LOCUS       NM_001005548            2161 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LEO1 homolog, Paf1/RNA polymerase II complex
            component (Leo1), mRNA.
ACCESSION   NM_001005548 XM_217193
VERSION     NM_001005548.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Nagaike,T., Logan,C., Hotta,I., Rozenblatt-Rosen,O., Meyerson,M.
            and Manley,J.L.
  TITLE     Transcriptional activators enhance polyadenylation of mRNA
            precursors
  JOURNAL   Mol Cell 41 (4), 409-418 (2011)
   PUBMED   21329879
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Muntean,A.G., Tan,J., Sitwala,K., Huang,Y., Bronstein,J.,
            Connelly,J.A., Basrur,V., Elenitoba-Johnson,K.S. and Hess,J.L.
  TITLE     The PAF complex synergizes with MLL fusion proteins at HOX loci to
            promote leukemogenesis
  JOURNAL   Cancer Cell 17 (6), 609-621 (2010)
   PUBMED   20541477
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Jaehning,J.A.
  TITLE     The Paf1 complex: platform or player in RNA polymerase II
            transcription?
  JOURNAL   Biochim Biophys Acta 1799 (5-6), 379-388 (2010)
   PUBMED   20060942
  REMARK    Review article
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Kim,J., Guermah,M. and Roeder,R.G.
  TITLE     The human PAF1 complex acts in chromatin transcription elongation
            both independently and cooperatively with SII/TFIIS
  JOURNAL   Cell 140 (4), 491-503 (2010)
   PUBMED   20178742
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Ding,L., Paszkowski-Rogacz,M., Nitzsche,A., Slabicki,M.M.,
            Heninger,A.K., de Vries,I., Kittler,R., Junqueira,M.,
            Shevchenko,A., Schulz,H., Hubner,N., Doss,M.X., Sachinidis,A.,
            Hescheler,J., Iacone,R., Anastassiadis,K., Stewart,A.F.,
            Pisabarro,M.T., Caldarelli,A., Poser,I., Theis,M. and Buchholz,F.
  TITLE     A genome-scale RNAi screen for Oct4 modulators defines a role of
            the Paf1 complex for embryonic stem cell identity
  JOURNAL   Cell Stem Cell 4 (5), 403-415 (2009)
   PUBMED   19345177
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Lin,L., Zhang,J.H., Panicker,L.M. and Simonds,W.F.
  TITLE     The parafibromin tumor suppressor protein inhibits cell
            proliferation by repression of the c-myc proto-oncogene
  JOURNAL   Proc Natl Acad Sci U S A 105 (45), 17420-17425 (2008)
   PUBMED   18987311
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082098.1.
            
            On Oct 8, 2004 this sequence version replaced XM_217193.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082098.1, FQ229860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2161
                     /gene="Leo1"
                     /note="LEO1 homolog, Paf1/RNA polymerase II complex
                     component"
                     /db_xref="GeneID:300837"
                     /db_xref="RGD:1549772"
     exon            1..70
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2049
                     /gene="Leo1"
                     /note="Leo1 Paf1/RNA polymerase II complex component"
                     /codon_start=1
                     /product="RNA polymerase-associated protein LEO1"
                     /protein_id="NP_001005548.1"
                     /db_xref="GeneID:300837"
                     /db_xref="RGD:1549772"
                     /translation="MADMEDLFGSEAESEAERKDSDSGSDSDSDQDNGASGSNASGSE
                     SDQDERGDSGQPSNKELFGDDSEEEGAPHHSGSDNHSEQSDNRSEASEERSDHEDNEP
                     SDVDQHSGSEAHNDDDDDDDDEDDDDEGHRSDEGSHHSEAEGSEKAQSDDEKWDGEDK
                     SDQSDDDEKLQNSDDEEREQGSDDEKLQNSADEEEKMQNTDDEDRAQLSDDDRQQLSE
                     EEKGNSDDERPAASDNDEEKQNSDDEDRPQVSDEEKMQNSDDERPQVSDEDRRHSDDE
                     EEQDQKSESARGSDSEDEVLRMKRKNAIPSDSEVDSDTEVPKDNNGTMDLFGGADDIS
                     SGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPN
