LOCUS       NM_001007556            1384 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Left-right determination factor 2 (Lefty2), mRNA.
ACCESSION   NM_001007556 XM_222999
VERSION     NM_001007556.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1384)
  AUTHORS   Gao,Q., Guan,L., Hou,R., Meng,R., Li,Q., Liu,J., Jin,Y., Shi,C.,
            Su,D. and Ma,X.
  TITLE     Role of EBAF/Nodal/p27 signaling pathway in development of placenta
            in normal and diabetic rats
  JOURNAL   Dev Biol 481, 172-178 (2022)
   PUBMED   34737126
  REMARK    GeneRIF: Role of EBAF/Nodal/p27 signaling pathway in development of
            placenta in normal and diabetic rats.
REFERENCE   2  (bases 1 to 1384)
  AUTHORS   Yang,Y.R., Hu,S., Bu,F.T., Li,H., Huang,C., Meng,X.M., Zhang,L.,
            Lv,X.W. and Li,J.
  TITLE     Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the
            hsa-miR-1291/LEFTY2 Axis
  JOURNAL   Front Pharmacol 12, 741151 (2021)
   PUBMED   34887753
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1384)
  AUTHORS   Yang,Y.R., Bu,F.T., Yang,Y., Li,H., Huang,C., Meng,X.M., Zhang,L.,
            Lv,X.W. and Li,J.
  TITLE     LEFTY2 alleviates hepatic stellate cell activation and liver
            fibrosis by regulating the TGF-beta1/Smad3 pathway
  JOURNAL   Mol Immunol 126, 31-39 (2020)
   PUBMED   32745796
  REMARK    GeneRIF: LEFTY2 alleviates hepatic stellate cell activation and
            liver fibrosis by regulating the TGF-beta1/Smad3 pathway.
REFERENCE   4  (bases 1 to 1384)
  AUTHORS   Arganaraz,M.E., Zampini,R., Apichela,S.A., Barraza,D.E., Angiono,G.
            and Lombardo,D.
  TITLE     Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in
            vivo
  JOURNAL   Mol Reprod Dev 86 (11), 1652-1662 (2019)
   PUBMED   31418961
  REMARK    GeneRIF: These observations have shed new light on the relevance of
            the NODAL/LEFTY2 pathway in the oviduct during early embryo
            development and the role of the embryo in modulating this pathway.
REFERENCE   5  (bases 1 to 1384)
  AUTHORS   Arganaraz,M.E., Apichela,S.A. and Miceli,D.C.
  TITLE     LEFTY2 expression and localization in rat oviduct during early
            pregnancy
  JOURNAL   Zygote 20 (1), 53-60 (2012)
   PUBMED   21205391
  REMARK    GeneRIF: LEFTY2 is expressed at a high level just before the
            embryos pass to the uterus; its biological effect might be relevant
            and significant for the preimplantation stage of embryo development
            in the oviduct.
REFERENCE   6  (bases 1 to 1384)
  AUTHORS   Arganaraz,M.E., Valdecantos,P.A., Abate,C.M. and Miceli,D.C.
  TITLE     Rat Lefty2/EBAF gene: isolation and expression analysis in the
            oviduct during the early pregnancy stage
  JOURNAL   Genes Genet Syst 82 (2), 171-175 (2007)
   PUBMED   17507784
  REMARK    GeneRIF: The highest expression of lefty2 was at the 4(th) day
            after mating (five folds respect to day one), just when the embryos
            have completed their transit through the oviduct.
REFERENCE   7  (bases 1 to 1384)
  AUTHORS   Cornet,P.B., Picquet,C., Lemoine,P., Osteen,K.G., Bruner-Tran,K.L.,
            Tabibzadeh,S., Courtoy,P.J., Eeckhout,Y., Marbaix,E. and Henriet,P.
  TITLE     Regulation and function of LEFTY-A/EBAF in the human endometrium.
            mRNA expression during the menstrual cycle, control by
            progesterone, and effect on matrix metalloprotineases
  JOURNAL   J Biol Chem 277 (45), 42496-42504 (2002)
   PUBMED   12215426
REFERENCE   8  (bases 1 to 1384)
  AUTHORS   Tabibzadeh,S., Mason,J.M., Shea,W., Cai,Y., Murray,M.J. and
            Lessey,B.
  TITLE     Dysregulated expression of ebaf, a novel molecular defect in the
            endometria of patients with infertility
  JOURNAL   J Clin Endocrinol Metab 85 (7), 2526-2536 (2000)
   PUBMED   10902804
REFERENCE   9  (bases 1 to 1384)
  AUTHORS   Meno,C., Ito,Y., Saijoh,Y., Matsuda,Y., Tashiro,K., Kuhara,S. and
            Hamada,H.
