LOCUS       NM_001012044            3436 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Rattus norvegicus lymphocyte cytosolic protein 1 (Lcp1), mRNA.
ACCESSION   NM_001012044 XM_224406
VERSION     NM_001012044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Zhang,W., Xu,L., Yu,Z., Zhang,M., Liu,J. and Zhou,J.
  TITLE     Inhibition of the Glycolysis Prevents the Cerebral Infarction
            Progression Through Decreasing the Lactylation Levels of LCP1
  JOURNAL   Mol Biotechnol 65 (8), 1336-1345 (2023)
   PUBMED   36574182
  REMARK    GeneRIF: Inhibition of the Glycolysis Prevents the Cerebral
            Infarction Progression Through Decreasing the Lactylation Levels of
            LCP1.
REFERENCE   2  (bases 1 to 3436)
  AUTHORS   Forster,F., Paster,W., Supper,V., Schatzlmaier,P., Sunzenauer,S.,
            Ostler,N., Saliba,A., Eckerstorfer,P., Britzen-Laurent,N.,
            Schutz,G., Schmid,J.A., Zlabinger,G.J., Naschberger,E., Sturzl,M.
            and Stockinger,H.
  TITLE     Guanylate binding protein 1-mediated interaction of T cell antigen
            receptor signaling with the cytoskeleton
  JOURNAL   J Immunol 192 (2), 771-781 (2014)
   PUBMED   24337748
REFERENCE   3  (bases 1 to 3436)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 3436)
  AUTHORS   Choi,J.H., Lee,M.Y., Ramakrishna,S., Kim,Y., Shim,J.Y., Han,S.M.,
            Kim,J.Y., Lee,D.H., Choi,Y.K. and Baek,K.H.
  TITLE     LCP1 up-regulated by partial pancreatectomy supports cell
            proliferation and differentiation
  JOURNAL   Mol Biosyst 7 (11), 3104-3111 (2011)
   PUBMED   21922118
  REMARK    GeneRIF: the LCP1 may play a critical role in the pancreas
            regeneration.
REFERENCE   5  (bases 1 to 3436)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 3436)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (bases 1 to 3436)
  AUTHORS   Ohsawa,K., Imai,Y., Sasaki,Y. and Kohsaka,S.
  TITLE     Microglia/macrophage-specific protein Iba1 binds to fimbrin and
            enhances its actin-bundling activity
  JOURNAL   J Neurochem 88 (4), 844-856 (2004)
   PUBMED   14756805
REFERENCE   8  (bases 1 to 3436)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   9  (bases 1 to 3436)
  AUTHORS   Chafel,M.M., Shen,W. and Matsudaira,P.
  TITLE     Sequential expression and differential localization of I-, L-, and
            T-fimbrin during differentiation of the mouse intestine and yolk
            sac
  JOURNAL   Dev Dyn 203 (2), 141-151 (1995)
   PUBMED   7655078
REFERENCE   10 (bases 1 to 3436)
  AUTHORS   Zu,Y., Kohno,M., Kubota,I., Nishida,E., Hanaoka,M. and Namba,Y.
  TITLE     Characterization of interleukin 2 stimulated 65-kilodalton
            phosphoprotein in human T cells
  JOURNAL   Biochemistry 29 (4), 1055-1062 (1990)
   PUBMED   2111166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083855.1.
            
            On Feb 11, 2005 this sequence version replaced XM_224406.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMD00132303
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..3436
                     /gene="Lcp1"
                     /note="lymphocyte cytosolic protein 1"
                     /db_xref="GeneID:306071"
                     /db_xref="RGD:1308288"
     exon            1..22
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            23..109
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1929
                     /gene="Lcp1"
                     /codon_start=1
                     /product="plastin-2"
                     /protein_id="NP_001012044.1"
                     /db_xref="GeneID:306071"
                     /db_xref="RGD:1308288"
                     /translation="MARGSVSDEEMMELREAFAKVDTDGNGYISCNELNDLFKAACLP
                     LPGYRVREITENLMATGDLDQDGKISFDEFIKVFHGLKSTEVAKTFRKAINKKEGICA
                     IGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFNAVGDG
                     IVLCKMVNLSVPDTIDERTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKE
                     GKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEELLLRWANY
                     HLENAGCTKITNFSTDIKDSKAYYHLLEQVAPRGDEEGIPAVVIDMSGLREKDDIQRA
                     ECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNKYPALHKPENQDIDWGALEG
                     ETREERTFRNWMNSLGVNPGVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNRPPYPKL
                     GGNMKKLENCNYAVDLGKNQAKFSLVGIAGQDLNEGNRTLTLALVWQLMRRYTLNILE
                     DIGGGQKVNDDIIVNWVNTTLKEAQKSSSITSFKDPKISTSLPVLDLIDAIQPGSINY
                     DLLKTENLDDEEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGM
                     KRV"
     exon            110..273
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..403
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..536
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..618
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..784
