LOCUS       NP_063969                135 aa            linear   ROD 02-JUN-2024
DEFINITION  galectin-1 [Rattus norvegicus].
ACCESSION   NP_063969
VERSION     NP_063969.1
DBSOURCE    REFSEQ: accession NM_019904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 135)
  AUTHORS   Kiss,T., Mir,Y., Stefancsik,G., Ganbat,G., Askarova,A.,
            Monostori,E., Dulka,K., Szebeni,G.J., Nyul-Toth,A., Csiszar,A. and
            Legradi,A.
  TITLE     Galectin-1 as a marker for microglia activation in the aging brain
  JOURNAL   Brain Res 1818, 148517 (2023)
   PUBMED   37557976
  REMARK    GeneRIF: Galectin-1 as a marker for microglia activation in the
            aging brain.
REFERENCE   2  (residues 1 to 135)
  AUTHORS   Fan,J., Fan,W., Lei,J., Zhou,Y., Xu,H., Kapoor,I., Zhu,G. and
            Wang,J.
  TITLE     Galectin-1 attenuates cardiomyocyte hypertrophy through
            splice-variant specific modulation of CaV1.2 calcium channel
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (1), 218-229 (2019)
   PUBMED   30463690
  REMARK    GeneRIF: Dysregulated Gal-1 and Ca(V)1.2 alternative exon 9* might
            be attributed to the pathological processes of cardiac hypertrophy,
            and provides a potential anti-hypertrophic target in the heart.
REFERENCE   3  (residues 1 to 135)
  AUTHORS   Sasaguri,K., Yamada,K., Narimatsu,Y., Oonuki,M., Oishi,A., Koda,K.,
            Kubo,K.Y., Yamamoto,T. and Kadoya,T.
  TITLE     Stress-induced galectin-1 influences immune tolerance in the spleen
            and thymus by modulating CD45 immunoreactive lymphocytes
  JOURNAL   J Physiol Sci 67 (4), 489-496 (2017)
   PUBMED   27573167
  REMARK    GeneRIF: Stress-induced Gal-1 immediately accumulates in the spleen
            and thymus, and may modulate the immune response through apoptosis
            by binding to CD45(+) lymphocytes in immune organs following
            physiological and/or psychological stress.
REFERENCE   4  (residues 1 to 135)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (residues 1 to 135)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (residues 1 to 135)
  AUTHORS   Salvatore,P., Contursi,C., Benvenuto,G., Bruni,C.B. and
            Chiariotti,L.
  TITLE     Characterization and functional dissection of the galectin-1 gene
            promoter
  JOURNAL   FEBS Lett 373 (2), 159-163 (1995)
   PUBMED   7589457
REFERENCE   7  (residues 1 to 135)
  AUTHORS   Cooper,D.N., Massa,S.M. and Barondes,S.H.
  TITLE     Endogenous muscle lectin inhibits myoblast adhesion to laminin
  JOURNAL   J Cell Biol 115 (5), 1437-1448 (1991)
   PUBMED   1955484
REFERENCE   8  (residues 1 to 135)
  AUTHORS   Hynes,M.A., Gitt,M., Barondes,S.H., Jessell,T.M. and Buck,L.B.
  TITLE     Selective expression of an endogenous lactose-binding lectin gene
            in subsets of central and peripheral neurons
  JOURNAL   J Neurosci 10 (3), 1004-1013 (1990)
   PUBMED   2319298
REFERENCE   9  (residues 1 to 135)
  AUTHORS   Clerch,L.B., Whitney,P., Hass,M., Brew,K., Miller,T., Werner,R. and
            Massaro,D.
  TITLE     Sequence of a full-length cDNA for rat lung
            beta-galactoside-binding protein: primary and secondary structure
            of the lectin
  JOURNAL   Biochemistry 27 (2), 692-699 (1988)
   PUBMED   3349058
REFERENCE   10 (residues 1 to 135)
  AUTHORS   Whitney,P.L., Powell,J.T. and Sanford,G.L.
  TITLE     Oxidation and chemical modification of lung
            beta-galactoside-specific lectin
  JOURNAL   Biochem J 238 (3), 683-689 (1986)
   PUBMED   3800956
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M19036.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M19036.1, FQ217640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..135
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..135
                     /product="galectin-1"
                     /note="lectin, galactose binding, soluble 1; RL 14.5;
                     lectin, galactoside-binding, soluble, 1; galaptin; 14 kDa
                     lectin; S-Lac lectin 1; lactose-binding lectin 1;
                     beta-galactoside-binding lectin L-14-I; gal-1"
                     /calculated_mol_wt=14726
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P09382; propagated from
                     UniProtKB/Swiss-Prot (P11762.2)"
     Region          11..135
                     /region_name="GLECT"
                     /note="Galectin; smart00276"
                     /db_xref="CDD:214596"
     Site            order(13..15,18,21,91..93,98,100,103)
                     /site_type="other"
                     /note="putative alternate dimerization interface
                     [polypeptide binding]"
                     /db_xref="CDD:238025"
     Site            13
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P16045; propagated from
                     UniProtKB/Swiss-Prot (P11762.2)"
     Site            19
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P16045; propagated from
                     UniProtKB/Swiss-Prot (P11762.2)"
     Site            29
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P09382; propagated from
                     UniProtKB/Swiss-Prot (P11762.2)"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09382; propagated from
                     UniProtKB/Swiss-Prot (P11762.2)"
     Site            order(45,47,49,60,62,69,72,74)
                     /site_type="other"
                     /note="sugar binding pocket [chemical binding]"
                     /db_xref="CDD:238025"
     Site            108
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P16045; propagated from
                     UniProtKB/Swiss-Prot (P11762.2)"
     Site            128
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P16045; propagated from
                     UniProtKB/Swiss-Prot (P11762.2)"
     CDS             1..135
                     /gene="Lgals1"
                     /coded_by="NM_019904.1:37..444"
                     /db_xref="GeneID:56646"
                     /db_xref="RGD:69355"
ORIGIN      
        1 macglvasnl nlkpgeclkv rgelapdaks fvlnlgkdsn nlclhfnprf nahgdantiv
       61 cnskddgtwg teqretafpf qpgsitevci tfdqadltik lpdghefkfp nrlnmeainy
      121 maadgdfkik cvafe
//
