LOCUS       NM_017208               1881 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Rattus norvegicus lipopolysaccharide binding protein (Lbp), mRNA.
ACCESSION   NM_017208 XM_346679
VERSION     NM_017208.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1881)
  AUTHORS   Zhu,Y.L., Meng,L.L., Ma,J.H., Yuan,X., Chen,S.W., Yi,X.R., Li,X.Y.,
            Wang,Y., Tang,Y.S., Xue,M., Zhu,M.Z., Peng,J., Lu,X.J., Huang,J.Z.,
            Song,Z.C., Wu,C., Zheng,K.Z., Dai,Q.Q., Huang,F. and Fang,H.S.
  TITLE     Loss of LBP triggers lipid metabolic disorder through H3K27
            acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic
            fatty liver disease
  JOURNAL   Zool Res 45 (1), 79-94 (2024)
   PUBMED   38114435
  REMARK    GeneRIF: Loss of LBP triggers lipid metabolic disorder through
            H3K27 acetylation-mediated C/EBPbeta- SCD activation in
            non-alcoholic fatty liver disease.
REFERENCE   2  (bases 1 to 1881)
  AUTHORS   Kobayashi,T., Sasaki,H., Asami,Y., Mori,G., Yoshinari,M. and
            Yajima,Y.
  TITLE     The characteristic regulation of gene expression Lbp and Sod3 in
            peri-implant connective tissue of rats
  JOURNAL   J Biomed Mater Res A 108 (3), 592-600 (2020)
   PUBMED   31714656
  REMARK    GeneRIF: The characteristic regulation of gene expression Lbp and
            Sod3 in peri-implant connective tissue of rats.
REFERENCE   3  (bases 1 to 1881)
  AUTHORS   Liu,A., Weiss,S., Fang,H., Claus,R.A., Rodel,J., Dirsch,O. and
            Dahmen,U.
  TITLE     Lipopolysaccharide-binding protein (LBP) blockade augments the
            protective effect of granulocyte colony-stimulating factor (G-CSF)
            in a rat sepsis model
  JOURNAL   Shock 43 (5), 497-503 (2015)
   PUBMED   25874537
  REMARK    GeneRIF: LBP has a role in augmentation of the host's response in a
            rat sepsis model via G-CSF
REFERENCE   4  (bases 1 to 1881)
  AUTHORS   Tsai,C.H., Yeh,C.H., Sheen-Chen,S.M., Huang,C.Y., Liu,Y.W.,
            Huang,C.C., Shen,S.C. and Tang,R.P.
  TITLE     The kinetic expression of lipopolysaccharide-binding protein and
            CD14 gene in obstructive jaundice
  JOURNAL   J Invest Surg 28 (1), 18-23 (2015)
   PUBMED   25093541
  REMARK    GeneRIF: Hepatic LBP mRNA expression increased significantly at
            five days after bile duct ligation.
REFERENCE   5  (bases 1 to 1881)
  AUTHORS   Tanimura,N., Saitoh,S., Ohto,U., Akashi-Takamura,S., Fujimoto,Y.,
            Fukase,K., Shimizu,T. and Miyake,K.
  TITLE     The attenuated inflammation of MPL is due to the lack of
            CD14-dependent tight dimerization of the TLR4/MD2 complex at the
            plasma membrane
  JOURNAL   Int Immunol 26 (6), 307-314 (2014)
   PUBMED   24380872
REFERENCE   6  (bases 1 to 1881)
  AUTHORS   Opal,S.M., Palardy,J.E., Jhung,J.W., Donsky,C., Romulo,R.L.,
            Parejo,N. and Marra,M.N.
  TITLE     Activity of lipopolysaccharide-binding
            protein-bactericidal/permeability-increasing protein fusion peptide
            in an experimental model of Pseudomonas sepsis
  JOURNAL   Antimicrob Agents Chemother 39 (12), 2813-2815 (1995)
   PUBMED   8593028
REFERENCE   7  (bases 1 to 1881)
  AUTHORS   Su,G.L., Freeswick,P.D., Geller,D.A., Wang,Q., Shapiro,R.A.,
            Wan,Y.H., Billiar,T.R., Tweardy,D.J., Simmons,R.L. and Wang,S.C.
  TITLE     Molecular cloning, characterization, and tissue distribution of rat
            lipopolysaccharide binding protein. Evidence for extrahepatic
            expression
  JOURNAL   J Immunol 153 (2), 743-752 (1994)
   PUBMED   8021509
REFERENCE   8  (bases 1 to 1881)
  AUTHORS   Dentener,M.A., Von Asmuth,E.J., Francot,G.J., Marra,M.N. and
            Buurman,W.A.
  TITLE     Antagonistic effects of lipopolysaccharide binding protein and
            bactericidal/permeability-increasing protein on
            lipopolysaccharide-induced cytokine release by mononuclear
            phagocytes. Competition for binding to lipopolysaccharide
  JOURNAL   J Immunol 151 (8), 4258-4265 (1993)
   PUBMED   8409400
REFERENCE   9  (bases 1 to 1881)
  AUTHORS   Geller,D.A., Kispert,P.H., Su,G.L., Wang,S.C., Di Silvio,M.,
            Tweardy,D.J., Billiar,T.R. and Simmons,R.L.
  TITLE     Induction of hepatocyte lipopolysaccharide binding protein in
            models of sepsis and the acute-phase response
  JOURNAL   Arch Surg 128 (1), 22-7 (1993)
   PUBMED   8418776
REFERENCE   10 (bases 1 to 1881)
  AUTHORS   Schumann,R.R., Leong,S.R., Flaggs,G.W., Gray,P.W., Wright,S.D.,
            Mathison,J.C., Tobias,P.S. and Ulevitch,R.J.
