LOCUS       NM_175762               3038 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus low density lipoprotein receptor (Ldlr), mRNA.
ACCESSION   NM_175762 XM_217091
VERSION     NM_175762.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3038)
  AUTHORS   Dettlaff-Pokora,A., Sucajtys-Szulc,E. and Sledzinski,T.
  TITLE     Up-regulation of PCSK9 gene expression and diminished level of
            LDL-receptor in rat liver as a potential cause of post-lipectomy
            hypercholesterolemia
  JOURNAL   Mol Cell Biochem 455 (1-2), 207-217 (2019)
   PUBMED   30483910
  REMARK    GeneRIF: This suggests that overexpression of HNF1alpha gene in
            liver of lipectomized rats can lead to overproduction of PCSK9. In
            conclusion, up-regulation of PCSK9, due to overexpression of
            HNF1alpha gene in liver of lipectomized rats and subsequently
            increase in circulating PCSK9 concentration lead to decrease in
            liver LDL-R level.
REFERENCE   2  (bases 1 to 3038)
  AUTHORS   Hao,C.L., Lin,H.L., Ke,L.Y., Yen,H.W. and Shen,K.P.
  TITLE     Pre-germinated brown rice extract ameliorates high-fat diet-induced
            metabolic syndrome
  JOURNAL   J Food Biochem 43 (3), e12769 (2019)
   PUBMED   31353547
REFERENCE   3  (bases 1 to 3038)
  AUTHORS   Farahnak,Z., Chapados,N. and Lavoie,J.M.
  TITLE     Exercise training increased gene expression of LDL-R and PCSK9 in
            intestine: link to transintestinal cholesterol excretion
  JOURNAL   Gen Physiol Biophys 37 (3), 309-317 (2018)
   PUBMED   29938676
  REMARK    GeneRIF: up-regulation of intestinal gene expression of LDL-R and
            PCSK9 following voluntary wheel running
REFERENCE   4  (bases 1 to 3038)
  AUTHORS   Zhao,Y., Yang,Y., Xing,R., Cui,X., Xiao,Y., Xie,L., You,P.,
            Wang,T., Zeng,L., Peng,W., Li,D., Chen,H. and Liu,M.
  TITLE     Hyperlipidemia induces typical atherosclerosis development in Ldlr
            and Apoe deficient rats
  JOURNAL   Atherosclerosis 271, 26-35 (2018)
   PUBMED   29459263
  REMARK    GeneRIF: Deficiency of either Ldlr or Apoe genes induced
            hyperlipidemia, which promoted endothelial inflammation and led to
            typical atherosclerosis in rats on normal or Western diets.
REFERENCE   5  (bases 1 to 3038)
  AUTHORS   Sithu,S.D., Malovichko,M.V., Riggs,K.A., Wickramasinghe,N.S.,
            Winner,M.G., Agarwal,A., Hamed-Berair,R.E., Kalani,A., Riggs,D.W.,
            Bhatnagar,A. and Srivastava,S.
  TITLE     Atherogenesis and metabolic dysregulation in LDL receptor-knockout
            rats
  JOURNAL   JCI Insight 2 (9), 86442 (2017)
   PUBMED   28469073
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3038)
  AUTHORS   Bishop,R.W.
  TITLE     Structure of the hamster low density lipoprotein receptor gene
  JOURNAL   J Lipid Res 33 (4), 549-557 (1992)
   PUBMED   1527478
REFERENCE   7  (bases 1 to 3038)
  AUTHORS   Meiner,V., Landsberger,D., Berkman,N., Reshef,A., Segal,P.,
            Seftel,H.C., van der Westhuyzen,D.R., Jeenah,M.S., Coetzee,G.A. and
            Leitersdorf,E.
  TITLE     A common Lithuanian mutation causing familial hypercholesterolemia
            in Ashkenazi Jews
  JOURNAL   Am J Hum Genet 49 (2), 443-449 (1991)
   PUBMED   1867200
REFERENCE   8  (bases 1 to 3038)
  AUTHORS   Lee,L.Y., Mohler,W.A., Schafer,B.L., Freudenberger,J.S.,
            Byrne-Connolly,N., Eager,K.B., Mosley,S.T., Leighton,J.K.,
            Thrift,R.N., Davis,R.A. et al.
  TITLE     Nucleotide sequence of the rat low density lipoprotein receptor
            cDNA
  JOURNAL   Nucleic Acids Res 17 (3), 1259-1260 (1989)
   PUBMED   2922268
REFERENCE   9  (bases 1 to 3038)
  AUTHORS   Cooper,A.D., Nutik,R. and Chen,J.
  TITLE     Characterization of the estrogen-induced lipoprotein receptor of
            rat liver
  JOURNAL   J Lipid Res 28 (1), 59-68 (1987)
   PUBMED   3559401
REFERENCE   10 (bases 1 to 3038)
  AUTHORS   Yamamoto,T., Davis,C.G., Brown,M.S., Schneider,W.J., Casey,M.L.,
            Goldstein,J.L. and Russell,D.W.
