LOCUS       NM_133393               1860 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LFNG O-fucosylpeptide
            3-beta-N-acetylglucosaminyltransferase (Lfng), mRNA.
ACCESSION   NM_133393
VERSION     NM_133393.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Kakuda,S. and Haltiwanger,R.S.
  TITLE     Deciphering the Fringe-Mediated Notch Code: Identification of
            Activating and Inhibiting Sites Allowing Discrimination between
            Ligands
  JOURNAL   Dev Cell 40 (2), 193-201 (2017)
   PUBMED   28089369
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Okubo,Y., Sugawara,T., Abe-Koduka,N., Kanno,J., Kimura,A. and
            Saga,Y.
  TITLE     Lfng regulates the synchronized oscillation of the mouse
            segmentation clock via trans-repression of Notch signalling
  JOURNAL   Nat Commun 3, 1141 (2012)
   PUBMED   23072809
REFERENCE   4  (bases 1 to 1860)
  AUTHORS   Ferjentsik,Z., Hayashi,S., Dale,J.K., Bessho,Y., Herreman,A., De
            Strooper,B., del Monte,G., de la Pompa,J.L. and Maroto,M.
  TITLE     Notch is a critical component of the mouse somitogenesis oscillator
            and is essential for the formation of the somites
  JOURNAL   PLoS Genet 5 (9), e1000662 (2009)
   PUBMED   19779553
REFERENCE   5  (bases 1 to 1860)
  AUTHORS   Tan,J.B., Xu,K., Cretegny,K., Visan,I., Yuan,J.S., Egan,S.E. and
            Guidos,C.J.
  TITLE     Lunatic and manic fringe cooperatively enhance marginal zone B cell
            precursor competition for delta-like 1 in splenic endothelial
            niches
  JOURNAL   Immunity 30 (2), 254-263 (2009)
   PUBMED   19217325
REFERENCE   6  (bases 1 to 1860)
  AUTHORS   Hahn,K.L., Johnson,J., Beres,B.J., Howard,S. and Wilson-Rawls,J.
  TITLE     Lunatic fringe null female mice are infertile due to defects in
            meiotic maturation
  JOURNAL   Development 132 (4), 817-828 (2005)
   PUBMED   15659488
REFERENCE   7  (bases 1 to 1860)
  AUTHORS   Yang,L.T., Nichols,J.T., Yao,C., Manilay,J.O., Robey,E.A. and
            Weinmaster,G.
  TITLE     Fringe glycosyltransferases differentially modulate Notch1
            proteolysis induced by Delta1 and Jagged1
  JOURNAL   Mol Biol Cell 16 (2), 927-942 (2005)
   PUBMED   15574878
REFERENCE   8  (bases 1 to 1860)
  AUTHORS   Mustonen,T., Tummers,M., Mikami,T., Itoh,N., Zhang,N., Gridley,T.
            and Thesleff,I.
  TITLE     Lunatic fringe, FGF, and BMP regulate the Notch pathway during
            epithelial morphogenesis of teeth
  JOURNAL   Dev Biol 248 (2), 281-293 (2002)
   PUBMED   12167404
  REMARK    GeneRIF: Lunatic fringe, FGF, and BMP regulate the Notch pathway
            during epithelial morphogenesis of teeth.
REFERENCE   9  (bases 1 to 1860)
  AUTHORS   Zhang,N., Norton,C.R. and Gridley,T.
  TITLE     Segmentation defects of Notch pathway mutants and absence of a
            synergistic phenotype in lunatic fringe/radical fringe double
            mutant mice
  JOURNAL   Genesis 33 (1), 21-28 (2002)
   PUBMED   12001066
REFERENCE   10 (bases 1 to 1860)
  AUTHORS   Moloney,D.J., Panin,V.M., Johnston,S.H., Chen,J., Shao,L.,
            Wilson,R., Wang,Y., Stanley,P., Irvine,K.D., Haltiwanger,R.S. and
            Vogt,T.F.
  TITLE     Fringe is a glycosyltransferase that modifies Notch
  JOURNAL   Nature 406 (6794), 369-375 (2000)
   PUBMED   10935626
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070933.1.
