LOCUS       NM_053841               6117 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus lactase (Lct), mRNA.
ACCESSION   NM_053841 XM_001055600 XM_001055660 XM_341115
VERSION     NM_053841.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6117)
  AUTHORS   Chaudhry,K.K., Mahmood,S. and Mahmood,A.
  TITLE     Hormone induced changes in lactase glycosylation in developing rat
            intestine
  JOURNAL   Mol Cell Biochem 318 (1-2), 183-190 (2008)
   PUBMED   18712286
  REMARK    GeneRIF: These findings suggest the role of these hormones in
            inducing changes in lactase glycosylation during postnatal
            development of intestine, which may contribute to adult-type
            hypolactasia in rats.
REFERENCE   2  (bases 1 to 6117)
  AUTHORS   Chaudhry,K.K., Mahmood,S. and Mahmood,A.
  TITLE     Hormone induced expression of brush border lactase in suckling rat
            intestine
  JOURNAL   Mol Cell Biochem 312 (1-2), 11-16 (2008)
   PUBMED   18273561
  REMARK    GeneRIF: Thyroxine, insulin or cortisone induced changes in lactase
            expression in suckling rat intestine.
REFERENCE   3  (bases 1 to 6117)
  AUTHORS   Akiyama,K., Morita,H., Suetsugu,S., Kuraba,S., Numata,Y.,
            Yamamoto,Y., Inui,K., Ideura,T., Wakisaka,N., Nakano,K., Oniki,H.,
            Takenawa,T., Matsuyama,M. and Yoshimura,A.
  TITLE     Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna
            rats
  JOURNAL   Mamm Genome 19 (1), 41-50 (2008)
   PUBMED   18064521
REFERENCE   4  (bases 1 to 6117)
  AUTHORS   Jurjus,A., Barada,K., Khoury,N., Assef,M.D., Foltzer,C.J.,
            Reimund,J.M. and Kedinger,M.
  TITLE     Morphological and biochemical alterations in the jejunum following
            iodoacetamide-induced colitis in rats
  JOURNAL   Can J Physiol Pharmacol 84 (11), 1191-1203 (2006)
   PUBMED   17218984
REFERENCE   5  (bases 1 to 6117)
  AUTHORS   Kuranuki,S., Mochizuki,K. and Goda,T.
  TITLE     Dietary sucrose enhances intestinal lactase gene expression in
            euthyroid rats
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 52 (5), 347-351 (2006)
   PUBMED   17190105
REFERENCE   6  (bases 1 to 6117)
  AUTHORS   Scherer,W., Penugonda,B., Allen,K., Ruiz,M. and Poveda,C.
  TITLE     Bonding amalgam to tooth structure: a scanning electron microscope
            study
  JOURNAL   J Esthet Dent 4 (6), 199-201 (1992)
   PUBMED   1299293
REFERENCE   7  (bases 1 to 6117)
  AUTHORS   Boukamel,R. and Freund,J.N.
  TITLE     The rat LPH gene 5' region: comparative structure with the human
            gene
  JOURNAL   DNA Seq 3 (2), 119-121 (1992)
   PUBMED   1339333
REFERENCE   8  (bases 1 to 6117)
  AUTHORS   Duluc,I., Boukamel,R., Mantei,N., Semenza,G., Raul,F. and
            Freund,J.N.
  TITLE     Sequence of the precursor of intestinal lactase-phlorizin hydrolase
            from fetal rat
  JOURNAL   Gene 103 (2), 275-276 (1991)
   PUBMED   1909681
REFERENCE   9  (bases 1 to 6117)
  AUTHORS   Buller,H.A., Kothe,M.J., Goldman,D.A., Grubman,S.A., Sasak,W.V.,
            Matsudaira,P.T., Montgomery,R.K. and Grand,R.J.
  TITLE     Coordinate expression of lactase-phlorizin hydrolase mRNA and
            enzyme levels in rat intestine during development
  JOURNAL   J Biol Chem 265 (12), 6978-6983 (1990)
   PUBMED   1691182
  REMARK    Erratum:[J Biol Chem 1990 Aug 5;265(22):13410]
REFERENCE   10 (bases 1 to 6117)
  AUTHORS   Leese,H.J. and Semenza,G.
