LOCUS       NM_020099               1966 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus leptin receptor overlapping transcript (Leprot),
            mRNA.
ACCESSION   NM_020099
VERSION     NM_020099.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Li,X., Shi,W., Wu,G., Qin,X., Wan,G., Zeng,Q. and Hu,Y.
  TITLE     OB-RGRP regulates the phosphorylation of JAK2 and STAT3 in primary
            rat adipocytes
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 3664-3670 (2019)
   PUBMED   31841394
  REMARK    GeneRIF: OB-RGRP regulated the phosphorylation of JAK2 and STAT3 in
            primary rat adipocytes
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Touvier,T., Conte-Auriol,F., Briand,O., Cudejko,C., Paumelle,R.,
            Caron,S., Bauge,E., Rouille,Y., Salles,J.P., Staels,B. and
            Bailleul,B.
  TITLE     LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone
            action in mice
  JOURNAL   J Clin Invest 119 (12), 3830-3838 (2009)
   PUBMED   19907080
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Couturier,C., Sarkis,C., Seron,K., Belouzard,S., Chen,P.,
            Lenain,A., Corset,L., Dam,J., Vauthier,V., Dubart,A., Mallet,J.,
            Froguel,P., Rouille,Y. and Jockers,R.
  TITLE     Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus
            increases leptin receptor signaling and prevents diet-induced
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 104 (49), 19476-19481 (2007)
   PUBMED   18042720
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Lindell,K., Bennett,P.A., Itoh,Y., Robinson,I.C., Carlsson,L.M. and
            Carlsson,B.
  TITLE     Leptin receptor 5'untranslated regions in the rat: relative
            abundance, genomic organization and relation to putative response
            elements
  JOURNAL   Mol Cell Endocrinol 172 (1-2), 37-45 (2001)
   PUBMED   11165038
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062003.1.
            
            On Jan 1, 2004 this sequence version replaced NM_020099.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062003.1, DY318247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..1966
                     /gene="Leprot"
                     /gene_synonym="Ob-Rgrp; Obrgrp"
                     /note="leptin receptor overlapping transcript"
                     /db_xref="GeneID:56766"
                     /db_xref="RGD:621034"
     exon            1..35
                     /gene="Leprot"
                     /gene_synonym="Ob-Rgrp; Obrgrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..415
                     /gene="Leprot"
                     /gene_synonym="Ob-Rgrp; Obrgrp"
                     /note="OB-R gene-related protein; OB-receptor gene related
                     protein (OB-RGRP); endospanin-1"
                     /codon_start=1
                     /product="leptin receptor gene-related protein"
                     /protein_id="NP_064484.1"
                     /db_xref="GeneID:56766"
                     /db_xref="RGD:621034"
                     /translation="MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFYVI
                     SPIPYFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVAVIKWGACGLV
                     LAGNAVIFLTIQGFFLVFGRGDDFSWEQW"
     exon            36..111
                     /gene="Leprot"
                     /gene_synonym="Ob-Rgrp; Obrgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            112..298
                     /gene="Leprot"
                     /gene_synonym="Ob-Rgrp; Obrgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            299..1946
                     /gene="Leprot"
                     /gene_synonym="Ob-Rgrp; Obrgrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccccagc tccagagaca tggcgggcgt taaagctctt gtggcactct ccttcagtgg
       61 ggcaattggg ctgacctttc ttatgctggg atgtgccttg gaggactatg gcgtttactg
      121 gcccctgttc gtcttgattt tctacgtcat ctcccccatc ccctacttca ttgccaaaag
      181 ggtcacctat gactcggacg cgactagcag tgcctgtcgg gaactggcat atttcttcac
      241 cactgggatt gttgtttctg cctttggatt tcctgttatt cttgctcgcg tggctgtgat
      301 caagtgggga gcctgtggtc ttgtgctggc tggcaatgct gttattttcc tcacgatcca
      361 aggcttcttc ctcgtctttg ggagaggaga tgatttcagt tgggaacagt ggtagcactt
      421 ccttctcatg ggaagcatgg agtgtcttag aatttgtatt gtacgtatat gtgtgcactt
      481 gtgttttctt acagatttga atatgctgag ttttatacct ttatatcatg atcatcttag
      541 ggaagatgtt gtaaacaaac gatgagtttt actcctggca aacaggtcac tccattgact
      601 caaagtgaat tgtttttatc ttctggttcc cagaaaacct gttactatgg ccctgtagac
      661 agccactcat ttacccaggg ggtctaaacc tttgggatat gcttgtgtaa tcagaaacac
      721 tggggcagca gatctcctac agctcaaacg taagtggcgc tctccccgta ccctgtagac
      781 tcatctcaga gtgagtctca tgcacacaga gcatcagtgt ctgctagggg gctactgggg
      841 atgcaggatc agagaatccc atcaggatca gagaatccca tgggtaccgt ggatgagatt
      901 ccacacttgg cacatactga tgtgtaagaa gatttgtgta gagaaatgta catcgcagct
      961 ctgctgtctt cctcttggca cagccacttg ccttctctgg gtgttgcatg ctcatttgca
     1021 gaaaaaacaa aacaaaacaa aacaaaaaaa acccacctgc cccatgttgt gaatgaattc
     1081 agactttagg tgtttctaac atgtttaagt ctataatatt tgtgttgttc ctgaaatttg
     1141 gggggcggga ggggctgttc ttaggaagga acagataagt cctaacatca tctaaaaggc
     1201 aatggctgat tgctcagaat aagttacaaa aataaccaaa aatcctctct ggggtgcaga
     1261 gagggaaatg gggctggaat tggtccctac tttaagtgga gggcaggtta gacaattctt
     1321 gaaaatgtcc cttcaagagg tggtgctccc cccgcccctc tgtggtgccc ccatccccga
     1381 ctcacattcc cctttggtag gtagtgggcc tcctgaaggg cttaagtcaa gagcaagcga
     1441 agggcagggg tcattgaagt cacacctcag cgcactgttc gtcctttgta ttgaacttga
     1501 tgtcacctcc tcaggaaaca caggggtcca cgtcacgttg gtttttctag ctcctctctt
     1561 ttatctggac cctagcggga gaaggttcaa aactacaatt accctctaag gatgtcatca
     1621 gcggcgtttc ggtgttgatg ctgctagtta atgagtgttc agagcactct cctttgaggc
     1681 ttgtggtcag aggaatggac acaccaggcc agggctggcc gctgtgacgc tgggaccagc
     1741 aggtgaacgg acagaggaca gtgtgcagtg ttactttttg gcctgtgcag tacattatgt
     1801 tttcaatatt ttgtgtacat ataaaattgt tagagctgtc atttctagta tttacattag
     1861 aaaaattatt tagatacatg atcatttaac tggcattttt aatcatggca cttgctgttg
     1921 taataaattt gacttttaac actgaaaaaa aaaaaaaaaa aaaaaa
//