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..927
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1023
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1219
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1298
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1413
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1547
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1671
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1796
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..3407
                     /gene="Lcp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgaggacag tgtctctaca aggtctgtca cctaaagcag tcaaaatggc cagaggatcc
       61 gtgtctgatg aagaaatgat ggagctcaga gaggcttttg ccaaagtcga tactgacggc
      121 aacgggtaca tcagctgcaa tgaactgaat gacttgttca aggcggcctg cctgcctctg
      181 cctggctacc gagtgagaga aatcacagag aacctgatgg ccacaggtga cctggaccaa
      241 gatgggaaga ttagctttga tgagtttatc aaggtcttcc atggcttaaa aagcaccgag
      301 gttgccaaaa ccttccgaaa agctatcaac aagaaggaag ggatctgtgc gatcggtggc
      361 acctctgagc agtccagcgt gggtacccag cattcctact cagaggaaga aaagtatgcc
      421 tttgtcaact ggataaacaa agccctggag aatgaccctg actgccggca cgtcatcccc
      481 atgaacccga acaccgatga tctcttcaat gctgtcgggg atggcatagt tctttgtaaa
      541 atggtcaacc tgtctgtgcc agacacaatt gatgaaagaa caatcaacaa gaagaagctc
      601 acaccgttca ccattcagga aaacttgaac ttagctctga actctgcctc ggccatcgga
      661 tgccatgtag ttaatatagg ggctgaggac ctgaaggagg ggaagccata tctggtcctg
      721 ggacttttgt ggcaagttat caagattggg ttgtttgctg acattgaact cagcagaaat
      781 gaagctctga ttgctctttt gagagaagga gagagcctag aggatttgat gaagttgtct
      841 cctgaagaac tcctgttgcg gtgggcgaac taccacctag aaaatgcagg ctgcaccaaa
      901 atcaccaact tcagcactga catcaaggac tcgaaagctt attaccacct gctcgagcag
      961 gtggctccga gaggagatga agaagggatc ccggctgtag tgattgacat gtcaggactg
     1021 agggagaagg atgacatcca gagagcagag tgtatgttgc agcaggcaga gaggctgggc
     1081 tgccggcagt ttgtcacagc cactgatgtt gtccgaggga accccaagtt gaacctggcc
     1141 ttcattgcca acctctttaa caaataccct gccttgcaca aaccggagaa ccaggacatt
     1201 gactgggggg ctctcgaagg tgagacgagg gaagagcgga cgttcaggaa ctggatgaac
     1261 tcactgggag ttaaccctgg agtcaatcat ttgtacagcg acttatccga cgccctggtc
     1321 atcttccagc tctatgaaaa gatcaaagtc cctgttgact ggaacagagt aaacagacct
     1381 ccatacccca agctgggggg caacatgaaa aagctcgaga actgtaatta tgcagtggat
     1441 ctggggaaga atcaagctaa attttcccta gttggtatcg caggacaaga cctcaatgaa
     1501 ggaaaccgca ctctgacgct ggcattggtt tggcagctca tgagaaggta cacactgaat
     1561 atcctggaag atattggagg tggtcagaag gtcaatgatg acattattgt caactgggtg
     1621 aacacgacat tgaaggaggc acagaaaagt tcgtccatca ctagcttcaa ggacccaaag
     1681 atcagcacca gcctcccggt tctggatctc atcgatgcca ttcagccagg ctccataaac
     1741 tatgaccttc tgaagacaga aaacctggat gatgaagaga agctcaacaa tgcaaagtat
     1801 gctatctcca tggccagaaa aatcggagca agagtgtatg cccttccaga agacctggtt
     1861 gaagtgaacc ccaaaatggt catgacagtg ttcgcttgcc tcatggggaa agggatgaag
     1921 agggtgtaag tcccacagga gcaagccaga aagagacacc atcaaccctg agggtcagca
     1981 tgtgatgctc ccaggataca gaggaccatt caagccattc caaagtcctg aaccttggag
     2041 acattgtctg aaattcgcat atttgttctg ccaagtagct tctgctatag tcgagcttct
     2101 cttttgttgt ccccaccccc aggagatcta ctcgcctaca gatttttttc ttttattctt
     2161 tgaaattctt tgggggaggg gggagagtta aaaagaagtt atttccagat gctcacccca
     2221 cccccgacac ccttgctttc actgatagcc aaggatatag actacattgt tcttaagggt
     2281 cacctgatct cttgagccag tttgatctag ctgctttttg ccttgttcaa actgaggacc
     2341 tggaagggat cgtcaaactt gccttaaata aagcctgtca ctagaggctg acactggatg
     2401 gtcacagccc ttccttgcat ctcctctcag cttgtctccc tgtgagtttg ctccaatccc
     2461 ctcagaacca tacctgctct gtggtcccca tttttgccag ccttgtctct aggctactgg
     2521 agtatctgac aaatcagtca agctcccagg agtctctggg agactgaaaa actggggtct
     2581 caaagaaagt gtaatggaga gtaaaaccac tagggggcag tatggtggga ccacaaagca
     2641 tctacccttc tgtgtatatc tccacacctt taactcctct tgttagagag ctgcttattg
     2701 tggtgttgac aaaatgtctg atgacagttg gaagcaatcc tgcataactt catttgcttt
     2761 tagacatcga catatttgat tgtcaccagg ccatattacc aatactcact ttgttggtac
     2821 tataaaagct tttgcctccc taaagtttct gtaagtgggg ggttgatatg tgccaataat
     2881 ctatgtccct gcctcaccca aatgcttgca cgggcacata cgcatatgta gctggatgcc
     2941 aagagtacca tgttgactag gaactgcctg gaattcaaaa cagaaaaggg acagcatgaa
     3001 tttgaatagc tcccactaga taagcaattt ccacgaaaac ttaccaaaag ctaaaactcc
     3061 acagagcatt gtgaaccaaa ggtagactcc ctttgcatta gtgaaagtct tactcccact
     3121 aatgggactt cgttgtcttc caaagcagtg gaaatgcagg atctcaactt catcccctga
     3181 cagtgggctc aggaaaccaa tagatggctc tttccagctc ccaaccagta ttcccgctgc
     3241 atccgaatgc aaagtgtttg gctgtgactt tagtctgaac atcatgtagc ctcagatgat
     3301 gtttgcccat ctgcctccac gaagtaagga tattattgtt gccttaatgg aaaaatgaag
     3361 ataaatcatg tttaaaaaaa tctttccaaa taaaatgttc ccaattcaaa aaaaaaaaaa
     3421 aaaaaaaaaa aaaaaa
//