  TITLE     On the identity between the small intestinal enzymes phlorizin
            hydrolase and glycosylceramidase
  JOURNAL   J Biol Chem 248 (23), 8170-8173 (1973)
   PUBMED   4752949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_001055660.1, XM_001055600.1, XM_341115.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-650               JAXUCZ010000013.1  42376223-42376872   c
            651-730             JAXUCZ010000013.1  42368221-42368300   c
            731-814             JAXUCZ010000013.1  42363329-42363412   c
            815-917             JAXUCZ010000013.1  42361272-42361374   c
            918-996             JAXUCZ010000013.1  42360240-42360318   c
            997-1714            JAXUCZ010000013.1  42356152-42356869   c
            1715-2360           JAXUCZ010000013.1  42352943-42353588   c
            2361-3911           JAXUCZ010000013.1  42348771-42350321   c
            3912-4180           JAXUCZ010000013.1  42346991-42347259   c
            4181-4471           JAXUCZ010000013.1  42343662-42343952   c
            4472-4670           JAXUCZ010000013.1  42342854-42343052   c
            4671-4873           JAXUCZ010000013.1  42341774-42341976   c
            4874-4983           JAXUCZ010000013.1  42340149-42340258   c
            4984-5118           JAXUCZ010000013.1  42338041-42338175   c
            5119-5342           JAXUCZ010000013.1  42337111-42337334   c
            5343-5573           JAXUCZ010000013.1  42336100-42336330   c
            5574-6117           JAXUCZ010000013.1  42334347-42334890   c
FEATURES             Location/Qualifiers
     source          1..6117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..6117
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /note="lactase"
                     /db_xref="GeneID:116569"
                     /db_xref="RGD:620823"
     exon            1..650
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..5791
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /EC_number="3.2.1.108"
                     /EC_number="3.2.1.62"
                     /note="lactase-phlorizin hydrolase;
                     lactase-glycosylceramidase"
                     /codon_start=1
                     /product="lactase/phlorizin hydrolase preproprotein"
                     /protein_id="NP_446293.1"
                     /db_xref="GeneID:116569"
                     /db_xref="RGD:620823"
                     /translation="MELPWTALFLSTVLLGLSCQGSDWESDRNFISAAGPLTNDLVLN
                     LNYPPGKQGSDVVSGNTDIYICQQPLPSFLSQYFSSLRASQVTHYKVLLSWAQLLPTG
                     SSKNPDQEAVQCYRQLLQSLKDAQLEPMVVLCHQTPPTSSAIQREGAFADLFADYATL
                     AFQSFGDLVEIWFTFSDLEKVIMDLPHKDLKASALQTLSNAHRRAFDIYHRKFSSQGG
                     KLSVVLKAEDIPELLPDPALAALVQGSVDFLSLDLSYECQSVATLPQKLSELQNLEPK
                     VKVFIYTLKLEDCPATGTSPSSLLISLLEAINKDQIQTVGFDVNAFLSCTSNSEESPS
                     CSLTDSLALQTEQQQETAVPSSPGSAYQRVWAAFANQSREERDAFLQDVFPEGFLWGI
                     STGAFNVEGGWAEGGRGPSIWDHYGNLNAAEGQATAKVASDSYHKPASDVALLRGIRA
                     QVYKFSISWSRLFPTGQKSTPNRQGVAYYNKLIDRLLDSHIEPMATLFHWDLPQALQE
                     QGGWQNESVVEAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHAPAISDPG
                     MASFKVAHLILKAHARTWHLYDLHHRLQQQGRVGIVLNSDWAEPLDRKSPQDLAAAER
                     FLHFMLGWFAHPIFVDGDYPTTLRAQIQHINQQCGHPLAQLPEFTEAEKRLLKGSADF
                     LGLSHYTSRLISKAGRQTCTSSYDNIGGFSQHVDPEWPQTASPWIRVVPWGIRRLLRF
                     ASMEYTKGKLPIFLAGNGMPVGEEADLFDDSVRVNYFNLYINEVLKAVKEDLVDVRSY
