LOCUS       NM_001277166            4706 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus LIM domain binding 3 (Ldb3), transcript variant
            2, mRNA.
ACCESSION   NM_001277166
VERSION     NM_001277166.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4706)
  AUTHORS   Xuan,T., Wang,D., Lv,J., Pan,Z., Fang,J., Xiang,Y., Cheng,H.,
            Wang,X. and Guo,X.
  TITLE     Downregulation of Cypher induces apoptosis in cardiomyocytes via
            Akt/p38 MAPK signaling pathway
  JOURNAL   Int J Med Sci 17 (15), 2328-2337 (2020)
   PUBMED   32922198
  REMARK    GeneRIF: Downregulation of Cypher induces apoptosis in
            cardiomyocytes via Akt/p38 MAPK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4706)
  AUTHORS   Levitas,A., Konstantino,Y., Muhammad,E., Afawi,Z., Marc
            Weinstein,J., Amit,G., Etzion,Y. and Parvari,R.
  TITLE     D117N in Cypher/ZASP may not be a causative mutation for dilated
            cardiomyopathy and ventricular arrhythmias
  JOURNAL   Eur J Hum Genet 24 (5), 666-671 (2016)
   PUBMED   26419279
REFERENCE   3  (bases 1 to 4706)
  AUTHORS   Yamashita,Y., Matsuura,T., Kurosaki,T., Amakusa,Y., Kinoshita,M.,
            Ibi,T., Sahashi,K. and Ohno,K.
  TITLE     LDB3 splicing abnormalities are specific to skeletal muscles of
            patients with myotonic dystrophy type 1 and alter its PKC binding
            affinity
  JOURNAL   Neurobiol Dis 69, 200-205 (2014)
   PUBMED   24878509
REFERENCE   4  (bases 1 to 4706)
  AUTHORS   Li,Z., Ai,T., Samani,K., Xi,Y., Tzeng,H.P., Xie,M., Wu,S., Ge,S.,
            Taylor,M.D., Dong,J.W., Cheng,J., Ackerman,M.J., Kimura,A.,
            Sinagra,G., Brunelli,L., Faulkner,G. and Vatta,M.
  TITLE     A ZASP missense mutation, S196L, leads to cytoskeletal and
            electrical abnormalities in a mouse model of cardiomyopathy
  JOURNAL   Circ Arrhythm Electrophysiol 3 (6), 646-656 (2010)
   PUBMED   20852297
REFERENCE   5  (bases 1 to 4706)
  AUTHORS   Arimura,T., Inagaki,N., Hayashi,T., Shichi,D., Sato,A.,
            Hinohara,K., Vatta,M., Towbin,J.A., Chikamori,T., Yamashina,A. and
            Kimura,A.
  TITLE     Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is
            associated with dilated cardiomyopathy
  JOURNAL   Cardiovasc Res 83 (1), 80-88 (2009)
   PUBMED   19377068
REFERENCE   6  (bases 1 to 4706)
  AUTHORS   Poole,A.W., Pula,G., Hers,I., Crosby,D. and Jones,M.L.
  TITLE     PKC-interacting proteins: from function to pharmacology
  JOURNAL   Trends Pharmacol Sci 25 (10), 528-535 (2004)
   PUBMED   15380937
  REMARK    Review article
REFERENCE   7  (bases 1 to 4706)
  AUTHORS   Arimura,T., Hayashi,T., Terada,H., Lee,S.Y., Zhou,Q., Takahashi,M.,
            Ueda,K., Nouchi,T., Hohda,S., Shibutani,M., Hirose,M., Chen,J.,
            Park,J.E., Yasunami,M., Hayashi,H. and Kimura,A.
  TITLE     A Cypher/ZASP mutation associated with dilated cardiomyopathy
            alters the binding affinity to protein kinase C
  JOURNAL   J Biol Chem 279 (8), 6746-6752 (2004)
   PUBMED   14660611
REFERENCE   8  (bases 1 to 4706)
  AUTHORS   Zhou,Q., Chu,P.H., Huang,C., Cheng,C.F., Martone,M.E., Knoll,G.,
            Shelton,G.D., Evans,S. and Chen,J.
  TITLE     Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a
            severe form of congenital myopathy
  JOURNAL   J Cell Biol 155 (4), 605-612 (2001)
   PUBMED   11696561
REFERENCE   9  (bases 1 to 4706)
  AUTHORS   Faulkner,G., Pallavicini,A., Formentin,E., Comelli,A.,
            Ievolella,C., Trevisan,S., Bortoletto,G., Scannapieco,P.,
            Salamon,M., Mouly,V., Valle,G. and Lanfranchi,G.
