LOCUS       NM_001109080            1572 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus left right determination factor 1 (Lefty1), mRNA.
ACCESSION   NM_001109080 XM_001061810 XM_573527
VERSION     NM_001109080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   Li,C.Y., Zhang,J.R., Li,X.X., Zhao,L., Xi,H., Hu,W.N. and Li,S.N.
  TITLE     Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2
            and p-ERK1/2 Signaling Pathways
  JOURNAL   J Cardiovasc Transl Res 14 (4), 636-646 (2021)
   PUBMED   33409963
  REMARK    GeneRIF: Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing
            p-Smad2 and p-ERK1/2 Signaling Pathways.
REFERENCE   2  (bases 1 to 1572)
  AUTHORS   Zhang,L., Liu,X., Liang,J., Wu,J., Tan,D. and Hu,W.
  TITLE     Lefty-1 inhibits renal epithelial-mesenchymal transition by
            antagonizing the TGF-beta/Smad signaling pathway
  JOURNAL   J Mol Histol 51 (1), 77-87 (2020)
   PUBMED   32065356
REFERENCE   3  (bases 1 to 1572)
  AUTHORS   Zhang,L., Xu,C., Hu,W., Wu,P., Qin,C. and Zhang,J.
  TITLE     Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial
            inflammation via regulation of the NF-kappaB pathway
  JOURNAL   Int J Mol Med 41 (3), 1293-1304 (2018)
   PUBMED   29286065
  REMARK    GeneRIF: Lefty1 may ameliorate renal tubulointerstitial
            inflammation by suppressing NFkappaB signaling.
REFERENCE   4  (bases 1 to 1572)
  AUTHORS   Chen,C. and Shen,M.M.
  TITLE     Two modes by which Lefty proteins inhibit nodal signaling
  JOURNAL   Curr Biol 14 (7), 618-624 (2004)
   PUBMED   15062104
REFERENCE   5  (bases 1 to 1572)
  AUTHORS   Yamamoto,M., Saijoh,Y., Perea-Gomez,A., Shawlot,W., Behringer,R.R.,
            Ang,S.L., Hamada,H. and Meno,C.
  TITLE     Nodal antagonists regulate formation of the anteroposterior axis of
            the mouse embryo
  JOURNAL   Nature 428 (6981), 387-392 (2004)
   PUBMED   15004567
REFERENCE   6  (bases 1 to 1572)
  AUTHORS   Tsukui,T., Capdevila,J., Tamura,K., Ruiz-Lozano,P.,
            Rodriguez-Esteban,C., Yonei-Tamura,S., Magallon,J.,
            Chandraratna,R.A., Chien,K., Blumberg,B., Evans,R.M. and
            Belmonte,J.C.
  TITLE     Multiple left-right asymmetry defects in Shh(-/-) mutant mice
            unveil a convergence of the shh and retinoic acid pathways in the
            control of Lefty-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11376-11381 (1999)
   PUBMED   10500184
REFERENCE   7  (bases 1 to 1572)
  AUTHORS   Yoshioka,H., Meno,C., Koshiba,K., Sugihara,M., Itoh,H.,
            Ishimaru,Y., Inoue,T., Ohuchi,H., Semina,E.V., Murray,J.C.,
            Hamada,H. and Noji,S.
