LOCUS       NM_001129880            2635 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus LBH regulator of WNT signaling pathway (Lbh),
            mRNA.
ACCESSION   NM_001129880 XM_001066790
VERSION     NM_001129880.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2635)
  AUTHORS   Wu A, Zhang L, Chen J, Li H, Yang P, Chen M and Liu Q.
  TITLE     Limb-bud and Heart (LBH) mediates proliferation,
            fibroblast-to-myofibroblast transition and EMT-like processes in
            cardiac fibroblasts
  JOURNAL   Mol Cell Biochem 476 (7), 2685-2701 (2021)
   PUBMED   33666830
  REMARK    GeneRIF: Limb-bud and Heart (LBH) mediates proliferation,
            fibroblast-to-myofibroblast transition and EMT-like processes in
            cardiac fibroblasts.
REFERENCE   2  (bases 1 to 2635)
  AUTHORS   Lindley LE, Curtis KM, Sanchez-Mejias A, Rieger ME, Robbins DJ and
            Briegel KJ.
  TITLE     The WNT-controlled transcriptional regulator LBH is required for
            mammary stem cell expansion and maintenance of the basal lineage
  JOURNAL   Development 142 (5), 893-904 (2015)
   PUBMED   25655704
REFERENCE   3  (bases 1 to 2635)
  AUTHORS   Antoni G, Oudot-Mellakh T, Dimitromanolakis A, Germain M, Cohen W,
            Wells P, Lathrop M, Gagnon F, Morange PE and Tregouet DA.
  TITLE     Combined analysis of three genome-wide association studies on vWF
            and FVIII plasma levels
  JOURNAL   BMC Med Genet 12, 102 (2011)
   PUBMED   21810271
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2635)
  AUTHORS   Deng Y, Li Y, Fan X, Yuan W, Xie H, Mo X, Yan Y, Zhou J, Wang Y, Ye
            X, Wan Y and Wu X.
  TITLE     Synergistic efficacy of LBH and alphaB-crystallin through
            inhibiting transcriptional activities of p53 and p21
  JOURNAL   BMB Rep 43 (6), 432-437 (2010)
   PUBMED   20587334
REFERENCE   5  (bases 1 to 2635)
  AUTHORS   Ai J, Wang Y, Tan K, Deng Y, Luo N, Yuan W, Wang Z, Li Y, Wang Y,
            Mo X, Zhu C, Yin Z, Liu M and Wu X.
  TITLE     A human homolog of mouse Lbh gene, hLBH, expresses in heart and
            activates SRE and AP-1 mediated MAPK signaling pathway
  JOURNAL   Mol Biol Rep 35 (2), 179-187 (2008)
   PUBMED   17390236
REFERENCE   6  (bases 1 to 2635)
  AUTHORS   Briegel KJ and Joyner AL.
  TITLE     Identification and characterization of Lbh, a novel conserved
            nuclear protein expressed during early limb and heart development
  JOURNAL   Dev Biol 233 (2), 291-304 (2001)
   PUBMED   11336496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000163.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001129880.4.
            
            On Nov 27, 2020 this sequence version replaced NM_001129880.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK355401.1, FQ084139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               JACYVU010000163.1  22592810-22593056   c
            248-350             JACYVU010000163.1  22589926-22590028   c
            351-2635            JACYVU010000163.1  22569238-22571522   c
FEATURES             Location/Qualifiers
     source          1..2635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2635
                     /gene="Lbh"
                     /note="LBH regulator of WNT signaling pathway"
                     /db_xref="GeneID:683626"
                     /db_xref="RGD:1584525"
     exon            1..247
                     /gene="Lbh"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..539
                     /gene="Lbh"
                     /note="limb bud and heart development"
                     /codon_start=1
                     /product="protein LBH"
                     /protein_id="NP_001123352.1"
                     /db_xref="GeneID:683626"