                     IVRSLIDGYEGPLGFSQRFGLYHVNFNDSSRPRTPRKSAYFFTSIIEKNGFSAKKVKR
                     NPLPVRADFTSRARVTDSLPSEVPSKAKIVWEKFSKQPRFERDLFYHGTFRDDFLWGV
                     SSSAYQIEGGWNADGKGPSIWDNFTHTPGNGVKDNATGDVACDSYHQLDADLNILRTL
                     KVKSYRFSISWSRIFPTGRNSTINKQGVDYYNRLIDSLVDNNIFPMVTLFHWDLPQAL
                     QDIGGWENPSLIELFDSYADFCFKTFGDRVKFWMTFNEPWCHVVLGYSSGIFPPSVQE
                     PGWLPYKVSHIVIKAHARVYHTYDEKYRSEQKGVISLSLNTHWAEPKDPGLQRDVEAA
                     DRMLQFTMGWFAHPIFKNGDYPDVMKWTVGNRSELQHLASSRLPTFTEEEKNYVRGTA
                     DVFCINTYTSVFVQHSTPRLNPPSYDDDMELKLIEMNSSTGVMHPDVPWGTRRLLNWI
                     KEEYGNIPIYITENGQGLENPTLDDTERIFYHKTYINEALKAYKLDGVDLRGYSAWTL
                     MDDFEWLLGYTMRFGLYHVDFNHVSRPRTARASARYYAEVIANNGMPLAREDEFLYGE
                     FPKGFIWSAASASYQVEGAWRADGKGLSIWDTFSHTPLRIGNDDNGDVACDSYHKIAE
                     DVVALQNLGVSHYRFSIAWSRILPDGTTKFINEAGLSYYVRFIDALLAAGITPQVTIY
                     HWDLPQALQDVGGWENETIVQRFKEYADVLFQRLGDRVKFWITLNEPFVIAAQGYGTG
                     VSAPGISFRPGTAPYIAGHNLIKAHAEAWHLYNDVYRARQGGTISITISSDWAEPRDP
                     TNQGDVEAARRYVQFMGGWFAHPIFKNGDYPEVMKTRIRDRSLAAGLNKSRLPEFTES
                     EKSRIKGTFDFFGFNHYTTVLAYNLDYPAAFSSFDADRGVASIADSSWPVSGSFWLKV
                     TPFGFRRILNWLKEEYNNPPIYVTENGVSRRGEPELNDTDRIYYLRSYINEALKAVQD
                     KVDLRGYTVWSIMDNFEWATGFAERFGVHFVNRSDPSLPRIPKASAKFYATIVRCNGF
                     PDPAQGPHPCLQQPEDAAPTASPVQSEVPFLGLMLGIAEAQTALYVLFALLLLGACSL
                     AFLTYKYCRRSKQGNAQPSQHQLSPISSF"
     exon            651..730
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            731..814
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            815..917
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            918..996
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1714
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..2360
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..3911
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4180
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            4181..4471
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4670
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            4671..4873
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            4874..4983
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            4984..5118
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            5119..5342
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            5343..5573
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
     exon            5574..6117
                     /gene="Lct"
                     /gene_synonym="Lph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggagctg ccttggacag cactcttcct gagtactgtc ctcctgggtc tttcatgcca
       61 gggctctgac tgggaatccg acagaaattt tatttcagcc gctggtcctc taacaaatga
      121 cttagtgctt aatctgaact atccaccggg aaagcagggc tctgatgtgg tatccggtaa
      181 caccgacatc tacatctgcc agcagccact gccctctttc ttgtctcagt atttcagcag
      241 tcttcgtgcc agccaggtta cccattacaa agttcttctg tcatgggcac aacttctccc
      301 aactggaagc tccaagaatc cagaccagga agcagtgcag tgctaccgac aactcctcca
      361 gtccctgaag gatgcccagc ttgagcccat ggtggtcctg tgccatcaga cgccacccac
      421 cagcagcgcc atccagagag aaggggcctt tgctgacctc tttgctgact atgccacatt
      481 ggcttttcag tcctttgggg accttgttga gatctggttc accttcagtg acttggagaa
