LOCUS       NM_017025               1598 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus lactate dehydrogenase A (Ldha), mRNA.
ACCESSION   NM_017025 XM_001080828
VERSION     NM_017025.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1598)
  AUTHORS   Chen,S.F., Pan,M.X., Tang,J.C., Cheng,J., Zhao,D., Zhang,Y.,
            Liao,H.B., Liu,R., Zhuang,Y., Zhang,Z.F., Chen,J., Lei,R.X.,
            Li,S.F., Li,H.T., Wang,Z.F. and Wan,Q.
  TITLE     Arginine is neuroprotective through suppressing
            HIF-1alpha/LDHA-mediated inflammatory response after cerebral
            ischemia/reperfusion injury
  JOURNAL   Mol Brain 13 (1), 63 (2020)
   PUBMED   32321555
  REMARK    GeneRIF: Arginine is neuroprotective through suppressing
            HIF-1alpha/LDHA-mediated inflammatory response after cerebral
            ischemia/reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1598)
  AUTHORS   Liang,B. and Dong,T.
  TITLE     Effects of propofol on invasion and migration of colon cancer cells
            and JAK2/STAT3 signaling pathway
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 45 (3), 290-296 (2020)
   PUBMED   32386021
REFERENCE   3  (bases 1 to 1598)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1598)
  AUTHORS   Gao,J., Wang,T., Wang,C., Wang,S., Wang,W., Ma,D., Li,Y., Zhao,H.
            and Chen,J.
  TITLE     Effects of Tianshu Capsule on Spontaneously Hypertensive Rats as
            Revealed by 1H-NMR-Based Metabolic Profiling
  JOURNAL   Front Pharmacol 10, 989 (2019)
   PUBMED   31572179
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1598)
  AUTHORS   Zhao,L., Dong,M., Ren,M., Li,C., Zheng,H. and Gao,H.
  TITLE     Metabolomic Analysis Identifies Lactate as an Important Pathogenic
            Factor in Diabetes-associated Cognitive Decline Rats
  JOURNAL   Mol Cell Proteomics 17 (12), 2335-2346 (2018)
   PUBMED   30171160
  REMARK    GeneRIF: LDH-A may be considered as a potential target for
            alleviating or treating Diabetes-associated Cognitive
            DeclineDiabetes-associated Cognitive Decline in the future.
REFERENCE   6  (bases 1 to 1598)
  AUTHORS   LeVan,K.M. and Goldberg,E.
  TITLE     Properties of human testis-specific lactate dehydrogenase expressed
            from Escherichia coli
  JOURNAL   Biochem J 273 (Pt 3) (Pt 3), 587-592 (1991)
   PUBMED   1996957
REFERENCE   7  (bases 1 to 1598)
  AUTHORS   Charles,D.J. and Pretsch,W.
  TITLE     Linear dose-response relationship of erythrocyte enzyme-activity
            mutations in offspring of ethylnitrosourea-treated mice
  JOURNAL   Mutat Res 176 (1), 81-91 (1987)
   PUBMED   3796661
REFERENCE   8  (bases 1 to 1598)
  AUTHORS   Williams,K.R., Reddigari,S. and Patel,G.L.
  TITLE     Identification of a nucleic acid helix-destabilizing protein from
            rat liver as lactate dehydrogenase-5
  JOURNAL   Proc Natl Acad Sci U S A 82 (16), 5260-5264 (1985)
   PUBMED   2991914
REFERENCE   9  (bases 1 to 1598)
  AUTHORS   Matrisian,L.M., Rautmann,G., Magun,B.E. and Breathnach,R.
  TITLE     Epidermal growth factor or serum stimulation of rat fibroblasts
            induces an elevation in mRNA levels for lactate dehydrogenase and
            other glycolytic enzymes
  JOURNAL   Nucleic Acids Res 13 (3), 711-726 (1985)
   PUBMED   3873645
REFERENCE   10 (bases 1 to 1598)
  AUTHORS   Jungmann,R.A., Kelley,D.C., Miles,M.F. and Milkowski,D.M.