                     FLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRMRRDEEGNEIKESNA
                     RIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHST
                     DSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQR
                     RMREKQHQRGLSASYLEPDRYDEEEEGEESVSLAAIKNRYKGGIREERARIYSSDSDE
                     GSEEDKAQRLLKAKKLNSDEEGESSGKRKAEDDDKANKKHKKYVISDEEEEEDD"
     exon            71..862
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..967
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1062
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1208
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1293
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1388
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1523
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1659
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1846
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1944
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2136
                     /gene="Leo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacccagctg ccatggcgga catggaggac ctcttcggga gcgaagctga gagcgaggcc
       61 gagcgcaaag attccgattc tgggtctgac tcagactctg accaggacaa cggtgcttct
      121 ggtagcaatg cctctggcag cgaaagtgat caagatgaaa ggggcgattc cgggcagccc
      181 agtaacaagg aactgtttgg agatgacagt gaggaggagg gggcccctca tcacagtggc
      241 agcgacaatc actctgaaca gtcagacaat aggtcagagg cttccgagga gagatctgac
      301 cacgaggata atgagccctc tgacgtggat cagcacagtg gctctgaagc ccacaacgat
      361 gacgacgacg atgatgatga cgaggacgat gatgatgagg gccacaggtc agatgaaggg
      421 agccatcact cagaggcaga aggttctgaa aaagcacagt cagatgatga gaaatgggac
      481 ggagaggata aaagcgacca gtcagacgat gacgaaaagc tgcagaactc tgatgatgag
      541 gagcgggaac aagggtccga cgatgaaaag ctgcagaact ctgccgatga agaggagaaa
      601 atgcagaaca cagatgatga ggaccgggcc cagctttctg atgatgacag acaacagctg
      661 tctgaggagg aaaaggggaa ctctgatgat gagcgtccag cagcttctga taacgatgag
      721 gagaagcaga attcagacga tgaggaccgg ccacaggtgt ccgatgaaga gaaaatgcaa
      781 aactcggatg atgaaaggcc acaggtctcc gatgaagatc gaaggcactc agacgatgag
      841 gaggagcagg accagaagtc ggaatctgca agaggcagtg acagtgagga cgaagtttta
      901 cgaatgaagc gcaagaacgc gattccatct gactcggaag tggacagcga caccgaggtg
      961 cccaaagata ataatggaac catggacttg ttcggaggtg cagatgacat atcttcaggg
     1021 agtgacggag aggacaagcc ccctactcca ggacagcctg tggatgaaaa tggcttgcct
     1081 caagatcagc aggaggagga gccgataccc gagaccagaa tagaagtgga gattcccaaa
     1141 gtgaacacag acttgggcaa tgacttatat tttgttaaac tgcccaactt cctcagcgta
     1201 gagcccaggc cttttgatcc tcagtattat gaagatgaat ttgaagatga ggagatgctg
     1261 gatgaagaag ggagaaccag gctaaaactg aaggtagaaa acactataag atggaggatg
     1321 cgcagagatg aggaaggaaa cgagattaaa gaaagcaacg cccgcatcgt caagtggtcg
     1381 gacggaagca tgtccctgca cctagggaat gaggtgtttg acgtctacaa agccccactg
     1441 cagggcgacc acaaccacct tttcatcaga caaggtactg ggctgcaggg acaggccgtc
     1501 tttaaaacga agctcacctt caggccacac tctacagaca gtgccacaca caggaagatg
     1561 accctgtcac tggcagatcg atgttcaaag acacagaaga tcagaatctt accaatggca
     1621 ggtcgtgacc ctgagtgcca gcgcacagag atgattaaga aagaagaaga acgcctgagg
     1681 gcctccatca ggagggagtc gcagcagcgc cggatgagag agaagcagca ccagcggggg
     1741 ctgagtgcca gctacctgga gcctgatcgc tacgatgagg aggaggaagg cgaggagtct
     1801 gtcagcctgg ctgccattaa aaaccgctac aaaggaggca tccgcgagga acgggccaga
     1861 atctactcct cagacagcga cgagggctcg gaagaagaca aagctcagag gctgctcaaa
     1921 gcaaagaagc tcaacagtga cgaggaaggt gagtcttctg ggaagaggaa agcagaggac
     1981 gatgacaagg ccaataaaaa gcataagaag tatgtgatca gcgatgaaga ggaggaggag
     2041 gatgactgaa gcacagactg tgaatgcatt tatgtattta ttgtacagct tgtctataaa
     2101 tatgatgtaa acatgagtta ttttgattga gattaaaaaa aaaaaaaaaa aaaaaaaaaa
     2161 a
//