      541 agtgatcatg gatcttcccc acaaagatct gaaagcttct gctcttcaaa ccctcagcaa
      601 tgcccacagg agagcctttg acatttacca cagaaagttc tcatctcagg ggggaaagct
      661 gtctgtggtc ctgaaggctg aagatattcc agagcttctg ccagacccgg cattggctgc
      721 tctcgtccag ggctcggtgg atttcctctc tcttgatttg tcttacgaat gccaaagtgt
      781 ggcgactcta ccacagaagc tgagtgaatt gcagaacctt gagccaaaag tgaaagtttt
      841 catctacacc ctaaaacttg aggactgccc agcgaccggg acgagcccct cctcactgct
      901 catcagcctc ctggaagcca taaataaaga ccaaatccaa actgttggct ttgatgttaa
      961 tgcattcctg agctgtacgt ccaattctga ggagagccca tcttgttctt taaccgacag
     1021 cctggccctt cagactgagc agcagcagga gacagctgta ccctcatccc ctggatcagc
     1081 ctaccagaga gtttgggcag cctttgctaa ccagtctagg gaggaaaggg atgctttcct
     1141 acaagatgtg tttccagaag ggttcctctg gggcatatcc acgggagcct ttaatgtgga
     1201 gggaggctgg gcagaaggcg gcagagggcc gagcatctgg gatcactacg gtaacctgaa
     1261 tgctgccgag ggacaagcca cagcaaaagt ggccagtgac agttaccaca aaccagcttc
     1321 tgatgtcgcc ctcctccgag gcatcagggc tcaggtgtac aagttctcca tctcctggtc
     1381 ccgcctcttc cccactgggc agaagagcac ccccaaccgc caaggtgtcg cctactacaa
     1441 caaactgatc gaccgcctgc tggactcaca catcgagccc atggctacac tgttccactg
     1501 ggacctgcct caggccctgc aggagcaagg cggctggcag aacgagagtg tggtggaggc
     1561 cttcctggac tacgcagcct tctgcttctc cactttcggg gaccgtgtga aactgtgggt
     1621 gaccttccac gagccatggg tgatgagcta tgcaggctat ggtactggac agcacgcacc
     1681 agccatctct gacccaggaa tggcttcctt taaggtggct cacctgatcc tcaaggcaca
     1741 tgccagaact tggcatctct acgaccttca ccatcgccta cagcagcagg ggcgcgtggg
     1801 catcgtcctc aattcagact gggcggagcc cctggatagg aagagtcctc aggaccttgc
     1861 tgctgctgag cgcttcctac acttcatgct gggctggttc gcacacccca tctttgtaga
     1921 tggggactac cccactaccc ttcgggccca gatccagcac ataaaccagc agtgtggcca
     1981 tcctctggcc caactcccag agttcactga agcggagaag cggctcctta agggctctgc
     2041 ggatttcctg ggtctgtctc attacacctc ccgcctcatc agcaaggctg ggcggcagac
     2101 ctgcacctcc agctacgata acatcggagg cttctcccag catgtggacc ccgagtggcc
     2161 ccagactgca tctccctgga tccgagtggt gccctggggc ataaggaggc tgcttcggtt
     2221 cgcgtctatg gagtacacga aagggaaact tccaatcttc ttggctggga atggcatgcc
     2281 agtaggggaa gaagcggacc tctttgacga ctcagtgaga gtaaactact tcaacttgta
     2341 catcaacgag gtgctcaagg ctgtcaagga ggatttggtg gatgtccgtt catacattgt
     2401 tcgttccctc attgacggct atgaaggacc cctgggcttc agtcagaggt ttgggctata
     2461 ccatgtcaac ttcaatgaca gcagcaggcc acgaactccc aggaaatctg catacttctt
     2521 caccagcatc attgaaaaga atggtttttc agccaagaaa gtcaaaagaa acccactgcc
     2581 cgtgagagca gacttcacct ccagagccag ggtcaccgac agccttccat cggaggtgcc
     2641 ctccaaggct aaaatagtgt gggagaagtt ctccaagcag cccaggtttg aaagagactt
     2701 gttctatcac ggcacattcc gggatgactt cctgtggggt gtatcctctt cagcctatca
     2761 gatcgaagga ggatggaatg ctgatggcaa aggccccagc atctgggata acttcaccca
     2821 caccccaggg aatggtgtga aagacaatgc caccggagac gtagcgtgcg acagctatca
     2881 ccaactggac gccgacctaa acatccttcg aaccctgaag gtcaagtcct atcgattttc
     2941 catctcctgg tctcgaattt tcccaacagg aagaaacagt accatcaaca aacaaggcgt
     3001 tgattattac aacagactga ttgacagctt ggtggacaac aacatcttcc ccatggtgac
     3061 actgtttcac tgggacctgc cccaggccct ccaggatatt ggaggttggg agaacccttc
     3121 tttgattgag ttgtttgaca gctatgcaga cttctgcttt aagacctttg gtgacagagt
     3181 caagttctgg atgaccttta acgagccctg gtgtcacgtg gtgttaggct acagttcagg
     3241 gatatttccc ccaagtgttc aggagccagg ctggctacct tataaggtta gccatatcgt
     3301 cattaaggca catgctaggg tctaccatac ttacgatgag aagtaccgct cggagcagaa
