LOCUS       NM_130429               3596 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus lymphoid enhancer binding factor 1 (Lef1), mRNA.
ACCESSION   NM_130429 XM_006233303
VERSION     NM_130429.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3596)
  AUTHORS   Kato,Y. and Yokose,S.
  TITLE     Oxytocin Facilitates Dentinogenesis of Rat Dental Pulp Cells
  JOURNAL   J Endod 47 (4), 592-599 (2021)
   PUBMED   33422572
  REMARK    GeneRIF: Oxytocin Facilitates Dentinogenesis of Rat Dental Pulp
            Cells.
REFERENCE   2  (bases 1 to 3596)
  AUTHORS   Cui,S.Y., Zhang,W., Cui,Z.M., Yi,H., Xu,D.W., Liu,W. and Zhu,X.H.
  TITLE     Knockdown of long non-coding RNA LEF1-AS1 attenuates apoptosis and
            inflammatory injury of microglia cells following spinal cord injury
  JOURNAL   J Orthop Surg Res 16 (1), 6 (2021)
   PUBMED   33407665
  REMARK    GeneRIF: Knockdown of long non-coding RNA LEF1-AS1 attenuates
            apoptosis and inflammatory injury of microglia cells following
            spinal cord injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3596)
  AUTHORS   Xian,S., Chen,A., Wu,X., Lu,C., Wu,Y., Huang,F. and Zeng,Z.
  TITLE     Activation of activin/Smad2 and 3 signaling pathway and
            the&nbsp;potential involvement of endothelial-mesenchymal
            transition in the valvular damage due to rheumatic heart disease
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179113
REFERENCE   4  (bases 1 to 3596)
  AUTHORS   Dong,T., Zhang,Z., Zhou,W., Zhou,X., Geng,C., Chang,L.K., Tian,X.
            and Liu,S.
  TITLE     WNT10A/beta-catenin pathway in tumorigenesis of papillary thyroid
            carcinoma
  JOURNAL   Oncol Rep 38 (2), 1287-1294 (2017)
   PUBMED   28677753
REFERENCE   5  (bases 1 to 3596)
  AUTHORS   Bauman,T.M., Vezina,C.M., Ricke,E.A., Halberg,R.B., Huang,W.,
            Peterson,R.E. and Ricke,W.A.
  TITLE     Expression and colocalization of beta-catenin and lymphoid
            enhancing factor-1 in prostate cancer progression
  JOURNAL   Hum Pathol 51, 124-133 (2016)
   PUBMED   27067790
REFERENCE   6  (bases 1 to 3596)
  AUTHORS   Okamura,R.M., Sigvardsson,M., Galceran,J., Verbeek,S., Clevers,H.
            and Grosschedl,R.
  TITLE     Redundant regulation of T cell differentiation and TCRalpha gene
            expression by the transcription factors LEF-1 and TCF-1
  JOURNAL   Immunity 8 (1), 11-20 (1998)
   PUBMED   9462507
REFERENCE   7  (bases 1 to 3596)
  AUTHORS   Brannon,M., Gomperts,M., Sumoy,L., Moon,R.T. and Kimelman,D.
  TITLE     A beta-catenin/XTcf-3 complex binds to the siamois promoter to
            regulate dorsal axis specification in Xenopus
  JOURNAL   Genes Dev 11 (18), 2359-2370 (1997)
   PUBMED   9308964
REFERENCE   8  (bases 1 to 3596)
  AUTHORS   Sheridan,P.L., Sheline,C.T., Cannon,K., Voz,M.L., Pazin,M.J.,
            Kadonaga,J.T. and Jones,K.A.
  TITLE     Activation of the HIV-1 enhancer by the LEF-1 HMG protein on
            nucleosome-assembled DNA in vitro
  JOURNAL   Genes Dev 9 (17), 2090-2104 (1995)
   PUBMED   7657162
REFERENCE   9  (bases 1 to 3596)
  AUTHORS   Giese,K., Kingsley,C., Kirshner,J.R. and Grosschedl,R.
  TITLE     Assembly and function of a TCR alpha enhancer complex is dependent
            on LEF-1-induced DNA bending and multiple protein-protein
            interactions
  JOURNAL   Genes Dev 9 (8), 995-1008 (1995)
   PUBMED   7774816
REFERENCE   10 (bases 1 to 3596)
  AUTHORS   Zhou,P., Byrne,C., Jacobs,J. and Fuchs,E.
