LOCUS       NM_001393665            3562 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus lamin B receptor (Lbr), mRNA.
ACCESSION   NM_001393665 NM_134453 XM_039091130
VERSION     NM_001393665.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3562)
  AUTHORS   Tsai,P.L., Zhao,C., Turner,E. and Schlieker,C.
  TITLE     The Lamin B receptor is essential for cholesterol synthesis and
            perturbed by disease-causing mutations
  JOURNAL   Elife 5, e16011 (2016)
   PUBMED   27336722
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3562)
  AUTHORS   Lu,R. and Wang,G.G.
  TITLE     Tudor: a versatile family of histone methylation 'readers'
  JOURNAL   Trends Biochem Sci 38 (11), 546-555 (2013)
   PUBMED   24035451
  REMARK    Review article
REFERENCE   3  (bases 1 to 3562)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3562)
  AUTHORS   Subramanian,G., Chaudhury,P., Malu,K., Fowler,S., Manmode,R.,
            Gotur,D., Zwerger,M., Ryan,D., Roberti,R. and Gaines,P.
  TITLE     Lamin B receptor regulates the growth and maturation of myeloid
            progenitors via its sterol reductase domain: implications for
            cholesterol biosynthesis in regulating myelopoiesis
  JOURNAL   J Immunol 188 (1), 85-102 (2012)
   PUBMED   22140257
REFERENCE   5  (bases 1 to 3562)
  AUTHORS   Verhagen,A.M., de Graaf,C.A., Baldwin,T.M., Goradia,A.,
            Collinge,J.E., Kile,B.T., Metcalf,D., Starr,R. and Hilton,D.J.
  TITLE     Reduced lymphocyte longevity and homeostatic proliferation in lamin
            B receptor-deficient mice results in profound and progressive
            lymphopenia
  JOURNAL   J Immunol 188 (1), 122-134 (2012)
   PUBMED   22105998
REFERENCE   6  (bases 1 to 3562)
  AUTHORS   Silve,S., Dupuy,P.H., Ferrara,P. and Loison,G.
  TITLE     Human lamin B receptor exhibits sterol C14-reductase activity in
            Saccharomyces cerevisiae
  JOURNAL   Biochim Biophys Acta 1392 (2-3), 233-244 (1998)
   PUBMED   9630650
REFERENCE   7  (bases 1 to 3562)
  AUTHORS   Kawahire,S., Takeuchi,M., Gohshi,T., Sasagawa,S., Shimada,M.,
            Takahashi,M., Abe,T.K., Ueda,T., Kuwano,R., Hikawa,A., Ichimura,T.,
            Omata,S. and Horigome,T.
  TITLE     cDNA cloning of nuclear localization signal binding protein NBP60,
            a rat homologue of lamin B receptor, and identification of binding
            sites of human lamin B receptor for nuclear localization signals
            and chromatin
  JOURNAL   J Biochem 121 (5), 881-889 (1997)
   PUBMED   9192729
REFERENCE   8  (bases 1 to 3562)
  AUTHORS   Kawahire,S., Tachibana,T., Umemoto,M., Yoneda,Y., Imai,N.,
            Saito,M., Ichimura,T., Omata,S. and Horigome,T.
  TITLE     Subcellular distribution and phosphorylation of the nuclear
            localization signal binding protein, NBP60
  JOURNAL   Exp Cell Res 222 (2), 385-394 (1996)
   PUBMED   8598227
REFERENCE   9  (bases 1 to 3562)
  AUTHORS   Lin,F., Noyer,C.M., Ye,Q., Courvalin,J.C. and Worman,H.J.
  TITLE     Autoantibodies from patients with primary biliary cirrhosis
            recognize a region within the nucleoplasmic domain of inner nuclear
            membrane protein LBR
  JOURNAL   Hepatology 23 (1), 57-61 (1996)
   PUBMED   8550049
REFERENCE   10 (bases 1 to 3562)
  AUTHORS   Haino,M., Kawahire,S., Omata,S. and Horigome,T.
