LOCUS       NM_001039032            2530 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus LEM domain nuclear envelope protein 2 (Lemd2),
            mRNA.
ACCESSION   NM_001039032 XM_039098815 XM_342100
VERSION     NM_001039032.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Gu,M., LaJoie,D., Chen,O.S., von Appen,A., Ladinsky,M.S.,
            Redd,M.J., Nikolova,L., Bjorkman,P.J., Sundquist,W.I., Ullman,K.S.
            and Frost,A.
  TITLE     LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in
            fission yeast and human cells
  JOURNAL   Proc Natl Acad Sci U S A 114 (11), E2166-E2175 (2017)
   PUBMED   28242692
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Tapia,O., Fong,L.G., Huber,M.D., Young,S.G. and Gerace,L.
  TITLE     Nuclear envelope protein Lem2 is required for mouse development and
            regulates MAP and AKT kinases
  JOURNAL   PLoS One 10 (3), e0116196 (2015)
   PUBMED   25790465
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Huber,M.D., Guan,T. and Gerace,L.
  TITLE     Overlapping functions of nuclear envelope proteins NET25 (Lem2) and
            emerin in regulation of extracellular signal-regulated kinase
            signaling in myoblast differentiation
  JOURNAL   Mol Cell Biol 29 (21), 5718-5728 (2009)
   PUBMED   19720741
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Ulbert,S., Antonin,W., Platani,M. and Mattaj,I.W.
  TITLE     The inner nuclear membrane protein Lem2 is critical for normal
            nuclear envelope morphology
  JOURNAL   FEBS Lett 580 (27), 6435-6441 (2006)
   PUBMED   17097643
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Brachner,A., Reipert,S., Foisner,R. and Gotzmann,J.
  TITLE     LEM2 is a novel MAN1-related inner nuclear membrane protein
            associated with A-type lamins
  JOURNAL   J Cell Sci 118 (Pt 24), 5797-5810 (2005)
   PUBMED   16339967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Feb 14, 2022 this sequence version replaced
            XM_039098815.1, NM_001039032.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.969746.1,
                                           SRR22582419.1735866.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-753               JAXUCZ010000020.1  5297397-5298149     c
            754-794             JAXUCZ010000020.1  5295302-5295342     c
            795-870             JAXUCZ010000020.1  5293100-5293175     c
            871-947             JAXUCZ010000020.1  5290826-5290902     c
            948-1027            JAXUCZ010000020.1  5289980-5290059     c
            1028-1173           JAXUCZ010000020.1  5288512-5288657     c
            1174-1275           JAXUCZ010000020.1  5287732-5287833     c
            1276-1378           JAXUCZ010000020.1  5287520-5287622     c
            1379-2530           JAXUCZ010000020.1  5284275-5285426     c
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2530
                     /gene="Lemd2"
                     /note="LEM domain nuclear envelope protein 2"
                     /db_xref="GeneID:361807"
                     /db_xref="RGD:1305341"
     exon            1..753
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1529
                     /gene="Lemd2"
                     /note="LEM domain containing 2; LEM domain-containing
                     protein 2-like"
                     /codon_start=1
                     /product="LEM domain-containing protein 2"
                     /protein_id="NP_001034121.2"
                     /db_xref="GeneID:361807"
                     /db_xref="RGD:1305341"
                     /translation="MAGLSDLELRRELQALGFQPGPITDTTRNVYRNKLRRLRGEARL
                     RDDERPREEARPRGPERQREEARLREEAPLRARPAAAVPRSEPWLSPPAPSAASDTPG
                     PYGNFGASAAPWAVSRGLSYPTHTGPGPLRRRASVRGSSEDDEDARTPDRAAPGRARH
                     WWVASSASARPHSALLGADTRPGLKGQRTGSAGVVRARPEAGRRLERCLSRLLLWASL
                     GLLLVFLAILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQARQKAALLELLHELY
