LOCUS       NM_001191000            3120 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus LEM domain containing 3 (Lemd3), mRNA.
ACCESSION   NM_001191000 XM_001055542
VERSION     NM_001191000.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3120)
  AUTHORS   Korekawa,A., Nakano,H., Toyomaki,Y., Takiyoshi,N., Rokunohe,D.,
            Akasaka,E., Nakajima,K. and Sawamura,D.
  TITLE     Buschke-Ollendorff syndrome associated with hypertrophic scar
            formation: a possible role for LEMD3 mutation
  JOURNAL   Br J Dermatol 166 (4), 900-903 (2012)
   PUBMED   21985280
REFERENCE   2  (bases 1 to 3120)
  AUTHORS   Yuste-Chaves,M., Canueto,J., Santos-Briz,A., Ciria,S.,
            Gonzalez-Sarmiento,R. and Unamuno,P.
  TITLE     Buschke-Ollendorff syndrome with striking phenotypic variation
            resulting from a novel c.2203C>T nonsense mutation in LEMD3
  JOURNAL   Pediatr Dermatol 28 (4), 447-450 (2011)
   PUBMED   20678097
REFERENCE   3  (bases 1 to 3120)
  AUTHORS   Yadegari,M., Whyte,M.P., Mumm,S., Phelps,R.G., Shanske,A.,
            Totty,W.G. and Cohen,S.R.
  TITLE     Buschke-Ollendorff syndrome: absence of LEMD3 mutation in an
            affected family
  JOURNAL   Arch Dermatol 146 (1), 63-68 (2010)
   PUBMED   20083694
REFERENCE   4  (bases 1 to 3120)
  AUTHORS   Huber,M.D., Guan,T. and Gerace,L.
  TITLE     Overlapping functions of nuclear envelope proteins NET25 (Lem2) and
            emerin in regulation of extracellular signal-regulated kinase
            signaling in myoblast differentiation
  JOURNAL   Mol Cell Biol 29 (21), 5718-5728 (2009)
   PUBMED   19720741
REFERENCE   5  (bases 1 to 3120)
  AUTHORS   Zhang,Y., Castori,M., Ferranti,G., Paradisi,M. and Wordsworth,B.P.
  TITLE     Novel and recurrent germline LEMD3 mutations causing
            Buschke-Ollendorff syndrome and osteopoikilosis but not isolated
            melorheostosis
  JOURNAL   Clin Genet 75 (6), 556-561 (2009)
   PUBMED   19438932
  REMARK    Erratum:[Clin Genet. 2011 Apr;79(4):401]
REFERENCE   6  (bases 1 to 3120)
  AUTHORS   Hershkovitz,D., Amitai,B. and Sprecher,E.
  TITLE     Familial cutaneous collagenomas resulting from a novel mutation in
            LEMD3
  JOURNAL   Br J Dermatol 156 (2), 375-377 (2007)
   PUBMED   17223882
  REMARK    Erratum:[Br J Dermatol. 2007 Mar;156(3):612. Amitai, D B [corrected
            to Amitai, B]]
REFERENCE   7  (bases 1 to 3120)
  AUTHORS   Ishimura,A., Ng,J.K., Taira,M., Young,S.G. and Osada,S.
  TITLE     Man1, an inner nuclear membrane protein, regulates vascular
            remodeling by modulating transforming growth factor beta signaling
  JOURNAL   Development 133 (19), 3919-3928 (2006)
   PUBMED   16943282
REFERENCE   8  (bases 1 to 3120)
  AUTHORS   Pan,D., Estevez-Salmeron,L.D., Stroschein,S.L., Zhu,X., He,J.,
            Zhou,S. and Luo,K.
  TITLE     The integral inner nuclear membrane protein MAN1 physically
            interacts with the R-Smad proteins to repress signaling by the
            transforming growth factor-{beta} superfamily of cytokines
  JOURNAL   J Biol Chem 280 (16), 15992-16001 (2005)
   PUBMED   15647271
REFERENCE   9  (bases 1 to 3120)
  AUTHORS   Lin,F., Blake,D.L., Callebaut,I., Skerjanc,I.S., Holmer,L.,
            McBurney,M.W., Paulin-Levasseur,M. and Worman,H.J.