  TITLE     ZASP: a new Z-band alternatively spliced PDZ-motif protein
  JOURNAL   J Cell Biol 146 (2), 465-475 (1999)
   PUBMED   10427098
REFERENCE   10 (bases 1 to 4706)
  AUTHORS   Zhou,Q., Ruiz-Lozano,P., Martone,M.E. and Chen,J.
  TITLE     Cypher, a striated muscle-restricted PDZ and LIM domain-containing
            protein, binds to alpha-actinin-2 and protein kinase C
  JOURNAL   J Biol Chem 274 (28), 19807-19813 (1999)
   PUBMED   10391924
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Transcript Variant: This variant (2) lacks one internal exon and
            includes two alternate internal exons, compared to variant 1. The
            encoded isoform (2) is shorter, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. There are no full-length
            transcripts supporting this RefSeq in rat and it is unknown if this
            exon combination exists in rat; however, it is predicted based on
            partial transcript alignments and on full-length transcript support
            from the mouse homolog (GeneID 24131, NM_001039072.2 and
            AY206013.1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JAXUCZ010000016.1  9924627-9924679     c
            54-172              JAXUCZ010000016.1  9924403-9924521     c
            173-324             JAXUCZ010000016.1  9915421-9915572     c
            325-400             JAXUCZ010000016.1  9914872-9914947     c
            401-423             JAXUCZ010000016.1  9909781-9909803     c
            424-627             JAXUCZ010000016.1  9908529-9908732     c
            628-797             JAXUCZ010000016.1  9904363-9904532     c
            798-834             JAXUCZ010000016.1  9903859-9903895     c
            835-1020            JAXUCZ010000016.1  9892159-9892344     c
            1021-1166           JAXUCZ010000016.1  9888953-9889098     c
            1167-1611           JAXUCZ010000016.1  9880999-9881443     c
            1612-1792           JAXUCZ010000016.1  9879609-9879789     c
            1793-1913           JAXUCZ010000016.1  9878520-9878640     c
            1914-2029           JAXUCZ010000016.1  9873021-9873136     c
            2030-4706           JAXUCZ010000016.1  9862161-9864837     c
FEATURES             Location/Qualifiers
     source          1..4706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p15"
     gene            1..4706
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /note="LIM domain binding 3"
                     /db_xref="GeneID:498587"
                     /db_xref="RGD:1564875"
     exon            1..53
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            54..172
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2119
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /note="isoform 2 is encoded by transcript variant 2; LIM
                     domain-binding protein 3; Cypher"
                     /codon_start=1
                     /product="LIM domain-binding protein 3 isoform 2"
                     /protein_id="NP_001264095.1"
                     /db_xref="GeneID:498587"
                     /db_xref="RGD:1564875"
                     /translation="MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLS
                     QGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPIQSPLPV
                     IPHQKVVANSPANADYQERFNPSVLKDSALSTHKPIEVKGLGGKATIIHAQYNTPISM
                     YSQDAIMDAIAGQAQAQGSDFSGSLPVKDLAVDSASPVYQAVIKTQSKPEDEADEWAR
                     RSSNLQSRSFRILAQMTGTEYMQDPDEEALRRSSTPIEHAPVCTSQATSPLLPASAPS
                     PAAASPIAASPTLATAAAAHAVAASAAGPASSPVENPRPQASAYSPAAATSPAPAAHT
                     SYSEGPAAPAPKPRVVTTASIRPSVYQPVPASPYSPSPGANYSPTPYTPSPAPAYTPS
