LOCUS       NP_786938                879 aa            linear   ROD 09-APR-2024
DEFINITION  low-density lipoprotein receptor precursor [Rattus norvegicus].
ACCESSION   NP_786938 XP_217091
VERSION     NP_786938.2
DBSOURCE    REFSEQ: accession NM_175762.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 879)
  AUTHORS   Dettlaff-Pokora,A., Sucajtys-Szulc,E. and Sledzinski,T.
  TITLE     Up-regulation of PCSK9 gene expression and diminished level of
            LDL-receptor in rat liver as a potential cause of post-lipectomy
            hypercholesterolemia
  JOURNAL   Mol Cell Biochem 455 (1-2), 207-217 (2019)
   PUBMED   30483910
  REMARK    GeneRIF: This suggests that overexpression of HNF1alpha gene in
            liver of lipectomized rats can lead to overproduction of PCSK9. In
            conclusion, up-regulation of PCSK9, due to overexpression of
            HNF1alpha gene in liver of lipectomized rats and subsequently
            increase in circulating PCSK9 concentration lead to decrease in
            liver LDL-R level.
REFERENCE   2  (residues 1 to 879)
  AUTHORS   Hao,C.L., Lin,H.L., Ke,L.Y., Yen,H.W. and Shen,K.P.
  TITLE     Pre-germinated brown rice extract ameliorates high-fat diet-induced
            metabolic syndrome
  JOURNAL   J Food Biochem 43 (3), e12769 (2019)
   PUBMED   31353547
REFERENCE   3  (residues 1 to 879)
  AUTHORS   Farahnak,Z., Chapados,N. and Lavoie,J.M.
  TITLE     Exercise training increased gene expression of LDL-R and PCSK9 in
            intestine: link to transintestinal cholesterol excretion
  JOURNAL   Gen Physiol Biophys 37 (3), 309-317 (2018)
   PUBMED   29938676
  REMARK    GeneRIF: up-regulation of intestinal gene expression of LDL-R and
            PCSK9 following voluntary wheel running
REFERENCE   4  (residues 1 to 879)
  AUTHORS   Zhao,Y., Yang,Y., Xing,R., Cui,X., Xiao,Y., Xie,L., You,P.,
            Wang,T., Zeng,L., Peng,W., Li,D., Chen,H. and Liu,M.
  TITLE     Hyperlipidemia induces typical atherosclerosis development in Ldlr
            and Apoe deficient rats
  JOURNAL   Atherosclerosis 271, 26-35 (2018)
   PUBMED   29459263
  REMARK    GeneRIF: Deficiency of either Ldlr or Apoe genes induced
            hyperlipidemia, which promoted endothelial inflammation and led to
            typical atherosclerosis in rats on normal or Western diets.
REFERENCE   5  (residues 1 to 879)
  AUTHORS   Sithu,S.D., Malovichko,M.V., Riggs,K.A., Wickramasinghe,N.S.,
            Winner,M.G., Agarwal,A., Hamed-Berair,R.E., Kalani,A., Riggs,D.W.,
            Bhatnagar,A. and Srivastava,S.
  TITLE     Atherogenesis and metabolic dysregulation in LDL receptor-knockout
            rats
  JOURNAL   JCI Insight 2 (9), 86442 (2017)
   PUBMED   28469073
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 879)
  AUTHORS   Bishop,R.W.
  TITLE     Structure of the hamster low density lipoprotein receptor gene
  JOURNAL   J Lipid Res 33 (4), 549-557 (1992)
   PUBMED   1527478
REFERENCE   7  (residues 1 to 879)
  AUTHORS   Meiner,V., Landsberger,D., Berkman,N., Reshef,A., Segal,P.,
            Seftel,H.C., van der Westhuyzen,D.R., Jeenah,M.S., Coetzee,G.A. and
            Leitersdorf,E.
  TITLE     A common Lithuanian mutation causing familial hypercholesterolemia
            in Ashkenazi Jews
  JOURNAL   Am J Hum Genet 49 (2), 443-449 (1991)
   PUBMED   1867200
REFERENCE   8  (residues 1 to 879)
  AUTHORS   Lee,L.Y., Mohler,W.A., Schafer,B.L., Freudenberger,J.S.,
            Byrne-Connolly,N., Eager,K.B., Mosley,S.T., Leighton,J.K.,
            Thrift,R.N., Davis,R.A. et al.
  TITLE     Nucleotide sequence of the rat low density lipoprotein receptor
            cDNA
  JOURNAL   Nucleic Acids Res 17 (3), 1259-1260 (1989)
   PUBMED   2922268
REFERENCE   9  (residues 1 to 879)
  AUTHORS   Cooper,A.D., Nutik,R. and Chen,J.
  TITLE     Characterization of the estrogen-induced lipoprotein receptor of
            rat liver
  JOURNAL   J Lipid Res 28 (1), 59-68 (1987)
   PUBMED   3559401
REFERENCE   10 (residues 1 to 879)
  AUTHORS   Yamamoto,T., Davis,C.G., Brown,M.S., Schneider,W.J., Casey,M.L.,
            Goldstein,J.L. and Russell,D.W.
  TITLE     The human LDL receptor: a cysteine-rich protein with multiple Alu
            sequences in its mRNA
  JOURNAL   Cell 39 (1), 27-38 (1984)
   PUBMED   6091915
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NP_786938.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13722.1, SRR26643429.29409.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     Protein         1..879
                     /product="low-density lipoprotein receptor precursor"
                     /note="LDL receptor"
                     /calculated_mol_wt=94480
     sig_peptide     1..21
                     /note="/evidence=ECO:0000250|UniProtKB:P01131; propagated
                     from UniProtKB/Swiss-Prot (P35952.1)"
                     /calculated_mol_wt=2188
     mat_peptide     22..879
                     /product="Low-density lipoprotein receptor.
