LOCUS       NM_001399130            2879 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lactate dehydrogenase D (Ldhd), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001399130 XM_006255631
VERSION     NM_001399130.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Monroe,G.R., van Eerde,A.M., Tessadori,F., Duran,K.J.,
            Savelberg,S.M.C., van Alfen,J.C., Terhal,P.A., van der
            Crabben,S.N., Lichtenbelt,K.D., Fuchs,S.A., Gerrits,J., van
            Roosmalen,M.J., van Gassen,K.L., van Aalderen,M., Koot,B.G.,
            Oostendorp,M., Duran,M., Visser,G., de Koning,T.J., Cali,F.,
            Bosco,P., Geleijns,K., de Sain-van der Velden,M.G.M., Knoers,N.V.,
            Bakkers,J., Verhoeven-Duif,N.M., van Haaften,G. and Jans,J.J.
  TITLE     Identification of human D lactate dehydrogenase deficiency
  JOURNAL   Nat Commun 10 (1), 1477 (2019)
   PUBMED   30931947
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   de Bari,L., Atlante,A., Guaragnella,N., Principato,G. and
            Passarella,S.
  TITLE     D-Lactate transport and metabolism in rat liver mitochondria
  JOURNAL   Biochem J 365 (Pt 2), 391-403 (2002)
   PUBMED   11955284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006255631.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.42796.1,
                                           SRR26643288.61528.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000019.1  56497594-56497695   c
            103-215             JAXUCZ010000019.1  56497307-56497419   c
            216-357             JAXUCZ010000019.1  56496831-56496972   c
            358-499             JAXUCZ010000019.1  56496526-56496667   c
            500-659             JAXUCZ010000019.1  56496222-56496381   c
            660-859             JAXUCZ010000019.1  56495705-56495904   c
            860-988             JAXUCZ010000019.1  56495495-56495623   c
            989-1116            JAXUCZ010000019.1  56495284-56495411   c
            1117-1207           JAXUCZ010000019.1  56494677-56494767   c
            1208-1319           JAXUCZ010000019.1  56494469-56494580   c
            1320-2879           JAXUCZ010000019.1  56492827-56494386   c
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2879
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /note="lactate dehydrogenase D"
                     /db_xref="GeneID:307858"
                     /db_xref="RGD:1308107"
     exon            1..102
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1485
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /EC_number="1.1.2.4"
                     /note="D-lactate dehydrogenase"
                     /codon_start=1
                     /product="probable D-lactate dehydrogenase, mitochondrial"
                     /protein_id="NP_001386059.1"
                     /db_xref="GeneID:307858"
                     /db_xref="RGD:1308107"
                     /translation="MLLRVATQRLSPWRGYCSRGSQGGLSQDFVEALKAVVGSPHVST
                     ASAVRQHHGHDESMHRCRPPDAVVWPQNVDQVSRLASLCYNQGVPIIPFGTGTGVEGG
                     VCAVQGGVCISLTHMDQIMELNTEDFSVVVEPGVTRKALNTHLRNSGLWFPVDPGADA
                     SLCGMAATGASGTNAVRYGTMRDNVINLEVVLPDGRLLHTAGRGRHYRKSAAGYNLTG
                     LFVGSEGTLGIITSATLRLHPAPEATVAATCAFPSVQAAVDSTVQILQAAVPVARIEF
                     LDEVMMDACNRHSKLNCPVAPTLFLEFHGSQQALAEQLQRTEAITQDNGGSHFSWAKE
                     AEKRNELWAARHNAWYAALALRPGSKAYSTDVCVPISRLPEILVETKEELKASKLTGV
                     IVGHVGDGNFHCILLVNPDDVEEQRRVKAFAENLGRRALALHGTCTGEHGIGLGKRQL
                     LQEEVGPVGVETMRQLKDTLDPRGLMNPGKVL"
     exon            103..215
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            216..357
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            358..499
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            500..659
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            660..859
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            860..988