                     NFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIANVTSSSSSRFKAALTWILSSNKDVG
                     IWLKGEDPSELVTTVDKVVCLESARPRMGMGCRLSRALLTAVTHVLIFFWCLAFLWGL
                     LILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPP
                     QSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER"
     exon            754..794
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
     exon            795..870
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..947
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1027
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1173
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1275
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1378
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..2530
                     /gene="Lemd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggggcgg tgtcctggcc atggccggcc tgtcggacct ggagttgcgg cgggagctgc
       61 aggccctggg cttccagcca ggccccatca ccgacaccac tcgcaacgtc taccgcaaca
      121 agctgcgccg cctgcggggc gaggcccggc tgcgtgacga cgagcggccg cgggaggagg
      181 cccggccgcg gggcccggag cgtcagcggg aggaggcccg gctacgcgag gaagcgccgc
      241 tgcgcgcgcg gcccgccgcg gccgtcccgc ggtcggagcc ctggctgtcc ccgccagccc
      301 cgagcgcggc ttccgacacc ccggggcctt acggcaactt cggggcctcc gccgctccct
      361 gggccgtgag ccggggcctc tcctacccga cccacaccgg gcccgggccg ctgcggcgcc
      421 gcgcctcggt ccggggcagc tccgaggacg acgaggatgc gcggacgccc gacagggccg
      481 ccccgggccg ggcccgccac tggtgggtcg cgtcgtccgc ctcggcgcgg ccgcactccg
      541 cgctcctcgg cgccgacacg cgtcccggcc ttaagggtca gcgcacgggc tccgcgggcg
      601 tggtgcgggc ccgacccgag gcgggccggc ggctggagcg ctgcctgtct cggctcctgc
      661 tctgggccag cctggggctg ctgctcgtct tcctggccat cctctgggtg aagatgggca
      721 agccctcggc gccacaggag gcggaggaca acatgaaatt gttgccggtg gactgtgaga
      781 gaaaaacaga tgagttctgc caggccaggc agaaggcggc cctgctggag ctgttgcatg
      841 agctgtacaa cttcctggcc atccaagcag gtaattttga gtgtggcaat ccggagaagc
      901 taaagagcaa atgcatccct gtcctggagg cccaggagta catagctaac gtgaccagca
      961 gttcctcttc gaggtttaag gctgcactga cctggatact gagcagcaac aaggatgtgg
     1021 gcatctggct gaaaggggaa gacccatctg agctagtgac caccgtggac aaagtggtct
     1081 gcctggagtc cgcccggccc cggatgggca tgggctgccg cctcagccgc gccctgctca
     1141 ccgcggttac ccatgtgctc atctttttct ggtgcctggc cttcctgtgg gggctgctga
     1201 tcctcctgaa gtaccgatgg cggaagcttg aagaggaaga gcaggccatg tatgagatgg
     1261 tgaagaagat catagatgtg gttcaggacc actatgtgga ctgggaacag gacatggagc
     1321 gctaccccta cgtgggcatc cttcacgtgc gcgacagtct aatcccccca cagagcaggc
     1381 ggcgcatgaa gcgagtatgg gaccgcgccg tggaattcct ggcttccaat gaatctcgga
     1441 tccagaccga gtcccaccga gtggccgggg aggacatgct ggtgtggaga tggactaagc
     1501 cttcctcctt ctctgactcg gagcgatagg acagggccta atcagccagc ctggcttggc
     1561 tgtgccaccc agctggggca aggacacaga ccctcggtgc tcattcacac ctgccttgat
     1621 tgccctcctg gtctccattc tgggacacat gggcttactt aggggagcca ggagaacggg
     1681 gaagcccctc ctctatgcca gtattactga cagaagggag aatggcttgt tctccctgga
     1741 taaatcctgg aggttctgca ctcagctaga cagcagacag tgatcctgaa gtccctcgct
     1801 tgggaggtgg gtcgggtggt gggctggggt agcaggggcc tggggaaagc ttggcccatg
     1861 tgcctttgtg ctgttcccag cgagcttaag ggtgagggga ggaatcccgc cccactcctg
     1921 catgggcctc tttgtccaga ggaggagatg ttagaactta cagaacagag gcggctggga
     1981 tccggaaggg gcggaagctc cagccacagc tgcctgtgcc tcagtgcatc tcacaggtca
     2041 gcagtgcagc ctgagccggg gtggagcaca gcctcatcac gactgtgacc gggcctctcc
     2101 tgaccggctg gccagaacag atagggtgca gcatcatggc tgcacactgc cctctgcagg
     2161 cctcatggag caacgtgggc cattagcact ctgctaggga agacctgctc caaaaacacc
     2221 cagtgggagg cctcattggc tgagggaggc tttccagcaa ctggtccagc gggcctcacc
     2281 cacagcagct ggagtagccc ctggaggtga cgcagctgcc ccttttggac ctattgctgt
     2341 tctgtttctt aataaagtac catctccgtc tagccatacg ttcactgcct tgtgtctggg
     2401 tggccgcagg cctagggact aagcaagcag gtgcccgcgg caaggcctgt tcgcacaatc
     2461 cggctccagc cagaaggctt ttgtattgag ggtggagtgt cagaaaaata aaatatttat
     2521 tgagaacgga
//