  TITLE     MAN1, an inner nuclear membrane protein that shares the LEM domain
            with lamina-associated polypeptide 2 and emerin
  JOURNAL   J Biol Chem 275 (7), 4840-4847 (2000)
   PUBMED   10671519
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 8, 2010 this sequence version replaced XM_001055542.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.25231.1,
                                           SRR26643429.26862.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1531              JAXUCZ010000007.1  58382978-58384508   c
            1532-1569           JAXUCZ010000007.1  58358509-58358546   c
            1570-1636           JAXUCZ010000007.1  58355480-58355546   c
            1637-1704           JAXUCZ010000007.1  58353503-58353570   c
            1705-1784           JAXUCZ010000007.1  58341465-58341544   c
            1785-1930           JAXUCZ010000007.1  58341233-58341378   c
            1931-2032           JAXUCZ010000007.1  58339931-58340032   c
            2033-2135           JAXUCZ010000007.1  58339720-58339822   c
            2136-2314           JAXUCZ010000007.1  58338802-58338980   c
            2315-2396           JAXUCZ010000007.1  58337853-58337934   c
            2397-2502           JAXUCZ010000007.1  58336087-58336192   c
            2503-2581           JAXUCZ010000007.1  58335911-58335989   c
            2582-3120           JAXUCZ010000007.1  58335170-58335708   c
FEATURES             Location/Qualifiers
     source          1..3120
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3120
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /note="LEM domain containing 3"
                     /db_xref="GeneID:680066"
                     /db_xref="RGD:1596822"
     CDS             1..2745
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /codon_start=1
                     /product="inner nuclear membrane protein Man1"
                     /protein_id="NP_001177929.1"
                     /db_xref="GeneID:680066"
                     /db_xref="RGD:1596822"
                     /translation="MAAAAATAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLK
                     KLKKLREEEQQQQQHRAGGRGNKTRNSNNNNTAAAASVAAAPAGMGVRPGSGDFAYLR
                     TPAGLGRLSASAPESPAGGSGVAAAVPAAGSKVLLGFSSDESDVEASPREQAGGGGAR
                     RDRAALQYRGLKAPPAPPVAGEATSGNSAERRKPHSWWGARRPVGPEPQLPSGSDGAA
                     EDVDEEVADGEDRDPEAEEPLWGSRAVNGSRLLPYSCREHYSDSEEEDDGGDVASARQ
                     VLKDDSLSRHRPRRSHSKPFSALTAKSGGSRQETSVQGGGGLAMNDRAAAAGSLDRSR
                     NLEEAAAEPGGGGGGGGCDQVDSIPRYRAGAKKLAPLLSPPSPDVDSTLESPTGPLKT
                     NNHIGGGGAFGVDSPSLYANSIPPGAAATAPGSLRINHANHTGSNHTYLKNAYSKPKL
                     CEPEEELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVPEDG
                     RLLKNPFDETFGKIQASEKNLMMSTLYKLHDRLAQIAGDHECGRSSQRMLSVQEAAAY
                     LKDLGPEYEDVFNTSLLWIFKNGKDVGIRCVGYGPEEDLTNITDVQFLQSTRPQMPFW
                     CRFRRAFITVTHRLLLLCLGVVLVCAVLRYMRYRWTKEEEETRQMYDMVVKIIDVLRS
                     HNEACQETKDLQPYMPIPHVRDSLIQPQDRKKMKKVWERAVDFLAANESRVRTETRRV
                     GGADFVVWRWVQPSASCDKTSVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPV
                     MEIGDHWHLAIQEAILEKCSDNDGIVHIAVDRNSREGCVYVKCLSPGHAGKAFKALHG
                     SWFDGKLVTVKYLRLDRYHHRFPQALTCSTPLKPSDKHMNSMSHLRLRTGLANSQGSS
                     "
     exon            1..1531
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1569
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1636
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1704
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1784
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1930
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2032
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2135
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2314
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2396
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2502
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2581
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..3120
