LOCUS       NM_130741                876 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lipocalin 2 (Lcn2), mRNA.
ACCESSION   NM_130741
VERSION     NM_130741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Gu,M., Li,X., Wu,R., Cheng,X., Zhou,S. and Gu,X.
  TITLE     The Transcription Factor Ets1 Influences Axonal Growth via
            Regulation of Lcn2
  JOURNAL   Mol Neurobiol 61 (2), 971-981 (2024)
   PUBMED   37672148
  REMARK    GeneRIF: The Transcription Factor Ets1 Influences Axonal Growth via
            Regulation of Lcn2.
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Kumfu,S., Siri-Angkul,N., Chattipakorn,S.C. and Chattipakorn,N.
  TITLE     Silencing of lipocalin-2 improves cardiomyocyte viability under
            iron overload conditions via decreasing mitochondrial dysfunction
            and apoptosis
  JOURNAL   J Cell Physiol 236 (7), 5108-5120 (2021)
   PUBMED   33319934
  REMARK    GeneRIF: Silencing of lipocalin-2 improves cardiomyocyte viability
            under iron overload conditions via decreasing mitochondrial
            dysfunction and apoptosis.
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Romi,M.M., Anggorowati,N., Maulida,D.S., Suskalanggeng,M.W.A.H.,
            Setyaningsih,W.A.W., Sari,D.C.R. and Arfian,N.
  TITLE     Upregulation of Megalin, Cubilin, NGAL mRNA expression in kidney
            may represent tubular injury and apoptosis in chronic condition of
            rat diabetic model
  JOURNAL   Med J Malaysia 76 (1), 87-92 (2021)
   PUBMED   33510115
  REMARK    GeneRIF: Upregulation of Megalin, Cubilin, NGAL mRNA expression in
            kidney may represent tubular injury and apoptosis in chronic
            condition of rat diabetic model.
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Liu,Z., Sun,F., Liu,Z., Wang,X., Jin,M., Mao,J., Wu,Q., Yan,S.,
            Xu,K., Wang,K. and Hu,S.
  TITLE     Effect of Sleeve Gastrectomy on Glycometabolism via Forkhead Box O1
            (FoxO1)/Lipocalin-2 (LCN2) Pathway
  JOURNAL   Med Sci Monit 26, e927458 (2020)
   PUBMED   32845875
  REMARK    GeneRIF: Effect of Sleeve Gastrectomy on Glycometabolism via
            Forkhead Box O1 (FoxO1)/Lipocalin-2 (LCN2) Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Nelson,A.L., Barasch,J.M., Bunte,R.M. and Weiser,J.N.
  TITLE     Bacterial colonization of nasal mucosa induces expression of
            siderocalin, an iron-sequestering component of innate immunity
  JOURNAL   Cell Microbiol 7 (10), 1404-1417 (2005)
   PUBMED   16153241
REFERENCE   7  (bases 1 to 876)
  AUTHORS   Gerhardinger,C., Costa,M.B., Coulombe,M.C., Toth,I., Hoehn,T. and
            Grosu,P.
  TITLE     Expression of acute-phase response proteins in retinal Muller cells
            in diabetes
  JOURNAL   Invest Ophthalmol Vis Sci 46 (1), 349-357 (2005)
   PUBMED   15623795
REFERENCE   8  (bases 1 to 876)
  AUTHORS   Kamezaki,K., Shimoda,K., Numata,A., Aoki,K., Kato,K., Takase,K.,
            Nakajima,H., Ihara,K., Haro,T., Ishikawa,F., Imamura,R.,
            Miyamoto,T., Nagafuji,K., Gondo,H., Hara,T. and Harada,M.
  TITLE     The lipocalin 24p3, which is an essential molecule in IL-3
            withdrawal-induced apoptosis, is not involved in the G-CSF
            withdrawal-induced apoptosis
  JOURNAL   Eur J Haematol 71 (6), 412-417 (2003)
   PUBMED   14703690
REFERENCE   9  (bases 1 to 876)
  AUTHORS   Hraba-Renevey,S., Turler,H., Kress,M., Salomon,C. and Weil,R.