                     /db_xref="RGD:1584525"
                     /translation="MSVYFPIHCSDYLRSAEMTEVMMNAPSMEEIGLSPRKDGLSYQI
                     FPDPSDFDRCCKLKDRLPSIVVEPTEGEVESGELRWPPEEFLVQEDEQDNCEETTKEK
                     KDQ"
     exon            248..350
                     /gene="Lbh"
                     /inference="alignment:Splign:2.1.0"
     exon            351..2635
                     /gene="Lbh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagagctt ggtctgcact gccgacgccg ctggcagcga ggctgtctcc ggaaggcaga
       61 cctgcgataa cccagtgccc gctctcggct gcccgttgct ctcctctgcg cccctgccaa
      121 tctcattcag gactcagtga ccgttttttt tttttttttt gttttgtttt gttttgtttt
      181 tcttaatcac aagggcgtgg gtcagcctcc cctaggactt catgtctgta tatttcccca
      241 ttcactgctc tgactatctg agatcggctg agatgactga ggtgatgatg aatgctccct
      301 ccatggaaga gattggcctc agcccccgca aggatggcct ttcctatcag atctttcccg
      361 acccatcaga ttttgaccgc tgttgcaaac tgaaggaccg cctgccctcc atagtggtgg
      421 aacccacaga aggggaggtg gagagtgggg agctccggtg gccccctgag gaattcctgg
      481 tccaggagga tgagcaggac aactgtgaag agacaacaaa agaaaagaag gatcagtaga
      541 gtccctcgcg ggctcgcccg ggtcgtgcca gccagcatac ctgaactgtt tttcccacgg
      601 cgatgggaga agagtgagac acagtcattc tgaaaatgtc aaatgaggct tccgtttttt
      661 gcacctgaaa atcaccgagt cggttttctt tctttctttc cttttttttt ttttttgtct
      721 ttttgttttg ttttgttttt gattcgttga gcaatggagc cctctgacaa cttgcaaggc
      781 tgagaaagga agctagctgc tgagaacagg ggttggggtg gggggaaggg ggtgctgctt
      841 ctaagatccc tatctgaact ctagtgccag aggccagagg cagtgctatg tgtgtgtgtt
      901 ggggaggggg tgggttctgg ctgaggtgga tgaggaaatg agcgagaaat attttggatt
      961 gaaacaacaa caacaacaaa aaacaaaaca aaccccacac ttttaaagag aagtacagct
     1021 aggaagtgct tctctccctg catttactct ggctactggg gcgtctttat ctcctgctct
     1081 gttggtcaaa gccaccagcc tttgctttcc tttcaagtgt gtttggtcgc ccgcagagaa
     1141 atagggtctg gagaagctgc ctatgaagcc agatggaggg atacataaga aaggaagatc
     1201 ccacctgtcc ttcttatgga ctctggcccc agctgcttca ggctctcgga gcccccagga
     1261 gctggaaggc tttaaggcat agtactcttg agttttctcc ctatttgccc ctctttgcct
     1321 cccggtatat agggggaaca gccagagcat ttcctgccct tgtgggacat tccaaggctg
     1381 caacctgaac agagagtgcc accttccact gtgggtctcc caagaattct tatgtagtct
     1441 ccatggagca aaagggtaga agagtcagct ctcccaggcc tgccctttct tctcctttgg
     1501 ccacagcagt taggtggatg gtccccagct ctgctgtggc cgtcatcatc cttctgacct
     1561 gcagcaggac cactccagtg gggatcccag tctggcttcc atgggcgctc aaagcagagt
     1621 gtgtttcctg gttggaagtt ggctagtggg tgtccatgca ggaaccatgg tgccgcattg
     1681 atatgttaaa gttcgccggt gggtaccagg cctccggtgg agcagctgtg ggatccagtt
     1741 tgagacagta gctgttatga gatcactgct tctcctcatc ttgctcctga gcacaggctg
     1801 ggagaagaca tggggtgcac tggggtatcc ttgtagaata gcagccttta ttccttcctc
     1861 accttacctg tctctggaag ggcagcaatt gcatgggaca attaacatct ggacttagcc
     1921 tctgatcata gctcagaacc ttctggaata gcgggttaga ggacagaatt ttcagagcag
     1981 ggctgtttgg tcaagaggtg gacttaagcc ttccttgggc ttcacttggc caactgaggc
     2041 actcacaatg tcccctcacg tctctgtcaa tccaggttga cccccatctt tggactagtg
     2101 tgtctggttc tatttaatac ctcaaagtca gtgtggctct ggggcacgtt ggggcaagag
     2161 cgtgggggtg tgctgttgac acggcattca gcaaggtttg gttctgggat gccgatggtc
     2221 accctcccct gccccccgcc tcttccctct gtcgtctgcc tgtgatacac accgatggca
     2281 ataacttttt tctggctcct tgcagaagtg ggagagagct gcagccaatc ccaccatggg
     2341 ggagcttctc tctcttgctt ccactctgtt ctgttttggc tacagagatc tgttcatcct
     2401 tctccccttc tcccacggca tttctcgtcc ctcgcctccc tttatggaca ggtgtttggc
     2461 ctttgaaatt cctgtgtttt ggtgtcttct cacccctacc ccgatctgtc ttggtcttgc
     2521 cgtgtgacgg gatgtgcttg taaatccagt atcaatcagc tttgtgtata tgtgtgtctg
     2581 tggggtggct tcttcctttt gccggtcact agaccatgtt gtacaaccgt gtgtt
//
