LOCUS       NM_001107267            4958 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus large tumor suppressor kinase 2 (Lats2), mRNA.
ACCESSION   NM_001107267 XM_001063422 XM_224169
VERSION     NM_001107267.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4958)
  AUTHORS   Du YL, Liang Y, Shi GQ, Cao Y, Qiu J, Yuan L, Yong Z, Liu L and Li
            J.
  TITLE     LINC00689 participates in proliferation, chemoresistance and
            metastasis via miR-31-5p/YAP/beta-catenin axis in colorectal cancer
  JOURNAL   Exp Cell Res 395 (1), 112176 (2020)
   PUBMED   32682784
REFERENCE   2  (bases 1 to 4958)
  AUTHORS   Tang F, Zhao L, Yu Q, Liu T, Gong H, Liu Z and Li Q.
  TITLE     Upregulation of miR-215 attenuates propofol-induced apoptosis and
            oxidative stress in developing neurons by targeting LATS2
  JOURNAL   Mol Med 26 (1), 38 (2020)
   PUBMED   32375631
  REMARK    GeneRIF: Upregulation of miR-215 attenuates propofol-induced
            apoptosis and oxidative stress in developing neurons by targeting
            LATS2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4958)
  AUTHORS   Gao S, Chen T, Hao Y, Zhang F, Tang X, Wang D, Wei Z and Qi J.
  TITLE     Exosomal miR-135a derived from human amnion mesenchymal stem cells
            promotes cutaneous wound healing in rats and fibroblast migration
            by directly inhibiting LATS2 expression
  JOURNAL   Stem Cell Res Ther 11 (1), 56 (2020)
   PUBMED   32054526
  REMARK    GeneRIF: Exosomal miR-135a derived from human amnion mesenchymal
            stem cells promotes cutaneous wound healing in rats and fibroblast
            migration by directly inhibiting LATS2 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4958)
  AUTHORS   Tian Y, Lv W, Lu C, Zhao X, Zhang C and Song H.
  TITLE     LATS2 promotes cardiomyocyte H9C2 cells apoptosis via the
            Prx3-Mfn2-mitophagy pathways
  JOURNAL   J Recept Signal Transduct Res 39 (5-6), 470-478 (2019)
   PUBMED   31829064
  REMARK    GeneRIF: The overexpression of LATS2 induces mitochondrial stress
            by repressing protective mitophagy in a manner dependent on
            Prx3-Mfn2 pathways, thus reducing the survival of H9C2 cells.
REFERENCE   5  (bases 1 to 4958)
  AUTHORS   Lorthongpanich C, Messerschmidt DM, Chan SW, Hong W, Knowles BB and
            Solter D.
  TITLE     Temporal reduction of LATS kinases in the early preimplantation
            embryo prevents ICM lineage differentiation
  JOURNAL   Genes Dev 27 (13), 1441-1446 (2013)
   PUBMED   23824537
REFERENCE   6  (bases 1 to 4958)
  AUTHORS   McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A,
            Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam
            F, Squire J, Bruneau BG, Hande MP and Hakem R.
  TITLE     Lats2/Kpm is required for embryonic development, proliferation
            control and genomic integrity
  JOURNAL   EMBO J 23 (18), 3677-3688 (2004)
   PUBMED   15343267
REFERENCE   7  (bases 1 to 4958)
  AUTHORS   Powzaniuk M, McElwee-Witmer S, Vogel RL, Hayami T, Rutledge SJ,
            Chen F, Harada S, Schmidt A, Rodan GA, Freedman LP and Bai C.
  TITLE     The LATS2/KPM tumor suppressor is a negative regulator of the
            androgen receptor
  JOURNAL   Mol Endocrinol 18 (8), 2011-2023 (2004)
   PUBMED   15131260
REFERENCE   8  (bases 1 to 4958)
  AUTHORS   Li Y, Pei J, Xia H, Ke H, Wang H and Tao W.
  TITLE     Lats2, a putative tumor suppressor, inhibits G1/S transition
  JOURNAL   Oncogene 22 (28), 4398-4405 (2003)
   PUBMED   12853976
REFERENCE   9  (bases 1 to 4958)
  AUTHORS   Hori T, Takaori-Kondo A, Kamikubo Y and Uchiyama T.
