LOCUS       NM_022945                754 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus lipocalin 1 (Lcn1), mRNA.
ACCESSION   NM_022945
VERSION     NM_022945.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 754)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 754)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 754)
  AUTHORS   Fornander,L., Ghafouri,B., Kihlstrom,E., Akerlind,B., Schon,T.,
            Tagesson,C. and Lindahl,M.
  TITLE     Innate immunity proteins and a new truncated form of SPLUNC1 in
            nasopharyngeal aspirates from infants with respiratory syncytial
            virus infection
  JOURNAL   Proteomics Clin Appl 5 (9-10), 513-522 (2011)
   PUBMED   21805676
REFERENCE   4  (bases 1 to 754)
  AUTHORS   Breustedt,D.A., Korndorfer,I.P., Redl,B. and Skerra,A.
  TITLE     The 1.8-A crystal structure of human tear lipocalin reveals an
            extended branched cavity with capacity for multiple ligands
  JOURNAL   J Biol Chem 280 (1), 484-493 (2005)
   PUBMED   15489503
REFERENCE   5  (bases 1 to 754)
  AUTHORS   Wojnar,P., Lechner,M., Merschak,P. and Redl,B.
  TITLE     Molecular cloning of a novel lipocalin-1 interacting human cell
            membrane receptor using phage display
  JOURNAL   J Biol Chem 276 (23), 20206-20212 (2001)
   PUBMED   11287427
REFERENCE   6  (bases 1 to 754)
  AUTHORS   Syed,V., Gomez,E. and Hecht,N.B.
  TITLE     mRNAs encoding a von Ebner's-like protein and the Huntington
            disease protein are induced in rat male germ cells by Sertoli cells
  JOURNAL   J Biol Chem 274 (16), 10737-10742 (1999)
   PUBMED   10196145
REFERENCE   7  (bases 1 to 754)
  AUTHORS   van't Hof,W., Blankenvoorde,M.F., Veerman,E.C. and Amerongen,A.V.
  TITLE     The salivary lipocalin von Ebner's gland protein is a cysteine
            proteinase inhibitor
  JOURNAL   J Biol Chem 272 (3), 1837-1841 (1997)
   PUBMED   8999869
REFERENCE   8  (bases 1 to 754)
  AUTHORS   Miyawaki,A., Matsushita,F., Ryo,Y. and Mikoshiba,K.
  TITLE     Possible pheromone-carrier function of two lipocalin proteins in
            the vomeronasal organ
  JOURNAL   EMBO J 13 (24), 5835-5842 (1994)
   PUBMED   7813422
REFERENCE   9  (bases 1 to 754)
  AUTHORS   Kock,K., Ahlers,C. and Schmale,H.
  TITLE     Structural organization of the genes for rat von Ebner's gland
            proteins 1 and 2 reveals their close relationship to lipocalins
  JOURNAL   Eur J Biochem 221 (3), 905-916 (1994)
   PUBMED   7514123
REFERENCE   10 (bases 1 to 754)
  AUTHORS   Schmale,H., Holtgreve-Grez,H. and Christiansen,H.
  TITLE     Possible role for salivary gland protein in taste reception
            indicated by homology to lipophilic-ligand carrier proteins
  JOURNAL   Nature 343 (6256), 366-369 (1990)
   PUBMED   1689010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022945.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52016.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JAXUCZ010000003.1  29930943-29931084
            143-279             JAXUCZ010000003.1  29931520-29931656
            280-350             JAXUCZ010000003.1  29932779-29932849
            351-461             JAXUCZ010000003.1  29933744-29933854
            462-563             JAXUCZ010000003.1  29934327-29934428
            564-590             JAXUCZ010000003.1  29934635-29934661
            591-754             JAXUCZ010000003.1  29935255-29935418
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..754
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /note="lipocalin 1"
                     /db_xref="GeneID:65039"
                     /db_xref="RGD:619872"
     exon            1..142
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..589
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /note="von Ebner gland protein 1; VEG protein 1; von
                     Ebners gland protein 1; lipocalin 1 pseudogene 1"
                     /codon_start=1
                     /product="von Ebner gland protein 1 precursor"
                     /protein_id="NP_075234.1"
                     /db_xref="GeneID:65039"
                     /db_xref="RGD:619872"
                     /translation="MKALLLTFGLSLLAALQAQAFPTTEENQDVSGTWYLKAAAWDKE
                     IPDKKFGSVSVTPMKIKTLEGGNLQVKFTVLIAGRCKEMSTVLEKTDEPAKYTAYSGK
                     QVLYIIPSSVEDHYIFYYEGKIHRHHFQIAKLVGRDPEINQEALEDFQSVVRAGGLNP
                     DNIFIPKQSETCPLGSN"
     exon            143..279
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..350
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..461
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..563
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..590
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..754
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctcctcag tctgccaagt gatctgctgt tcacctgtga gcacagactc tggagatgaa
       61 ggccctgctc ctgaccttcg gcctcagcct cctggctgcc ctgcaggccc aggccttccc
      121 caccacggaa gagaatcagg atgtgtcagg aacgtggtat ttgaaagctg cagcatggga
      181 caaggagatt cctgacaaga agtttggatc tgtgtctgtg actcccatga aaatcaagac
      241 cctggaaggg ggcaacctgc aagtgaagtt cactgtcctg attgcaggac gatgcaagga
      301 gatgagcact gtcctagaga agacagatga acctgccaaa tacacagcct atagtggcaa
      361 acaggtactc tacatcatac catcttcagt ggaggaccac tacatcttct actatgaggg
      421 caaaatacac agacatcatt tccaaattgc aaaactcgtg ggcagagacc ctgagatcaa
      481 ccaggaggcc ctggaagatt ttcagagtgt tgtaagagct ggaggcctca acccagacaa
      541 catcttcatc cccaagcaga gtgaaacatg ccctctagga agcaattagg gaagtgatgc
      601 ctcataccag gcctgcctca cagcattgct ctactctgca cagatccact gagcttggga
      661 cacagaagca gctccttcac tgtcccttct ggctctgccc aacccttccc tctgccgccc
      721 tcttccttgc ttctccataa agaactttat catc
//
