LOCUS       NM_012596               3647 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus leptin receptor (Lepr), mRNA.
ACCESSION   NM_012596
VERSION     NM_012596.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3647)
  AUTHORS   Jolic,M., Ruscsak,K., Emanuelsson,L., Norlindh,B., Thomsen,P.,
            Shah,F.A. and Palmquist,A.
  TITLE     Leptin receptor gene deficiency minimally affects osseointegration
            in rats
  JOURNAL   Sci Rep 13 (1), 15631 (2023)
   PUBMED   37730735
  REMARK    GeneRIF: Leptin receptor gene deficiency minimally affects
            osseointegration in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3647)
  AUTHORS   Schaffer,A., Ducza,E., Bodi,N., Bagyanszki,M., Szalai,Z.,
            Mirdamadi,M., Barna,T., Szucs,K.F. and Gaspar,R.
  TITLE     The ontogenies of endometrial and myometrial leptin and adiponectin
            receptors in pregnant rats: Their putative impact on uterine
            contractility
  JOURNAL   Life Sci 297, 120465 (2022)
   PUBMED   35271883
  REMARK    GeneRIF: The ontogenies of endometrial and myometrial leptin and
            adiponectin receptors in pregnant rats: Their putative impact on
            uterine contractility.
REFERENCE   3  (bases 1 to 3647)
  AUTHORS   Zhang,Y., Jin,W., Zhang,D., Lin,C., He,H., Xie,F., Gan,L., Fu,W.,
            Wu,L. and Wu,Y.
  TITLE     TNF-alpha Antagonizes the Effect of Leptin on Insulin Secretion
            through FOXO1-Dependent Transcriptional Suppression of LepRb in
            INS-1 Cells
  JOURNAL   Oxid Med Cell Longev 2022, 9142798 (2022)
   PUBMED   35198097
  REMARK    GeneRIF: TNF-alpha Antagonizes the Effect of Leptin on Insulin
            Secretion through FOXO1-Dependent Transcriptional Suppression of
            LepRb in INS-1 Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3647)
  AUTHORS   Abdellatif,M., Trummer-Herbst,V., Koser,F., Durand,S., Adao,R.,
            Vasques-Novoa,F., Freundt,J.K., Voglhuber,J., Pricolo,M.R.,
            Kasa,M., Turk,C., Aprahamian,F., Herrero-Galan,E., Hofer,S.J.,
            Pendl,T., Rech,L., Kargl,J., Anto-Michel,N., Ljubojevic-Holzer,S.,
            Schipke,J., Brandenberger,C., Auer,M., Schreiber,R., Koyani,C.N.,
            Heinemann,A., Zirlik,A., Schmidt,A., von Lewinski,D., Scherr,D.,
            Rainer,P.P., von Maltzahn,J., Muhlfeld,C., Kruger,M., Frank,S.,
            Madeo,F., Eisenberg,T., Prokesch,A., Leite-Moreira,A.F.,
            Lourenco,A.P., Alegre-Cebollada,J., Kiechl,S., Linke,W.A.,
            Kroemer,G. and Sedej,S.
  TITLE     Nicotinamide for the treatment of heart failure with preserved
            ejection fraction
  JOURNAL   Sci Transl Med 13 (580) (2021)
   PUBMED   33568522
REFERENCE   5  (bases 1 to 3647)
  AUTHORS   Schauer,A., Draskowski,R., Jannasch,A., Kirchhoff,V., Goto,K.,
            Mannel,A., Barthel,P., Augstein,A., Winzer,E., Tugtekin,M.,
            Labeit,S., Linke,A. and Adams,V.
  TITLE     ZSF1 rat as animal model for HFpEF: Development of reduced
            diastolic function and skeletal muscle dysfunction
  JOURNAL   ESC Heart Fail 7 (5), 2123-2134 (2020)
   PUBMED   32710530
REFERENCE   6  (bases 1 to 3647)
  AUTHORS   Takaya,K., Ogawa,Y., Isse,N., Okazaki,T., Satoh,N., Masuzaki,H.,
            Mori,K., Tamura,N., Hosoda,K. and Nakao,K.
  TITLE     Molecular cloning of rat leptin receptor isoform complementary
            DNAs--identification of a missense mutation in Zucker fatty (fa/fa)
            rats
  JOURNAL   Biochem Biophys Res Commun 225 (1), 75-83 (1996)
   PUBMED   8769097
REFERENCE   7  (bases 1 to 3647)
  AUTHORS   Chua,S.C. Jr., White,D.W., Wu-Peng,X.S., Liu,S.M., Okada,N.,
            Kershaw,E.E., Chung,W.K., Power-Kehoe,L., Chua,M., Tartaglia,L.A.
            and Leibel,R.L.
