LOCUS       NM_130421               3407 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lymphocyte cytosolic protein 2 (Lcp2), mRNA.
ACCESSION   NM_130421
VERSION     NM_130421.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Devkota,S., Joseph,R.E., Min,L., Bruce Fulton,D. and Andreotti,A.H.
  TITLE     Scaffold Protein SLP-76 Primes PLCgamma1 for Activation by
            ITK-Mediated Phosphorylation
  JOURNAL   J Mol Biol 427 (17), 2734-2747 (2015)
   PUBMED   25916191
  REMARK    GeneRIF: PLCgamma1 can be primed for ITK-mediated phosphorylation
            on Y783 by a specific region of the adaptor protein, SLP-76.
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Lasserre,R., Charrin,S., Cuche,C., Danckaert,A., Thoulouze,M.I., de
            Chaumont,F., Duong,T., Perrault,N., Varin-Blank,N.,
            Olivo-Marin,J.C., Etienne-Manneville,S., Arpin,M., Di Bartolo,V.
            and Alcover,A.
  TITLE     Ezrin tunes T-cell activation by controlling Dlg1 and microtubule
            positioning at the immunological synapse
  JOURNAL   EMBO J 29 (14), 2301-2314 (2010)
   PUBMED   20551903
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   Wu,J.N., Jordan,M.S., Silverman,M.A., Peterson,E.J. and
            Koretzky,G.A.
  TITLE     Differential requirement for adapter proteins Src homology 2
            domain-containing leukocyte phosphoprotein of 76 kDa and adhesion-
            and degranulation-promoting adapter protein in FcepsilonRI
            signaling and mast cell function
  JOURNAL   J Immunol 172 (11), 6768-6774 (2004)
   PUBMED   15153494
REFERENCE   5  (bases 1 to 3407)
  AUTHORS   Roose,J.P., Diehn,M., Tomlinson,M.G., Lin,J., Alizadeh,A.A.,
            Botstein,D., Brown,P.O. and Weiss,A.
  TITLE     T cell receptor-independent basal signaling via Erk and Abl kinases
            suppresses RAG gene expression
  JOURNAL   PLoS Biol 1 (2), E53 (2003)
   PUBMED   14624253
REFERENCE   6  (bases 1 to 3407)
  AUTHORS   Hendricks-Taylor,L.R., Motto,D.G., Zhang,J., Siraganian,R.P. and
            Koretzky,G.A.
  TITLE     SLP-76 is a substrate of the high affinity IgE receptor-stimulated
            protein tyrosine kinases in rat basophilic leukemia cells
  JOURNAL   J Biol Chem 272 (2), 1363-1367 (1997)
   PUBMED   8995445
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100066.1.
            
            On Aug 7, 2005 this sequence version replaced NM_130421.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100066.1, AB072980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3407
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /note="lymphocyte cytosolic protein 2"
                     /db_xref="GeneID:155918"
                     /db_xref="RGD:619743"
     exon            1..238
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1738
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /note="lymphocyte cytosolic protein 2 (SH2
                     domain-containing leukocyte protein of 76kD)"
                     /codon_start=1
                     /product="lymphocyte cytosolic protein 2"
                     /protein_id="NP_569105.1"
                     /db_xref="GeneID:155918"
                     /db_xref="RGD:619743"
                     /translation="MALKNVPFRSEVLAWNPDNLADYFRKLNYRDCEKAVKKYHIDGA
                     RFLNLTENDIQKFPKLRMPILSKLSQDINKNEERRSIFTRKPPVPRYPEEIEIHEEDD
                     GGWSSFEDDYESPNDDDPDGEDDGDYESPNEEEETLVDDAADYEPPPSNDEEALQNSI
                     LPAKPFPNTNSMYIDRPPTGKVSQQPPVPPQRPMAALPPLPTGRNHSPNHEEPSRNRN
                     HKTAKLPAPSIDRSTKPPLDRSLAPPLDREPLLGKKPSDKPSAPLGREHLPKIQKPPL
                     PPAMDRHERNERIGPLTARKPPVPRHGRGPDRRDNDEDDVHQRPLPHPSLPSMSSNTF
                     PSRSTKPSPKNTFPLPHMPGAISESNIGFQQSASLPSYFSQGPSSRPPVRNEVRNLPL
                     PVPNRPQPPSPGEEESPLDEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTVNNP
                     YVLMVLYKDKVYNIQIRYQEESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGK
                     NRGSRYQCTLTHAAGCL"
     exon            239..301
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            302..348
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            349..414
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            415..446
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            447..484
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            485..683
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            684..781
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            782..830
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            831..914
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            915..934
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            935..954
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1062
