LOCUS       NM_013076               3290 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Rattus norvegicus leptin (Lep), mRNA.
ACCESSION   NM_013076
VERSION     NM_013076.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3290)
  AUTHORS   Ren,S.G., Li,D.M. and Liu,H.
  TITLE     Baroreflex afferent function is a part of insights of
            Leptin-mediated blood pressure reduction and Leptin-resistance
            hypertension
  JOURNAL   Neuropeptides 105, 102418 (2024)
   PUBMED   38442503
  REMARK    GeneRIF: Baroreflex afferent function is a part of insights of
            Leptin-mediated blood pressure reduction and Leptin-resistance
            hypertension.
REFERENCE   2  (bases 1 to 3290)
  AUTHORS   Pavithra,S., Kishor Kumar,D.G., Ramesh,G., Panigrahi,M., Sahoo,M.,
            Madhu,C.L., Singh,T.U., Kumar,D. and Parida,S.
  TITLE     Leptin decreases the transcription of BKCa channels and Gs to Gi
            protein-ratio in late pregnant rat uterus
  JOURNAL   Gene 891, 147831 (2024)
   PUBMED   37769981
  REMARK    GeneRIF: Leptin decreases the transcription of BKCa channels and Gs
            to Gi protein-ratio in late pregnant rat uterus.
REFERENCE   3  (bases 1 to 3290)
  AUTHORS   Alonso-Bernaldez,M., Asensio,A., Palou-March,A., Sanchez,J.,
            Palou,A., Serra,F. and Palou,M.
  TITLE     Breast Milk MicroRNAs Related to Leptin and Adiponectin Function
            Can Be Modulated by Maternal Diet and Influence Offspring Phenotype
            in Rats
  JOURNAL   Int J Mol Sci 23 (13), 7237 (2022)
   PUBMED   35806240
  REMARK    GeneRIF: Breast Milk MicroRNAs Related to Leptin and Adiponectin
            Function Can Be Modulated by Maternal Diet and Influence Offspring
            Phenotype in Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3290)
  AUTHORS   Baral,A. and Park,P.H.
  TITLE     Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3
            Inflammasome Activation in Rat Hepatocytes
  JOURNAL   Int J Mol Sci 22 (22), 12589 (2021)
   PUBMED   34830465
  REMARK    GeneRIF: Leptin Induces Apoptotic and Pyroptotic Cell Death via
            NLRP3 Inflammasome Activation in Rat Hepatocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3290)
  AUTHORS   He,Q., Qin,R., Glowacki,J., Zhou,S., Shi,J., Wang,S., Gao,Y. and
            Cheng,L.
  TITLE     Synergistic stimulation of osteoblast differentiation of rat
            mesenchymal stem cells by leptin and 25(OH)D3 is mediated by
            inhibition of chaperone-mediated autophagy
  JOURNAL   Stem Cell Res Ther 12 (1), 557 (2021)
   PUBMED   34717752
  REMARK    GeneRIF: Synergistic stimulation of osteoblast differentiation of
            rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by
            inhibition of chaperone-mediated autophagy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3290)
  AUTHORS   Chehab,F.F., Lim,M.E. and Lu,R.
  TITLE     Correction of the sterility defect in homozygous obese female mice
            by treatment with the human recombinant leptin
  JOURNAL   Nat Genet 12 (3), 318-320 (1996)
   PUBMED   8589726
REFERENCE   7  (bases 1 to 3290)
  AUTHORS   Ogawa,Y., Masuzaki,H., Isse,N., Okazaki,T., Mori,K., Shigemoto,M.,
            Satoh,N., Tamura,N., Hosoda,K., Yoshimasa,Y. et al.
  TITLE     Molecular cloning of rat obese cDNA and augmented gene expression
            in genetically obese Zucker fatty (fa/fa) rats
  JOURNAL   J Clin Invest 96 (3), 1647-1652 (1995)
   PUBMED   7657834
REFERENCE   8  (bases 1 to 3290)
  AUTHORS   Pelleymounter,M.A., Cullen,M.J., Baker,M.B., Hecht,R., Winters,D.,
            Boone,T. and Collins,F.