  TITLE     Molecular cloning of a novel human protein kinase, kpm, that is
            homologous to warts/lats, a Drosophila tumor suppressor
  JOURNAL   Oncogene 19 (27), 3101-3109 (2000)
   PUBMED   10871863
REFERENCE   10 (bases 1 to 4958)
  AUTHORS   Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi
            H, Endo Y, Toji S, Tanaka H, Nishimune Y and Nojima H.
  TITLE     Structure, expression, and chromosome mapping of LATS2, a mammalian
            homologue of the Drosophila tumor suppressor gene lats/warts
  JOURNAL   Genomics 63 (2), 263-270 (2000)
   PUBMED   10673337
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474049.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001063422.1, XM_224169.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..4958
                     /gene="Lats2"
                     /note="large tumor suppressor kinase 2"
                     /db_xref="GeneID:305922"
                     /db_xref="RGD:1305906"
     exon            1..504
                     /gene="Lats2"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..3291
                     /gene="Lats2"
                     /EC_number="2.7.11.1"
                     /note="large tumor suppressor, homolog 2; large tumor
                     suppressor 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LATS2"
                     /protein_id="NP_001100737.1"
                     /db_xref="GeneID:305922"
                     /db_xref="RGD:1305906"
                     /translation="MRPKTFPATTYSGNSRQRLQEIREGLKQPAKSSTQGLLVGPNSD
                     TSSLDAKVLGNKDASRQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQ
                     MLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGK
                     GLVPTAVTRRPSFEGTGEAFPSHHQLGGANYEGPAALEEMPRQYLDFLFPGASVHGAP
                     AHQHPPKGYSTAVDAGTHFPGAHYGRAHLLSEQPGYGVQRSPSFQSKTPPDTYSSLAK
                     AQGGPPASLTFPAHAGLYTTSHHKPAAAVPGAHPLHVLGTRGPTFTGDSSTQAVLAPS
                     RNSLNNDLYELGSPVPWPAAPLARRDSLQKQSLEASRPHVAFRAGPSRTNSFSSPQPE
                     PSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPTAPAAAEGLESK
                     EGSAGPPPLDMDFGGSERRCPPPPYPKHLLLPSKSEQYSAGLDRLCTGVEQSLRGGTE
                     QDRNDKGHKGAKGDKAGRDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQ
                     HVENVIKTYQQKVSRRLQLEQEMAKAGLCETEQEQMRKILYQKESNYNRLKRAKMDKS
                     MFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEAD
                     NEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESV
                     HKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPGD
                     LWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWS
                     VGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQVKLSAEARDLITKLCCAAD
                     CRLGRDGADDLKAHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEESPWHEA
                     SGESAKAWDTLASPNSKHPEHAFYEFTFRRFFDDNGYPFRCPKPSEPAESADPGDAEL
                     GGAVEGCQPVYV"
     exon            505..637
                     /gene="Lats2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..1935
                     /gene="Lats2"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2518
                     /gene="Lats2"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2701
