradi,A.
  TITLE     Galectin-1 as a marker for microglia activation in the aging brain
  JOURNAL   Brain Res 1818, 148517 (2023)
   PUBMED   37557976
  REMARK    GeneRIF: Galectin-1 as a marker for microglia activation in the
            aging brain.
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Fan,J., Fan,W., Lei,J., Zhou,Y., Xu,H., Kapoor,I., Zhu,G. and
            Wang,J.
  TITLE     Galectin-1 attenuates cardiomyocyte hypertrophy through
            splice-variant specific modulation of CaV1.2 calcium channel
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (1), 218-229 (2019)
   PUBMED   30463690
  REMARK    GeneRIF: Dysregulated Gal-1 and Ca(V)1.2 alternative exon 9* might
            be attributed to the pathological processes of cardiac hypertrophy,
            and provides a potential anti-hypertrophic target in the heart.
REFERENCE   3  (bases 1 to 519)
  AUTHORS   Sasaguri,K., Yamada,K., Narimatsu,Y., Oonuki,M., Oishi,A., Koda,K.,
            Kubo,K.Y., Yamamoto,T. and Kadoya,T.
  TITLE     Stress-induced galectin-1 influences immune tolerance in the spleen
            and thymus by modulating CD45 immunoreactive lymphocytes
  JOURNAL   J Physiol Sci 67 (4), 489-496 (2017)
   PUBMED   27573167
  REMARK    GeneRIF: Stress-induced Gal-1 immediately accumulates in the spleen
            and thymus, and may modulate the immune response through apoptosis
            by binding to CD45(+) lymphocytes in immune organs following
            physiological and/or psychological stress.
REFERENCE   4  (bases 1 to 519)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (bases 1 to 519)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 519)
  AUTHORS   Salvatore,P., Contursi,C., Benvenuto,G., Bruni,C.B. and
            Chiariotti,L.
  TITLE     Characterization and functional dissection of the galectin-1 gene
            promoter
  JOURNAL   FEBS Lett 373 (2), 159-163 (1995)
   PUBMED   7589457
REFERENCE   7  (bases 1 to 519)
  AUTHORS   Cooper,D.N., Massa,S.M. and Barondes,S.H.
  TITLE     Endogenous muscle lectin inhibits myoblast adhesion to laminin
  JOURNAL   J Cell Biol 115 (5), 1437-1448 (1991)
   PUBMED   1955484
REFERENCE   8  (bases 1 to 519)
  AUTHORS   Hynes,M.A., Gitt,M., Barondes,S.H., Jessell,T.M. and Buck,L.B.
  TITLE     Selective expression of an endogenous lactose-binding lectin gene
            in subsets of central and peripheral neurons
  JOURNAL   J Neurosci 10 (3), 1004-1013 (1990)
   PUBMED   2319298
REFERENCE   9  (bases 1 to 519)
  AUTHORS   Clerch,L.B., Whitney,P., Hass,M., Brew,K., Miller,T., Werner,R. and
            Massaro,D.
  TITLE     Sequence of a full-length cDNA for rat lung
            beta-galactoside-binding protein: primary and secondary structure
            of the lectin
  JOURNAL   Biochemistry 27 (2), 692-699 (1988)
   PUBMED   3349058
REFERENCE   10 (bases 1 to 519)
  AUTHORS   Whitney,P.L., Powell,J.T. and Sanford,G.L.
  TITLE     Oxidation and chemical modification of lung
            beta-galactoside-specific lectin
  JOURNAL   Biochem J 238 (3), 683-689 (1986)
   PUBMED   3800956
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M19036.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M19036.1, FQ217640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..519
                     /gene="Lgals1"
                     /note="galectin 1"
                     /db_xref="GeneID:56646"
                     /db_xref="RGD:69355"
     exon            1..45
                     /gene="Lgals1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..444
                     /gene="Lgals1"
                     /note="lectin, galactose binding, soluble 1; RL 14.5;
                     lectin, galactoside-binding, soluble, 1; galaptin; 14 kDa
                     lectin; S-Lac lectin 1; lactose-binding lectin 1;
                     beta-galactoside-binding lectin L-14-I; gal-1"
                     /codon_start=1
                     /product="galectin-1"
                     /protein_id="NP_063969.1"
                     /db_xref="GeneID:56646"
                     /db_xref="RGD:69355"
                     /translation="MACGLVASNLNLKPGECLKVRGELAPDAKSFVLNLGKDSNNLCL
                     HFNPRFNAHGDANTIVCNSKDDGTWGTEQRETAFPFQPGSITEVCITFDQADLTIKLP
                     DGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE"
     exon            46..125
                     /gene="Lgals1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..297
                     /gene="Lgals1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..506
                     /gene="Lgals1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggagcag gtcgcaggaa tctcttcgct tcaatcatgg cctgtggtct ggtcgccagc
       61 aacctgaatc tcaaacctgg ggaatgtctc aaagttcggg gagagctggc cccggacgcc
      121 aagagctttg tgttgaacct ggggaaagac agcaacaacc tgtgcctaca cttcaacccc
      181 cgcttcaacg cccacggaga tgccaacacc attgtgtgta acagcaagga cgatgggacc
      241 tggggaacag aacaacggga gactgccttc cctttccagc ctgggagcat cacggaggtg
      301 tgcatcacct ttgaccaggc tgacctgacc atcaagctgc cagacgggca tgaattcaaa
      361 ttccccaacc gcctcaacat ggaggccatc aactacatgg cggcggatgg tgacttcaag
      421 attaagtgtg tggcctttga gtgaagccag ccagccccag cccgtagccc ccaataaagg
      481 cagctgcctc tgctccctgt aacccaaaaa aaaaaaaaa
//
