LOCUS       NM_017024               1372 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lecithin cholesterol acyltransferase (Lcat),
            mRNA.
ACCESSION   NM_017024
VERSION     NM_017024.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Rotimi,O.A., Rotimi,S.O., Duru,C.U., Ebebeinwe,O.J., Abiodun,A.O.,
            Oyeniyi,B.O. and Faduyile,F.A.
  TITLE     Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression
            and disrupts lipid and lipoprotein metabolism in rats
  JOURNAL   Toxicol Rep 4, 408-414 (2017)
   PUBMED   28959666
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Piper,D.E., Romanow,W.G., Gunawardane,R.N., Fordstrom,P.,
            Masterman,S., Pan,O., Thibault,S.T., Zhang,R., Meininger,D.,
            Schwarz,M., Wang,Z., King,C., Zhou,M. and Walker,N.P.
  TITLE     The high-resolution crystal structure of human LCAT
  JOURNAL   J Lipid Res 56 (9), 1711-1719 (2015)
   PUBMED   26195816
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   La Marca,V., Spagnuolo,M.S., Cigliano,L., Marasco,D. and
            Abrescia,P.
  TITLE     The enzyme lecithin-cholesterol acyltransferase esterifies
            cerebrosterol and limits the toxic effect of this oxysterol on
            SH-SY5Y cells
  JOURNAL   J Neurochem 130 (1), 97-108 (2014)
   PUBMED   24620755
REFERENCE   4  (bases 1 to 1372)
  AUTHORS   Hirsch-Reinshagen,V., Donkin,J., Stukas,S., Chan,J., Wilkinson,A.,
            Fan,J., Parks,J.S., Kuivenhoven,J.A., Lutjohann,D., Pritchard,H.
            and Wellington,C.L.
  TITLE     LCAT synthesized by primary astrocytes esterifies cholesterol on
            glia-derived lipoproteins
  JOURNAL   J Lipid Res 50 (5), 885-893 (2009)
   PUBMED   19065001
REFERENCE   5  (bases 1 to 1372)
  AUTHORS   Sangeetha,T. and Darlin Quine,S.
  TITLE     Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac
            marker enzymes and lipids in isoproterenol-induced myocardial
            injury
  JOURNAL   J Pharm Pharmacol 58 (5), 617-623 (2006)
   PUBMED   16640830
REFERENCE   6  (bases 1 to 1372)
  AUTHORS   Jansen,H., van Tol,A., Auwerx,J., Skretting,G. and Staels,B.
  TITLE     Opposite regulation of hepatic lipase and lecithin: cholesterol
            acyltransferase by glucocorticoids in rats
  JOURNAL   Biochim Biophys Acta 1128 (2-3), 181-185 (1992)
   PUBMED   1420288
REFERENCE   7  (bases 1 to 1372)
  AUTHORS   Furukawa,Y., Urano,T., Hida,Y., Itoh,H., Takahashi,C. and Kimura,S.
  TITLE     Interaction of rat lecithin-cholesterol acyltransferase with rat
            apolipoprotein A-I and with lecithin-cholesterol vesicles
  JOURNAL   J Biochem 111 (3), 413-418 (1992)
   PUBMED   1587806
REFERENCE   8  (bases 1 to 1372)
  AUTHORS   Meroni,G., Malgaretti,N., Magnaghi,P. and Taramelli,R.
  TITLE     Nucleotide sequence of the cDNA for lecithin-cholesterol acyl
            transferase (LCAT) from the rat
  JOURNAL   Nucleic Acids Res 18 (17), 5308 (1990)
   PUBMED   2402469
REFERENCE   9  (bases 1 to 1372)
  AUTHORS   Cheung,M.C., Wolf,A.C., Lum,K.D., Tollefson,J.H. and Albers,J.J.
  TITLE     Distribution and localization of lecithin:cholesterol
            acyltransferase and cholesteryl ester transfer activity in
            A-I-containing lipoproteins
  JOURNAL   J Lipid Res 27 (11), 1135-1144 (1986)
   PUBMED   3104518
REFERENCE   10 (bases 1 to 1372)
  AUTHORS   Bojesen,E.
  TITLE     Reversible inhibition of LCAT by penicillins. Kinetic and
            mechanistic investigations
  JOURNAL   Scand J Clin Lab Invest Suppl 150, 26-31 (1978)
   PUBMED   746355
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091155.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_017024.3.