                     PAPTYTPSPAPTYSPSPAPAYTPSPAPNYNPTPSAAYSGGPSESASRPPWVTDDSFSQ
                     KFAPGKSTTSVSKQTLPRGAPAYNPTGPQVTPLARGTFQRAERFPASSRTPLCGHCNN
                     VIRGPFLVAMGRSWHPEEFNCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPICAKCN
                     TKIMGEVMHALRQTWHTTCFICAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGC
                     DFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDKPLCKKHAHAINV"
     exon            173..324
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            325..400
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            401..423
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            424..627
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            628..797
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            798..834
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1020
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1166
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1611
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1792
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1913
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2029
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..4706
                     /gene="Ldb3"
                     /gene_synonym="RGD1564875; ZASP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctattctt aggagctctg cacagcctga ccaggcagca aggaacacag cagaggaagc
       61 caccgctgtc ggcaccagta tgtcttacag tgtgactctg actgggcctg ggccctgggg
      121 cttccgtctg cagggaggca aggacttcaa tatgcccctc actatctccc ggatcacccc
      181 aggcagcaag gcggcccagt cccagctcag tcaaggagat cttgtggtgg ccattgatgg
      241 agtcaacaca gacaccatga cccacctgga ggcccagaac aagatcaagt cggccagcta
      301 caacctgagc ctcactctgc agaagtccaa gcgtcctatc cccatctcca cgacagcacc
      361 ccctatccag tccccattgc cagtgatccc ccaccaaaag gtggtagcca attctccagc
      421 caacgccgac taccaggaac gcttcaaccc cagtgtcctg aaggactcag ccctgtccac
      481 ccacaagccc attgaggtga agggcttggg aggcaaagct accatcatcc acgctcagta
      541 caacacccca atcagcatgt actctcagga cgccatcatg gacgccatcg ctgggcaggc
      601 ccaggcccag ggcagtgact tcagtgggag cctccctgtg aaagacctgg cggtggacag
      661 cgcctctccc gtgtaccagg ctgtgatcaa aacccaaagc aagccagaag atgaggctga
      721 tgagtgggcc cgccggtcct ccaacctgca gtctcgttcc ttccgaatct tggcccagat
      781 gaccgggaca gaatacatgc aagaccctga tgaggaagct ctgcgaaggt caagcacccc
      841 tattgagcat gctccagtgt gcacaagcca ggccacttcc ccgctgctgc ctgcttctgc
      901 cccgtcgcct gctgctgcct ctcccattgc ggcctcgcca accctggcca cagctgctgc
      961 cgcccatgct gttgctgcct ccgctgcagg ccctgcctca agccccgtgg agaatccgag
     1021 gccacaggct tctgcttaca gccctgcagc agccacttct ccagcacctg ctgcccatac
     1081 cagctacagt gaaggtccag ctgcccctgc acccaagcct cgggttgtaa ccactgccag
     1141 catccggcct tcggtctacc agccagtgcc tgcatctccc tacagcccat ctccaggagc
     1201 caattatagt ccgactccct atactccttc accagctcct gcttacaccc cctcacctgc
     1261 tcccacctat accccctcac ctgcacccac ctactccccc tctcctgcac cagcttatac
     1321 cccatcacct gccccaaact ataaccctac accatcagct gcctacagtg ggggcccttc
     1381 agaatctgcc agccgcccac cctgggtgac cgacgacagc ttctctcaga agtttgctcc
     1441 cggaaagagc accacctctg tcagcaagca gaccctgccc aggggggctc cagcctacaa
     1501 cccaacaggc ccacaagtga ctcctcttgc caggggcacc ttccagagag ctgagcgctt
     1561 cccagcaagc agccggactc ccctctgtgg gcactgtaac aatgtcatca ggggtccttt
     1621 tctggtagcc atgggccgct cttggcaccc agaagagttc aattgtgcct actgcaagac
     1681 ctccctagca gacgtgtgct ttgtggagga gcagaacaat gtttactgtg agcggtgtta
     1741 cgagcagttt tttgccccga tctgtgccaa gtgtaacacc aagatcatgg gggaagtgat
