LOCUS       NM_001107601            2293 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus LIM domain binding 1 (Ldb1), mRNA.
ACCESSION   NM_001107601 XM_001058773 XM_219948
VERSION     NM_001107601.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150.
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Song,S.H., Kim,A., Ragoczy,T., Bender,M.A., Groudine,M. and Dean,A.
  TITLE     Multiple functions of Ldb1 required for beta-globin activation
            during erythroid differentiation
  JOURNAL   Blood 116 (13), 2356-2364 (2010)
   PUBMED   20570862
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Visvader,J.E., Mao,X., Fujiwara,Y., Hahm,K. and Orkin,S.H.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol Cell Biol 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Bach,I., Carriere,C., Ostendorff,H.P., Andersen,B. and
            Rosenfeld,M.G.
  TITLE     A family of LIM domain-associated cofactors confer transcriptional
            synergism between LIM and Otx homeodomain proteins
  JOURNAL   Genes Dev 11 (11), 1370-1380 (1997)
   PUBMED   9192866
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Agulnick,A.D., Taira,M., Breen,J.J., Tanaka,T., Dawid,I.B. and
            Westphal,H.
  TITLE     Interactions of the LIM-domain-binding factor Ldb1 with LIM
            homeodomain proteins
  JOURNAL   Nature 384 (6606), 270-272 (1996)
   PUBMED   8918878
REFERENCE   10 (bases 1 to 2293)
  AUTHORS   Jurata,L.W., Kenny,D.A. and Gill,G.N.
  TITLE     Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting
            protein, is expressed early in neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11693-11698 (1996)
   PUBMED   8876198
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058773.1, XM_219948.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2293
                     /gene="Ldb1"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
     exon            1..563
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..666
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             647..1774
                     /gene="Ldb1"
                     /codon_start=1
                     /product="LIM domain-binding protein 1"
                     /protein_id="NP_001101071.1"
                     /db_xref="GeneID:309447"
                     /db_xref="RGD:1310359"
                     /translation="MLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQN
                     WTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATE
                     LYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKT
                     WHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQE
                     LMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGG
                     NTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAAN
                     GIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ"
     exon            667..711
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..787
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..890
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1063
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1186
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1270
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1394
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1543
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..2293
                     /gene="Ldb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggagag ggagggagga gggagagaaa gggagaaagg aaggagcagg cgggcgctgc
       61 gtgtgtctga gtgtgccagt gtgagtgagt gtgagtgccg ggccctgcct ctcccgcctc
      121 ccctgcagag gggcccggtg gcctagggag ggcgggcggg ctgcttggag gcagaggcag
      181 cgagaggcgg cggcgggcag agccgaggag gaggaggaga gaggaaagag ccgagcagcc
      241 attgttgagg gaaaccttgc aaacaaagaa ggctccggac tccccgcggc cccccgcccc
      301 ccaggccggc cccctggccc ccagcccccg gcccagtggc cattgtaact ttccccccgg
      361 gctgtggacc ccgcggggcg ggcggaggct gtgcatgcga gtctttgtgc ggcctgcgga
      421 gtggagctcc cagccagacc ggcctgtccc actcgggaca tgagctgctg aagttggctc
      481 caccttagtc ctcacccttg ccagggtccc tgaggacttc caggcgctcc ccgcacctcc
      541 cctgaccccc tcagttctcc caggttgttc ctcaaagtca ttcaagctgt actccccgaa
      601 ggagcccccg aacggcaacg ccttccctcc cttccatccc ggcaccatgc tggatcggga
      661 tgtgggccca actcccatgt acccacctac atacctggag cctgggatag ggaggcacac
      721 gccatatggt aaccagacag actatagaat atttgaactt aacaaacgac tacagaactg
      781 gacagaggag tgtgacaatc tctggtggga cgctttcacg accgagttct tcgaggatga
      841 tgctatgctg accatcactt tctgcctgga ggatggacca aagagatata ccattggccg
      901 gaccctgata ccacgctact tccgaagcat tttcgagggg ggtgctacgg agctgtatta
      961 cgtacttaag caccccaagg aggcattcca cagcaacttc gtgtccctcg actgtgacca
     1021 gggcagcatg gtgacccagc atggcaaacc catgtttacc caggtgtgtg tggaaggccg
     1081 gttgtacctg gagttcatgt ttgacgacat gatgcggata aagacatggc acttcagtat
     1141 ccggcagcac agagagctca tccccaggag tatcctggcc atgcacgccc aggaccccca
     1201 gatgttggat cagctctcca aaaacattac ccggtgtggg ttgtccaatt ccactctcaa
     1261 ctacctccga ctctgtgtga tactggagcc catgcaggaa ctcatgtccc gtcacaagac
     1321 ctacagcctc agcccccgag actgcctcaa gacctgcctt ttccagaagt ggcagcggat
     1381 ggtagcacct cccgcggagc ctgcacgaca gcagcccagc aaacggagga aacggaagat
     1441 gtcagggggt agcaccatga gctcgggggg cggcaacacc aacaacagca acagcaagaa
     1501 gaagagccca gccagcacct tcgctctctc cagccaggta cctgatgtga tggtggtggg
     1561 ggagcccacc ctgatgggcg gggagttcgg ggacgaggac gagaggctca tcactcggct
     1621 ggagaacacc cagtttgacg cggccaacgg cattgacgac gaggacagct ttaacaactc
     1681 ccctgcactg ggcgccaaca gcccctggaa cagcaagcct ccgtccagcc aagaaagcaa
     1741 atcggagaac cccacgtcac aggcttccca gtaaaggccc taccacggcc acccaggtct
     1801 ctgcctgcta cccctcacag ctccagggag cagaagccag aacgaagaga ctgggcgtct
     1861 gaaatgggca acctccatct acccacttca gggagggact ggactcgctg ggggcaggtg
     1921 ccaagatttg cccccgagtt gccctgggct gggcctggcc cctgcagagc cttttggggg
     1981 aagggggtac tcatgtggat gcctatatgg accctgggct tctgagaaat gtcctgaccc
     2041 tcctctcccc agggcatttg tccccattcg taccccaggt tctgggtacc ccatcttcct
     2101 gatttatccc tttgagcctg gggtttatac ccacagccct taggggctaa atgttggggc
     2161 cttggttgaa tgccctttcc cctaggcggc tgtcaacaga gggtaaaatt ctgggctcct
     2221 cccttttgcc acttacccag ctccaagttt ttaaaaaaaa ataatattat taaaaatgta
     2281 aattaaaaaa aaa
//