  TITLE     Lymphoid enhancer factor 1 directs hair follicle patterning and
            epithelial cell fate
  JOURNAL   Genes Dev 9 (6), 700-713 (1995)
   PUBMED   7537238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 3, 2022 this sequence version replaced
            XM_006233303.4, NM_130429.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.3682.1,
                                           SRR26643292.10813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1419              JAXUCZ010000002.1  222340713-222342131
            1420-1486           JAXUCZ010000002.1  222344297-222344363
            1487-1620           JAXUCZ010000002.1  222345873-222346006
            1621-1753           JAXUCZ010000002.1  222416753-222416885
            1754-1844           JAXUCZ010000002.1  222421554-222421644
            1845-1928           JAXUCZ010000002.1  222423214-222423297
            1929-2051           JAXUCZ010000002.1  222425145-222425267
            2052-2214           JAXUCZ010000002.1  222426774-222426936
            2215-2322           JAXUCZ010000002.1  222432136-222432243
            2323-2371           JAXUCZ010000002.1  222435905-222435953
            2372-2412           JAXUCZ010000002.1  222436568-222436608
            2413-3596           JAXUCZ010000002.1  222452748-222453931
FEATURES             Location/Qualifiers
     source          1..3596
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..3596
                     /gene="Lef1"
                     /note="lymphoid enhancer binding factor 1"
                     /db_xref="GeneID:161452"
                     /db_xref="RGD:620241"
     exon            1..1419
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1213..2406
                     /gene="Lef1"
                     /note="LEF-1"
                     /codon_start=1
                     /product="lymphoid enhancer-binding factor 1"
                     /protein_id="NP_569113.2"
                     /db_xref="GeneID:161452"
                     /db_xref="RGD:620241"
                     /translation="MPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEE
                     EGDLADIKSSLVNESEIIPASNGHEVVRQTQSSQEPYHDKAREHPDDGKHPDGGLYNK
                     GPSYSSYSGYIMMPNMNSDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSD
                     EHFSPGSHPSHIPSEVNPKQGMSRHPPAPEMPTFYPLSPGGVGQITPPLGWQGQPVYP
                     ITGGFRQAYPSSLSGDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSD
                     LMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRR
                     WHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGTGPRM
                     TAAYI"
     exon            1420..1486
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1620
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1753
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1844
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1928
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2051
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2214
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2322
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2371
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2412
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..3596
                     /gene="Lef1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggagaagc ggtgggaagg cgcaaccgct cacctgcggg gctgcgcgca ccggagggac
       61 cgggctgcgc tctcgtgggc cctggcattc ggactcgccc gaagccttgc aagcggccac
      121 gctccggctg ttccccgccg gtctgccggg aggagccgag gggccaccgg caagctcttt
      181 gctttgacag aggggaggcg gggagagagg cgagtaacag cgccagcgag ccaggcagaa
      241 actcgagccg ggaacaaaga gggattgggc tcgagtgtgt gtgcgtgcgt gtgtgtgtgt
      301 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcgcgcgc gcgcgcgtgt gtgtgtgtac
      361 gtgtgtgtat cggcccgagc tacgggctgg aacatttgaa cccgaagctc ctgctgtgac
      421 tccccaagac tccgccgtgc cagccactgc cgattcccag cgctcatcag cacaaacttt
