LOCUS       NP_001102550             368 aa            linear   ROD 03-APR-2024
DEFINITION  left-right determination factor 1 precursor [Rattus norvegicus].
ACCESSION   NP_001102550 XP_001061810 XP_573527
VERSION     NP_001102550.1
DBSOURCE    REFSEQ: accession NM_001109080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 368)
  AUTHORS   Li,C.Y., Zhang,J.R., Li,X.X., Zhao,L., Xi,H., Hu,W.N. and Li,S.N.
  TITLE     Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2
            and p-ERK1/2 Signaling Pathways
  JOURNAL   J Cardiovasc Transl Res 14 (4), 636-646 (2021)
   PUBMED   33409963
  REMARK    GeneRIF: Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing
            p-Smad2 and p-ERK1/2 Signaling Pathways.
REFERENCE   2  (residues 1 to 368)
  AUTHORS   Zhang,L., Liu,X., Liang,J., Wu,J., Tan,D. and Hu,W.
  TITLE     Lefty-1 inhibits renal epithelial-mesenchymal transition by
            antagonizing the TGF-beta/Smad signaling pathway
  JOURNAL   J Mol Histol 51 (1), 77-87 (2020)
   PUBMED   32065356
REFERENCE   3  (residues 1 to 368)
  AUTHORS   Zhang,L., Xu,C., Hu,W., Wu,P., Qin,C. and Zhang,J.
  TITLE     Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial
            inflammation via regulation of the NF-kappaB pathway
  JOURNAL   Int J Mol Med 41 (3), 1293-1304 (2018)
   PUBMED   29286065
  REMARK    GeneRIF: Lefty1 may ameliorate renal tubulointerstitial
            inflammation by suppressing NFkappaB signaling.
REFERENCE   4  (residues 1 to 368)
  AUTHORS   Chen,C. and Shen,M.M.
  TITLE     Two modes by which Lefty proteins inhibit nodal signaling
  JOURNAL   Curr Biol 14 (7), 618-624 (2004)
   PUBMED   15062104
REFERENCE   5  (residues 1 to 368)
  AUTHORS   Yamamoto,M., Saijoh,Y., Perea-Gomez,A., Shawlot,W., Behringer,R.R.,
            Ang,S.L., Hamada,H. and Meno,C.
  TITLE     Nodal antagonists regulate formation of the anteroposterior axis of
            the mouse embryo
  JOURNAL   Nature 428 (6981), 387-392 (2004)
   PUBMED   15004567
REFERENCE   6  (residues 1 to 368)
  AUTHORS   Tsukui,T., Capdevila,J., Tamura,K., Ruiz-Lozano,P.,
            Rodriguez-Esteban,C., Yonei-Tamura,S., Magallon,J.,
            Chandraratna,R.A., Chien,K., Blumberg,B., Evans,R.M. and
            Belmonte,J.C.
  TITLE     Multiple left-right asymmetry defects in Shh(-/-) mutant mice
            unveil a convergence of the shh and retinoic acid pathways in the
            control of Lefty-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11376-11381 (1999)
   PUBMED   10500184
REFERENCE   7  (residues 1 to 368)
  AUTHORS   Yoshioka,H., Meno,C., Koshiba,K., Sugihara,M., Itoh,H.,
            Ishimaru,Y., Inoue,T., Ohuchi,H., Semina,E.V., Murray,J.C.,
            Hamada,H. and Noji,S.
  TITLE     Pitx2, a bicoid-type homeobox gene, is involved in a
            lefty-signaling pathway in determination of left-right asymmetry
  JOURNAL   Cell 94 (3), 299-305 (1998)
   PUBMED   9708732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001061810.1, XP_573527.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680421,
                              SAMN06680424 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     Protein         1..368
                     /product="left-right determination factor 1 precursor"
                     /calculated_mol_wt=39247
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2525
     Region          <62..203
                     /region_name="TGFb_propeptide"
                     /note="TGF-beta propeptide; cl46657"
                     /db_xref="CDD:480997"
     Region          264..355
                     /region_name="TGF_beta_LEFTY1_2"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in left-right determination factor 1
                     (lefty-1), factor 2 (lefty-2) and similar proteins;
                     cd13758"
                     /db_xref="CDD:381636"
     Site            order(270..272,275..277,279,290,292..296,317..320,323,
                     346..350)
                     /site_type="other"
                     /note="putative homodimer interface [polypeptide binding]"
                     /db_xref="CDD:381636"
     CDS             1..368
                     /gene="Lefty1"
                     /gene_synonym="RGD1561867"
                     /coded_by="NM_001109080.1:83..1189"
                     /db_xref="GeneID:498299"
                     /db_xref="RGD:1561867"
ORIGIN      
        1 mrflwlcwal walfqvspge altgeqvlgs llqqlrldrp pvldkadveg mvipshvraq
       61 yvallqhshd srsrgkrfsq nfrevagrfl vsetsshllv fgmeqrlppn selvqavlrl
      121 fqepvprtal rrqkrlsphs ararvtiewl rfredgsnrt alidsrlvsi hesgwkvfdv
      181 teavnfwqql srprqplllq vsvqrehlgp gtwsahklvr faaqgtpdgk glgepqlelh
      241 tldlkdygaq gncdpetpvt egtrccrqem yldlqgmkwa enwileppgf ltyecvgscl
      301 qppesltirw pflgprqcva semtslpliv sikedgrtrp qvvslpnmrv qrcscasdga
      361 liprrlep
//
