LOCUS       NP_075234                177 aa            linear   ROD 01-APR-2024
DEFINITION  von Ebner gland protein 1 precursor [Rattus norvegicus].
ACCESSION   NP_075234
VERSION     NP_075234.1
DBSOURCE    REFSEQ: accession NM_022945.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 177)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (residues 1 to 177)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (residues 1 to 177)
  AUTHORS   Fornander,L., Ghafouri,B., Kihlstrom,E., Akerlind,B., Schon,T.,
            Tagesson,C. and Lindahl,M.
  TITLE     Innate immunity proteins and a new truncated form of SPLUNC1 in
            nasopharyngeal aspirates from infants with respiratory syncytial
            virus infection
  JOURNAL   Proteomics Clin Appl 5 (9-10), 513-522 (2011)
   PUBMED   21805676
REFERENCE   4  (residues 1 to 177)
  AUTHORS   Breustedt,D.A., Korndorfer,I.P., Redl,B. and Skerra,A.
  TITLE     The 1.8-A crystal structure of human tear lipocalin reveals an
            extended branched cavity with capacity for multiple ligands
  JOURNAL   J Biol Chem 280 (1), 484-493 (2005)
   PUBMED   15489503
REFERENCE   5  (residues 1 to 177)
  AUTHORS   Wojnar,P., Lechner,M., Merschak,P. and Redl,B.
  TITLE     Molecular cloning of a novel lipocalin-1 interacting human cell
            membrane receptor using phage display
  JOURNAL   J Biol Chem 276 (23), 20206-20212 (2001)
   PUBMED   11287427
REFERENCE   6  (residues 1 to 177)
  AUTHORS   Syed,V., Gomez,E. and Hecht,N.B.
  TITLE     mRNAs encoding a von Ebner's-like protein and the Huntington
            disease protein are induced in rat male germ cells by Sertoli cells
  JOURNAL   J Biol Chem 274 (16), 10737-10742 (1999)
   PUBMED   10196145
REFERENCE   7  (residues 1 to 177)
  AUTHORS   van't Hof,W., Blankenvoorde,M.F., Veerman,E.C. and Amerongen,A.V.
  TITLE     The salivary lipocalin von Ebner's gland protein is a cysteine
            proteinase inhibitor
  JOURNAL   J Biol Chem 272 (3), 1837-1841 (1997)
   PUBMED   8999869
REFERENCE   8  (residues 1 to 177)
  AUTHORS   Miyawaki,A., Matsushita,F., Ryo,Y. and Mikoshiba,K.
  TITLE     Possible pheromone-carrier function of two lipocalin proteins in
            the vomeronasal organ
  JOURNAL   EMBO J 13 (24), 5835-5842 (1994)
   PUBMED   7813422
REFERENCE   9  (residues 1 to 177)
  AUTHORS   Kock,K., Ahlers,C. and Schmale,H.
  TITLE     Structural organization of the genes for rat von Ebner's gland
            proteins 1 and 2 reveals their close relationship to lipocalins
  JOURNAL   Eur J Biochem 221 (3), 905-916 (1994)
   PUBMED   7514123
REFERENCE   10 (residues 1 to 177)
  AUTHORS   Schmale,H., Holtgreve-Grez,H. and Christiansen,H.
  TITLE     Possible role for salivary gland protein in taste reception
            indicated by homology to lipophilic-ligand carrier proteins
  JOURNAL   Nature 343 (6256), 366-369 (1990)
   PUBMED   1689010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52016.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..177
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     Protein         1..177
                     /product="von Ebner gland protein 1 precursor"
                     /note="von Ebner gland protein 1; VEG protein 1; von
                     Ebners gland protein 1; lipocalin 1 pseudogene 1"
                     /calculated_mol_wt=17869
     sig_peptide     1..18
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P20289.1)"
                     /calculated_mol_wt=1874
     mat_peptide     19..177
                     /product="von Ebner gland protein 1. /id=PRO_0000017976"
                     /note="propagated from UniProtKB/Swiss-Prot (P20289.1)"
                     /calculated_mol_wt=17869
     Region          26..173
                     /region_name="lipocalin_1_3_4_13-like"
                     /note="lipocalin-1, -3, -4, -13 and similar proteins;
                     cd19414"
                     /db_xref="CDD:381189"
     Site            order(30,34,45,58,60,68,70,72,83,85,87,96,98,102..103,105,
                     107,116,118,120,129,131,133,135)
                     /site_type="other"
                     /note="ligand binding cavity [chemical binding]"
                     /db_xref="CDD:381189"
     Site            order(45,83,102..103,129,131)
                     /site_type="other"
                     /note="citrate-binding site [ion binding]"
                     /db_xref="CDD:381189"
     CDS             1..177
                     /gene="Lcn1"
                     /gene_synonym="Lcn1p1; Vegp1"
                     /coded_by="NM_022945.2:56..589"
                     /db_xref="GeneID:65039"
                     /db_xref="RGD:619872"
ORIGIN      
        1 mkallltfgl sllaalqaqa fptteenqdv sgtwylkaaa wdkeipdkkf gsvsvtpmki
       61 ktleggnlqv kftvliagrc kemstvlekt depakytays gkqvlyiips svedhyifyy
      121 egkihrhhfq iaklvgrdpe inqealedfq svvragglnp dnifipkqse tcplgsn
//