  TITLE     Purification of a 60 kDa nuclear localization signal binding
            protein in rat liver nuclear envelopes and characterization of its
            properties
  JOURNAL   J Biochem 113 (3), 308-313 (1993)
   PUBMED   8486604
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Mar 1, 2021 this sequence version replaced
            NM_134453.1, XM_039091130.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1137626.1,
                                           SRR21887620.1346006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000013.1  96095602-96095709   c
            109-287             JAXUCZ010000013.1  96091846-96092024   c
            288-503             JAXUCZ010000013.1  96089677-96089892   c
            504-587             JAXUCZ010000013.1  96086877-96086960   c
            588-780             JAXUCZ010000013.1  96086295-96086487   c
            781-977             JAXUCZ010000013.1  96083698-96083894   c
            978-1032            JAXUCZ010000013.1  96080399-96080453   c
            1033-1224           JAXUCZ010000013.1  96077525-96077716   c
            1225-1328           JAXUCZ010000013.1  96076777-96076880   c
            1329-1454           JAXUCZ010000013.1  96075581-96075706   c
            1455-1623           JAXUCZ010000013.1  96074501-96074669   c
            1624-1704           JAXUCZ010000013.1  96073249-96073329   c
            1705-1827           JAXUCZ010000013.1  96073024-96073146   c
            1828-3562           JAXUCZ010000013.1  96071070-96072804   c
FEATURES             Location/Qualifiers
     source          1..3562
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..3562
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /note="lamin B receptor"
                     /db_xref="GeneID:89789"
                     /db_xref="RGD:620813"
     exon            1..108
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            109..287
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1988
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /EC_number="1.3.1.70"
                     /note="integral nuclear envelope inner membrane protein;
                     delta-14-SR; sterol C14-reductase; C-14 sterol reductase;
                     3-beta-hydroxysterol Delta (14)-reductase"
                     /codon_start=1
                     /product="delta(14)-sterol reductase LBR"
                     /protein_id="NP_001380594.1"
                     /db_xref="GeneID:89789"
                     /db_xref="RGD:620813"
                     /translation="MPSRKFAEGEVVRGRWPGSSLYYEVEILSHDNKSQVYTVKYKDG
                     TELELKESDIKPLKSFKQRKSGSTSSSPSRRRSSRSRSRSRSRSPGRAPKGSRRSVSA
                     SYQADAKEKEMRREILQVKLTPLVLKPFANSVSVYNGEPEHMEKSATPPKNKQERVIL
                     STEDSYIATQYSLRPRREEVKTKNIESEEQNLVTRGPVPLGTFQVTTPQRRDLEFGGV
                     PGALLIMLGLPACVFLLLLQCAQKDPGLLQFPPPLPALRELWEARVCGVYLLWFFLQA
                     LFSLLPVGKVVEGTPLVDGRRLKYRLNGLYAFILTSAAVGTAVFWDIELYYLYTHFLQ
                     FALAAIVFSVVLSVYLYARSLKVPRDELSPASSGNAVYDFFIGRELNPRIGAFDLKFF
                     CELRPGLIGWVVINLVMLLAEMKVQERSAPSLAMTLVNSFQLLYVVDALWFEEALLTT
                     MDIIHDGFGFMLAFGDLVWVPFTYSLQAFYLVNHPQDLSWPLASVIIALKLCGYVIFR
                     CANSQKNAFRKNPTDPKLAHLKTIPTSTGKSLLVSGWWGFVRHPNYLGDLIMALAWSL
                     PCGFNHILPYFYVIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY"
     exon            288..503
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            504..587
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            588..780
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            781..977
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1032
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1224
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1328
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1454
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1623
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1704
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1827
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..3562
                     /gene="Lbr"
                     /gene_synonym="C14SR; Nbp60"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacctcgg gggcgcgaga gcgcggccgg ctgtgtcgcg cgctggatcg ccgcgggctg
       61 ctggtgactg tcccggagtg gctggagttc ccgccggagc gcggccagac tgattttgaa