  TITLE     Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and
            N6,O2-dibutyryl cyclic amp increase the rate of transcription and
            change the stability of lactate dehydrogenase a subunit messenger
            RNA in rat C6 glioma cells
  JOURNAL   J Biol Chem 258 (8), 5312-5318 (1983)
   PUBMED   6300127
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017025.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168737.1, X01964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000001.1  106508092-106508168
            78-227              JAXUCZ010000001.1  106509845-106509994
            228-345             JAXUCZ010000001.1  106511611-106511728
            346-519             JAXUCZ010000001.1  106512605-106512778
            520-693             JAXUCZ010000001.1  106513120-106513293
            694-811             JAXUCZ010000001.1  106514103-106514220
            812-935             JAXUCZ010000001.1  106516267-106516390
            936-1598            JAXUCZ010000001.1  106516849-106517511
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1598
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /note="lactate dehydrogenase A"
                     /db_xref="GeneID:24533"
                     /db_xref="RGD:2996"
     exon            1..77
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            78..227
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1100
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /EC_number="1.1.1.27"
                     /note="LDH-A; LDH-M; LDH muscle subunit"
                     /codon_start=1
                     /product="L-lactate dehydrogenase A chain"
                     /protein_id="NP_058721.1"
                     /db_xref="GeneID:24533"
                     /db_xref="RGD:2996"
                     /translation="MAALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDL
                     ADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQE
                     GESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIG
                     SGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQL
                     GTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTM
                     IKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF"
     exon            228..345
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..519
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..693
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..811
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..935
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1598
                     /gene="Ldha"
                     /gene_synonym="CDK1; Ldh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgctggagc cactgtcgcc gatctcgcgc acgctactgc tgctgctcgc ccgtcgtccc
       61 ccatcgtgca ctaagcggtc ccaaaagatt caaagtccaa gatggcagcc ctcaaggacc
      121 agctgattgt gaatcttctt aaggaagaac aggtccccca gaacaagatt acagttgttg
      181 gggttggtgc tgttggcatg gcttgtgcca tcagtatctt aatgaaggac ttggctgatg
      241 agcttgccct tgttgatgtc atagaagata agctaaaggg agagatgatg gatcttcagc
      301 atggcagcct tttccttaag acaccaaaaa ttgtctccag caaagattat agtgtgactg
      361 caaactccaa gctggtcatt atcaccgcgg gggcccgtca gcaagaggga gagagccggc
      421 tcaatttggt ccagcgaaac gtgaacatct tcaagttcat cattccaaat gttgtgaaat
      481 acagtccaca gtgcaaactg ctcatcgtct caaacccagt ggatatcttg acctacgtgg
      541 cttggaagat cagcggcttc cccaaaaaca gagttattgg aagtggttgc aatctggatt
      601 cggctcggtt ccgttacctg atgggagaaa ggctgggagt tcatccactg agctgtcacg
      661 ggtgggtcct gggagagcat ggcgactcca gtgtgcctgt gtggagtggt gtgaatgtcg
      721 ccggcgtctc cctgaagtct ctgaacccgc agctgggcac ggatgcagac aaggagcagt
      781 ggaaggatgt gcacaagcag gtggttgaca gtgcatacga agtgatcaag ctgaaaggtt
      841 acacatcctg ggccattggc ctctccgtgg cagacttggc cgagagcata atgaagaacc
      901 ttaggcgggt gcatcccatt tccaccatga ttaagggtct ctatggaatc aaggaggatg
      961 tcttcctcag cgtcccatgt atcctgggac aaaatggaat ctcagatgtt gtgaaggtga
     1021 cactgactcc tgacgaggag gcccgcctga agaagagtgc agataccctc tggggaatcc
     1081 agaaggagct gcagttctaa agtcttccca gtgtcctagc acttcactgt ccaggctgca
     1141 gcagggtttc tatggagacc acgcacttct catctgagct gtggttggtc cagttgtgtt
     1201 gaggtggtct gggggaaatc tcagttccac agctctaccc tgctaagtgg tacttgtgta
     1261 gtggtaacct ggttagtgtg acaatcccac tgtctccaag acacactgcc aactgcatgc
     1321 aggctttgat taccctgtga gcctgctgca ttgctgtgct acgcaccctc accaaacatg
     1381 cctaggccat gagttcccag ttagttataa gctggctcca gtgtgtaagt ccatcgtgca
     1441 tatcttgtgc ataaatgttc tacaggatat tttctgtatt atatgtgtct gtagtgtaca
     1501 ttgcaatatt atgtgaaatg taagatctgc atatggatga tggaaccaac cactcaagtg
     1561 tcatgccaag gaaaacacca aataaacctt gaacagtg
//