  TITLE     Structure and function of lipopolysaccharide binding protein
  JOURNAL   Science 249 (4975), 1429-1431 (1990)
   PUBMED   2402637
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC101906.1.
            
            On Apr 4, 2007 this sequence version replaced NM_017208.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1881
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1881
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /note="lipopolysaccharide binding protein"
                     /db_xref="GeneID:29469"
                     /db_xref="RGD:61865"
     exon            1..145
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1467
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /note="BPI fold containing family D, member 2"
                     /codon_start=1
                     /product="lipopolysaccharide-binding protein precursor"
                     /protein_id="NP_058904.2"
                     /db_xref="GeneID:29469"
                     /db_xref="RGD:61865"
                     /translation="MKSATGPLLPTLLGLLLLSIPRTQGVNPAMVVRITDKGLEYAAK
                     EGLLSLQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQSCQLRGSSLKPLPGRGLS
                     LSISDSSISVRGKWKVRRSFVKLHGSFDLDVKGVTISVDLLLGVDPSGRPTVTASGCS
                     NRIRDLELHVSGNVGWLLNLFHNQIESKLQKVLESKICEMIQKSVTSDLQPYLQTLPV
                     TADIDTILGIDYSLVAAPQAKAQTLDVMFKGEIFNRNHRSPVTTPTPTMSLPEDSKQM
                     VYFAISDQAFNIATRVYHQAGYLNFTITDDMLPPDSNIRLNTKAFRPFTPLITRKYPD
                     MNLELLGTVVSAPLLNVSPGNLSLAPQMEIEGFVILPSSARESVFRLGVVTNVFVSLT
                     FDNSKVTGMLHPEKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNDELAKGFPL
                     PLPRRIKLHDLDFQIHKNFLYLGANVQYMRV"
     exon            146..260
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..389
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..545
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..609
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..673
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..765
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..942
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1002
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1170
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1238
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1281
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1345
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1422
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1857
                     /gene="Lbp"
                     /gene_synonym="Bpifd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcactcacg gagcatccag gatgaagtct gcgactgggc ctctgcttcc tacattgctg
       61 gggctactgc tcctgtctat accaaggact cagggtgtca atcccgccat ggtggtcagg
      121 atcaccgaca agggcctgga gtacgcggcc aaggaggggc tgttgagtct gcagagagag
      181 ctgtacaaga tcacactgcc tgacttcagc ggggacttca agatcaaggc tgtgggccgt
      241 gggcagtacg agtttcatag cctggagatc cagagctgtc agctgcgtgg ctcgtccctg
      301 aagccgctcc caggccgagg cctgagtctc tccatctctg actcttcgat cagcgtccgg
      361 ggcaaatgga aagtgcgcag atccttcgtg aaacttcacg gctcctttga cctggatgtc
      421 aaaggtgtca ctatttcagt ggacctcctc ctgggcgtgg atccctcagg acggcccaca
      481 gtcaccgcct ctggatgcag caaccgcatt cgtgatttgg aattgcacgt atcaggaaat
      541 gtggggtggc tgctgaatct tttccacaac cagatcgagt ccaagctcca gaaagtattg
      601 gagagtaaga tttgtgagat gatccagaag tctgtgacct ctgatctgca gccttatctc
      661 caaactctgc cagtcacagc ggatatcgac actatcctgg gcattgacta cagtttggtg
      721 gcggctcccc aagcaaaggc ccagacgctg gatgtgatgt ttaagggtga aatttttaat
      781 cggaatcacc gctccccagt cactaccccc accccgacca tgagcctacc tgaggacagt
      841 aaacaaatgg tctactttgc catctcagat caggccttca acatagccac ccgggtttac
      901 caccaggccg ggtacctgaa ctttaccatc acagatgaca tgttaccgcc tgactccaac
      961 atccggctga acaccaaggc cttccgcccc ttcactcctc tgataaccag aaagtacccc
     1021 gacatgaact tggagcttct tggaacagtg gtctctgccc cacttctgaa tgtcagtcct
     1081 gggaatctgt ccttggcccc acagatggag attgaaggct ttgtgatcct gcccagctcc
     1141 gcccgcgaat ctgtcttccg gcttggcgtg gtcacgaatg tattcgtctc attaactttt
     1201 gacaacagca aggtcaccgg gatgctgcat ccagagaagg cgcaagtgag actgatcgaa
     1261 tccaaagtcg gcatgttcaa tgtgaacctg ttccaggcat tcctcaacta ctaccttctc
     1321 aacagcctct accctgatgt caacgatgag ctggccaagg gcttccccct ccctctacca
     1381 aggcgtatta agctccacga cctcgacttc cagatccaca agaacttcct atacttgggt
     1441 gccaatgtcc agtacatgag agtctgagga caagaagaaa gatgggcctc agaggccaca
     1501 gcgggacctg ccatttgtaa ttccagatgc gtagcacatc tccagagagt ctcaaaatac
     1561 aaagaagttt ctgttcctgg ctctggtgga tcctgtcccc acagtcctct tcaccaggtg
     1621 caccctcagc ctggacttga ctctgacctc tccagggaga agccctcccc tcaccaacct
     1681 ctccagggag agcccctccc cccaccaacc tctccaggga gacccctctc ccaccactga
     1741 cctggaatca cttaaagagc aggcactgtg gttttgagtg caccttctca ccttcatgtc
     1801 tgacggagtg ctggcactta gtaggtcctc aataaatatt tatagaatga catgacaaaa
     1861 aaaaaaaaaa aaaaaaaaaa a
//
