LOCUS       NM_001109271            3296 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus low density lipoprotein receptor adaptor protein
            1 (Ldlrap1), mRNA.
ACCESSION   NM_001109271 XM_001067557 XM_575931
VERSION     NM_001109271.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3296)
  AUTHORS   Gabunia,K., Herman,A.B., Ray,M., Kelemen,S.E., England,R.N., DeLa
            Cadena,R., Foster,W.J., Elliott,K.J., Eguchi,S. and Autieri,M.V.
  TITLE     Induction of MiR133a expression by IL-19 targets LDLRAP1 and
            reduces oxLDL uptake in VSMC
  JOURNAL   J Mol Cell Cardiol 105, 38-48 (2017)
   PUBMED   28257760
REFERENCE   2  (bases 1 to 3296)
  AUTHORS   Shah,M., Baterina,O.Y. Jr., Taupin,V. and Farquhar,M.G.
  TITLE     ARH directs megalin to the endocytic recycling compartment to
            regulate its proteolysis and gene expression
  JOURNAL   J Cell Biol 202 (1), 113-127 (2013)
   PUBMED   23836931
  REMARK    GeneRIF: ARH knockdown leads to fast recycling of megalin via a
            Rab35 pathway.
REFERENCE   3  (bases 1 to 3296)
  AUTHORS   Dvir,H., Shah,M., Girardi,E., Guo,L., Farquhar,M.G. and Zajonc,D.M.
  TITLE     Atomic structure of the autosomal recessive hypercholesterolemia
            phosphotyrosine-binding domain in complex with the LDL-receptor
            tail
  JOURNAL   Proc Natl Acad Sci U S A 109 (18), 6916-6921 (2012)
   PUBMED   22509010
REFERENCE   4  (bases 1 to 3296)
  AUTHORS   Lehtonen,S., Shah,M., Nielsen,R., Iino,N., Ryan,J.J., Zhou,H. and
            Farquhar,M.G.
  TITLE     The endocytic adaptor protein ARH associates with motor and
            centrosomal proteins and is involved in centrosome assembly and
            cytokinesis
  JOURNAL   Mol Biol Cell 19 (7), 2949-2961 (2008)
   PUBMED   18417616
  REMARK    GeneRIF: the endocytic adaptor protein ARH associates with motor
            and centrosomal proteins and is involved in centrosome assembly and
            cytokinesis
REFERENCE   5  (bases 1 to 3296)
  AUTHORS   Mameza,M.G., Lockard,J.M., Zamora,E., Hillefors,M., Lavina,Z.S. and
            Kaplan,B.B.
  TITLE     Characterization of the adaptor protein ARH expression in the brain
            and ARH molecular interactions
  JOURNAL   J Neurochem 103 (3), 927-941 (2007)
   PUBMED   17727637
REFERENCE   6  (bases 1 to 3296)
  AUTHORS   Jones,C., Hammer,R.E., Li,W.P., Cohen,J.C., Hobbs,H.H. and Herz,J.
  TITLE     Normal sorting but defective endocytosis of the low density
            lipoprotein receptor in mice with autosomal recessive
            hypercholesterolemia
  JOURNAL   J Biol Chem 278 (31), 29024-29030 (2003)
   PUBMED   12746448
REFERENCE   7  (bases 1 to 3296)
  AUTHORS   Mishra,S.K., Watkins,S.C. and Traub,L.M.
  TITLE     The autosomal recessive hypercholesterolemia (ARH) protein
            interfaces directly with the clathrin-coat machinery
  JOURNAL   Proc Natl Acad Sci U S A 99 (25), 16099-16104 (2002)
   PUBMED   12451172
REFERENCE   8  (bases 1 to 3296)
  AUTHORS   Eden,E.R., Patel,D.D., Sun,X.M., Burden,J.J., Themis,M.,
            Edwards,M., Lee,P., Neuwirth,C., Naoumova,R.P. and Soutar,A.K.
  TITLE     Restoration of LDL receptor function in cells from patients with
            autosomal recessive hypercholesterolemia by retroviral expression
            of ARH1
  JOURNAL   J Clin Invest 110 (11), 1695-1702 (2002)
   PUBMED   12464675
REFERENCE   9  (bases 1 to 3296)
  AUTHORS   Wilund,K.R., Yi,M., Campagna,F., Arca,M., Zuliani,G., Fellin,R.,
            Ho,Y.K., Garcia,J.V., Hobbs,H.H. and Cohen,J.C.
