LOCUS       NM_001012158            1787 bp    mRNA    linear   ROD 28-OCT-2024
DEFINITION  Rattus norvegicus leucine zipper and EF-hand containing
            transmembrane protein 2 (Letm2), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001012158 XM_341454
VERSION     NM_001012158.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1787)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1787)
  AUTHORS   Tamai,S., Iida,H., Yokota,S., Sayano,T., Kiguchiya,S., Ishihara,N.,
            Hayashi,J., Mihara,K. and Oka,T.
  TITLE     Characterization of the mitochondrial protein LETM1, which
            maintains the mitochondrial tubular shapes and interacts with the
            AAA-ATPase BCS1L
  JOURNAL   J Cell Sci 121 (Pt 15), 2588-2600 (2008)
   PUBMED   18628306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087079.1.
            
            On Feb 11, 2005 this sequence version replaced XM_341454.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1787
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..1787
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /note="leucine zipper and EF-hand containing transmembrane
                     protein 2"
                     /db_xref="GeneID:361169"
                     /db_xref="RGD:1311220"
     exon            1..53
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     exon            54..138
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1471
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; LETM1 domain-containing protein LETM2,
                     mitochondrial; leucine zipper-, EF-hand motif- containing
                     transmembrane protein 2; leucine zipper-, EF-hand motif-
                     containing transmembrane protein 2S; LETM1 and EF-hand
                     domain-containing protein 2; leucine zipper-EF-hand
                     containing transmembrane protein 2"
                     /codon_start=1
                     /product="LETM1 domain-containing protein LETM2,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_001012158.1"
                     /db_xref="GeneID:361169"
                     /db_xref="RGD:1311220"
                     /translation="MAFYSYNSFLAIFWTRLPGHSVHPPCSHFPPLAFFHLPDSHLRT
                     AYMKNCGSRKYSYPGLTGNNKVHPLRTRLPQKLHTTCWLQNHPGKPQPEQIPEEPKAT
                     DPQPTKDDQTEVAEGKWSLRQKIIDEVKYYYNGFSLLWIDTKVAARIVWRLLHGQVLT
                     RRERRRLLRTCADVFRLVPFVVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQ
                     KKMMGAKLEIAKFLQETMTEMAKRNRAKLDDDSSDSSQLSSYVKQVQTGHKPSTKEIV
                     RFSKLFEDQLALEHLRRPQLVALCKLLELQAFGTNNLLRFQLLMTLRSIKADDEVIAK
                     EGVKALSVSELQAACRARGMRSLGLTEEQLRQQLTEWLDLHLKENVPPSLLLLSRTFY
                     LIDVKPKPIELPPSIETPKTNLGIPSSPPPESKEDITDPAPQLNGTKILQAKSQETSQ
                     NSKANSKGA"
     exon            139..589
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     exon            590..733
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     exon            734..880
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1081
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1201
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1315
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1408
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1721
                     /gene="Letm2"
                     /gene_synonym="LETM2S"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggagactgg gcttccggcc tctctaacgt gggggcgggg aggcattggg aaggtctctg
       61 tgttggttgg ttgaaacaaa caaaaaaaaa aatggccttc tacagttata attcattctt
      121 agctattttc tggacaagat tgcctggcca ttccgtgcac cctccctgct ctcacttccc
      181 tccacttgca tttttccact tgccagattc tcatttgcgt acagcctata tgaaaaactg
      241 tggaagcagg aagtactcct accctgggct cacaggcaac aataaagtcc atcccttacg
      301 aaccagactc ccccaaaaac tgcacacgac ttgctggcta caaaatcacc ctggtaaacc
      361 tcagccggag caaatcccgg aagagccaaa ggcgacagac cctcagccta ccaaagatga
      421 ccagaccgag gttgcagaag gaaagtggtc cttgagacag aaaatcatag atgaagttaa
      481 atactattac aatggattca gtttactttg gattgacacc aaagtcgctg ccagaatagt
      541 ttggaggctg ctgcacggac aggtgctaac cagacgagag aggcgaaggc tgttgagaac
      601 gtgcgctgat gtcttccgct tggtcccatt cgtggtgttc ataattgtac cttttatgga
      661 attcttgata ccagtgtttc tgaagctctt cccagacatg ttgccatcaa cttttgaaag
      721 tgaatccaaa aaggaagaaa aacagaaaaa gatgatgggt gccaaattgg aaatagcaaa
      781 attccttcaa gagacgatga cagagatggc gaagaggaac cgagccaagt tggacgacga
      841 ctcctccgat tcctcacagc tctcctctta tgtaaaacag gtccaaacag gtcacaagcc
      901 ctccactaag gagatagttc gcttctccaa actcttcgag gatcagttag ccctggaaca
      961 cttacgtcga ccccagctag tcgccctgtg taagctgctg gagttgcagg ccttcggcac
     1021 aaacaatttg ctccgcttcc agctcctgat gaccctgagg tctataaaag cagatgatga
     1081 agtcattgcc aaagaagggg tgaaggcttt aagtgtgtca gaacttcagg ctgcgtgtcg
     1141 ggcccggggg atgaggtcgc tgggcctcac tgaagaacaa ctgcgccagc agctcacaga
     1201 gtggctggac ctccacttga aggagaacgt ccccccttct ctcttgctcc tgtcccgcac
     1261 cttctacctg atagacgtga agccaaagcc tattgaactc ccacccagta tagagactcc
     1321 aaagacaaac cttgggatac cgtcatctcc gccccccgag tcaaaggagg acattacgga
     1381 ccctgcacct cagctaaatg gaacgaagat cctccaggcc aagtctcagg agacctcaca
     1441 gaacagcaag gctaattcaa aaggagccta aagatacctt gaagatgggc ctcactctct
     1501 ccaatcactg ccagtcagca gtggcgtcca tgaaggagtt ctagcggaga ctgtctggct
     1561 tgagataaag gatcagccat taagtcgttg gaggcctcgt gaccattcgt gatccgagca
     1621 gtgacaccaa gttcaggcca cttagagaag cttaattaca gcctatctct actgtataat
     1681 ttcgtcatct tactaaacgt tgcataaagc cactcccacc aaaaaaaaaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