            
            On May 24, 2004 this sequence version replaced NM_133393.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070933.1, AB054539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840124 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1860
                     /gene="Lfng"
                     /note="LFNG O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:170905"
                     /db_xref="RGD:620587"
     exon            1..488
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1196
                     /gene="Lfng"
                     /EC_number="2.4.1.222"
                     /note="beta-1,3-N-acetylglucosaminyltransferase lunatic
                     fringe; O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase; lunatic fringe
                     gene homolog"
                     /codon_start=1
                     /product="beta-1,3-N-acetylglucosaminyltransferase lunatic
                     fringe precursor"
                     /protein_id="NP_596884.1"
                     /db_xref="GeneID:170905"
                     /db_xref="RGD:620587"
                     /translation="MLQRCGRRLLLALVGALLACLLVLTADPPPTPVPAERGRRALRS
                     LAGSSGAAPGPGSRAAVDPGVLVREVHSLSEYFSLLTRARRDADPPPGVASRQGDGHP
                     RPPAEVLSPRDVFIAVKTTRKFHRARLDLLFETWISRHKEMTFIFTDGEDEALAKHTG
                     NVVLTNCSAAHSRQALSCKMAVEYDRFIESGKKWFCHVDDDNYVNLRALLRLLASYPH
                     TQDVYIGKPSLDRPIQATERISEHRVRPVHFWFATGGAGFCISRGLALKMGPWASGGH
                     FMSTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTTELHEQVTLSYG
                     MFENKRNAVHIKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIL"
     exon            489..537
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            538..637
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            638..791
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            792..877
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1043
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1129
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1837
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcagact gcctggccgg ttggcactgg ggcgatatta cgttcggccg ccggccacca
       61 tgctccagcg ctgcggccgg cgcctactgc tggcgctggt gggtgcgctg ctggcttgtc
      121 tcctggtgct caccgccgac ccgccgccaa ctccggtgcc cgctgagcgc ggaaggcgcg
      181 cgctgcgtag cctggcgggc tcctctgggg cggctccggg tccagggtcc agggcggccg
      241 tggatcccgg agtcctcgtc cgcgaggtgc acagcctttc cgagtacttc agtctactca
      301 cccgcgcgcg cagagacgcc gatccaccgc ccggggtcgc ttctcgccag ggcgacggcc
      361 atccgcgtcc ccccgccgag gttctgtccc ctcgcgatgt cttcatcgcc gtcaagacca
      421 ccagaaagtt tcaccgcgcg cggcttgacc tgctgttcga gacctggatc tcgcgccaca
      481 aggagatgac attcatcttc acggacgggg aggatgaagc tttggccaag cacacaggca
      541 atgtggtact caccaactgc tctgcggccc acagccgcca ggcgctgtct tgcaagatgg
      601 ctgtggagta cgaccgtttc attgagtcgg ggaagaagtg gttctgccac gtggacgatg
      661 acaactacgt caacctccgg gcactgctgc ggctgctggc cagctatccc cacacccaag
      721 acgtgtacat cggcaagccc agcctggaca gacccatcca ggccacggag cggatcagcg
      781 agcacagagt gagacctgtc cacttttggt ttgccaccgg aggagctggc ttctgcatta
      841 gccgaggact ggccctaaag atgggcccat gggccagtgg gggacacttc atgagcacag
      901 cagagcgcat ccgcctcccg gatgattgca ccattggcta cattgtggag gctctgctgg
      961 gcgtgcccct catccggagt ggcctcttcc actcgcacct ggagaacctg cagcaggtgc
     1021 ccaccaccga gctccatgaa caggtgaccc tgagctatgg catgtttgaa aacaagcgga
     1081 acgccgtgca catcaaggga cccttctcag tggaggctga cccttccagg ttccgctcta
     1141 tccactgcca tctgtacccg gacacaccct ggtgtccccg cactgccatc ctctagcaac
     1201 catggttgag accctgtccc tgggtgcccc tggtatccaa agggcccagg gacccctgtt
     1261 gtatgtcctg gccttggtgt acgaggctct tcagggctct gtgtatgtgc gtatgtctat
     1321 atttgtgtgt ttgtgtggcg tgcccaccca tgttgcagac tgctgggcag tcgtgttctt
     1381 cagggagtgg caggtctgtc cctaactact ctatactcca agggcagttc tgtgggatct
     1441 gtgtttggat ctctgcagtg ggggtgggcg agaggactca gggctcccgt cgggtgtcca
     1501 tgggtactgt cttgtagcac agtctcttat gttggggtgc tagtgcctac tggaaccttc
     1561 cctgtcaact gagctgtacc cagtgctatg gaagctggtt tggttcgtaa aaggcctggg
     1621 tccctctgag ctctggccca gaggctgcct gtggccattc tggtgaatag tgctcccctc
     1681 cttgccctcc ggggtggggg tggtcttcag ccccaccctc tgatctccta tctttgtctc
     1741 ccacaccagt ggggttcaga gctatgaatt ttatctcctc tccaaagtag agagaaagtc
     1801 gcccatagtg ggtgtgtctg taaatattgt gacagtaaaa aaaaaaaaaa aaaaaaaaaa
//