  TITLE     Phenotype of fatty due to Gln269Pro mutation in the leptin receptor
            (Lepr)
  JOURNAL   Diabetes 45 (8), 1141-1143 (1996)
   PUBMED   8690163
REFERENCE   8  (bases 1 to 3647)
  AUTHORS   Iida,M., Murakami,T., Ishida,K., Mizuno,A., Kuwajima,M. and
            Shima,K.
  TITLE     Substitution at codon 269 (glutamine --> proline) of the leptin
            receptor (OB-R) cDNA is the only mutation found in the Zucker fatty
            (fa/fa) rat
  JOURNAL   Biochem Biophys Res Commun 224 (2), 597-604 (1996)
   PUBMED   8702432
REFERENCE   9  (bases 1 to 3647)
  AUTHORS   Iida,M., Murakami,T., Ishida,K., Mizuno,A., Kuwajima,M. and
            Shima,K.
  TITLE     Phenotype-linked amino acid alteration in leptin receptor cDNA from
            Zucker fatty (fa/fa) rat
  JOURNAL   Biochem Biophys Res Commun 222 (1), 19-26 (1996)
   PUBMED   8630068
REFERENCE   10 (bases 1 to 3647)
  AUTHORS   Phillips,M.S., Liu,Q., Hammond,H.A., Dugan,V., Hey,P.J.,
            Caskey,C.J. and Hess,J.F.
  TITLE     Leptin receptor missense mutation in the fatty Zucker rat
  JOURNAL   Nat Genet 13 (1), 18-19 (1996)
   PUBMED   8673096
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012596.3.
            
            On Nov 27, 2020 this sequence version replaced NM_012596.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN16093044
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000005.1  121409735-121409788
            55-114              JAXUCZ010000005.1  121484239-121484298
            115-444             JAXUCZ010000005.1  121487604-121487933
            445-568             JAXUCZ010000005.1  121490321-121490444
            569-774             JAXUCZ010000005.1  121500199-121500404
            775-917             JAXUCZ010000005.1  121504411-121504553
            918-1062            JAXUCZ010000005.1  121506153-121506297
            1063-1353           JAXUCZ010000005.1  121515459-121515749
            1354-1471           JAXUCZ010000005.1  121515901-121516018
            1472-1671           JAXUCZ010000005.1  121518672-121518871
            1672-1820           JAXUCZ010000005.1  121520883-121521031
            1821-1980           JAXUCZ010000005.1  121522410-121522569
            1981-2063           JAXUCZ010000005.1  121522685-121522767
            2064-2280           JAXUCZ010000005.1  121553001-121553217
            2281-2463           JAXUCZ010000005.1  121555634-121555816
            2464-2559           JAXUCZ010000005.1  121559947-121560042
            2560-2665           JAXUCZ010000005.1  121561547-121561652
            2666-2741           JAXUCZ010000005.1  121562701-121562776
            2742-3647           JAXUCZ010000005.1  121590308-121591213
FEATURES             Location/Qualifiers
     source          1..3647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..3647
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /note="leptin receptor"
                     /db_xref="GeneID:24536"
                     /db_xref="RGD:3001"
     exon            1..54
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            55..114
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..3563
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /note="OB-R; LEP-R; OB receptor; Leptin receptor (fatty)"
                     /codon_start=1
                     /product="leptin receptor precursor"
                     /protein_id="NP_036728.2"
                     /db_xref="GeneID:24536"
                     /db_xref="RGD:3001"
                     /translation="MTCQKFYVVLLHWEFLYVITALNLAYPTSPWRFKLFCAPPSTTD
                     DSFLSPAGVPNNTSSLKGASEALVEAKFNSTGIYVSELSKTIFHCCFGNEQGQNCSAL