  TITLE     Pitx2, a bicoid-type homeobox gene, is involved in a
            lefty-signaling pathway in determination of left-right asymmetry
  JOURNAL   Cell 94 (3), 299-305 (1998)
   PUBMED   9708732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001061810.1, XM_573527.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680421,
                              SAMN06680424 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..1572
                     /gene="Lefty1"
                     /gene_synonym="RGD1561867"
                     /note="left right determination factor 1"
                     /db_xref="GeneID:498299"
                     /db_xref="RGD:1561867"
     exon            1..332
                     /gene="Lefty1"
                     /gene_synonym="RGD1561867"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1189
                     /gene="Lefty1"
                     /gene_synonym="RGD1561867"
                     /codon_start=1
                     /product="left-right determination factor 1 precursor"
                     /protein_id="NP_001102550.1"
                     /db_xref="GeneID:498299"
                     /db_xref="RGD:1561867"
                     /translation="MRFLWLCWALWALFQVSPGEALTGEQVLGSLLQQLRLDRPPVLD
                     KADVEGMVIPSHVRAQYVALLQHSHDSRSRGKRFSQNFREVAGRFLVSETSSHLLVFG
                     MEQRLPPNSELVQAVLRLFQEPVPRTALRRQKRLSPHSARARVTIEWLRFREDGSNRT
                     ALIDSRLVSIHESGWKVFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPGTWSAHKL
                     VRFAAQGTPDGKGLGEPQLELHTLDLKDYGAQGNCDPETPVTEGTRCCRQEMYLDLQG
                     MKWAENWILEPPGFLTYECVGSCLQPPESLTIRWPFLGPRQCVASEMTSLPLIVSIKE
                     DGRTRPQVVSLPNMRVQRCSCASDGALIPRRLEP"
     exon            333..579
                     /gene="Lefty1"
                     /gene_synonym="RGD1561867"
                     /inference="alignment:Splign:2.1.0"
     exon            580..825
                     /gene="Lefty1"
                     /gene_synonym="RGD1561867"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1572
                     /gene="Lefty1"
                     /gene_synonym="RGD1561867"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaccagccc tcagcagact caagaccctt tcaagacacc tgagggacac aagagctaca
       61 ggttctcttc ctgggcagca ccatgcggtt cctatggctc tgttgggcac tctgggcact
      121 attccaggtt agccctggag aagccctgac tggagagcag gtcctgggca gccttctgca
      181 acagctgcgg cttgatcgac cgccagtctt ggacaaggct gatgtggagg gaatggtcat
      241 cccctcgcat gtgagggccc agtatgtggc cctgctccag cacagccatg acagccgctc
      301 ccgaggcaag aggtttagcc agaactttcg agaggtggca ggcaggttcc tggtgtcaga
      361 gacctccagt cacctgctgg tgttcggcat ggagcagcgg ctgccgccta acagtgagct
      421 ggtgcaggct gtgctgcggc tgttccagga gcctgtgccc agaacagctc tccggaggca
      481 aaagaggctg tccccacaca gcgcccgggc tcgggtcacc attgaatggc tgcgcttccg
      541 cgaggatggc tccaaccgta ccgcccttat cgattctagg ctcgtgtcca tccacgagag
      601 cggctggaag gtcttcgatg tgaccgaggc cgtgaacttc tggcagcagc tgagccggcc
      661 gaggcagccg ctgctgctcc aggtgtcggt gcagagggag catctgggac cggggacctg
      721 gagcgcacac aagttggtcc ggttcgcggc gcaggggacg ccggacggca aggggctggg
      781 cgagccacag ctggagctgc acacgctgga cctcaaggac tatggggctc aaggcaattg
      841 tgaccccgag acaccagtga ctgaaggcac ccgatgctgt cgccaagaga tgtacctgga
      901 cctgcagggg atgaagtggg ctgagaactg gatcctagaa cccccaggat tcctgactta
      961 cgaatgtgtg ggcagctgcc tgcagccacc agagtccctg accatcaggt ggccatttct
     1021 ggggcctcgg cagtgtgtgg cctcagagat gacttccttg cccctgattg tcagcataaa
     1081 ggaggacggc aggaccaggc ctcaagtggt cagcctgccc aacatgaggg tgcagaggtg
     1141 tagctgtgcc tcggatgggg cgctcatacc caggaggctg gagccatagg cacagggcgt
     1201 ggcctcccca aggacgtgac ggtaatatac ggggagagat ggggattcta aatccctaag
     1261 gggcgaatgc tctgcgtggt cctctgaacc agccccatcc ctaaatttta ccttcaagga
     1321 atgtgactcg ctggccactg gaggcgccac ctagtggtct ctgtccttca tattgtttac
     1381 tgcactgtat acgaagcact tacctgtata gaaaccgtaa actaaggaca gaatcccgaa
     1441 ctgccattgc tcccttaatc tgtccctgta tctgggctga gccccagtct tgtctctgga
     1501 cctaagaccc aagtgtatca aactaggtaa taccagcttt gctagatggg aataaaatat
     1561 gttttgcttt gt
//