     1801 gcacgcgctg cgacagacct ggcataccac ctgcttcatc tgcgccgcct gtaagaagcc
     1861 ttttgggaac agcctcttcc acatggagga tggagagcca tactgtgaga aagactacat
     1921 caacctgttc agcacgaagt gtcatggatg tgatttccct gtggaagctg gtgacaagtt
     1981 tatcgaggca ttggggcaca cctggcacga cacctgcttc atttgtgcgg tctgccacgt
     2041 gaatctggag gggcagccat tctactccaa gaaagacaaa ccgctgtgca agaagcacgc
     2101 gcatgccatc aacgtgtagg agcctagagt ggctggtgtg ggccaagccc aggctgctcc
     2161 tgctactgat aaggaaggag tcaaagaagc tgatgattct tctgggggga aagagggacg
     2221 agaggaaatg atcgagccct tttgaagtct aactttattc ttttcttgta cacacagaat
     2281 gtgtattatt ttagttcaga ctagaagcca aaagaagatt ctaaacccag ctagtaatta
     2341 atccacggct ggaattggac ttcagatttg ttttgggaaa tggctccaag aatccaacag
     2401 tgaaaaagaa aaaaaaagtt caaaaatcat agtctccctg gccatgtgag ttgccagtgt
     2461 ggggatggag ctctgggcag ttatggagtc tctaaagcat gcggcggagt tccagagaga
     2521 cccttggcaa gcacagtgat atgccaaaca gtatttgctg tgcggatatt tttagagccg
     2581 gcactaagag ctccttagct aagacccatt ggactttcct caccaaaaaa ggaagagttg
     2641 ttccattagc atcacagagt tacctctgtg caccagactt cagatgttga atgaacttga
     2701 aactcgtaag gggagctcag acgcctgaag caatggcggg ccaccacagg gcaagtgaaa
     2761 acaagcgaga cctccagaga ggtcttaggc tcatgccccc agcagctgag gaaagatgag
     2821 atttctctgc ctctccccct ctttccatcc tctgaaacat ctaacgtccc tggaaggctt
     2881 tgctcctttt gaattgttaa ggcaaagtga aacttgggtt tctccagttt tgctttacaa
     2941 tgtatcagaa gaggtttgaa aaaggcaggg ttgggtgtag cctttgtttg gcttgaagag
     3001 ggtcctttct gcgcatgagc gttctgtgca tgtatttcac ccccctaccc acaacggctc
     3061 aggtacattt tcctcagccc caccctcaaa caggctcagt gggaaagaga gagagacagt
     3121 gtcaaacaca ggatggtaga acaggctcac ctgctcatgg ggagaggact tccgagctat
     3181 cctcaggaag aaggcaggaa gaccctccca cctccagggc tgcaccgtcc tccttacctg
     3241 taatttaagt gcagcatacc aagtatatag tcatgctgac tgctgcaagg agaaaaaggt
     3301 gcctttgcca tttgggccaa tattttgaaa atatttgaat ggatttagaa tattttttga
     3361 aatagacctg gccttcagac tttttttaca acacaggtga ctcttttaca tagacatgga
     3421 gttaggtaag cttggtaaag ctatttagaa gtaaagaaag tggcttcctt tctgggttct
     3481 gagatggcac atttgctttc atttctagga agtgctgtta ggatggacgt tcattgaaaa
     3541 tggcatcgaa gcagggtgtg tgtgtgtgtg tgtgtctgtg tgtctcactg gagcacaata
     3601 tgtaggcact accaactcac tgcccatctc tccttggtcc tgctttggat ttttcgcttt
     3661 gcacgtttga aatgctttat aggaatgtat tcaaactctt cttttgagaa ctaaggcttc
     3721 caagagaccg tcaccctgct tgagggtctc ccctccctgg aagactctga gttagtcaaa
     3781 cattgtgtag caggaagtcc acagtttgga atcaccaatc ccacccaggc agcaccaggg
     3841 aaggtcagaa ctgtgctccc accaaacagc tcttctttac tttatgcaaa gctccagact
     3901 gagtaaattc tgctgggaca gcctggagat ttgtccagac atgcagaaca gtaccttgcg
     3961 tagtctgtta tttttggaaa gttcaaatat tcagggacaa ggagcttgct gacgaaacag
     4021 agggcttcta agcagttgat taaaaaaaaa aacaattatc tattaaatga ttaggaattg
     4081 atcgtaagga agggaaataa aagtctctac cattacattt ccaaaacata tttttaaagg
     4141 ttttctacat gatcacaggc actgctcctg tgtaatcgtt atcgttttct gtaggatcct
     4201 taagaagaaa atcaaaatat cccaaaggaa agcatcagca ttattctata ttagttttaa
     4261 aaatatttaa tagttcacaa atgtttttaa atgactctta ttttttaagt acaaaacgat
     4321 ttttagaggc tgggtataat ccaggggtac ggagtttccc tagaatttag agttctttag
     4381 ctttggtctc ccagcactgc caaaaaccaa tataaaggta gcagaaagaa gctagtctca
     4441 agagtggtcc acaggttgag cgtgcacagt gttaagatta aggctgtatg gtgatcggtt
     4501 aacatcacat ctttcctgtg gcagcaaaca gcttgtacta gtgcacagga ggaatacagt
     4561 ttgtcttgtc ttcttattct tggcattact ccaacatact gaaaagcact caccttctga
     4621 gtagaatggc ttgtattggc agcgtttgtg ttagcaatgt agcctttgta atgtgacctt
     4681 ttcaacccaa gtattctggg gttggg
//