                     TGNTEGKTLASVVKPLVFRQLGVNWDIECWMKGDLTLFICHMEPLLKNPFKNYDSKVH
                     LLYDLPEVIDDLPLPPLKDSFQTVQCNCSVQECECHVPVPRAKVNYALLMYLEITSAG
                     VSFQSPLMSLQPMLVVKPDPPLGLRMEVTDDGNLKISWDSQTKAPFPLQYQVKYLENS
                     TIVREAAEIVSDTSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSLPQLFTTQDVMYF
                     PPKILTSVGSNASFCCIYKNENQTISSKQIVWWMNLAEKIPETQYNTVSDHISKVTFS
                     NLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPS
                     TIQSLVGSTVQLRYHRRSLYCPDNPSIRPTSELKNCVLQTDGFYECVFQPIFLLSGYT
                     MWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITINTGLLKVSWEKPVFPENNL
                     QFQIRYGLNGKEIQWKTHEVFDAKSKSASLPVSDLCAVYVVQVRCRRLDGLGYWSNWS
                     SPAYTLVMDVKVPMRGPEFWRIMDGDITKKERNVTLLWKPLMKNDSLCSVRRYVVKHR
                     TAHNGTWSQDVGNQTNLTFLWAESAHTVTVLAINSIGASLVNFNLTFSWPMSKVNAVQ
                     SLSAYPLSSSCVILSWTLSPNDYSLLYLVIEWKNLNDDDGMKWLRIPSNVNKYYIHDN
                     FIPIEKYQFSLYPVFMEGVGKPKIINGFTKDDIAKQQNDAGLYVIVPIIISSCVLLLG
                     TLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFGPLLLEPE
                     PVSEEISVDTAWKNKDEMVPAAMVSLLLTTPDSTRGSICISDQCNSANFSGAQSTQGT
                     CEDECQSQPSVKYATLVSNVKPVETDEEQGAIHSSVSQCIARKHSPLRQSFSSSSWEI
                     EAQAFFLLSDHPPNVISPQLSFSGLDELLELEGNFPEENHGEKSVYYLGVSSGNKREN
                     DMLLTDEAGVLCPFPAHCLFSDIRILQESCSHFVENNLNLGTSGKNFVPYMPQFQSCS
                     THSHKIIENKMCDLTV"
     exon            115..444
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            445..568
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            569..774
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            775..917
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1062
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1353
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1471
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1671
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1820
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1980
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2063
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2280
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2463
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2559
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2665
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2741
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..3647
                     /gene="Lepr"
                     /gene_synonym="Fa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggggcaatt gggctgacct ttcttatgct gggatgtgcc ttggaggact atgggtgtct
       61 atctctgaag taagatgacg tgtcagaaat tctatgtggt tttgttacac tgggaatttc
      121 tgtatgtgat aactgcactt aacctggcct atccaacctc tccctggaga tttaagctgt
      181 tttgtgcgcc accgagtaca actgatgact cctttctctc tcctgctgga gtcccaaaca
      241 atacttcgtc tttgaagggg gcttctgaag cacttgttga agctaaattt aattcaactg
      301 gtatctacgt ttctgagtta tccaaaacca ttttccactg ttgctttggg aatgagcaag
      361 gtcaaaactg ctccgcactc acaggcaaca ctgaagggaa gacgctggct tcagtggtga
      421 agcctttagt tttccgccaa ctaggtgtaa actgggacat agagtgctgg atgaaagggg
      481 acttgacatt attcatctgt catatggaac cattacttaa gaaccccttc aagaattatg
      541 actctaaggt tcacctttta tatgatctgc ctgaagttat agatgatttg cctctgcccc
      601 cactgaaaga cagctttcag actgtccagt gcaactgcag tgttcaggaa tgcgaatgtc
      661 atgtaccagt acccagagcc aaagtcaact acgctcttct gatgtattta gaaatcacat
      721 ctgccggtgt gagtttccag tcacctctaa tgtcactgca gcccatgctt gttgtgaagc