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1116
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1207
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1319
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..2879
                     /gene="Ldhd"
                     /gene_synonym="Ac2-202"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttactctc accttaactg cgggctggtt agggccatgc tccttcgggt ggcaacccag
       61 aggctttctc cctggagggg ctactgctcc agggggtcgc agggtggact cagccaggac
      121 tttgtggagg ctctgaaggc agttgtaggg agcccccatg tgtccactgc ttctgcggtc
      181 agacagcatc atgggcatga tgaatcaatg cacaggtgtc gacctcctga tgctgtggtg
      241 tggcctcaga atgtggacca ggtcagccga ctggcaagcc tgtgctacaa tcaaggtgtt
      301 cccatcatcc catttggcac aggcaccggt gttgaggggg gagtgtgtgc tgtgcagggt
      361 ggagtgtgca tcagcctgac tcacatggac cagatcatgg agctgaacac agaagacttc
      421 tcagtggttg tggagcctgg cgtcacccgt aaagctctca atacccacct gcgtaacagc
      481 ggcctttggt ttccagttga cccaggtgca gatgcttctc tgtgtggcat ggcagccact
      541 ggggcctcgg gcaccaatgc tgtgcgctat ggaaccatgc gtgacaatgt gatcaacctg
      601 gaggtggtgc tgcctgacgg caggctgctt cacacggcag gccggggccg ccattatagg
      661 aagagtgcag ctggctacaa tctcacagga ctctttgtgg gctctgaggg gactctgggc
      721 atcattacat ctgccaccct gcgcctgcac cctgcacccg aagccacagt ggctgctacc
      781 tgtgcgttcc ccagcgttca agctgctgtg gatagcacag ttcagatcct ccaggctgca
      841 gtgcctgtgg cccgcatcga gttcctggat gaagtcatga tggatgcctg caacagacac
      901 agcaaactta actgccctgt ggcccccaca cttttcctgg agttccacgg ttcccagcag
      961 gcactggcag aacagttgca gcgcacagag gcaatcactc aggataatgg cggctctcac
     1021 ttctcctggg ccaaggaggc cgaaaagcgc aatgaacttt gggctgcacg gcacaatgct
     1081 tggtatgcag ctttggccct gcgtccagga agtaaggcct attccacgga cgtgtgtgtg
     1141 cccatctccc ggttgccaga gatcttggta gagaccaagg aggagcttaa ggcctcaaaa
     1201 ctcacaggag tcattgttgg gcatgtgggt gacggcaact ttcactgcat cctgttggtc
     1261 aacccagatg atgtggagga gcagaggagg gtcaaggcct ttgcagaaaa tctgggcagg
     1321 cgtgccctgg cactccatgg gacatgtacc ggagaacatg gcatcggtct gggcaagagg
     1381 cagctgcttc aagaggaagt gggtcctgtg ggtgtggaga ccatgaggca actcaaagac
     1441 acactggatc cccgaggtct catgaaccca ggcaaagtgc tatgaggagc ttataacact
     1501 tggcccgcaa tccccagaat gcaaagcccc tgttttggac ttttccttca tgccaatgat
     1561 catgcaagaa atagaacggc tgatgctctc tatgcctgcc ctctgtagct ggggctcaag
     1621 atgaagggga ggaagatggg ctcgctcaca gaaagctact gcctttgttc ttagaaaaaa
     1681 cccagggtgt ttctcagtgg agtttcttcc tggctggcag agggggtgtg ggtctattcc
     1741 aagctaagat cagatcccac tgtggaggcc tctctgctgg cgttcagcat actgtgattc
     1801 accctatata tatagtgata agagcacccc tttccttgca aagggaagga gcattccagt
     1861 ccacattgtt aggccttttc cttgtctgtc catgtgtcgt gtccggtccc ccacccttca
     1921 tgaatgtgaa ctccatttgc agctcctccc cgctaggtcc ctgaccttgg gccaatgagc
     1981 catttgtttt gggctggccc acagactaat agcctgggga gggggataga gttcaagctt
     2041 tggaagaaag ccagtcccag cccctctgct tttgacctga ggcagaaaaa cctgcctgtg
     2101 gtggaggtca cctgacagtt ttcccaccag gaaactgaag cactttcttc aagctgtcat
     2161 ggaggacatt tgaaatacag atgagataat ccactgtgta cctcccctct ccatggtata
     2221 atgcagtcca ccagttttta cttccaaagt cagggccttg tccactttgg gacctggcag
     2281 ttttgagatt ccctggccag agctcttgtc aggaggtact gggtagctgt tccccagaag
     2341 cccacgagag ggcgcgcaac accagaaaca tagcagacac ttcagggtgg ccggtctcta
     2401 gacactttac cccttgtggg tcccagtcaa ctgtagtacc atcttctcta ctcctaggtc
     2461 ttagggttgg aaaaaatgaa ggaagcaggg caggggaagc agcaggttgt cacccccacc
     2521 gtgccacttt ctcagtgcaa cttcaggtct tagatccctt ctcggtaatg tctgtctcat
     2581 gatcctttgg ccttcttcca aactacttca ggatggagta acccaaacat cagcattgta
     2641 ctctccaagg agagatcact agtgaacccc cctcacccca gacagattgc tcacccctcc
     2701 ctcaccctcc caagtcgaat tccactgggc agggctccta cacacaccct ccaataactg
     2761 gcaactcaat agacagccat ttccccacaa tttcttttat taaagaaaac cccaaacata
     2821 cagaaaagtt gaaagaacaa atacactatt cactgaaata tcagtcgttg aagattcaa
//
