LOCUS       NM_001401134            2431 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lactase-like (Lctl), mRNA.
ACCESSION   NM_001401134 XM_039081499
VERSION     NM_001401134.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Fan,J., Lerner,J., Wyatt,M.K., Cai,P., Peterson,K., Dong,L. and
            Wistow,G.
  TITLE     The klotho-related protein KLPH (lctl) has preferred expression in
            lens and is essential for expression of clic5 and normal lens
            suture formation
  JOURNAL   Exp Eye Res 169, 111-121 (2018)
   PUBMED   29425878
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   3  (bases 1 to 2431)
  AUTHORS   Ito,S., Fujimori,T., Hayashizaki,Y. and Nabeshima,Y.
  TITLE     Identification of a novel mouse membrane-bound family 1
            glycosidase-like protein, which carries an atypical active site
            structure
  JOURNAL   Biochim Biophys Acta 1576 (3), 341-345 (2002)
   PUBMED   12084582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 2, 2022 this sequence version replaced XM_039081499.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-660               JAXUCZ010000008.1  73514197-73514856
            661-824             JAXUCZ010000008.1  73515807-73515970
            825-912             JAXUCZ010000008.1  73516447-73516534
            913-1022            JAXUCZ010000008.1  73516757-73516866
            1023-1151           JAXUCZ010000008.1  73518098-73518226
            1152-1247           JAXUCZ010000008.1  73518315-73518410
            1248-1302           JAXUCZ010000008.1  73523368-73523422
            1303-1464           JAXUCZ010000008.1  73523509-73523670
            1465-1739           JAXUCZ010000008.1  73528132-73528406
            1740-1866           JAXUCZ010000008.1  73529532-73529658
            1867-2051           JAXUCZ010000008.1  73529825-73530009
            2052-2115           JAXUCZ010000008.1  73530943-73531006
            2116-2431           JAXUCZ010000008.1  73534353-73534668
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2431
                     /gene="Lctl"
                     /note="lactase-like"
                     /db_xref="GeneID:315750"
                     /db_xref="RGD:1305177"
     exon            1..660
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     CDS             546..2231
                     /gene="Lctl"
                     /note="lactase-like protein"
                     /codon_start=1
                     /product="lactase-like protein precursor"
                     /protein_id="NP_001388063.1"
                     /db_xref="GeneID:315750"
                     /db_xref="RGD:1305177"
                     /translation="MKPVWVVILGWILLVPRVGTAQRGPPEEASFYHGTFPPGFSWGM
                     GSSAYQTKDAWDQDGEGPSSWDNFTHGRKGQVLGGDTADSACDSYYKLQEDIALLKEL
                     QVSHYQFSLSWPRLLPTGIRAEQVNKNEIKFYSDFIDALLRSNITPIVTLYHWELPQM
                     LQVTYGGWQNVSMTGYFRDYADLCFEVFGDRVKHWLTFSDPRTMVEKVYETGLHTPGL
                     RLQGTGLYMAAHHIIKAHAQAWHSYNNTWRSKQHGLVGISLDCDWGEPMDIHNPDDLE
                     AAERYLQFCLGWFANPIYAGDYPQVMKDHIGTKSAKQGLEMSRLPTFSLQEKSYLKGT
                     SDFLGLGHFTTRYITQRKYPSHQGPSYQNDRDLIELVDPNWPEIGSPWLYSVPWGFRR
                     LLNFAQTQYGDPLIYVTESGAPQNLHCTQFCDEWRIQYLKGYINEMLKAIKDGVDIKG
                     YTSRSLLDKFEWEKYGFYYIEFNVRNKPRYPKASVQYYKEIITANGFPNSQEVESWRL
                     KALETCSINNQMLATEPLLRRMHVPSEIVVPTVCVLSILIAALLLTLLLRSHS"
     exon            661..824
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            825..912
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1022
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1151