  TITLE     The human LDL receptor: a cysteine-rich protein with multiple Alu
            sequences in its mRNA
  JOURNAL   Cell 39 (1), 27-38 (1984)
   PUBMED   6091915
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_175762.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13722.1, SRR26643429.29409.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000008.1  28546191-28546411
            222-344             JAXUCZ010000008.1  28553764-28553886
            345-467             JAXUCZ010000008.1  28554403-28554525
            468-851             JAXUCZ010000008.1  28555349-28555732
            852-974             JAXUCZ010000008.1  28556971-28557093
            975-1097            JAXUCZ010000008.1  28558956-28559078
            1098-1217           JAXUCZ010000008.1  28559594-28559713
            1218-1343           JAXUCZ010000008.1  28559870-28559995
            1344-1515           JAXUCZ010000008.1  28560342-28560513
            1516-1740           JAXUCZ010000008.1  28560594-28560818
            1741-1859           JAXUCZ010000008.1  28562685-28562803
            1860-1999           JAXUCZ010000008.1  28563142-28563281
            2000-2141           JAXUCZ010000008.1  28563960-28564101
            2142-2294           JAXUCZ010000008.1  28564304-28564456
            2295-2522           JAXUCZ010000008.1  28566300-28566527
            2523-2600           JAXUCZ010000008.1  28567025-28567102
            2601-2758           JAXUCZ010000008.1  28567962-28568119
            2759-3038           JAXUCZ010000008.1  28568796-28569075
FEATURES             Location/Qualifiers
     source          1..3038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3038
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /note="low density lipoprotein receptor"
                     /db_xref="GeneID:300438"
                     /db_xref="RGD:2998"
     exon            1..221
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2794
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /note="LDL receptor"
                     /codon_start=1
                     /product="low-density lipoprotein receptor precursor"
                     /protein_id="NP_786938.2"
                     /db_xref="GeneID:300438"
                     /db_xref="RGD:2998"
                     /translation="MSTADLMLRWAIALLLAAAGVAAEDSCGKNEFQCRDGKCIVSKW
                     VCDGSRECPDGSDESPETCMSVTCRSGEFSCGGRVSRCIPDSWRCDGRTDCENGSDEL
                     DCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDGSDEAHCAATTCGPAHFRCNSSSC
                     IPSLWACDGDRDCDDGSDEWPQNCGGRDTAAEVVSSPCSSLEFHCGSSECIHRSWVCD
                     GAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCINVTQ
                     CDGPNKFKCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHICKDLK
                     IGYECLCPSGFRLVDGHQCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFHMDPHTRV
                     CKAVGSIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQR
                     KIYSAVMDQGTSLSYDAIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRR
                     RTLFREKGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGI
                     TLDLPSGRLYWVDSKLHSISSIDVNGGGRKTILEDEKQLAHPFSLAIYEDKVYWTDVL
                     NEAIFSANRLTGSDVNLVAKNLMSPEDIVLFHNVTQPRGVNWCEATVLPNGGCQYMCL
                     PAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDTVPTTQGTSTIGPVVTTSAAVSLK
                     RKEDPSATRHKEDPSATRHKEDPSATSTSRQPGDTPELSTVESVTVSSQVQGDMAGRG
                     DEVQRHGVGFLSIFLPIALVALLVFGAILLWRNWRLRNINSINFDNPVYQKTTEDEIH
                     ICRSQDGYTYPSRQMVSLEDDVA"
     exon            222..344
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            345..467
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            468..851
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            852..974
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1097
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1217
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1343
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1515
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1740
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1859
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1999