  TITLE     Effects of the obese gene product on body weight regulation in
            ob/ob mice
  JOURNAL   Science 269 (5223), 540-543 (1995)
   PUBMED   7624776
REFERENCE   9  (bases 1 to 3290)
  AUTHORS   Funahashi,T., Shimomura,I., Hiraoka,H., Arai,T., Takahashi,M.,
            Nakamura,T., Nozaki,S., Yamashita,S., Takemura,K., Tokunaga,K. et
            al.
  TITLE     Enhanced expression of rat obese (ob) gene in adipose tissues of
            ventromedial hypothalamus (VMH)-lesioned rats
  JOURNAL   Biochem Biophys Res Commun 211 (2), 469-475 (1995)
   PUBMED   7794258
REFERENCE   10 (bases 1 to 3290)
  AUTHORS   Murakami,T. and Shima,K.
  TITLE     Cloning of rat obese cDNA and its expression in obese rats
  JOURNAL   Biochem Biophys Res Commun 209 (3), 944-952 (1995)
   PUBMED   7733988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 24, 2010 this sequence version replaced NM_013076.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.15609.1,
                                           SRR26643296.12853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                JAXUCZ010000004.1  58626538-58626551
            15-192              JAXUCZ010000004.1  58635821-58635998
            193-3290            JAXUCZ010000004.1  58637564-58640661
FEATURES             Location/Qualifiers
     source          1..3290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3290
                     /gene="Lep"
                     /gene_synonym="OB; obese"
                     /note="leptin"
                     /db_xref="GeneID:25608"
                     /db_xref="RGD:3000"
     exon            1..14
                     /gene="Lep"
                     /gene_synonym="OB; obese"
                     /inference="alignment:Splign:2.1.0"
     exon            15..192
                     /gene="Lep"
                     /gene_synonym="OB; obese"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..552
                     /gene="Lep"
                     /gene_synonym="OB; obese"
                     /note="obesity factor"
                     /codon_start=1
                     /product="leptin precursor"
                     /protein_id="NP_037208.1"
                     /db_xref="GeneID:25608"
                     /db_xref="RGD:3000"
                     /translation="MCWRPLCRFLWLWSYLSYVQAVPIHKVQDDTKTLIKTIVTRIND
                     ISHTQSVSARQRVTGLDFIPGLHPILSLSKMDQTLAVYQQILTSLPSQNVLQIAHDLE
                     NLRDLLHLLAFSKSCSLPQTRGLQKPESLDGVLEASLYSTEVVALSRLQGSLQDILQQ
                     LDLSPEC"
     exon            193..3290
                     /gene="Lep"
                     /gene_synonym="OB; obese"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcagctg caaggtccaa gaagaagaag aagaccccag cgaggaaaat gtgctggaga
       61 cccctgtgcc ggttcctgtg gctttggtcc tatctgtcct atgttcaagc tgtgcctatc
      121 cacaaagtcc aggatgacac caaaaccctc atcaagacca ttgtcaccag gatcaatgac
      181 atttcacaca cgcagtcggt atccgccagg cagagggtca ccggtttgga cttcattccc
      241 gggcttcacc ccattctgag tttgtccaag atggaccaga ccctggcagt ctatcaacag
      301 atcctcacca gcttgccttc ccaaaacgtg ctgcagatag ctcatgacct ggagaacctg
      361 cgagacctcc tccatctgct ggccttctcc aagagctgct ccctgccgca gacccgtggc
      421 ctgcagaagc cagagagcct ggatggcgtc ctggaagcct cgctctactc cacagaggtg
      481 gtggctctga gcaggctgca gggctctctg caggacattc ttcaacagtt ggaccttagc
      541 cctgaatgct gaggtttcca agaccaccgg gctcccgagg atcatgttga gggaagaaac