     3361 aggtgtcatc tctctcagcc tcaacactca ctgggcagaa cccaaggacc cagggctcca
     3421 aagggatgtg gaagccgctg accggatgct gcagtttacc atgggctggt ttgcccaccc
     3481 gatttttaaa aacggggact atccagacgt catgaaatgg actgtgggga acaggagtga
     3541 gctgcagcac ctggccagct cccgcctgcc taccttcaca gaggaagaga agaattacgt
     3601 cagaggcacc gctgatgtct tttgcatcaa cacctacacg tctgtgtttg tgcagcacag
     3661 cactcccagg ctgaacccac ccagctatga tgatgacatg gagttgaagc taatcgaaat
     3721 gaactcgtcg acgggtgtga tgcacccaga cgtgccctgg gggacgagga ggctgctgaa
     3781 ctggatcaag gaggagtatg gcaacattcc tatttatatc actgaaaatg gacagggact
     3841 ggaaaacccc acactggatg acacagaaag gatcttctac cacaaaacct atatcaacga
     3901 ggctctgaaa gcctacaagc tggatggtgt ggaccttcga gggtactctg cctggacgct
     3961 gatggacgac ttcgagtggc tgcttggcta caccatgaga tttggattgt atcacgttga
     4021 ctttaatcat gtgagcagac ctcgcacagc aagagcctca gccagatact atgcagaggt
     4081 cattgccaac aatggcatgc ccctggccag ggaagatgag ttcctgtatg gagagtttcc
     4141 caagggcttc atctggagtg cggcttctgc ttcataccag gttgaaggcg cgtggagagc
     4201 agatggcaaa ggactcagta tctgggacac attttcccac acaccactga ggatcgggaa
     4261 tgatgacaac ggagacgtgg catgtgacag ttaccacaag attgccgagg atgtggtggc
     4321 ccttcagaac ctgggcgtgt cccactatcg cttctccatt gcctggtcta gaatcctccc
     4381 agacggaacc accaagttca tcaatgaagc gggcctcagt tactatgttc gattcattga
     4441 tgccctgctg gctgctggca tcacaccaca ggtgaccatt tatcactggg acctgcccca
     4501 ggcactgcaa gacgtggggg gctgggagaa cgagacaatt gtgcagcggt ttaaggagta
     4561 cgcggatgtg ctcttccaga ggctggggga cagagtcaag ttctggatca ctctgaacga
     4621 gcccttcgtc attgcagccc aaggctacgg cactggggtg tctgctccag gaatctcctt
     4681 caggcctggc acagctccgt acattgctgg acacaaccta ataaaggccc acgctgaggc
     4741 ctggcatctc tacaacgatg tataccgcgc ccgccaggga ggcaccatct ccatcacgat
     4801 cagcagtgac tgggctgaac ccagggatcc caccaaccag ggagacgtgg aggcagccag
     4861 gagatacgta cagtttatgg ggggctggtt tgctcacccc atcttcaaaa acggagatta
     4921 cccggaggtg atgaagacac ggatccgcga cagaagcctg gcggcaggcc tcaacaagtc
     4981 caggctccct gagtttacgg agagtgagaa gagtaggatc aagggcacct ttgacttttt
     5041 cgggttcaac cactacacca ctgtcctagc ttacaacctc gactacccgg ctgccttctc
     5101 ctcctttgat gcagacaggg gcgttgcttc cattgcagac agctcttggc cagtctctgg
     5161 ctccttctgg ctgaaggtga ccccttttgg cttccggagg atcttgaact ggctgaagga
     5221 ggagtacaat aatcctccga tttatgtcac cgagaatggt gtctccagac gaggagagcc
     5281 ggaactcaac gacaccgaca ggatctacta cctgcgcagc tacattaacg aagccctcaa
     5341 ggctgtacag gacaaggtgg accttcgagg ctacacggta tggagcatca tggacaactt
     5401 tgaatgggcc acaggcttcg cagagaggtt cggtgtgcac tttgtgaacc gctctgaccc
     5461 atctttgcca aggatcccca aggcatcagc caagttctat gccaccatcg tccgctgcaa
     5521 tggctttccc gaccctgcac aaggacctca tccttgtctc cagcaaccag aagacgctgc
     5581 acccactgcc agtcccgtgc agtcggaagt gcccttcctg gggctgatgc tgggcatcgc
     5641 agaagcacag acagcgctgt acgtgctctt cgctctgctg ctgcttggag cctgcagcct
     5701 ggcatttctg acctacaaat actgccggcg ctccaagcaa gggaacgcgc agccaagcca
     5761 gcaccagctg agtccaattt cctccttctg aaagttgtac agagtggcct gatttcttta
     5821 agaagccatg ctagcaccag acccctccct gcctgcagca agcgtcttcc tcgttcctcg
     5881 tggctttgcg cactgttcga ggtaatttct gttggtatca ggaattgccc ctagcagtga
     5941 caccttttgg ctactgttgg catggcaatg gccaaacatt cccagaagac cttttggatc
     6001 aattcgcacc tccacctggg aataaaaggc agattccctg ccccctaggt ctgtttttct
     6061 cttctttctg tcaccccttt cctttgtctc cttcccccat taaaatctcc ccacgtg
//