  TITLE     Two closely-related left-right asymmetrically expressed genes,
            lefty-1 and lefty-2: their distinct expression domains, chromosomal
            linkage and direct neuralizing activity in Xenopus embryos
  JOURNAL   Genes Cells 2 (8), 513-524 (1997)
   PUBMED   9348041
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY758558.1.
            
            On Nov 29, 2004 this sequence version replaced XM_222999.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY758558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..1384
                     /gene="Lefty2"
                     /gene_synonym="Ebaf2"
                     /note="Left-right determination factor 2"
                     /db_xref="GeneID:289316"
                     /db_xref="RGD:1359679"
     exon            1..314
                     /gene="Lefty2"
                     /gene_synonym="Ebaf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1165
                     /gene="Lefty2"
                     /gene_synonym="Ebaf2"
                     /note="endometrial bleeding associated factor"
                     /codon_start=1
                     /product="left-right determination factor 2 precursor"
                     /protein_id="NP_001007557.1"
                     /db_xref="GeneID:289316"
                     /db_xref="RGD:1359679"
                     /translation="MQSLWLCWTLCVLPLAGPGAAVTEEQVLSSLLKQLQLSQAPVLD
                     RVDVEGMAIPTHVSSQYVALLQGSHADRSRGKRFSQNFREVAGRFLVSETSSHLLVFG
                     MEQRLPPNSELVQAMLRLFQEPVPRTALRRLERLPPHSAQARVTIEWLRVREDGSNRT
                     ALIDSRLVSIYESGWKVFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPGTWSAHKL
                     VRFAAQGTPDGKGEPQLELHTLDLKDYGAQGNCDPEAPVTEGTRCCRKEMYLDLQGMK
                     WAENWILEPPGFLIYECVGSCRQLPESLTIGWPFLGPRQCVASEMTSLPMIVSIKEDG
                     KTRPQVVSLPNMRVQTCSCASDGALIPRGIDL"
     exon            315..561
                     /gene="Lefty2"
                     /gene_synonym="Ebaf2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..801
                     /gene="Lefty2"
                     /gene_synonym="Ebaf2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1384
                     /gene="Lefty2"
                     /gene_synonym="Ebaf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagatcatct aggtcccaag ggcactttag gggcacgtat atccagttcc tcctgggcag
       61 cgccatgcag tccctgtggc tttgctggac actctgcgta ctgcccctgg ctggccctgg
      121 ggcagcggtg actgaggaac aggttctgag cagtctcctg aagcagctgc agctcagcca
      181 ggccccggtc ctggacagag tggatgtgga ggggatggcc atccctaccc atgtgagctc
      241 ccagtatgtg gccctgctgc agggaagtca tgctgaccgc tcccgaggca agaggttcag
      301 ccagaacttt cgagaggtgg caggcaggtt cctggtgtca gagacctcca gtcacctgct
      361 ggtgttcggc atggagcagc ggctgccgcc taacagtgag ctggtgcagg ccatgctgcg
      421 gctgttccag gagcccgtgc ccagaacagc tctccggagg cttgagaggc tgccccctca
      481 tagtgcccaa gctcgggtca ccatcgagtg gctgagagtc cgtgaggatg gctccaaccg
      541 caccgccctc atcgattcca ggctcgtgtc catctacgag agcggctgga aggtcttcga
      601 tgtgaccgag gccgtgaact tctggcagca gctgagccgg ccgaggcagc cgctgctgct
      661 ccaggtgtcg gtgcagaggg agcatctggg accggggacc tggagcgcac acaagttggt
      721 ccggttcgcg gcgcagggga cgccggacgg caagggcgag ccacagctgg aactgcacac
      781 gctggacctc aaggactacg gagctcaagg caattgtgac cccgaggcac cagtgactga
      841 aggcacccga tgctgtcgca aggagatgta cctggacctg caggggatga agtgggctga
      901 gaactggatc ctagaacccc cagggttcct catttatgaa tgtgtgggca gctgccggca
      961 gctgccagag tctctgacca tcgggtggcc atttctgggg cctcggcagt gtgtggcctc
     1021 agagatgact tccctgccca tgattgtcag cataaaggag gacggcaaga ccaggcctca
     1081 agtggtcagc ctgcccaaca tgagggtgca gacgtgtagt tgtgcctcgg atggggcact
     1141 catacctagg gggatagatc tgtaggtgcc gtgtctacat tttttttttt tttttttttt
     1201 tttttttttt ttgtcctttt tcttttcttt tctttttttt tttttttcgg agctggggac
     1261 cgaacccagg gccttgcgct tgctaggcaa gcgctctacc actgagctaa atccccaacc
     1321 ccgtgtctac agctttattg tcctaactta gtacccacac tttacctttg ccctacagtc
     1381 cttg
//