  TITLE     SV40-induced expression of mouse gene 24p3 involves a
            post-transcriptional mechanism
  JOURNAL   Oncogene 4 (5), 601-608 (1989)
   PUBMED   2542864
REFERENCE   10 (bases 1 to 876)
  AUTHORS   Chan,Y.L., Paz,V. and Wool,I.G.
  TITLE     The primary structure of rat alpha 2 mu globulin-related protein
  JOURNAL   Nucleic Acids Res 16 (23), 11368 (1988)
   PUBMED   2462726
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X13295.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_130741.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13295.1, BC089053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..876
                     /gene="Lcn2"
                     /gene_synonym="Sip24"
                     /note="lipocalin 2"
                     /db_xref="GeneID:170496"
                     /db_xref="RGD:69408"
     exon            1..183
                     /gene="Lcn2"
                     /gene_synonym="Sip24"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..642
                     /gene="Lcn2"
                     /gene_synonym="Sip24"
                     /note="neutrophil gelatinase-associated lipocalin; p25;
                     NGAL; alpha-2U globulin-related protein;
                     alpha-2-microglobulin-related protein; lipocalin 2
                     (oncogene 24p3); siderocalin LCN2; lipocalin 24p3"
                     /codon_start=1
                     /product="neutrophil gelatinase-associated lipocalin
                     precursor"
                     /protein_id="NP_570097.1"
                     /db_xref="GeneID:170496"
                     /db_xref="RGD:69408"
                     /translation="MGLGVLCLALVLLGVLQRQAQDSTQNLIPAPPLISVPLQPGFWT
                     ERFQGRWFVVGLAANAVQKERQSRFTMYSTIYELQEDNSYNVTSILVRGQGCRYWIRT
                     FVPSSRPGQFTLGNIHSYPQIQSYDVQVADTDYDQFAMVFFQKTSENKQYFKVTLYGR
                     TKGLSDELKERFVSFAKSLGLKDNNIVFSVPTDQCIDN"
     exon            184..320
                     /gene="Lcn2"
                     /gene_synonym="Sip24"
                     /inference="alignment:Splign:2.1.0"
     exon            321..400
                     /gene="Lcn2"
                     /gene_synonym="Sip24"
                     /inference="alignment:Splign:2.1.0"
     exon            401..520
                     /gene="Lcn2"
                     /gene_synonym="Sip24"
                     /inference="alignment:Splign:2.1.0"
     exon            521..622
                     /gene="Lcn2"
                     /gene_synonym="Sip24"
                     /inference="alignment:Splign:2.1.0"
     exon            623..874
                     /gene="Lcn2"
                     /gene_synonym="Sip24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttcctcc tccggcacac atcggaccta gtagctgctg aaaccatggg cctgggtgtc
       61 ctgtgtctgg cccttgtcct gcttggggtc ctgcagaggc aggcccagga ctcaactcag
      121 aacttgatcc ctgccccacc tctgatcagt gtgcccctgc agccaggctt ctggaccgaa
      181 cggttccagg gcaggtggtt cgttgtcggc ctggcagcga atgcggtcca gaaagaaaga
      241 caaagccgct ttaccatgta cagcaccatc tatgagctac aggaagacaa tagctacaac
      301 gtcacttcca tcctcgtcag gggccagggc tgtcgctact ggatcagaac attcgttcca
      361 agctccaggc ctggccagtt caccctgggg aatattcaca gctaccctca gatacagagc
      421 tacgatgtgc aagtggccga cactgactac gaccagtttg ccatggtatt tttccagaag
      481 acctctgaaa acaaacagta cttcaaagtc accctgtacg gaagaaccaa ggggctgtcc
      541 gatgaactga aggagcgatt cgtcagcttt gccaagtctc tgggcctcaa ggataacaac
      601 atcgttttct ctgttcccac cgaccaatgc attgacaact gaacagacgg tgagcgtggc
      661 tgactgggat gtgcagtggc ctgatggttc aggtcccacc tgtctgtctg ccgctccatc
      721 tttcctgttg ccagagaatc acctggctgc cccaccagcc atgattccac caagcatctg
      781 atccctctta tttgatcagc tctccccatc cacctgtgtt aacgctgccc caccaacggg
      841 ctcccccttt ctgctgaata aacacatgtc cccaaa
//
