LOCUS       NM_017266               1193 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lactate dehydrogenase C (Ldhc), mRNA.
ACCESSION   NM_017266
VERSION     NM_017266.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1193)
  AUTHORS   Huang,L., Lin,Y., Jin,S., Liu,W., Xu,Y. and Zheng,Y.
  TITLE     Alternative splicing of testis-specific lactate dehydrogenase C
            gene in mammals and pigeon
  JOURNAL   Anim Biotechnol 23 (2), 114-123 (2012)
   PUBMED   22537060
REFERENCE   2  (bases 1 to 1193)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1193)
  AUTHORS   Odet,F., Duan,C., Willis,W.D., Goulding,E.H., Kung,A., Eddy,E.M.
            and Goldberg,E.
  TITLE     Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is
            required for male fertility
  JOURNAL   Biol Reprod 79 (1), 26-34 (2008)
   PUBMED   18367675
REFERENCE   4  (bases 1 to 1193)
  AUTHORS   Krisfalusi,M., Miki,K., Magyar,P.L. and O'Brien,D.A.
  TITLE     Multiple glycolytic enzymes are tightly bound to the fibrous sheath
            of mouse spermatozoa
  JOURNAL   Biol Reprod 75 (2), 270-278 (2006)
   PUBMED   16687649
REFERENCE   5  (bases 1 to 1193)
  AUTHORS   Read,J.A., Winter,V.J., Eszes,C.M., Sessions,R.B. and Brady,R.L.
  TITLE     Structural basis for altered activity of M- and H-isozyme forms of
            human lactate dehydrogenase
  JOURNAL   Proteins 43 (2), 175-185 (2001)
   PUBMED   11276087
REFERENCE   6  (bases 1 to 1193)
  AUTHORS   Tsuji,S., Qureshi,M.A., Hou,E.W., Fitch,W.M. and Li,S.S.
  TITLE     Evolutionary relationships of lactate dehydrogenases (LDHs) from
            mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA
            sequences from Xenopus, pig, and rat
  JOURNAL   Proc Natl Acad Sci U S A 91 (20), 9392-9396 (1994)
   PUBMED   7937776
REFERENCE   7  (bases 1 to 1193)
  AUTHORS   LeVan,K.M. and Goldberg,E.
  TITLE     Properties of human testis-specific lactate dehydrogenase expressed
            from Escherichia coli
  JOURNAL   Biochem J 273 (Pt 3) (Pt 3), 587-592 (1991)
   PUBMED   1996957
REFERENCE   8  (bases 1 to 1193)
  AUTHORS   Pan,Y.C., Sharief,F.S., Okabe,M., Huang,S. and Li,S.S.
  TITLE     Amino acid sequence studies on lactate dehydrogenase C4 isozymes
            from mouse and rat testes
  JOURNAL   J Biol Chem 258 (11), 7005-7016 (1983)
   PUBMED   6343385
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078862.1.
            
            On Aug 8, 2004 this sequence version replaced NM_017266.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1193
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /note="lactate dehydrogenase C"
                     /db_xref="GeneID:29634"
                     /db_xref="RGD:69366"
     exon            1..96
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            97..229
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1102
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /EC_number="1.1.1.27"
                     /note="LDH-C; LDH-X; LDH testis subunit; lactate
                     dehydrogenase 3, C chain, sperm specific"
                     /codon_start=1
                     /product="L-lactate dehydrogenase C chain"
                     /protein_id="NP_058962.2"
                     /db_xref="GeneID:29634"
                     /db_xref="RGD:69366"
                     /translation="MSTVKEQLIQNLAPDEKQSRCKITVVGVGNVGMACAISILLKGL
                     ADELALVDADENKLKGEALDLLHGSLFLSTPKIVFGKDYSVSANSKLVIITAGARMVS
                     GESRLALLQRNVTIMKAIVPGVIQNSPDCKIMIVTNPVDILTYVVWKISGLPVSSVIG
                     SGCNLDSARFRYLIGEKLGVNPSSCHGWVLGEHGDSSVPIWSGVNIAGVTLKSLNPAI
                     GSDSDKEQWKTVHKQVVDGGYEVLNLKGYTSWAIALSVTDIAASILKNLKRVHAVTTL
                     VKGLYGIKEEIFLSIPCVLGQSGITDLVKVNMNTEEEALFKKSCDILWNIQKDLQL"
     exon            230..347
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            348..521
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            522..695
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..813
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..937
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1171
                     /gene="Ldhc"
                     /gene_synonym="Ldh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgggccta acggtcatcc ttgtttctta actgctgcgg ggtgtgtttt cgacatcctt
       61 tgaggaagtg ggcagtgcct tcatccacct gtgaaggctc aacatgtcca ctgtcaagga
      121 gcagctaatt cagaacctag ctccagatga aaaacaatcc cggtgtaaga tcactgtggt
      181 cggagttgga aatgtgggca tggcgtgtgc cattagtatt ttactgaagg gtctggctga
      241 tgaacttgcc cttgttgatg ctgatgagaa caaactgaag ggagaggcac tggatcttct
      301 gcatggcagc cttttcctca gcactccaaa aatcgtcttt ggaaaagatt acagtgtatc
      361 tgccaactcc aaactggtta ttatcactgc tggtgcaaga atggtgagtg gagaatctcg
      421 tcttgccctg ctccaacgta atgtcactat catgaaagcc atcgttcccg gcgtaatcca
      481 aaacagtccg gactgtaaaa taatgattgt cacaaaccca gtcgatattt tgacatacgt
      541 ggtttggaag ataagtggcc tccctgtaag cagtgtgatt ggaagtggct gtaacctaga
      601 ctccgctcgt ttccgttacc tgattggaga gaagctgggt gtcaaccctt cgagctgcca
      661 tggctgggtt cttggagaac atggggactc cagtgtgccc atatggagtg gtgtgaacat
      721 tgctggcgta actctgaagt cactgaaccc agcaatagga tccgactccg ataaggaaca
      781 gtggaaaacc gttcacaagc aggtggtgga tggtggctat gaggtcctta acctgaaggg
      841 ctatacctct tgggccattg cgctgtctgt gactgatatc gctgcatcaa tcttgaagaa
      901 tcttaagagg gtgcatgctg ttactacgct ggttaagggc ttatatggga taaaggaaga
      961 aatcttcctc agtatcccgt gtgtcttggg acaaagtggc atcacagacc ttgtgaaagt
     1021 caacatgaac accgaggagg aagctctttt taagaagagt tgcgacatac tctggaacat
     1081 ccagaaagat ctgcaattat aaagtctgca ccttcgactg tttgataacc accatcattc
     1141 ataaattcaa taaaagtttg gaaacctaaa aaaaaaaaaa aaaaaaaaaa aaa
//