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1247
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1302
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1464
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1739
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1866
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2051
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2115
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2431
                     /gene="Lctl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaccaca cccctgacta gaggcttcca tgtctgtagt ctctgctttg tggggaagtg
       61 tggggcccag gagtcattca gagagacctg tagctgacaa cagtggcctt gggtgtccag
      121 ggctgaggat catcttgggt aagctggtgg gcttaatcag aaaggggttc ccagtggaag
      181 aggtcagagg gccctagata gggagatcac cccatacagg ctacacagta gggcagggcg
      241 gtaggaggct gaggggtttt cgggctcccc aagcagactg gcactttctg aggcagaggt
      301 gggttcccat tagataagag tcacttgaga ggtgtgggct gcatcattcc aacgcaccat
      361 ggtcagaaga ggaaccgatt tgaagtttgg cccattagct cagcttctgc acattgttaa
      421 atgcagggtc ctacacacag ctggtgtgcg cccagacaag ctgctctgtg acctctttct
      481 cttccctcct gtcctacgtc cctgagctga caggggctct taggcatgga ggagggtggg
      541 gtgtcatgaa gccagtgtgg gtcgttatcc ttgggtggat cctgctggtg cccagggtag
      601 ggactgccca gagaggaccc ccagaagagg catccttcta ccatggaacc tttccaccag
      661 gcttctcctg gggcatgggc agttctgcct accagacaaa agatgcatgg gaccaggatg
      721 gggaagggcc cagcagctgg gacaacttca cacatggcag aaagggacag gtgctagggg
      781 gtgacacagc agactcagcc tgtgacagct actataaact tcaggaggac attgccctgc
      841 tgaaggaact acaagtcagc cactaccaat tttccctgtc ttggcccagg ctcctgccca
      901 ccgggatcag agctgaacag gtgaacaaga atgaaatcaa attctacagc gactttattg
      961 acgcccttct gaggagcaac atcaccccca ttgtgacctt gtaccactgg gaactgccac
     1021 agatgctcca ggtgacatat ggtgggtggc agaatgtgag tatgaccgga tacttcaggg
     1081 actatgctga cctgtgtttt gaggtctttg gggaccgagt gaagcattgg ctcacgttca
     1141 gtgatcctcg gacaatggtg gaaaaggtct atgagactgg tctccacact ccaggcctga
     1201 ggctccaggg tactggcctg tacatggccg cacaccatat cattaaggca cacgcccaag
     1261 cttggcattc ttataacaac acatggcgca gtaaacagca cggcctagtg gggatttcat
     1321 tggactgtga ctggggggaa cccatggaca tccacaaccc cgacgatctt gaggctgctg
     1381 agcgatacct acagttctgt cttggttggt ttgccaaccc tatttatgct ggtgactatc
     1441 cccaagtcat gaaggaccac attggaacaa agagcgccaa gcaaggcctg gagatgtcga
     1501 ggttgcccac gttctccctg caggagaaga gctaccttaa aggcacatct gacttcctgg
     1561 gactgggcca ttttaccact cggtacatca ctcaaaggaa atatccctcc caccaggggc
     1621 ccagctacca gaatgaccgt gacttaatag agcttgtgga ccccaactgg ccagaaatag
     1681 gatctccatg gctttattct gtgccgtggg gattcaggag gcttctcaac tttgcccaga
     1741 ctcagtacgg tgaccctctt atatatgtga cagaaagtgg agcaccccaa aatttacact
     1801 gcactcagtt ctgcgatgag tggagaattc agtaccttaa aggatacatc aatgaaatgt
     1861 taaaagctat aaaagatggt gtggatataa aagggtatac ttcccggtct ctgttggata
     1921 agtttgaatg ggagaaatat ggattctact atattgagtt caatgtgaga aacaagccgc
     1981 ggtatcccaa ggcttctgtt cagtattaca aggagattat cacagccaac gggtttccaa
     2041 actcacaaga ggtggaaagt tggcgtctca aagccttgga aacttgctcc atcaacaacc
     2101 agatgcttgc cacagagccc ttgcttaggc gcatgcacgt gccttcagag atcgtggtcc
     2161 ctaccgtctg cgtcctctcc atcctcattg ctgccctgct gctgacactt ctcctcagga
     2221 gccacagctg agatgtgatc tcatcccggc ctccacatgt cagagcatct tcaggatggc
     2281 ccttctcttc tgcttcagag ttcatgtgat ggctatttct taggctctga aaattaactc
     2341 actctttccc ccctttgtgt ttcgtgctgg gatttaagaa taagaaaata aaaataagca
     2401 taaataaaat gaaagtaacc tgcagtctca a
//