      121 aaatgccaag tcggaagttt gctgagggcg aagtggtcag aggccggtgg cctgggagct
      181 ccctgtatta tgaggtagag attctgagcc atgacaacaa gtcccaggtc tacaccgtaa
      241 aatacaaaga tggcaccgag ctggagctga aggagagtga catcaagcct ttaaagtcct
      301 ttaagcagag aaagagtggc tcaacttcca gctctccttc aagacgccgc agcagccgca
      361 gccgctcccg atcacgctcc cgatccccgg gccgggcacc caaaggttcc agaagatcag
      421 tctctgcttc ctaccaggct gacgctaagg aaaaggaaat gaggagggag attttgcaag
      481 ttaaattgac tccgctcgtg ctgaagccgt ttgcaaacag cgtcagtgtg tacaacgggg
      541 agcccgaaca catggaaaag agcgccacac ctcctaaaaa caagcaggaa agagtcattt
      601 tgtcaacaga agacagttat atagctacac agtacagcct tcgccccaga agagaagagg
      661 tcaaaaccaa aaacatagag tccgaggaac aaaaccttgt caccagagga cctgtacctt
      721 tgggaacctt tcaagtgacc actccacaga ggagggactt ggagttcgga ggagtacctg
      781 gtgcgctcct cattatgctt ggcctgcctg cctgtgtctt cctgctgctg ctgcagtgtg
      841 cgcagaagga ccccgggctg ctccagttcc ctccacctct gccagctctc cgtgagctgt
      901 gggaagccag agtgtgtggc gtttacctcc tctggttctt ccttcaagct ctcttctccc
      961 ttctaccagt tgggaaggtt gtagaaggaa cacctcttgt tgatggaaga agactcaagt
     1021 acagactgaa tggactgtat gccttcatcc tgacatcagc agccgtgggg acagctgtct
     1081 tctgggacat agaactatat tacctgtaca ctcacttcct gcagtttgca ctggcagcca
     1141 ttgtgttttc agtggtcctg agtgtttacc tctatgcccg ctctttgaaa gtccccaggg
     1201 atgagctgtc acctgccagt tctggaaatg ctgtctatga cttcttcatt ggccgtgagt
     1261 taaaccctcg aattggtgct ttcgatctca agttcttctg tgaattgcgc cctggattga
     1321 tcggatgggt ggttattaac ttggtgatgc ttttggctga aatgaaagtc caggagcgta
     1381 gtgctccgtc cttggcgatg accctggtca acagcttcca gctcctgtat gtggtggacg
     1441 ccctctggtt tgaggaagca ttgctgacca ccatggacat catccacgat ggctttggct
     1501 tcatgctggc ctttggggat ttagtgtggg ttccatttac ctacagtctc caggccttct
     1561 acctggtcaa ccatccccag gacttgtcct ggccattggc ttctgtcatc atcgctctga
     1621 agctgtgtgg atatgtaata ttccgttgtg caaactctca gaaaaatgct tttcggaaga
     1681 atcccactga tccaaagctt gcacatttga agaccatccc tacttcgacg gggaagagtc
     1741 tgcttgtgtc tggatggtgg ggctttgttc gccatcccaa ttacttgggt gatctcatca
     1801 tggctctggc gtggtccctc ccatgtggct tcaaccacat cctgccttac ttctatgtca
     1861 tctacttcac cgcattgctt atccatcgag aagcccgtga tgaacaccag tgcaggagga
     1921 agtacggcct ggcctgggag aagtactgtc agcgcgtgcc ctaccgcata ttcccctaca
     1981 tttactgacc tgtgccgctt gccccgcagc tcagactccc agaaacaagg gaaagtccaa
     2041 atgaactaac acgatgcact gacaggatct ccaggttgtt tctgagtcag gactctagag
     2101 ccaaatagta catcttttaa tgtagctgga tttattctta ttaaagtggc agttaatgta
     2161 aggtgaaata caagaatgct ataatttgct tattaatagg aacattttaa tccctaaaaa
     2221 tctgaagttt tatttttgta gttttttttt tttcagtttt tttccctttt tgcatttgat
     2281 ttttcttaat tgagatctct taaagtacat ctatgtttca ttgtgtttag aacaaattct
     2341 ttttaagtca gtttattagt ctataaatca agcaaaaacc tgcccagtat ttattggtgg
     2401 tctgtctgaa gaataagggc agatattgca ggacctgttg aagggagacc agtcatagca
     2461 gtgactccac gtcagccttt aaaagtgcat ttggaaatgt aaacacagac tagttttatg
     2521 taatataagg tgacttttgg tttttctgta cagtttttga atgtgagata attgtcagaa
     2581 actaagtagt tttttaacaa aatattttca gtgttttaaa ttaagttttg taaagtaatg
     2641 tgaatttaaa agtataaagg aattacaatt catttaaagt taaaatatag gaaagttatt
     2701 tttctttatc caaagtttgt gaatttggct ttgctacctc aatttgcagg tgtgtgtttg
     2761 cctttataaa ctgttgcaaa tggaaaaaat atatttttga gtaagagcaa tatttaaaca
     2821 tttttacaca catcggtgtt ggaaaattgc cattttaggc cactattttt atatattttt
     2881 tgacttgcaa ttcaacagtg tttttgctac tgttagctaa tacaatttat actattttgt
     2941 atcctttatg tttttagaac tctctagaaa ggagttctac ctgatacaac tttttaagtt
     3001 ttctctctgt ttggtagatg tgcgagcata agctggttgt agccattcaa gtctagtgag
     3061 gttgagtttg acggtaactg tcctggagca ggacaagtgg caaattcact agacttttat
     3121 tcaacgctac attgtcctca gaacctaagg atgcatacac atacagtgta tacgtgtggg
     3181 tttgtttctc ctgcacatat cacatatgag ccagatgcag tgttcatcct gtcctgtagc
     3241 ttagagtata cgcaaagaag ctgtgctcat gtaattgcga cgtgtcactc tgcattctgt
     3301 aactctttac tgtttatgac agtgtcattg ttcaatagta ctaaggtgtt catgggggtt
     3361 tgctatcgtg ctctctcttc tggtatcaac atggtgtgtg cccagcagct tagaaggaaa
     3421 ctttgggtaa gactttgggc tctttgcctg gtagtgatag ggcgggccag ggcagtgcca
     3481 ccatatctgg atatcaggtg caagttgttt ttaatatgat ctttggcaag ttttataata
     3541 aaattttggt cagaaacaaa aa
//