      481 attcttggca aacttctctt tttctcccct cctcctctgc cccctccccc tccagcagat
      541 taaatgctcc tccagaagga aaaccgaagc gaaagggaag gaaagaagct ctaacgcgga
      601 cgtctgcagc ccgggtggct ctttattgtt tactcagaag gaagtggact tttcggcatt
      661 ttctgatttt cctcgcacct ccgcggaggc aaacggagcc ttcttgaacc agctcttctc
      721 ttctcaaaag aaaaaaaaaa tctaaaaaca ccgaaatcag catccgagga atccgcggag
      781 aggttttgca cggcgacgcg ccacgggact ctcgtttgca ctttggaaag tcgtgttccc
      841 tccggaaccg gtgtcctcgg agcacagacc ccagcagcga aggcggcgtg gggtggccac
      901 ccagccctgg cagtctagcc tagtgcacgc ggagcggggc agacgctccc agaggcgcca
      961 gcggctgccg ccctcgcagt ctggtgccct tcgccccagg gccgggagcc ggcgtccttc
     1021 taagtgggaa agcgcggcaa tcgcagaggc tcttgcagct gctccagtcg tgggcccctc
     1081 gcttgcccac ccagcttcca ttcacagtcc tcccacactc agtcttccag ccctccccac
     1141 ctcacatcga cctccccttc ctgctgtctc cgagtgttcc cgcggcggag cggagattac
     1201 acagccgccg ggatgcccca actttccgga ggaggcggtg ggggggaccc ggaactctgc
     1261 gccaccgatg agatgatccc cttcaaggac gagggcgatc cccagaagga gaagattttc
     1321 gccgagatca gtcaccccga agaggagggc gacttagcag acatcaagtc atccttggta
     1381 aacgagtccg aaatcatccc agccagcaac gggcatgagg tggtcagaca aacacagtcc
     1441 tctcaggagc cctaccacga caaggccaga gagcacccgg atgacggaaa gcatccggac
     1501 ggaggtctat ataacaaggg cccctcctac tccagttact ctggctacat catgatgccc
     1561 aatatgaata gcgacccata catgtcaaat ggatcccttt ctccacccat cccgaggacc
     1621 tcaaataaag tgccggtggt gcagccatct cacgcggtcc accccctcac gcccctcatc
     1681 acgtacagcg acgagcactt ttctccagga tctcacccgt cacacatccc gtcagaggtc
     1741 aaccccaagc aaggcatgtc cagacaccct ccagctcctg aaatgcccac cttctacccc
     1801 ctgtctccag gcggcgttgg acagatcacc ccacccctcg gctggcaagg tcagcctgtt
     1861 tatcccatca cgggtggatt caggcaagcc tacccatcct cactgtcagg cgacacttcc
     1921 atgtccaggt tttcccatca catgattcct ggtccccctg gcccccacac aactggcatc
     1981 cctcatccag caattgtaac acctcaggtc aaacaggagc acccccacac ggacagcgac
     2041 ctaatgcacg tgaagcctca gcacgaacag agaaaggaac aggagcctaa aagacctcat
     2101 attaagaagc ctctgaatgc tttcatgtta tacatgaaag aaatgagggc gaatgtcgta
     2161 gccgagtgta cgctaaagga gagcgcagct atcaaccaga tcctgggcag aaggtggcac
     2221 gccctctccc gggaagagca ggccaaatat tatgaattag cgcggaaaga aagacagcta
     2281 catatgcagc tctatccagg ctggtcagcg agagacaatt atggcaagaa gaagaagagg
     2341 aagagagaga agctacagga atctacttca ggtacaggtc ccagaatgac agctgcctac
     2401 atctgaaaca tggtggcaaa agaaactcat tcccaacgtg caaagccaag gcagcgaccc
     2461 caggccctct cctggagatg gaagcttgtt gaaaacccag actgtctcca cagcttgccc
     2521 ggctgacccc aaggagcact gacagcaact ttaccctgag gtcactgcta gcgctgaccc
     2581 acagacacag tcactgccag ccctcccttc tgtctactgc aagcgctgac ttccaaaaga
     2641 aagccgaata cggtcgtttc tgaaaaagaa aaaaaaaata aaattaaaaa gtccatgaga
     2701 aagctagcag gccctgccca ctgagcagca ttgcttccag tcttcatgcg cttcttgagc
     2761 atcttctgcg cagacctgtc acccttcagc aaggacagac agttccttgg ctgtgtttgc
     2821 ctcgtcacgt gcaactggag ccagcgaccc aagcaggcat cagcatcctg gcgtgagaat
     2881 cgtggaagac tcctctcgtt cctgtcttca ttttcctatc tcttcaagtt tttatttaac
     2941 agtacaaaag gatcaagttt gtgtttgctt cttttttttt ttaacttgaa tttttaagtt
     3001 tacctttttt ttttttaact tttattttcc ttgtatattt tgctagctct gagcttttaa
     3061 gtgaaattca taggtctgaa ataaaaacaa gatgaaaaga agcctttttt ttttcctgag
     3121 agatcttgtc cagtaagtgg cttctctgtg atacacagtg gcctctgccc tgtgaggtgt
     3181 ctgacaaagc taaacaggta gccaagccca ctcttgttgg aggtcacgtt tggcaatccg
     3241 tctcacttta ttttctgatt tttttctttt atataaataa caaaccttaa catctccttt
     3301 gggcgaaccc atttgcagtg gattttcttt ttctttcctt tcactcctgt aaaaagccca
     3361 gcacttgaat tgttcttact ttaaatgttc cgtatttgta tctgttttta ttagccgatt
     3421 agtgggagtt tatgccagtt gttaaaacga gcatcgatgt acctgttatt ttttaaatag
     3481 caaggcgcag cctccgcccc aaactgtcat ttaacgtttg tcactccagt ttgagttaac
     3541 gtgctgagca ttttttaaaa gaagctttgt aataaaacat ttttttaaaa gtgtca
//