            
            On Oct 13, 2007 this sequence version replaced NM_017024.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091155.1, FQ209624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1372
                     /gene="Lcat"
                     /note="lecithin cholesterol acyltransferase"
                     /db_xref="GeneID:24530"
                     /db_xref="RGD:2993"
     exon            1..161
                     /gene="Lcat"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1330
                     /gene="Lcat"
                     /EC_number="2.3.1.43"
                     /EC_number="3.1.1.47"
                     /note="phosphatidylcholine-sterol acyltransferase;
                     phospholipid-cholesterol acyltransferase;
                     Lecithin-cholesterol acyltransferase; PAF acetylhydrolase;
                     platelet-activating factor acetylhydrolase;
                     1-alkyl-2-acetylglycerophosphocholine esterase"
                     /codon_start=1
                     /product="phosphatidylcholine-sterol acyltransferase
                     precursor"
                     /protein_id="NP_058720.2"
                     /db_xref="GeneID:24530"
                     /db_xref="RGD:2993"
                     /translation="MGLPGSPWQWVLLLLGLLLPPATSFWLLNVLFPPHTTPKAELSN
                     HTRPVILVPGCMGNRLEAKLDKPNVVNWLCYRKTEDFFTIWLDFNMFLPLGVDCWIDN
                     TRVVYNRSSGHMSNAPGVQIRVPGFGKTYSVEYLDDNKLAGYLHTLVQNLVNNGYVRD
                     ETVRAAPYDWRLAPRQQDEYYQKLAGLVEEMYAAYGKPVFLIGHSLGCLHVLHFLLRQ
                     PQSWKDHFIDGFISLGAPWGGSIKPMRILASGDNQGIPIMSNIKLREEQRITTTSPWM
                     FPAHHVWPEDHVFISTPNFNYTGQDFERFFADLHFEEGWHMFLQSRDLLAGLPAPGVE
                     VYCLYGVGMPTAHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQWQGRQSQAVH
                     LLPMNGTDHLNMVFSNKTLEHINAILLGAYRHGTPKSPTASLGPPTKE"
     exon            162..318
                     /gene="Lcat"
                     /inference="alignment:Splign:2.1.0"
     exon            319..434
                     /gene="Lcat"
                     /inference="alignment:Splign:2.1.0"
     exon            435..530
                     /gene="Lcat"
                     /inference="alignment:Splign:2.1.0"
     exon            531..755
                     /gene="Lcat"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1344
                     /gene="Lcat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgtaatg gggctgcctg gctccccttg gcagtgggtg ctgttgctgt tggggctact
       61 gctccctcct gccacctcct tctggctcct caatgtgctc ttccccccgc acaccacgcc
      121 caaggctgaa ctcagtaacc acacacggcc tgtcatcctc gtgcctggct gcatggggaa
      181 ccggctagaa gccaagctgg ataaaccaaa tgtggtaaac tggctgtgct accgaaagac
      241 agaggacttt tttaccatct ggctggattt caacatgttt ctacccctcg gggtggactg
      301 ctggattgat aacaccaggg ttgtctacaa ccgaagctct gggcacatgt ccaatgcccc
      361 tggtgtacag atccgtgtcc ctggctttgg caagacctac tctgttgaat acttggatga
      421 caacaagcta gcaggctacc tgcacacact ggtgcagaat ctggttaaca atgggtatgt
      481 gcgggatgag acagtgcggg ctgcacccta tgactggcgt ctggcacccc gccagcagga
      541 tgaatactac cagaagctgg caggactggt agaggagatg tatgctgctt acgggaagcc
      601 tgttttcctt attggacaca gccttggctg cctacatgtg ctccatttct tactgcgtca
      661 gccacagtcc tggaaggacc acttcattga tggcttcatc tctcttgggg ccccatgggg
      721 cggttccatc aagcccatgc ggatcctggc ctcaggtgac aaccagggca tcccgatcat
      781 gtccaacata aagctgagag aagaacagcg cataaccaca acttccccct ggatgtttcc
      841 agctcaccac gtgtggcctg aagaccacgt gttcatttcc acaccaaact tcaactacac
      901 aggccaagac ttcgagcgtt tttttgcaga tcttcatttt gaagaaggct ggcacatgtt
      961 tctacagtct cgtgacctac tagcaggcct cccagcgcct ggtgtagaag tatattgtct
     1021 atacggtgta ggcatgccca cagcccacac ctacatctat gaccacaact ttccctacaa
     1081 agacccggtg gctgcactct atgaagatgg ggacgacact gtagccacac gtagcactga
     1141 gctctgtggc cagtggcagg gccgccagtc acaggctgta cacttgctgc ccatgaatgg
     1201 gacagatcat ctcaacatgg tcttcagcaa taagacactg gagcatatta atgctatcct
     1261 actgggtgcc taccgccatg gcactcctaa gtccccaacc gccagcctag gtccccccac
     1321 caaggaataa agacttagct gttaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