                     /gene="Lats2"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2808
                     /gene="Lats2"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..4958
                     /gene="Lats2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagtgatgg tcttcaaaat gaaaactctg gaaaatttta ggttctcttt aggagctaca
       61 gaaattgaag gaagttgttc tggaagcatg tttacaactc actgacagta ttacctgttc
      121 ttaagaagat tgtatttatg gtaaaaggaa actggactaa cgatgaggcc aaagactttt
      181 cctgctacaa cttactctgg aaatagccgg cagcgactgc aagagattcg agaaggactg
      241 aagcagccgg ccaagtcttc cacccagggg ctgctggtgg gaccaaacag tgacacttct
      301 tccctggatg ccaaagtcct ggggaacaaa gatgcctcca ggcagcagca gatgagagcc
      361 accccgaagt ttggacctta tcaaaaagcg ctcagggaaa tccgatattc cctcctgcct
      421 tttgccaatg agtcaggcac gtcggcagct gcagaggtga accggcagat gctgcaggag
      481 ttggtgaatg caggatgtga ccaggagatg gctggcagag cgctcaagca gacaggcagt
      541 aggagtattg aagccgcctt ggagtacatc agtaagatgg gctacttgga ccccaggaat
      601 gagcaaattg tgcgagtcat caagcagacc tccccaggaa agggcctggt gcccactgca
      661 gtgactcgac gacccagctt tgagggcaca ggggaagcat tcccatccca ccaccagttg
      721 ggcggtgcaa actatgaggg ccccgctgcc ctggaggaga tgccacggca atatttagac
      781 ttcctcttcc ccggggccag cgtccacggc gccccggctc accagcatcc ccccaaaggc
      841 tacagcactg cagtggatgc gggcacacac ttcccaggcg cacactatgg tcgtgctcat
      901 ctactgtcag agcagcctgg gtatggggtt cagcgcagcc cctccttcca gagcaagacg
      961 ccaccagaca cctattccag cctggccaag gcccagggtg gccctcctgc cagcctcacc
     1021 ttccctgccc atgctggtct gtacaccacc tcgcaccaca agccagcggc tgcagtacct
     1081 ggggcccacc ccttacatgt gttgggcacc cggggcccca cgttcactgg ggacagctct
     1141 acgcaggccg ttctggcacc gtccaggaac agcctcaata atgacttgta cgagctgggc
     1201 tctcccgtgc cctggcccgc agctccactg gcacgccgtg actcgctgca gaagcagagt
     1261 ctagaggcct cccggccgca tgtggccttc cgggctgggc ccagcaggac caactccttc
     1321 agcagcccac aacctgagcc ctcactgccc gcccccaaca cagtcactgc tgtgacggct
     1381 gcacacatcc ttcaccctgt gaagagcgtg cgcgtgctgc ggcccgagcc tcagacagcc
     1441 gtggggccct cgcaccccgc ctgggtgcct gcccccacag cacctgcagc cgccgagggc
     1501 ctggagagca aggagggcag tgcaggccca cccccgctgg atatggactt cgggggctcc
     1561 gagcgcaggt gcccaccgcc tccttaccca aagcacttgc tgctgcccag taagtctgag
     1621 cagtacagcg ctggtctgga ccgcctgtgc accggtgtgg agcagagtct gcgcgggggc
     1681 accgagcaag acaggaatga caagggccac aagggtgcta agggggacaa agctggcagg
     1741 gacaaaaagc agatccagac ctccccagtg cctgtccgca agaatagcag ggatgaagag
     1801 aagagagagt ctcgaatcaa gagttactcc ccatatgcct tcaaattctt catggaacaa
     1861 catgtggaga atgtcatcaa aacctaccag cagaaggtca gccggaggct acagctggag
     1921 caggaaatgg ccaaagctgg actgtgcgag actgagcagg agcagatgag gaagatcctc
     1981 taccagaagg agtcgaacta caacagactc aagagggcca agatggacaa gtccatgttt
     2041 gtgaaaatca aaactctggg cattggtgcc tttggagaag tgtgccttgc ctgtaaggtg
     2101 gatactcacg ctctgtatgc catgaagacg ctgaggaaaa aagatgtcct gaaccggaac
     2161 caagtggccc atgtcaaggc tgagagggac atcctggctg aagcagacaa tgagtgggtg
     2221 gtcaaactct actattcctt ccaggacaag gacagcctgt actttgtgat ggactacata
     2281 cctggtgggg acatgatgag cctgctgatc cggatggagg tcttccctga acacctcgcc