                     /id=PRO_0000017314"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
                     /calculated_mol_wt=94480
     Region          25..58
                     /region_name="Ldl_recept_a"
                     /note="Low-density lipoprotein receptor domain class A;
                     pfam00057"
                     /db_xref="CDD:395011"
     Site            order(32,40,51..52)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(44,47,51,57..58)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            54..58
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          66..104
                     /region_name="Ldl_recept_a"
                     /note="Low-density lipoprotein receptor domain class A;
                     pfam00057"
                     /db_xref="CDD:395011"
     Site            order(73,83,94..95)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(87,90,94,100..101)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            97..101
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Region          107..143
                     /region_name="Ldl_recept_a"
                     /note="Low-density lipoprotein receptor domain class A;
                     pfam00057"
                     /db_xref="CDD:395011"
     Site            order(114,122,133..134)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(126,129,133,139..140)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            136..140
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            156
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Region          196..232
                     /region_name="Ldl_recept_a"
                     /note="Low-density lipoprotein receptor domain class A;
                     pfam00057"
                     /db_xref="CDD:395011"
     Site            order(203,211,222..223)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(215,218,222,228..229)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            225..229
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          235..271
                     /region_name="Ldl_recept_a"
                     /note="Low-density lipoprotein receptor domain class A;
                     pfam00057"
                     /db_xref="CDD:395011"
     Site            order(242,250,261..262)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(254,257,261,267..268)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            264..268
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            273
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Region          279..309
                     /region_name="Ldl_recept_a"
                     /note="Low-density lipoprotein receptor domain class A;
                     pfam00057"
                     /db_xref="CDD:395011"
     Site            order(283,291,302..303)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(295,298,302,308..309)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            305..309
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          319..353
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          355..389
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(355,358,371)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          398..439
                     /region_name="LDL-receptor class B 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Region          <435..628
                     /region_name="NHL"
                     /note="NHL repeat unit of beta-propeller proteins;
                     cl18310"
                     /db_xref="CDD:302697"
     Region          435..469
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          440..485
                     /region_name="LDL-receptor class B 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Region          476..514
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          486..528
                     /region_name="LDL-receptor class B 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Region          529..572
                     /region_name="LDL-receptor class B 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Region          529..569
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          555..600
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          573..615
                     /region_name="LDL-receptor class B 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Region          606..628
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          616..658
                     /region_name="LDL-receptor class B 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Region          616..656
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Site            657
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Region          674..711
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          717..788
                     /region_name="Clustered O-linked oligosaccharides"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Site            717
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Region          718..797
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Site            724
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Site            732
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Site            733
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Site            734
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P35952.1)"
     Site            808..829
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Region          830..879
                     /region_name="Required for MYLIP-triggered down-regulation
                     of LDLR. /evidence=ECO:0000250|UniProtKB:P01130"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     Region          842..847
                     /region_name="NPXY motif.
                     /evidence=ECO:0000250|UniProtKB:P01130"
                     /note="propagated from UniProtKB/Swiss-Prot (P35952.1)"
     CDS             1..879
                     /gene="Ldlr"
                     /gene_synonym="LDLRA"
                     /coded_by="NM_175762.3:155..2794"
                     /db_xref="GeneID:300438"
                     /db_xref="RGD:2998"
ORIGIN      
        1 mstadlmlrw aialllaaag vaaedscgkn efqcrdgkci vskwvcdgsr ecpdgsdesp
       61 etcmsvtcrs gefscggrvs rcipdswrcd grtdcengsd eldcspktcs ldefrcqdgk
      121 cisrqfvcdq dwdcldgsde ahcaattcgp ahfrcnsssc ipslwacdgd rdcddgsdew
      181 pqncggrdta aevvsspcss lefhcgssec ihrswvcdga adckdksdee ncavttcrpd
      241 efqcadgsci hgsrqcdreh dckdmsdelg cinvtqcdgp nkfkchsgec isldkvcnsa
      301 rdcrdwsdep ikecktnecl dnnggcshic kdlkigyecl cpsgfrlvdg hqcedidecq
      361 epdtcsqlcv nlegsfkcec ragfhmdpht rvckavgsig fllftnrhev rkmtldrsey
      421 tslipnlknv valdtevann riywsdlsqr kiysavmdqg tslsydaiis gdlhapdgla
      481 vdwihgniyw tdsvpgtvsv adtkgvrrrt lfrekgsrpr aivvdpvhgf mywtdwgtpa
      541 kikkgglngv diyslvtedi qwpngitldl psgrlywvds klhsissidv ngggrktile
      601 dekqlahpfs laiyedkvyw tdvlneaifs anrltgsdvn lvaknlmspe divlfhnvtq
      661 prgvnwceat vlpnggcqym clpapqisah spkftcacpd gmllakdmrs clpevdtvpt
      721 tqgtstigpv vttsaavslk rkedpsatrh kedpsatrhk edpsatstsr qpgdtpelst
      781 vesvtvssqv qgdmagrgde vqrhgvgfls iflpialval lvfgaillwr nwrlrninsi
      841 nfdnpvyqkt tedeihicrs qdgytypsrq mvsleddva
//
