LOCUS       NM_199405               1310 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus leucine carboxyl methyltransferase 1 (Lcmt1),
            mRNA.
ACCESSION   NM_199405 XM_341922 XM_347177
VERSION     NM_199405.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Lei,L., Feng,J., Wu,G., Wei,Z., Wang,J.Z., Zhang,B., Liu,R.,
            Liu,F., Wang,X. and Li,H.L.
  TITLE     HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau
            Hyperphosphorylation and Cognitive Dysfunction during Chronic
            Hypoxia
  JOURNAL   Int J Mol Sci 23 (24), 16140 (2022)
   PUBMED   36555780
  REMARK    GeneRIF: HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau
            Hyperphosphorylation and Cognitive Dysfunction during Chronic
            Hypoxia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   MacKay,K.B., Tu,Y., Young,S.G. and Clarke,S.G.
  TITLE     Circumventing embryonic lethality with Lcmt1 deficiency: generation
            of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A
            methyltransferase expression and defects in insulin signaling
  JOURNAL   PLoS One 8 (6), e65967 (2013)
   PUBMED   23840384
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Stanevich,V., Jiang,L., Satyshur,K.A., Li,Y., Jeffrey,P.D., Li,Z.,
            Menden,P., Semmelhack,M.F. and Xing,Y.
  TITLE     The structural basis for tight control of PP2A methylation and
            function by LCMT-1
  JOURNAL   Mol Cell 41 (3), 331-342 (2011)
   PUBMED   21292165
  REMARK    GeneRIF: A dominant-negative LCMT-1 mutant attenuates the cell
            cycle without causing cell death, likely by inhibiting uncontrolled
            phosphatase activity
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Lee,J.A. and Pallas,D.C.
  TITLE     Leucine carboxyl methyltransferase-1 is necessary for normal
            progression through mitosis in mammalian cells
  JOURNAL   J Biol Chem 282 (42), 30974-30984 (2007)
   PUBMED   17724024
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   De Baere,I., Derua,R., Janssens,V., Van Hoof,C., Waelkens,E.,
            Merlevede,W. and Goris,J.
  TITLE     Purification of porcine brain protein phosphatase 2A leucine
            carboxyl methyltransferase and cloning of the human homologue
  JOURNAL   Biochemistry 38 (50), 16539-16547 (1999)
   PUBMED   10600115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 9, 2021 this sequence version replaced NM_199405.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063186.1, SRR26643288.4253.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000001.1  187335234-187335451
            219-310             JAXUCZ010000001.1  187353230-187353321
            311-432             JAXUCZ010000001.1  187354313-187354434
            433-509             JAXUCZ010000001.1  187359654-187359730
            510-571             JAXUCZ010000001.1  187361231-187361292
            572-674             JAXUCZ010000001.1  187369153-187369255
            675-795             JAXUCZ010000001.1  187376438-187376558
            796-897             JAXUCZ010000001.1  187382452-187382553
            898-989             JAXUCZ010000001.1  187383627-187383718
            990-1087            JAXUCZ010000001.1  187388967-187389064
            1088-1310           JAXUCZ010000001.1  187390973-187391195
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1310
                     /gene="Lcmt1"
                     /note="leucine carboxyl methyltransferase 1"
                     /db_xref="GeneID:361643"
                     /db_xref="RGD:735118"
     exon            1..218
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1110
                     /gene="Lcmt1"
                     /EC_number="2.1.1.233"
                     /note="[Phosphatase 2A protein]-leucine-carboxy
                     methyltransferase 1"
                     /codon_start=1
                     /product="leucine carboxyl methyltransferase 1"
                     /protein_id="NP_955437.2"
                     /db_xref="GeneID:361643"
                     /db_xref="RGD:735118"
                     /translation="MATGSRESSFSSCASSCDFDDEGVRGTCEDASLCKRFAVSIGYW
                     HDPYIEHLVRQSKERKAPEINRGYFARVHGVSQLIKAFLRKTECRCQILNLGAGMDTT
                     FWKLKDEGLLPNKYFEVDFPMIVTRKLHTIKNKPLLFRPIMELHPEDTLQIDSHMLDS
                     KRYAIIGADLRDLSELEEKLKKCNMNTQLPTLLITECVLVYMTPEQSANLLKWAARSF
                     ETAMFINYEQVNMDDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLLNGWETASA
                     VNMMELYSGLPRAEVNRIESLEFLDEMELLEQLMRHYCLCWATRGGQELGLKEITY"
     exon            219..310
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..432
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..509
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..571
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..674
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..795
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..897
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..989
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1087
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1310
                     /gene="Lcmt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttatcct tgctgcttta gtctgtgcct gtttcttgcc tcttttccca ctgctctttt
       61 ccccgtttcc atgtccctgg tgggtgccac accccagaac atcccacgca catggccacc
      121 ggctcgaggg agtcctcgtt ttcttcctgc gcgtcgagct gtgactttga cgacgaggga
      181 gtgcgcggca cctgcgaaga tgcttctctc tgcaagaggt ttgcggtgag cattggctac
      241 tggcatgatc catacatcga acatcttgtg aggcagtcta aagagaggaa ggcccctgaa
      301 attaacagag gatattttgc tcgtgttcat ggtgtcagtc agcttattaa agcttttctc
      361 cggaagacag aatgccgttg tcaaattctc aaccttgggg ctgggatgga taccaccttc
      421 tggaaattaa aggatgaagg tcttctccca aataaatatt ttgaagttga ctttccaatg
      481 atagtcacaa gaaaactgca caccatcaaa aacaagccac ttctattcag acccatcatg
      541 gagttacacc cagaggatac tcttcaaata gatagtcaca tgctggattc aaaaagatat
      601 gccatcattg gagcagatct ccgagacctt tctgagctgg aagagaaact aaagaaatgt
      661 aacatgaata cacagttgcc cacactcctg ataaccgaat gtgtgctggt gtacatgact
      721 ccggagcagt cagccaacct cctaaagtgg gcagcccgca gttttgagac ggccatgttc
      781 ataaattatg aacaggtcaa catggatgac cggtttgggc agatcatgat tgaaaacctc
      841 cggaggcgac agtgtgacct ggcaggagtg gaaacctgca aatcactgga gtctcagaag
      901 gaacgactgc tgttgaatgg gtgggagacg gcgtctgcag tgaacatgat ggagctgtac
      961 agtgggcttc ctcgggcaga ggtaaacaga atagaatccc tcgagttcct ggatgaaatg
     1021 gagcttctag agcagctcat gcggcattac tgcctgtgct gggccacccg agggggccag
     1081 gagctgggtt tgaaggagat aacctattga tctgctgaag gcttgtgctg aggtggaagg
     1141 tgaaggctcc agttaaggga gtgcctgggc ctcctgaggg atgggtagct tcatcgccat
     1201 tgctggtcct gtcgcacatc cggaaccctt ggttacaaag gtggtcacac cagatcctgt
     1261 tcctgtcagt atcattgttt aaataaattt cacttgccat ttgtgtcaga
//