  TITLE     Molecular mechanisms of autosomal recessive hypercholesterolemia
  JOURNAL   Hum Mol Genet 11 (24), 3019-3030 (2002)
   PUBMED   12417523
REFERENCE   10 (bases 1 to 3296)
  AUTHORS   He,G., Gupta,S., Yi,M., Michaely,P., Hobbs,H.H. and Cohen,J.C.
  TITLE     ARH is a modular adaptor protein that interacts with the LDL
            receptor, clathrin, and AP-2
  JOURNAL   J Biol Chem 277 (46), 44044-44049 (2002)
   PUBMED   12221107
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575931.2, XM_001067557.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676788
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3296
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /note="low density lipoprotein receptor adaptor protein 1"
                     /db_xref="GeneID:500564"
                     /db_xref="RGD:1563417"
     exon            1..160
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..999
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /note="autosomal recessive hypercholesterolemia protein
                     homolog"
                     /codon_start=1
                     /product="low density lipoprotein receptor adapter protein
                     1"
                     /protein_id="NP_001102741.1"
                     /db_xref="GeneID:500564"
                     /db_xref="RGD:1563417"
                     /translation="MDALKSAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEG
                     MVFSLKYLGMTLVERPKGEELSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSL
                     TSQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNESLECHAFLCTKRKVAQAVTLTV
                     AQAFKVAFEFWQVSKEEKEKREKANQEGGDVPGTRRDSTPSLKTSVATGNLLDLEELA
                     KAPLSTVSANTKNMDDALRPQVLGNNSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLT
                     AQDIHYAQCLSPTDWDKPDSSGFDQDDVFSF"
     exon            161..303
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
     exon            304..416
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
     exon            417..531
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
     exon            532..604
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
     exon            605..688
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
     exon            689..819
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
     exon            820..854
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
     exon            855..3296
                     /gene="Ldlrap1"
                     /gene_synonym="RGD1563417"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagttttcc tggaggactt ttggcggcgg cagcggcggc agaggcagca gcggcggcgg
       61 caaccggagc gggccatgga cgcgctcaag tcggcggggc gcgcgctaat ccggagcccc
      121 agtctggcca agcagagctg ggcgggcggc cggcaccgca agttgccaga gaactggacg
      181 gacactcggg agacactgct ggagggcatg gtttttagcc tcaagtacct tggtatgaca
      241 ttggtggaga ggcccaaggg tgaggagctg tctgcagctg ctgtcaaaag aatcgtggct
      301 acggccaagg cgagcgggaa gaagctgcag aaggtgacac tgaaggtgtc accccggggg
      361 atcatcctga ctgacagcct cactagccaa ctcattgaga acgtgtccat ttacaggatc
      421 tcctactgca ccgcagacaa gatgcatgac aaggtgttcg cgtacatcgc ccagagccag
      481 cagaacgaga gcctggagtg tcatgcgttc ctctgcacca agcggaaagt ggcacaagct
      541 gtcaccctca ctgtagccca agccttcaaa gttgcctttg agttttggca ggtgtccaag