     2341 cgcttctaca tcgcagagct gactctggcc attgagagtg tgcacaagat gggcttcatc
     2401 cacagggaca tcaagcctga caacatcttg attgacctgg atggtcatat taagctgacc
     2461 gattttggcc tctgcactgg attcaggtgg actcacaatt ccaagtacta ccagaaaggg
     2521 aaccacatca gacaggacag catggagcct ggtgacctct gggacgacgt ttccaactgt
     2581 cgttgtggag acaggttgaa gaccctggag cagagagcac agaagcagca ccagaggtgc
     2641 ctggcacatt ctctggttgg gacaccaaat tacattgctc ctgaggtgct tcttcgcaaa
     2701 gggtacacac agctctgtga ctggtggagt gtcggtgtga ttctttttga gatgctggtt
     2761 gggcagccac ctttcttggc gcccaccccc acagaaaccc agctgaaggt gatcaactgg
     2821 gagaacacgc tgcacatccc tacgcaggtg aaactcagtg ctgaggcccg agacctcatc
     2881 accaagctgt gctgcgcggc tgactgccgc ctgggcaggg acggggcaga tgacctcaag
     2941 gcacacccgt tcttcagcac catcgacttt tcccgtgaca tccggaaaca gcctgcaccc
     3001 tacgtcccca ccatcagcca ccccatggac acctccaatt ttgacccagt ggatgaagaa
     3061 agcccctggc acgaggccag cggagaaagt gccaaggcct gggacacgct ggcgtccccc
     3121 aacagcaagc acccagagca cgccttctat gagttcacct tccgcaggtt cttcgacgac
     3181 aatggctatc ccttccggtg cccgaagccc tcagagccgg ctgagagtgc agacccaggg
     3241 gatgcagagt taggaggtgc ggtcgagggc tgccagccag tgtatgtgta aggggcccgt
     3301 ggcctcagtt gatcacaact tgaggaaacc ccaaaccaga tgtttttcaa aagacaaact
     3361 gaagcttaga aatccttcat ttttagctct ggttaatggg caacaggaag ggtcaccatg
     3421 acatcgaatt atccctttga ggactttcac tgcgttaaaa caatattttt aaaaatttag
     3481 tacagtatgg aaagagcact tattttatgg acacccattt tttcttacta aattataagg
     3541 actgactgac aaaccatgct gctgttactc ccgttgtgtc gtatctgata gcacttgtcc
     3601 acattaggaa aggaagccct gaagaccgcg tggtgagaag tctgtgcaat aagagagaat
     3661 gaggccgggc tctgctccaa gtcaggagga ccgtctatct acacagtggc tttgttttgc
     3721 attttcccac atttcaaatt gtgatgtaat gttaaaaagc tgcttttgtg tgttttttct
     3781 ttgcatatta gagttcctag agagtgagcg cagagacggt gggtgtgact ccggtgtctg
     3841 gtgtggagag agagtactgc atgagcagag cttcctagtc taaagttacc gtatcttgcc
     3901 attcacagca ggtcctgtga atacgttttt taaatgaggt attctagaca gtgtgcagat
     3961 aatgtattgt gtgggtgatg attgtagccc ttattgttaa agaagtgcat atgtataact
     4021 gaagtgtgac ttttttttta atgtgtgtgt cttgaatatg actgggttct ttgggaggca
     4081 aatgtaaacg tttgtcatat ataaaacaca tcaaaaggga ttaaatcagc tatgccaaaa
     4141 cattggacgt aattagagcg ttttgtccat ttctctagtc cagtacgctg tcaggcttgg
     4201 tgtgtagaca gctagagctg ggaccctgct acttcatatc gtcacataca gggttcccac
     4261 agcaaaaggt gatgtaagtc cttcctgctt tctcgacagc caggaggtcc cgtgaaactc
     4321 agttctctct gcatctttca tatgtgaggt gtctgtcaca tctcaatgtg gcttaatcaa
     4381 tacgtttttc caactttgta aaaagaaaaa cagattcttc gaagtgacat tggagtacaa
     4441 aaacaagcca tacttttttt cttagacata taggtgtgta tataactata gataaacaca
     4501 caaaatattc cttatttcaa attagtacgc ttcctacata aggtgattta tatttgagta
     4561 cattcaattt cttttgcttt ttaaaggatg gaatgcatca cattttcgtc atactattcc
     4621 acatactttc attgaggttc ttagcacagt gtatccgtta cttaatatgt atctaggcag
     4681 aaacacttac aaatttatct atgtctaaga aacattcccg tgtcctggtt tacatttgta
     4741 tgaatggcat gttctggtct gctgtgcttg tattgtgact tacagtattc ttgctatttt
     4801 gtagtaatgc cgtgttattt acagcgctct gacatagttt catgtggtag gttctttctc
     4861 aggaactcaa tttaactatt atttattgat atatcattgc ctttgaaagc ttctactggc
     4921 acaatttatt attaaaactt taaaccctag tctcttca
//