      601 cttggctccc aggtatcctc aggagaagag agccatgtgt tcacacccgt catccaggac
      661 cctgtccgtt tctcctactc ctctagaccg cccttcagaa ggcatggctc tgcaaggctt
      721 gactaaagtt atccgcacga ttccatgagc actaggaggg gattgaagcc ttgaagaggg
      781 gattctcacc tggttcttcg gcaaatatag ataagagccg tcctgtcccc tccgtgttcc
      841 acctcctctg ggtgcgtgtt tcactgtggc ccagcggatg tgaggaaggg gtgggtggag
      901 cctctggact gtctcagagt ctttgggagc accatgaagg ctacatctgc acacagctgg
      961 aaactcccaa agcagcacat gctggaagac gcacttattt atttattctg cattttattt
     1021 tggatggatt tgaagcaaag catcagcttt ttcaggcttt ggggtcagct ggggctagga
     1081 aggctcctag ggtgctgttt tcaatcctac tgatgggtct tgcccgaggc aaacctactt
     1141 ttttgagtga ctggaaggaa ggttgggaat cttccaaaca agagtctatg caggtagctc
     1201 tcaagtttgt cctctggtgg ctggtttgtt tctgtcgtga ctgactctat gcaaacacgt
     1261 ttgccgtggc attgcctgga gcgcaggcta ggttattatg aaaagaagat gaattttgtc
     1321 aagtgtaata tgcatctatg tgcacctgag ggtaggggat gtgtcagagg gagagagaag
     1381 gatccagaag cattctctga ataacagagc tgtggtagac ttttctgaaa aggtgaggca
     1441 ttttctcacc tctgcagcca catagtgtgg ctttgtgaaa aggacaaagg agttgactct
     1501 tttagggaca tttgaagtat accagacacc cttagagggg gctaaagtta caggcctttt
     1561 gttggcatat tgctgagctc agggagtgag ggccccacat tggagacagt gagccccaag
     1621 aaaagggtcc ctggtgtagc cctccaaagt tgcccagggt tgatcccaca atgcatttct
     1681 taagcaggca agtatccctg gtagatgttt gcctgtcaat atgtggttct catctgattg
     1741 gttcatccaa agtaaaacca ggtctcccac ccattctgtg gggcagtttt gttccagtgg
     1801 gaatgagaaa tcacttagca gatggtcctg agccctgggc cagcactcct gaggaagtgc
     1861 cagggcctca ggccaggctg ccagaattgc ccttcgggct ggaggatgaa caaaggggct
     1921 tgggtttttc caccacccct gcacccttgt gtcaccatcc agctgtgggt ggcagatcaa
     1981 tgcaagaaaa cttgatcgaa cgcaatacac ttttaagact gagcacagct ctgtgctcag
     2041 ccctgactgg tgctgtgggc tagagaagct caccaaataa acataaaaat cagaggcttt
     2101 tgtccctgcg gtcagaccct actcaacagc gtgccaaggc gcgtacttcg ccacagcagc
     2161 cccacacagt tgaaaataca gtgctgtctt caacggagga gaaaggaccg gagctggggg
     2221 tggcagtgcc caggggaccc ctgcttacag tctatagcat ctccatacct ttcagggcac
     2281 attagcatcc acagctatcg tagcacactg ttgacacagg ataactggga tcataaaaat
     2341 aagaaaatac aggttgactg tcccttatcc aaagtgctcg ggactagaag aagggttttg
     2401 gattttagag tctttccagg cataggtata tttgagtata tataatgaga tatcttgggg
     2461 gtgggaccca agtataaaca tgaagctcat ttatatttca taataccgta tacacactgc
     2521 ttgaaggtag ttttatacag tgttttaaat aatgttgtgt gcatgaaaga agttttcaca
     2581 gcgtgaaatt ttcttctcgt ggcatcatgt ctgcactcaa aaacccttca ggttttggag
     2641 cgttttggat ctgttaagag atgtttaacc tatacctaaa gctatactga caaacaggtt
     2701 acaggaccag accagaccct ggatcctcag ccctgtgaag tgtgtccttc cagtcaggtg
     2761 gaggtgaact ggatcgggtt tcgtggtgct gactaaaaga gaggaatttg aggtagattt
     2821 tggaggagct gagggatgtg atgttttact agacagtggg tatgtggagg ggtaagagtc
     2881 ggaacaggat gtgacaagga agactgaaaa gaacgggaca gaacaacagg aagtgctgag
     2941 aggactttgt gggccgagaa agtggctatt gaaagagtcc caagtgccac agtctggagc
     3001 gaaggcttgt ggtagctggt gtcatggctg gtgtcagact gctctggggt agcgctatgt
     3061 caccttggtc acctcatcaa gctggaatgt cctgatcctt ttgctcagaa aaccttgcac
     3121 tgtggcttgt tcccagattg tgaaacttcc catatgcaaa aatgcttggt ttgggttttg
     3181 tttttttttt tgttgttgtt gttgtttttg tttttaaata tatgtgtaac aacagcaaca
     3241 acaaattttt gttttatttt gtgtaaattc aaataaatta atgatgcctc
//