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1093
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1106
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1236
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1286
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1381
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1459
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1615
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..3385
                     /gene="Lcp2"
                     /gene_synonym="Slp76"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctacagca gaaaagactc ctgctcaaca acggtgttcc tgacggtagc tggaaatcag
       61 aagaaccaag gacaccactg aactctggat ctgggctttt tctctgttca tggctgcagc
      121 acctctcccc agtttgtgag cctctccctg aatagcagcc atggccttga agaatgtccc
      181 ctttcgctca gaggtcttag cctggaaccc agacaacctt gctgattatt tcaggaagct
      241 gaactacaga gactgtgaga aggctgtgaa gaaataccac attgatggcg ctcggttttt
      301 gaacctgaca gaaaacgaca ttcagaagtt tcctaaactg aggatgccga ttctcagtaa
      361 gttgagtcaa gatatcaaca agaacgaaga gagaaggagc attttcacac gcaaaccccc
      421 ggttccacga tatcctgagg aaatagaaat ccatgaagaa gacgatggtg gctggtcatc
      481 ctttgaagat gactatgaaa gtcccaatga cgacgatcca gatggggagg atgatggtga
      541 ctatgagtcc cctaacgagg aggaagagac gctagtggac gatgctgctg actatgagcc
      601 gccaccctcc aacgatgagg aggctctgca gaactccatc ctgcctgcca agcctttccc
      661 caacaccaac tccatgtaca ttgaccggcc tcccaccggc aaggtctccc agcagcctcc
      721 ggtgcccccg cagagaccaa tggccgccct ccctcccctg ccaacaggcc ggaatcactc
      781 gcccaaccat gaagaaccta gcagaaatcg gaaccataaa acagcaaagc tgcctgctcc
      841 atcaatagac agaagcacaa aacctcccct ggaccgctca ttggctcctc ctcttgaccg
      901 agagccctta ctgggaaaga aaccctctga taagccctcc gctccactgg gaagggagca
      961 tttacccaag atacagaagc ctcctttgcc gccagccatg gacagacacg aaagaaatga
     1021 aagaatcgga cccctgacag caaggaagcc accagttcca aggcatggaa ggggaccaga
     1081 cagaagagac aatgatgaag atgatgtgca ccagaggcct ttgccacacc catcactacc
     1141 ttctatgagc tccaacacat ttccttcgag atctaccaag cccagcccca agaacacatt
     1201 cccattgcct cacatgccgg gagccatctc agaaagtaac attggctttc agcagagtgc
     1261 ctccctgcca tcatacttct ctcaaggtcc cagcagcagg ccacctgtca gaaatgaagt
     1321 cagaaactta cctttaccag ttccaaacag gcctcagcct ccatctcctg gggaagaaga
     1381 gtctccatta gacgaagaat ggtatgtctc ttatattacc cggccagagg cagaagctgc
     1441 tctgaggaag ataaaccagg atggcacctt cctggttaga gacagctcta agaagacagt
     1501 gaacaatcca tatgtcctca tggtgttgta caaagacaaa gtttacaaca tccagatccg
     1561 ttaccaggag gaaagtcaag tctatttgtt gggtactggg cttcggggaa aagaggactt
     1621 cctgtctgta tcagatatta ttgactactt caggaaaatg ccactgttac tcattgatgg
     1681 aaaaaaccga gggtctagat accagtgcac actaacacat gctgcaggct gtctgtagca
     1741 agttacccaa gaaacgagcc ttcctgactc tgtcatcggt gtggcaagag cttgacctga
     1801 gcaaacggac accaggacta aaacagactg tcaatatggg ccctgagttc tgccctgtcc
     1861 tgtaaagtat ctgaaaattg ttgaatacca catgatttat ttattttctt tgatgtttat
     1921 aaagtgtaga agtgatcatg ttcacgtttg aagtctaaga gtgcatggca gacatgagat
     1981 tttgaacatc cacctcaaaa tacagtactt tatacagtag agaaacaatg tgggacaagc
     2041 tggaaaagga ctgaaatgga tggttctgga tatataacga aacttttgtc aggccaaggc
     2101 acaatctgtt ttttacacaa cttaaaatga ttaaaattca tttttggggc agccattact
     2161 taagagactc caaaaactcc attgtttctt atttggtttt acagggtgtg tttttctgtg
     2221 ttcttttcat aatgagatta gtgcatgttg ggataacttc ctgggattaa agttgtcctt
     2281 tgctttactc ttttagatcc ttaagacaac tttgtttggt ccgtgctgtt atatttttgt
     2341 tttaaagcaa atgtaagcta catttctgaa tttacaagaa gaaaatagtc ttagattcgg
     2401 tgatgcagct ctgctgttga atacacgggg gtttctgttg cttttctatc acagtcctcc
     2461 atgtctatat ccacggtggg ctccctcctc tcccgccttg aaaagcattt catagtactg
     2521 aaggtctcct gggaagatga gcactgcttt gtacacacac acacacacac acacacacac
     2581 gcacacgcac acgcacacgc acacgcacac gcacacgcac acacttggag cccaccttcc
     2641 tactagatgc tacttgtatt agctggtttt cagttagaaa gtttgacttg ctccaatggt
     2701 cgcctgttcc cgtttctttg ggcctgcaac agttcatata ggatattgaa gtaagagtgt
     2761 gaggccatct attcatctcg tgatggctgg gaaacaaaag gaaaggacaa gaagcaaatt
     2821 tccctcaagg tcttctacct gctgacctaa cttcacccca ctgggcttca cctcctaagg
     2881 ctccgccact gcccaatgct accctggtgg agggtcaaga ctcttaacct gtgggcctct
     2941 ggagaatacc tgtccaaacc cctgctctgg ttctctgtct cattaaccca acaagtgtgt
     3001 tgcaaaactg ttgtcttgtc cctcttagat gggtgtttaa acccttcaaa gcacctcaga
     3061 tctcctttag tttttaagtt acacttaaca aaaggcactg gtggacttct ggtgtgtgtt
     3121 ggtttaactc gccatgtttt actatgaagt agtatgatgg tgtgaactga aagcgatgcc
     3181 tgttaagcac aaactgtaca gcaaggtttg cattttgctt tgcctgggcc agcagcagct
     3241 ggtatgagat gtgaaagtgt tgactggctg gccatgggat cacagggtac gcatcagtac
     3301 ttcacatgtt ttatgttgca ggtggttttc ttctttgggg gggctatgaa cactcaataa
     3361 attaaacaat atattcagta ttaaaaaaaa aaaaaaaaaa aaaaaaa
//