      781 ccgatccacc gctgggtttg cgtatggaag tcacagatga tggtaattta aagatttcat
      841 gggacagcca aacaaaagca ccatttccac ttcaatatca ggtgaaatat ttagagaatt
      901 ctacaatcgt aagagaggct gctgaaatcg tctcggatac atctctgctg gtagacagcg
      961 tgcttcctgg gtcttcatac gaggtccagg tgaggagcaa gagactggat ggctcaggag
     1021 tctggagtga ctggagttta cctcaactct ttaccacaca agatgtcatg tattttccac
     1081 ccaaaattct gacgagtgtt ggatccaatg cttccttttg ctgcatctac aaaaatgaga
     1141 accagactat ctcctcaaaa caaatagttt ggtggatgaa tctagccgag aagatccccg
     1201 agacacagta caacactgtg agtgaccaca ttagcaaagt cactttctcc aacctgaaag
     1261 ccaccagacc tcgagggaag tttacctatg atgcagtgta ctgctgcaat gagcaggcat
     1321 gccatcaccg ctacgctgaa ttatatgtga tcgatgtcaa tatcaatata tcatgtgaaa
     1381 ctgacgggta cttaactaaa atgacttgca gatggtcacc cagcacaatc caatcactag
     1441 tgggaagcac tgtgcagttg aggtatcaca ggcgcagcct gtactgtccc gataatccat
     1501 ctattcgtcc tacatcagag ctcaaaaact gcgtcttaca gacagatggc ttttatgaat
     1561 gtgttttcca gccaatcttt ctattatctg gctatacaat gtggatcagg atcaaccatt
     1621 ctttaggttc acttgactct ccaccaacgt gtgtccttcc tgactccgta gtaaaaccac
     1681 tacctccatc taatgtaaaa gcagagatta ctataaacac tggattattg aaagtatctt
     1741 gggaaaagcc agtctttcca gagaataacc ttcagttcca gattcgatat ggcttaaatg
     1801 gaaaagaaat acaatggaag acacacgagg tattcgatgc aaaatcaaaa tcggccagcc
     1861 tgccagtgtc agatctctgt gcggtctatg tggtacaggt tcgctgccgg cggttggatg
     1921 gactagggta ttggagtaat tggagcagtc cagcctacac tcttgtcatg gatgtaaaag
     1981 ttcctatgag agggcctgaa ttctggagaa taatggatgg ggatattact aaaaaggaga
     2041 gaaatgtcac cttgctttgg aagccactga tgaaaaatga ctcactgtgt agtgtgagga
     2101 ggtatgtggt gaagcatcgt actgcccaca atgggacatg gtcacaagat gtgggaaatc
     2161 agaccaatct cacttttctg tgggcagaat cagcacacac tgttacagtt ctggccatca
     2221 attccatcgg tgcctccctt gtgaatttta accttacgtt ctcatggccc atgagtaaag
     2281 tgaatgctgt gcagtcactc agtgcttatc ccctgagcag cagctgcgtc atcctttcct
     2341 ggacactgtc acctaatgat tatagtctgt tatatctggt tattgaatgg aagaacctta
     2401 atgatgatga tggaatgaag tggcttagaa tcccttcgaa tgttaacaag tattatatcc
     2461 atgataattt tattcctatc gagaaatatc agtttagtct ttacccagta tttatggaag
     2521 gagttggaaa accaaagata attaatggtt tcaccaaaga tgatatcgcc aaacagcaaa
     2581 atgatgcagg gctgtatgtc attgtaccga taattatttc ctcttgtgtc ctgctgctcg
     2641 gaacactgtt aatttcacac cagagaatga aaaagttgtt ttgggatgat gttccaaacc
     2701 ccaagaattg ttcctgggca caaggactta atttccaaaa gcctgaaaca tttgagcatc
     2761 tttttaccaa gcatgcagaa tcagtgatat ttggtcctct tcttctggag cctgaaccag
     2821 tttcagaaga aatcagtgtc gatacagctt ggaaaaataa agatgagatg gtaccagcag
     2881 ctatggtctc acttcttttg accactccag attccacaag gggttctatt tgtatcagtg
     2941 accagtgtaa cagtgctaac ttctctgggg ctcagagcac ccagggaacc tgtgaggatg
     3001 agtgtcagag tcaaccctca gttaaatatg caacgctggt cagcaacgtg aaaccagtgg
     3061 aaactgatga agagcaaggg gctatacata gttctgtcag ccagtgcatc gccaggaaac
     3121 attccccgct gagacagtct ttttctagca gctcctggga gatagaggcc caggcatttt
     3181 tccttttatc agatcatcca cccaatgtga tttcaccaca actttcattc tcagggttgg
     3241 atgagctttt ggaactggag ggaaattttc ctgaagaaaa tcacggggaa aaatctgtgt
     3301 attatctagg agtctcctca ggaaacaaaa gagagaatga tatgcttttg actgatgagg
     3361 caggggtatt gtgcccattc ccagctcact gtctgttcag tgacatcaga atcctccagg
     3421 agagttgttc acactttgta gaaaataatt tgaatttagg gacctctggt aagaactttg
     3481 taccttacat gccccagttt caatcctgtt ccactcacag tcataagata atagaaaata
     3541 agatgtgtga cttaactgtg taatcttgtc caaaaacttc caggttccat tccagtagag
     3601 tgtgtcatgt ataatatgtt cttttattgt tgtggatgtg ggagaaa
//