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2141
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2294
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2522
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2600
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2758
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..3038
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgacccagt gcggcgtagg attgcagccc gcataccgtg gggcttgcca cccaggtttt
       61 gcagctgaga caccgtggga cccgtgatcc tgtgtttgca gcgggaacat ttcgggtctg
      121 tgatccgagt ggggacgcga cgcagaggct gaggatgagc accgcggatc tgatgctacg
      181 ctgggccatc gccctgctcc tggctgctgc tggagttgca gcagaagatt catgtggcaa
      241 gaacgagttc cagtgtagag acggaaaatg catcgtcagc aagtgggtgt gtgacggcag
      301 ccgcgagtgc ccggatggct ccgatgagtc ccctgagaca tgcatgtctg tcacctgtcg
      361 atccggtgag ttcagctgtg gaggccgcgt cagccgatgc attcctgact cctggagatg
      421 tgatgggcgg accgactgtg aaaatggctc ggatgaacta gactgctccc ccaagacgtg
      481 ctccctggat gagttccgct gccaggatgg caagtgcatc tcccggcagt ttgtgtgtga
      541 ccaagactgg gattgcctgg atggctctga cgaggcccac tgtgcggcca ccacttgtgg
      601 ccctgctcac ttccgctgca actcctcttc ctgcatcccc agcctgtggg cctgcgacgg
      661 ggaccgggac tgtgacgatg gctccgatga gtggccgcag aactgcgggg gccgagacac
      721 ggccgctgag gtggtcagca gcccctgctc ctccctcgag ttccactgtg gcagtagtga
      781 gtgtatccat cgcagctggg tctgtgacgg tgcggctgac tgcaaggaca agtcggacga
      841 ggagaactgc gcggtgacca cctgccgacc tgacgaattc cagtgtgcag atggctcctg
      901 tattcacggt agccgccagt gtgaccgtga acatgactgc aaagacatga gcgacgagct
      961 tggctgcatc aatgtgaccc agtgcgatgg ccctaacaaa ttcaagtgcc acagtgggga
     1021 gtgcatcagc ttggacaagg tgtgcaactc cgcccgggac tgtcgtgact ggtcggatga
     1081 gcccatcaag gagtgcaaga ccaacgagtg cttggacaac aatggtggct gttcccacat
     1141 ctgcaaggac ctcaagattg gctatgagtg cctatgtccc agcggtttcc ggttggtgga
     1201 cggccaccag tgtgaagata ttgacgagtg tcaggagcca gacacctgca gccagctctg
     1261 tgtgaacctg gagggcagct tcaagtgcga gtgtcgggcc ggcttccaca tggaccctca
     1321 caccagggtc tgcaaggctg tgggttccat agggtttctg ctcttcacca accgccatga
     1381 ggtacgtaag atgaccctgg accgcagcga gtataccagc ctgatcccca acctgaagaa
     1441 tgtggtggcg ctggacactg aggtggccaa caatagaatt tactggtctg acctgtccca
     1501 gagaaagatc tacagcgccg tgatggacca gggcaccagc ttgtcctatg atgccatcat
     1561 cagtggggac ctgcacgccc ctgacgggct ggcggtagac tggatccatg gcaacatcta
     1621 ctggacggat tcagttccgg gcactgtttc cgtggctgac accaagggtg tcaggaggag
     1681 aactctgttc cgagagaaag ggtccagacc cagagccatc gtagtggacc ctgtgcatgg
     1741 cttcatgtac tggacagatt gggggacacc tgccaagatc aagaaagggg gtttgaatgg
     1801 tgtagacatc tactctctgg tgaccgagga catccagtgg ccaaatggca tcacactaga
     1861 tcttcccagt ggccgcctct attgggttga ttccaaactc cactccatct ccagcatcga
     1921 tgtcaatggg ggtggtcgga aaaccatttt ggaggatgag aagcagctag ctcacccctt
     1981 ctccttggcc atctatgagg acaaagtgta ttggacagat gtcttaaatg aagccatttt
     2041 cagtgccaac cgcctcacgg gttcagatgt gaatttggtg gctaaaaacc tcatgtcccc
     2101 ggaggacatt gtcctgtttc acaacgtcac gcagcctaga ggggtaaact ggtgtgaggc
     2161 aacggttctc cccaacggtg gctgccagta catgtgcctg cctgcccctc agatcagtgc
     2221 ccactcaccc aagttcacct gcgcttgccc tgatggtatg ctactggcca aggacatgag
     2281 gagctgcctc ccagaagtcg acactgtacc gaccacccag gggacatcca ccattgggcc
     2341 tgtggtcacc acatcagctg ctgtgtcact gaagcgcaag gaggatccct cagctactag
     2401 gcacaaggag gatccctcag ctactaggca caaggaggat ccctcagcta ccagcacctc
     2461 taggcagcct ggggataccc cagagctcag cacagtggag tcggtgacag tgtcctccca
     2521 agtccaaggt gacatggctg gcagagggga cgaggtgcag cggcacggtg tggggttctt
     2581 gtccatcttc ctccccattg cactggtggc cctccttgtc ttcggagcca tcctcctgtg
     2641 gaggaactgg cggctgagga acattaacag cataaacttt gacaacccag tctaccagaa
     2701 gaccacggag gacgagatcc acatttgccg cagccaggat ggctatacct acccctcgag
     2761 acagatggtc agcctggagg atgatgtggc atgaacagct gaggggagcc atctctttcc
     2821 gggatccgct gccaccctta ggcaggaagg acgctttctc acacctcccc gccctgcact
     2881 ggtccttcca cctcagtggt ctctgtgttg ctcaaagcaa gataagagca aaactgggct
     2941 ggggccaagc tcagcggcct gtctgccctg ggtcctgttt tatatattta ttgtctgggg
     3001 acagaaaagg ctactggcca tgctccagat gggaattc
//