      601 gaagagaaag agaagagaga gaaagccaac caggagggag gagacgtccc agggacccga
      661 cgtgacagca ccccctcgtt gaaaacctcg gtcgctactg ggaacctgct ggatctggaa
      721 gagctggcta aggccccgtt gtccacagtc agcgctaata ctaagaacat ggacgacgca
      781 ctgcggcctc aagtcttggg caacaacagc gtcgtctggg agctggatga cggtctggat
      841 gaagcgtttt caaggctggc gcagtcacgg acaaaccctc aagtcctgga cactggactg
      901 acagcacagg atatccatta cgcacagtgc ttatcgccca ctgactggga caagcctgac
      961 agcagtggct ttgatcaaga cgacgtcttc agcttctgag ggcctgaggc tggcagtaca
     1021 cggctggcct agccatgtgg tggaccacca gccacctgca gcaggacaac cagccccagg
     1081 agccatcagc tgcctttggc cagtggcgtc agagcctgca gatttgagtt gcacagtcac
     1141 gcagggagag gggttagaaa gatgcctggg gtatctggtt gatgactcct ggtttatgct
     1201 cggaaaccag gttcaattca ggtgctcatg gtgtgtgcag ggcagggctg gcctcctggc
     1261 ctctctcctg gagccagtat ccccgctgtg ggtgtccaga caatgaccaa agtgttgctt
     1321 gttcctcttc tctggggcat ccttactcct gaagcagtag gagcctgtcg ttctttgtgt
     1381 gctggatggg acatggcttt caggaaagtc ggggtcctca agctcggctt cctcagggct
     1441 gagaagctga ggctttcaaa gaggcagccc ctgaccaaag acatttaatc tgcactttaa
     1501 ctctcacgta atggacgtaa tggacgtggt tcgaggtccg tgatggtgct ctaggagtag
     1561 agtttgcttc ctgccctccc tccacaagag ggccccagtc cctgacatgg tccacatagt
     1621 gctaggacct agtgtaccag ctgactacga ctccagagtc actgcaacca tagggatctc
     1681 ctttgtggct cctgggagcc cccaaaacag acaaagctgg gcctgctctt ctgtcttgtc
     1741 tgtatgtccc tgtgcgtgct ccgttttctg cctccccata actcctggga cgataccgaa
     1801 gcctggtact aggttgtggc aggatatttt gcatccattt tacagataaa gaaactgagg
     1861 caacacgttg gggtgggggg cggtggagtt gagaatagaa cccagatctg ataccaaagc
     1921 tgccgtctgt gctgccgcct tgcagcccac gcctctttct ctccggcttt gttgtcctcc
     1981 caggaaccag aacgccccag ctattttctg accaaaatgt gtttcataac aaaccgtctg
     2041 gtgcctttcc acacagcgct ggcgcaggcc gccatgccct gctagctgct acgtggctga
     2101 cttctgtgca gatgtgtttg gaagtctgtt aattccctgg gtgaaacaga atcctgctct
     2161 agaaacacct cgctgtcctt tcctgacctg cagccttaga ggtccctcag ccctagctgg
     2221 tggtggttgg gaggtccagt ggtgagcttc ccttagtctc tcttttctcc cttcgctgtt
     2281 acgcaggctc tggcatcctg aaccacagcc aaatcacaac catctttcca tcccaaggag
     2341 cccccagtgg ccggccgggc ttgtgaaagc aggtctcagt atccccggga aaaacacact
     2401 cttcctgagt ggctgagtca aacccgtgcc ttggggaggg cacttggaga attccggcta
     2461 gaataaaggt tgctagctcc ctttccggcc agctccgggg cctgctccca gcccaggcgg
     2521 cgggggtccg ggcgcaaggg gggctactgt gcttgctgcc ggtgctgctg tgtgaggctg
     2581 gggcttctga gtaggaaaca ataaatgttc tctttctaag tgtgagcacc gcctggggtg
     2641 ctgcgggtga caaagggcag ggtcgtcatg gcttctgccc tccgtgatgg gggcagcagt
     2701 tatgtcaaga gactggggta ggctgctgca ccagaatgga gggtgatggc aggtccccag
     2761 ttggtgggcc agcagggtac ctttctttct ctgtagactg ccattgtgac aaggtcgctg
     2821 ttgggtgatg tgagaccccg ccagtgggcc agcacataag cgctcactgt ttctaactgt
     2881 gtgttctagt caggcctgaa cccctgagac acgagtgtga gagtgagtgt gcccatgtgt
     2941 accccttccc agggctggtg gtatccccat gcctctccag tgactcagac ttttaggttt
     3001 actctgctac tcaagtttgg accagggctc cgtgctagga atttgaattc aagttgtgtg
     3061 gctttgtgtt gaagggggac agaggcaaag gaatgggtgg gtggagtcct gtgacttaag
     3121 acatccaaag tccagctact gctatgggtc agttacctat ttccttgagc ctcagttttc
     3181 ctgtctgtaa acagggtaca gcagtctcct gtgcctatgt tcctggggtt ttatgagacc
     3241 attgcccttt aacacatgat tggcagtacc tatccagtgg ctcaaaggtt ttctca
//
