LOCUS       NM_001106009            1937 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus LIM domain binding 2 (Ldb2), mRNA.
ACCESSION   NM_001106009 XM_001059368 XM_214054
VERSION     NM_001106009.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Storbeck CJ, Wagner S, O'Reilly P, McKay M, Parks RJ, Westphal H
            and Sabourin LA.
  TITLE     The Ldb1 and Ldb2 transcriptional cofactors interact with the
            Ste20-like kinase SLK and regulate cell migration
  JOURNAL   Mol Biol Cell 20 (19), 4174-4182 (2009)
   PUBMED   19675209
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Xu X, Mannik J, Kudryavtseva E, Lin KK, Flanagan LA, Spencer J,
            Soto A, Wang N, Lu Z, Yu Z, Monuki ES and Andersen B.
  TITLE     Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal
            homeostasis and maintenance of hair follicle stem cells
  JOURNAL   Dev Biol 312 (2), 484-500 (2007)
   PUBMED   17991461
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Ostendorff HP, Peirano RI, Peters MA, Schluter A, Bossenz M,
            Scheffner M and Bach I.
  TITLE     Ubiquitination-dependent cofactor exchange on LIM homeodomain
            transcription factors
  JOURNAL   Nature 416 (6876), 99-103 (2002)
   PUBMED   11882901
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Bach I, Rodriguez-Esteban C, Carriere C, Bhushan A, Krones A, Rose
            DW, Glass CK, Andersen B, Izpisua Belmonte JC and Rosenfeld MG.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Ueki N, Oda T, Kondo M, Yano K, Noguchi T and Muramatsu M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Bach I, Carriere C, Ostendorff HP, Andersen B and Rosenfeld MG.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214054.4, XM_001059368.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1937
                     /gene="Ldb2"
                     /note="LIM domain binding 2"
                     /db_xref="GeneID:289664"
                     /db_xref="RGD:1307921"
     exon            1..356
                     /gene="Ldb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1346
                     /gene="Ldb2"
                     /codon_start=1
                     /product="LIM domain-binding protein 2"
                     /protein_id="NP_001099479.1"
                     /db_xref="GeneID:289664"
                     /db_xref="RGD:1307921"
                     /translation="MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTE
                     DSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYY
                     ILKHSKESYHNSSITVDCDQCAMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHF
                     TIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMS
                     RHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNTT
                     NSAGSKKKTTAASLSLSTQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGM
                     DDEEDFNNSPALGNNSPWNSKPPATQETKSENPPPQASQ"
     exon            357..459
                     /gene="Ldb2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..632
                     /gene="Ldb2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..755
                     /gene="Ldb2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..839
                     /gene="Ldb2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..963
                     /gene="Ldb2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1115
                     /gene="Ldb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1937
                     /gene="Ldb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctccctcc ctccctcttc gttccctctc ctctctcgct atagagggct cccacagcac
       61 ttcccagcca gtgtgctcag cctgcctgcc tgcctgcctc tctgtgtgtg tgtgtgtgag
      121 cgtgtgtgcg tgcgtctact ttgtactgtg aagaacacag cccatgtgct ctgcatggac
      181 gttcctgata ctctattaag cttgattttc gacaagcagg caagatgtcc agcacaccac
      241 atgacccctt ctattcttct cctttcggcc cattttatag gagacataca ccatacatgg
      301 tacagccaga gtaccgaatc tatgagatga acaagagact gcagtctcgt acagaggaca
      361 gtgacaacct ctggtgggat gcatttgcca ctgaattttt cgaagatgat gccacattaa
      421 cactttcatt ttgtttggaa gatggaccaa agcgatacac tatcggcagg accctcatcc
      481 cccgttattt tagcaccgta tttgaaggag gggtgacaga cctgtactac attctcaaac
      541 actcgaagga gtcgtaccac aactcatcca tcacagtaga ctgtgaccag tgtgccatgg
      601 tcacacagca tgggaagccc atgtttacca aggtatgcac ggaaggcagg ctgatcttgg
      661 agttcacctt tgatgacctc atgagaataa aaacatggca ctttaccatt agacagtaca
      721 gggagctggt ccccagaagc atactagcca tgcacgcaca agatcctcag gtcctggatc
      781 agctgtccaa aaatatcacc aggatgggtc taacaaactt caccctcaac tacctcaggt
      841 tgtgtgtaat actggagcca atgcaggaac tgatgtcgag acacaaaacc tacaacctca
      901 gtccccggga ctgcctgaag acctgtctgt ttcagaagtg gcagcggatg gtggcaccgc
      961 cagcagaacc cacaaggcaa ccgacaacca aaaggagaaa acgaaaaaac tccacgagca
     1021 gcacgtccaa cagcagtgct gggaacacaa ccaacagcgc cggcagcaag aagaagacca
     1081 cagccgcgag cctgagcctg tccactcagg tacctgatgt gatggtggta ggagagccaa
     1141 ctctgatggg aggtgagttt ggggacgagg acgaaaggct aatcactaga ttagaaaaca
     1201 cgcagtatga tgcggccaac ggcatggacg acgaggaaga cttcaacaat tcacctgccc
     1261 tggggaacaa cagcccgtgg aacagtaaac ctcccgccac gcaagagacc aaatcagaaa
     1321 accccccacc ccaggcttcc cagtaagatg ggctactggc tcctgatttc gctgtccata
     1381 ggccccgtgg ggtagaattc cagtcgcaaa tctctactat caggagagaa aagagatgaa
     1441 atttaaaaca cacaagcaaa acgtttccat gcaaacatct atttctaaat ataatgacct
     1501 gattttcttt cttgcaattt tttccctttt taattgagag gatcgttcgt tcaaatgagc
     1561 ctccatggcc tctctttgga ggccttcaca agaaatatag acactgtccc tgatggtaat
     1621 tagaagcagc agaggctcat gcacctcctg gcacggtctt acctccctca tgtgttgaac
     1681 atcctgtcca tgcaccctac gaaggccatg ctgtctaaac gtgctcagga tctcagtaac
     1741 atgccgaccc caactacaga tgacttttta atattgtaaa atattttctg ctttttgact
     1801 tgcatttgag agtttcttgt ttcagtaaaa aagaaagaaa aagaaaaaga aaagaaaaat
     1861 atcagttttg ggaaagtaac ttaaaggtac ttctcccaac ccctccactc tccactggtt
     1921 ttccatgtgg caagatc
//