                     /gene="Lemd3"
                     /gene_synonym="RGD1561001"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggcgg cggcggctac ggcggcttcg gcgcctcagc agctctcaga tgaggagctt
       61 ttctctcagc tccgccgtta cggcttgtct ccgggtcccg tgacagagag cactcggccg
      121 gtctacctca agaagctgaa gaagcttcgc gaggaagagc agcagcagca gcagcaccgg
      181 gcggggggcc gcggcaacaa gacgcggaac agtaataaca ataacacggc ggccgcggcg
      241 agtgtagccg cggcaccggc ggggatgggg gtccggccgg gctcggggga cttcgcgtac
      301 ttacggactc ccgcgggcct cggccgcctg tcggcctccg ctccggagag ccccgcggga
      361 ggctccgggg tcgcggcggc cgtccccgcg gcgggcagca aagtgctgct gggctttagc
      421 tccgacgagt cggacgtgga ggccagtccg cgggagcagg cgggcggcgg cggagcgcgg
      481 agggaccggg ctgctctcca gtaccgcggg ctcaaagcgc caccggcgcc cccggtcgcg
      541 ggtgaggcga cgagcggcaa ctcggccgag cggaggaagc cccactcgtg gtggggggcg
      601 cggaggccgg tgggccccga gccgcagctc ccgtcgggga gcgacggggc cgcggaggac
      661 gtggacgagg aggtagcgga cggtgaggac agggacccgg aggcggagga gccgctgtgg
      721 ggcagccgag ccgtgaacgg cagccggctt ctcccctaca gctgccggga gcattactcg
      781 gactcggagg aggaggacga cggcggcgac gtggcctcgg ctagacaggt attaaaggac
      841 gactcccttt cccggcatcg acccagacgg agccatagta agccgttctc cgcgctgact
      901 gctaaatctg gcggcagccg gcaggagact tcagttcagg gagggggagg actcgcgatg
      961 aatgacaggg cggcggctgc ggggagtcta gacaggagcc gaaacctcga ggaggcggcg
     1021 gccgagccgg gaggcggagg aggaggagga gggtgcgatc aagtggactc cattcctcga
     1081 taccgtgctg gcgcgaagaa gctggcaccg ctcctgtcgc cgccgagtcc cgacgtggac
     1141 tcaaccttgg agtcgcccac agggcccctc aaaaccaata atcacatagg cggcggcggg
     1201 gccttcggcg tggattcccc cagtctgtat gccaacagca tccctcccgg agcggccgcg
     1261 accgcccctg gttcactcag gatcaaccac gccaaccata cgggctccaa tcatacctac
     1321 ctgaaaaacg cctacagcaa gccaaagctc tgcgagcccg aagaggaact tctccagcag
     1381 tttaaacgtg aggaggtgtc tccgacgggg agtttcagtg ctcactacct gtcgatgttc
     1441 ctcctaactg cagcctgctt atttttccta atattgggac tgacttacct aggaatgaga
     1501 gggacaggag tacccgagga cggaagactc ttaaaaaacc cctttgatga aacatttgga
     1561 aaaatacaag caagtgaaaa aaatcttatg atgagcacat tatacaaact tcatgatcga
     1621 ttggctcaga ttgcaggaga tcatgaatgt ggccgttcca gccaaaggat gctttctgtc
     1681 caagaagcag ctgcatattt aaaagattta ggtcctgagt atgaagatgt atttaacact
     1741 tcactgctgt ggatttttaa aaatgggaaa gatgttggaa taaggtgtgt tggttatgga
     1801 cctgaggaag acctgacaaa cataaccgat gtgcagtttt tacagtccac cagaccacag
     1861 atgccgttct ggtgccgttt ccgccgtgct ttcattaccg tgacccatag gttactgctg
     1921 ttgtgcttag gtgtagtcct ggtctgtgct gtcctccgtt atatgagata ccgctggacg
     1981 aaggaggaag aagagacaag gcagatgtat gacatggtgg tgaagatcat agatgtttta
     2041 cgaagtcata atgaagcctg tcaggaaact aaggacttac agccttacat gcctattcca
     2101 catgttcgag attccctaat acagccccag gacaggaaaa agatgaagaa agtgtgggaa
     2161 agagctgttg acttccttgc tgctaatgag tctagagtgc gaacagagac tcgaagagtg
     2221 ggtggtgcag acttcgtagt ctggcggtgg gtccagcctt ctgcatcttg tgacaagacg
     2281 tcagtcatac cctctaaagt atggcaaggt caagcatttc atttagatag aagaaattca
     2341 ccaccaaata gtttgacgcc atgtttaaag attcggaata tgtttgaccc agttatggaa
     2401 ataggagatc actggcatct ggcaattcaa gaagcaattt tagagaagtg cagcgataac
     2461 gacggcattg ttcatatcgc ggtagacagg aactcccgtg agggctgcgt gtatgttaag
     2521 tgtctgtctc cgggacatgc tgggaaggct tttaaagccc tgcacggctc ctggttcgat
     2581 ggaaaattgg taacagtaaa atacttacga ctagatagat accaccaccg cttcccccag
     2641 gctcttacgt gcagcactcc cttgaagcca tcagacaaac acatgaactc catgtctcac
     2701 ctgcgcctgc gaactggcct agctaattct caaggaagtt cctgaaaaga tgtcttcact
     2761 cctaggactg ttaatttaaa taggaaaatt cccatttggc ttcctgtctt ccttttaaaa
     2821 tgctttttgt atgtaatatt tttattgctg aagacagctg tttgaaagtt ccggaaatct
     2881 cacggttcca aatggattca gcagtgaggc agcaacactc agtagtagaa cagttgcttt
     2941 actccgtttg ggagctcagt taagccagcg catttggggt tgtgcatgag gaacacttga
     3001 ctttatagta agcgattcag agatggtggt catctttttg cagaagtgtt tgatagccat
     3061 gtaagtctgg cagagcagcc tttgtgtttt ccataatttg tgaactaatg tgagtgtttg
//
